Cognitive disorder

This Phase 1 trial tests an experimental vaccine called AV-1980R that targets tau protein, a key player in Alzheimer's disease. The study enrolls 48 cognitively healthy adults aged 65-80 who have biological signs of early Alzheimer's. Researchers will check if the vaccine is safe…

This study tests an investigational drug called KarXT to see if it can prevent the return of psychosis (like hallucinations or delusions) in people with Alzheimer's disease. About 410 participants aged 55-90 will receive either KarXT or a placebo for 38 weeks. The main goal is to…

This study tests whether listening to a specific 40 Hz sound for one hour a day, five days a week over 12 weeks, can improve memory, brain activity, sleep, and quality of life in older adults with mild cognitive impairment or mild dementia. Half of the participants will receive t…

This trial is testing whether huperzine A, given as a controlled-release tablet, can improve thinking and daily living skills in people with mild-to-moderate Alzheimer's dementia. Participants will receive either huperzine A, a placebo, or an existing Alzheimer's drug (donepezil)…

This study tests an experimental drug called senicapoc in people with mild Alzheimer's or mild cognitive impairment. The goal is to see if it can reduce brain inflammation and slow down memory loss. About 55 participants will take either the drug or a placebo for 52 weeks, with r…

This study tests an experimental drug called ABBV-1758 in about 210 people with Alzheimer's disease. The drug is given by IV or injection every 4 weeks for 24 weeks. Researchers are checking if it is safe and whether it can reduce amyloid plaques in the brain, a hallmark of Alzhe…

This early-stage study tests a new drug called ALN-5288 in 50 adults with mild cognitive impairment or dementia caused by Alzheimer's disease. The drug is given via a spinal injection and aims to safely reduce tau protein levels in the brain. The main goal is to check safety and …

This study tests whether a combination drug called OLZ/SAM (olanzapine plus samidorphan) causes less weight gain than olanzapine alone in teenagers with schizophrenia or bipolar I disorder. About 220 teens aged 10-17 will take either the combo or olanzapine for 52 weeks. The main…

This early-stage study tests a new drug called VV119 in healthy adults and people with schizophrenia. The main goal is to check if the drug is safe and how the body processes it. About 40 participants will take multiple doses to find the right amount for future studies.

This study tests an experimental drug called MK-2214 in 340 people with early Alzheimer's disease. The goal is to see if it can slow the buildup of a harmful protein called tau in the brain, which damages brain cells. Participants will receive either the drug or a placebo, and re…

This trial is testing the safety of a medication called lumateperone in children and teenagers who have schizophrenia, bipolar disorder, or autism spectrum disorder. Participants take the drug once daily for 26 weeks, and researchers monitor for side effects. The goal is to see i…

This study is checking the long-term safety of a drug called KarXT in teenagers (13-17) with schizophrenia, and a combination of KarXT and KarX-EC in children (5-17) with irritability linked to autism. About 400 participants who completed earlier studies will take the drug for up…

This phase 3 trial is testing whether the drug KarXT can safely and effectively treat schizophrenia in adolescents aged 13 to 17. About 166 teens will receive either KarXT or a placebo, and researchers will track changes in symptoms like delusions and social withdrawal. The goal …

This early-phase trial tests a gene therapy called AVB-101 for people with frontotemporal dementia caused by GRN gene mutations. The therapy delivers a working copy of the GRN gene directly into the brain during a one-time procedure. The study will enroll 18 adults aged 30-75 to …

This study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will …

This study tests whether a combination of two drugs, KarXT and KarX-EC, can improve cognitive impairment in people with mild to moderate Alzheimer's disease. About 586 participants will receive either the drug combo or a placebo. The trial measures changes in thinking, daily func…

This study tests a drug called mivelsiran in 58 adults with Down syndrome who have early-stage Alzheimer's. Participants receive either the drug or a placebo via injection into the spine every few months for two years. The goal is to see if the drug can reduce brain changes linke…

This early-stage trial tests a drug called ALN-APP (mivelsiran) in 60 adults with mild cognitive impairment or mild dementia due to early-onset Alzheimer's disease. The drug is given via a spinal injection to see if it safely lowers certain proteins linked to Alzheimer's in the b…

This study compares a new, lower-energy seizure therapy (LAP-ST) to standard electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression, bipolar disorder, or schizoaffective disorder. The goal is to see if the gentler approach works just as w…

This trial tests whether 16 weeks of high-intensity interval training (HIIT) can improve blood vessel function and thinking skills in adults aged 50 and older living with HIV. Participants are randomly assigned to either HIIT or continuous moderate exercise. The study also explor…

This study tests a program called LAGOM designed to improve heart health and quality of life for people with psychotic disorders. 644 adults from six clinics in Gothenburg will either receive the LAGOM program or standard care. The program includes regular check-ups, motivational…

This phase 2 trial tests whether an oral drug called SAR448851 can slow the progression of early Alzheimer's disease. It includes people with mild cognitive impairment or mild dementia due to Alzheimer's, who have brain amyloid plaques. Participants receive either the drug or a p…

This trial tests whether a wearable device called RGn600 can slow cognitive decline in people with mild-to-moderate Alzheimer's disease. The device, worn as a helmet and abdominal belt, delivers red-to-near-infrared light and static magnetic fields, aiming to reduce inflammation …

This study tests a drug called LHP588 in 300 people with mild-to-moderate Alzheimer's who also have a gum infection from P. gingivalis bacteria. The drug aims to target that bacteria to slow down memory and thinking decline. Participants take a daily capsule for up to 48 weeks, a…

This study tests whether adding brenipatide to standard schizophrenia medication is safe and effective. About 450 adults with schizophrenia will receive either brenipatide or a placebo for up to 12 months. The study looks at weight changes, cognitive function, and time to relapse…

This study tests two approaches to improve thinking and reduce inflammation in people with HIV who drink alcohol. One approach uses a probiotic supplement to restore healthy gut bacteria. The other uses a mild electrical device worn on the ear to stimulate a nerve linked to infla…

This study tests donanemab, an experimental drug, against a placebo in 140 Chinese adults who show early signs of Alzheimer's risk. Participants receive the drug intravenously every few weeks for up to 3 years. The goal is to see if donanemab can delay memory loss and help mainta…

This phase 2 trial tests whether donanemab, an antibody given by IV, can slow worsening of thinking and daily function in people with early cognitive decline and Lewy body dementia. The study enrolls 350 participants who also have signs of two brain proteins (amyloid and alpha-sy…

This Phase 3 trial tests trontinemab, an antibody given by IV, in 800 people with early Alzheimer's (mild cognitive impairment to mild dementia). Half get the drug, half get a placebo, for 72 weeks. The goal is to see if it slows decline in memory, thinking, and daily activities.

This Phase 3 trial tests whether trontinemab can slow down Alzheimer's in people with early symptoms like mild memory problems. About 800 volunteers will receive either the drug or a placebo by IV for 72 weeks. The study measures changes in thinking, daily function, and safety.

This trial tests whether a natural compound from citrus fruits, hesperidin, can improve cognitive function in overweight and obese adults aged 55 to 75. Participants take either a placebo, a low dose, or a high dose of hesperidin daily for 10 weeks. The study measures changes in …

This study tests whether combining yoga with a mild electrical brain stimulation technique, called tDCS, can improve thinking and memory in people with psychosis. Participants will be randomly assigned to receive either active tDCS during yoga or a sham (inactive) version, and re…

This trial tests whether a single dose of levetiracetam, a drug used for epilepsy, can reduce overactivity in the hippocampus — a brain area linked to thinking and memory problems in psychosis. People aged 18–40 who are at risk of psychosis will take either the drug or a placebo …

This expanded access program offers continued treatment with OLZ/SAM, a combination of olanzapine and samidorphan, to adolescents with schizophrenia or bipolar I disorder who have already completed a year-long study of the drug. The goal is to provide ongoing access to the medica…

This study tests whether combining aerobic exercise with computerized cognitive training, both delivered via telehealth, can improve thinking and motivation in people who have recently experienced a first episode of schizophrenia. About 100 participants will receive cognitive tra…

This study tests whether the diabetes drug metformin can prevent blood sugar increases caused by statins in people with schizophrenia. Researchers will give 400 patients either metformin or a placebo alongside atorvastatin for six months. The goal is to see if metformin helps kee…

This study is for people aged 18-35 experiencing their first episode of psychosis. Researchers will use genetic tests and MRI brain scans to see if certain markers can predict which antipsychotic drug (aripiprazole, risperidone, or clozapine) will work best. The goal is to improv…

This study tests the drug acoramidis in people with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal proteins build up in the heart, weakening it. Over 36 months, researchers measure whether acoramidis improves heart function and structure using cardiac …

This study tests whether combining a daily oral diabetes medication (semaglutide) with a nasal insulin spray can improve memory, thinking, and blood flow in the brain. The trial enrolls older adults with mild cognitive impairment and metabolic syndrome, a group at high risk for d…

This phase 2 trial investigates whether ozanimod, an oral drug that regulates the immune system, can reduce brain amyloid plaques and inflammation in people with moderate Alzheimer's disease. Forty participants aged 55 to 80 will receive either ozanimod or standard Alzheimer's me…

This Phase 3 trial is testing whether two existing drugs—atomoxetine, typically used for ADHD, and metformin, a diabetes medication—can slow cognitive and functional decline in people with Alzheimer's disease. Around 1,200 participants aged 55 and older with mild to moderate Alzh…

This phase 2 trial tests whether ublituximab, an immune-modulating drug, can reduce symptoms in people with treatment-resistant schizophrenia. Participants receive the drug by IV infusion, and researchers measure changes in symptom scores over time. The goal is to see if targetin…

This study tests a Transition Care Team (TCT) designed to help people with first episode psychosis successfully move from hospital to outpatient mental health services. The TCT provides short-term support including therapy, case management, and coordination with community program…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in people with schizophrenia. Thirty participants receive both real and sham stimulation in separate sessions while pe…

This study tests whether a non-invasive brain stimulation technique called closed-loop transcranial alternating current stimulation (tACS) can improve memory and brain activity in people with mild cognitive impairment likely due to Alzheimer's disease. Participants receive four d…

This study tests whether a drug called CORT108297, which blocks a stress hormone, can improve memory and thinking in people with mild cognitive impairment or those at risk for Alzheimer's disease. Participants take the drug or a placebo for two weeks, then complete memory and att…

This study tests whether adding a four-week aerobic exercise program to a new antipsychotic medication (olanzapine-samidorphan) can prevent the early weight gain often seen with these drugs. Thirty adults with schizophrenia, schizoaffective disorder, or bipolar disorder will take…

This study compares two ways of using a breathing machine (mechanical ventilator) in adults who need help breathing. One mode lets the patient trigger each breath, while the other delivers a set number of breaths regardless of patient effort. The goal is to see which approach lea…

This study tests whether personalized nutrition counseling can lower inflammation in adults with schizophrenia who are on long-term antipsychotic medication. Participants receive either a tailored diet plan or standard hospital meals. The goal is to see if better nutrition can re…

This early-stage trial tests an investigational drug called SSGJ-716, given as an injection, to see if it is safe and tolerable. The study first enrolls healthy adults to test a single dose, then moves to people with moderate-to-severe atopic dermatitis (a type of eczema) who rec…

This study tests whether very low doses of radiation delivered to the whole brain are safe and can help preserve thinking and memory in people with Alzheimer's disease or certain dementias with inflammation. Participants receive an initial course of 10 radiation sessions, followe…

This study tests a single intravenous dose of an experimental drug called CGB3002 in healthy adults aged 18 to 55. The main goal is to see if the drug is safe and how the body processes it. This is a first step toward possibly developing a treatment for Alzheimer's disease.

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve the brain's wiring and connectivity in people with schizophrenia. Participants receive multiple sessions of rTMS using a special coil designe…

This study tests whether combining a non-invasive brain stimulation technique called rTMS with computer-based cognitive training can strengthen brain connections in people with schizophrenia. Participants will receive up to 10 sessions over two weeks, and researchers will use bra…

This phase 4 trial tests lecanemab, an antibody treatment for Alzheimer's disease, in 100 people with mild cognitive impairment or mild Alzheimer's dementia. Participants receive lecanemab infusions every two weeks for 18 months. The study also evaluates a new blood test that use…

This study tests whether people with Alzheimer's who already took the drug donanemab benefit from getting it just once a year. About 550 volunteers who finished a previous donanemab study will receive either the drug or a placebo for up to 2.5 years. Researchers will track change…

This early-stage trial tests whether the experimental drug aticaprant is safe and tolerable when added to standard antipsychotic treatment for schizophrenia. About 64 clinically stable outpatients will receive either aticaprant or a placebo. The main goals are to see if the study…

This study explores whether personalized exercise and music-based therapy can help prevent dementia in older veterans who show early warning signs. Participants have motoric cognitive risk syndrome, meaning they walk slowly and have memory or concentration concerns. The study tes…

This study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin o…

This study tests whether a special probiotic supplement can change fat-related molecules in the blood of people with ALS and frontotemporal dementia (FTD). Researchers will compare those taking the probiotic to those taking a placebo over 24 weeks. The goal is to see if the probi…

This study tests whether deep brain stimulation (DBS) can help people with schizophrenia whose symptoms haven't improved with medication. First, doctors map the brain using electrodes to find the problem areas. Then, they implant a device that delivers mild electrical pulses to t…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This trial tests a gene therapy for metachromatic leukodystrophy (MLD), a rare and life-threatening genetic disorder that damages the nervous system. The treatment uses a lentivirus to deliver a working copy of the ARSA gene directly into the spinal fluid and bloodstream. Up to 1…

This study tests an experimental oral drug called KDS2010 in people with mild cognitive impairment or mild dementia due to Alzheimer's disease. Participants take either a low dose, a higher dose, or a placebo daily for 24 weeks. Researchers measure changes in memory, thinking, an…

This pilot study explores whether computer-assisted music remediation can improve memory, attention, and thinking in young people aged 18 to 30 who have had a first psychotic episode. Participants attend weekly group sessions using music software to practice memory and executive …

This study tests whether adding sodium benzoate—a substance that affects brain glutamate—to standard antipsychotic medication can improve symptoms and thinking in people with treatment-resistant schizophrenia. About 90 adults who have not responded well to at least two antipsycho…

This early-phase trial tests whether combining interleukin-2 (IL-2) with semaglutide (a diabetes drug) can safely reduce harmful inflammation in the brains of people with Alzheimer's disease. The study will enroll 30 adults aged 50–86 with mild-to-moderate Alzheimer's. Participan…

This study tests whether cannabidiol (CBD) can slow the progression of Alzheimer's disease in people aged 55-85 with mild cognitive impairment (early memory loss). Over 236 participants will receive either CBD or a placebo for a period, and researchers will measure changes in mem…

This study tests whether a daily polyphenol supplement (like berry capsules) can slow cognitive decline in 300 older adults at risk for Alzheimer's. Participants take the supplement or a placebo for 12 months, providing blood, stool, and brain scans. The goal is to see if the sup…

This trial investigates whether playing a virtual reality (VR) cognitive stimulation game can help older adults with mild memory problems stay mentally sharp and avoid delirium after major surgery. Participants, aged 65 and older, will use an Oculus Quest 2 headset for 20 minutes…

This study tests whether taking silkworm pupa powder daily for four months can improve thinking, daily living, and nutrition in people with Alzheimer's disease. About 300 participants will receive either the powder or a placebo. Researchers will track changes in memory, frailty, …

This pilot study is testing a brain implant called deep brain stimulation (DBS) for people with schizophrenia that hasn't improved with standard treatments. The device delivers electrical pulses to specific brain areas to try to reduce psychotic symptoms. Ten participants will be…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study tests whether adding a single infusion of human stem cells to standard antibody therapy can slow memory and thinking decline in people with mild Alzheimer's or mild cognitive impairment. Ten participants aged 55-90 who are already on antibody treatment will receive one…

This study tests whether adding lumateperone (Caplyta) to clozapine can reduce common side effects like weight gain and high blood sugar in people with schizophrenia or schizoaffective disorder. Fifty participants will take either lumateperone or a placebo for 12 weeks while cont…

This study tests a drug called lecanemab in 200 people with early-stage Alzheimer's. Participants receive either lecanemab or standard care for 24 months. Researchers use eye and brain scans along with memory tests to see if the drug slows the disease and to check for side effect…

This study tests whether giving blood transfusions quickly when hemoglobin drops can prevent delirium (sudden confusion) in patients 75 and older after hip fracture surgery. About 198 participants will be randomly assigned to either early transfusion or standard care. Researchers…

This study tests whether a drug called leronlimab is safe for people with mild Alzheimer's or mild cognitive impairment. Twenty volunteers over age 50 will receive weekly injections for 12 weeks. Researchers will use brain scans and blood tests to see if the drug lowers brain inf…

This study tests a device called HiDO-ALZ that uses facial recognition and video to help people with dementia take their daily medications correctly. About 50 participants will use the device at home, and a study partner will get alerts if doses are missed. Researchers will measu…

This study explores whether daily mindfulness practice, combined with heart rate biofeedback, can improve attention and memory in adults aged 50-70. Participants will practice breathing patterns that either increase or decrease heart rate swings. Researchers will measure changes …

This study tests a smartphone app that uses motion-sensing cognitive games and interactive stories to help people with schizophrenia improve their thinking, mood, and daily skills. 84 hospitalized adults will be randomly assigned to use the app or receive standard care. The goal …

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can slow cognitive decline in people with early Alzheimer's disease. The treatment targets a key brain region affected by Alzheimer's. Fifty-five partici…

This early-stage study tests whether it is safe to combine a drug called etanercept with repeated ultrasound sessions to temporarily open the blood-brain barrier in people with mild Alzheimer's disease. The goal is to let more of the drug reach the brain to reduce inflammation. O…

This Phase 2 trial tests whether ambroxol, a common cough medicine ingredient, can slow cognitive decline and improve symptoms in people with early dementia with Lewy bodies. 180 participants will receive either ambroxol or a placebo for 18 months. The study measures changes in t…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cannabis use in people with schizophrenia. 110 motivated participants will receive either real or sham stimulation over 5 days. Researchers will track changes in cannabis consumption, cravi…

This Phase 2 trial tests whether fasudil, a drug already used in Japan and China for brain blood vessel spasms, can improve memory and brain function in people with early Alzheimer's disease. Two hundred participants will receive either fasudil or a placebo for 12 months, with re…

This study tests whether 6 months of supervised aerobic exercise can improve fitness, brain health, and memory in adults aged 65 and older with mild cognitive impairment or early Alzheimer's disease. Participants will exercise, undergo memory tests, and have MRI scans over a year…

This study compares a procedure to remove blood clots (endovascular therapy) with standard medical care for people who have had a mild stroke caused by a blockage in a large brain artery. About 264 adults with mild symptoms (NIHSS score 2-5) will be enrolled within 24 hours of st…

This study tests a smart system that uses facial expressions to adjust computerized brain training in real time, aiming to keep older adults engaged and motivated. Researchers will enroll 80 people aged 60-89 with mild cognitive concerns. The goal is to see if this personalized a…

This study will follow 3,000 South Korean Alzheimer's patients taking LEQEMBI for up to 6 years to monitor safety, especially brain swelling or bleeding. Researchers will use real-world data from a national registry. The goal is to understand how often these side effects occur in…

This Phase 3 trial tests a personalized care plan for 500 young people aged 15-30 with early psychosis. The plan combines cognitive training (using apps and virtual reality) with supplements (vitamin B12, folinic acid, Omega 3, NAC) tailored to each person's needs. The goal is to…

This study tests whether a clinical pharmacist calling a patient's general practitioner 90 days after hospital discharge can reduce readmissions and emergency visits. It includes 800 patients aged 65 and older who take at least seven medications. The goal is to improve communicat…

This study looks at whether taking antipsychotic medication every other day is as effective as taking it daily for people with schizophrenia. 120 participants will be randomly assigned to either daily dosing or every-other-day dosing for one year. The goal is to see if extended d…

This study is testing whether a daily synbiotic supplement (a mix of probiotics and prebiotics) can reduce symptoms of schizophrenia when taken alongside standard antipsychotic medications. Researchers are enrolling 68 adults with schizophrenia or schizoaffective disorder who hav…

This study is testing a new version of a gut antibiotic called rifaximin in 20 people with mild-to-moderate Alzheimer's or vascular dementia. The goal is to see if changing the bacteria in the gut can improve brain function and reduce inflammation. Participants will take the drug…

This study tests whether ocrelizumab, a drug that suppresses certain immune cells, can reduce psychosis symptoms in people whose schizophrenia or bipolar disorder may be caused by auto-antibodies attacking brain receptors. Forty participants aged 18–35 will receive either ocreliz…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This trial tests whether a single injection of [18F]-APN-1607, a radioactive tracer that binds to tau protein, can produce PET images that match the actual tau buildup found in the brain after death. It includes healthy volunteers and people with mild cognitive impairment or Alzh…

This phase III trial is evaluating whether an experimental PET imaging agent, [18F]Fluorbetazine, can accurately detect amyloid-beta plaques in the brain—a hallmark of Alzheimer's disease. The study will include about 400 adults aged 40 and older with normal cognitive function, m…

This study tests whether a small, home-use lancet device can collect blood samples that accurately measure p-tau217, a key Alzheimer's biomarker, compared to standard blood draws. Researchers will enroll 1,000 adults aged 40–90, including those with confirmed Alzheimer's, healthy…

This study tests whether a special imaging agent called 18F-FPyCO/SMBT-1 can help diagnose Parkinson's disease and related conditions by detecting a brain enzyme called MAO-B. About 200 adults with suspected or confirmed Parkinson's will receive a single injection of the agent an…

This study looks at whether measuring certain proteins in the blood (p-tau217 and neurofilament light) can help doctors diagnose Alzheimer's disease more quickly and confidently in people with memory problems. About 550 participants visiting a memory clinic will have their blood …

This study is testing whether a blood test that measures specific proteins (pTau217) can help primary care doctors diagnose Alzheimer's disease in people with memory concerns. Researchers will compare the test's accuracy against standard evaluations and track how it changes docto…

This study tests a new radioactive tracer called 18F-Fluselenamyl for PET scans to safely detect amyloid plaques in the brain, a hallmark of Alzheimer's disease. Researchers will compare it to an existing tracer in 60 healthy volunteers and people with mild cognitive impairment o…

This early-stage study tests a radioactive tracer called [18F]Flortaucipir, used during a PET scan to detect tau protein tangles in the brain—a hallmark of Alzheimer's disease. Researchers will enroll 18 Chinese adults aged 50-85 with normal cognition, mild cognitive impairment, …

This study is testing whether blood tests can help screen for Alzheimer's disease in older adults during routine check-ups. Researchers will enroll 3,000 people aged 60-80 from communities and clinics. Participants will give blood samples, and those with abnormal results will tak…

This study is testing a new, non-invasive way to detect Alzheimer's disease by looking for specific proteins (amyloid and tau) in stool samples. The goal is to see if these proteins can serve as early warning signs, potentially allowing for earlier diagnosis and treatment. Resear…

This study is testing a new memory assessment tool called NEM (New evaluation of Episodic Memory) to see if it can better diagnose Alzheimer's disease in people with mild memory problems. Researchers will compare the NEM test with standard memory tests in 150 adults aged 50 and o…

This study is testing a non-invasive eye camera that takes pictures of the retina using different colors of light. Researchers want to see if these images can help detect signs of Alzheimer's, Parkinson's, and other neurodegenerative diseases. About 930 adults over age 30 with or…

This study tests a quick, 5-minute cognitive assessment called the 5-Cog to help primary care doctors identify older adults with undiagnosed dementia or mild cognitive impairment. The trial will involve 6,600 patients aged 65 and older across 22 clinics in the Bronx and Indiana. …

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. Researchers will scan 200 adults (including healthy volunteers) after injecting a radioactive tracer, aiming to see if shorter …

This study is testing whether new blood tests can accurately diagnose the cause of memory loss or dementia, potentially replacing the need for a spinal tap. Researchers will compare blood test results with standard spinal fluid tests in 1,200 people at a memory clinic. If success…

This study tests whether using hearing aids and related support can help slow memory decline in adults aged 55-75 who have mild to moderate hearing loss and early signs of memory problems. Participants are randomly assigned to receive either a hearing intervention or a health edu…

This study tests whether the drug HT-4253 can lower Alzheimer's risk in people aged 50-75 who carry the APOE4 gene and have high levels of amyloid in their blood. The 112 participants will receive either the drug or a placebo for 48 weeks. The main goal is to see if the drug can …

This phase 3 trial tests whether acoramidis can prevent or delay transthyretin amyloidosis (ATTR) in 587 adults who carry a faulty gene but have no symptoms yet. ATTR causes sticky plaques to build up in the heart and nerves, leading to heart failure and nerve damage. Acoramidis …

This study tests whether specific goal-setting techniques can help adults aged 45 to 65 become more physically active and stick with it. Participants are overweight or obese and currently get little exercise. They will receive a behavioral program designed to boost self-regulatio…

This study tests whether a device that flashes light and plays sound at 40Hz can prevent Alzheimer's disease in people at risk. 200 adults aged 55-90 with a family history of Alzheimer's will use the device at home for 60 minutes daily over 12 months. Researchers will measure cha…

This study tests whether giving ICU patients 0.5 liters of wheat beer each evening for 6 days can lower their risk of developing delirium, compared to patients who receive water. Delirium is a sudden confused state common in intensive care. The trial will include 380 adults who h…

This study tests whether using audio and visual tools—like familiar sounds, pictures, and better sleep conditions—can prevent delirium (sudden confusion) in intensive care patients. About 196 adults over 50 who are expected to stay in the ICU for more than a day will take part. T…

This study tests whether lifestyle changes like diet and exercise can help prevent dementia in adults aged 55 and older. Researchers will track 2,000 participants over three years, measuring memory, thinking skills, and how well people stick to healthy habits. The goal is to find…

This study tests if a daily probiotic powder can prevent or reduce weight gain, high blood sugar, and high cholesterol caused by certain antipsychotic drugs. About 112 adults starting or recently starting olanzapine, quetiapine, risperidone, or clozapine will take either the prob…

This study explores whether mindfulness training can help prevent cognitive decline in Latino adults aged 65 and older, a group at higher risk for Alzheimer's disease. Researchers will measure brain activity and thinking skills in 60 participants before and after mindfulness prac…

This study tests whether a 4-week Resilience Training program can prevent serious mental illness in college students who already have mild psychotic experiences. 192 students aged 18-30 will be randomly assigned to either Resilience Training or a general Life Skills program. The …

This study tests a brief problem-solving therapy to prevent suicide in adults aged 50 and older who have suicidal thoughts. The therapy is delivered in three formats: face-to-face, by phone, or via a smartphone app. 212 participants will be randomly assigned to one of these forma…

This study tests a tailored program called REMINDER4Care for adults aged 65 and older living in residential or daycare facilities. The program focuses on social and cognitive activities to reduce dementia risk. Researchers will compare the program's effects on thinking skills, mo…

This study tests whether regular aerobic exercise can prevent or slow memory decline in older adults (ages 50-80) who have memory complaints but no dementia. Participants will be randomly assigned to either an aerobic exercise program or a stretching and toning group for six mont…

This study tests a simple program for people aged 60+ having heart surgery. Before surgery, participants will get help improving sleep and do brain exercises. After surgery, they receive extra pain relief. The goal is to see if this bundle reduces delirium (sudden confusion and a…

This study tests Exercogs®, a digital game that uses augmented reality to combine mental challenges, physical exercise, and social interaction. Researchers will enroll 150 adults aged 55 and older who have at least one risk factor for dementia. Participants will play the game thr…

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce psychiatric symptoms in people with early bipolar disorder. Fifty participants will follow either the ketogenic diet or standard dietary guidelines for 12 weeks. Researchers will me…

This study tests whether an adapted questionnaire, called the Care Partner Hospital Assessment Tool (CHAT-AD), can help care partners of hospitalized people with Alzheimer's disease or related dementias feel more prepared to provide care after discharge. Participants are unpaid f…

This study looks at whether over-the-counter hearing aids can improve communication for older adults with mild cognitive impairment and mild to moderate hearing loss. Fifty participants and their communication partners will be randomly assigned to try hearing aids first or receiv…

This trial tests a short virtual program designed to help older adults with early-stage dementia and their family caregivers work together on medication management. The program includes education about dementia, discussions about beliefs around independence and help, and creating…

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits.…

This study tests two experimental drugs, EXV-802 and EXV-801, to see if they can safely reduce agitation in people with Alzheimer's dementia. About 300 participants aged 55-90 with moderate to severe agitation will receive either the drug or a placebo twice daily for 6 weeks. The…

This study explores whether rhythmic auditory stimulation (like a metronome beat) can improve walking and brain function in people with Alzheimer's disease or mild cognitive impairment. Participants will walk while listening to rhythmic sounds, and researchers will measure change…

This study tests an experimental oral medication (BMS-986368) to reduce agitation in people with Alzheimer's disease. About 120 participants will receive either a low dose, high dose, or placebo. The main goal is to see if the drug safely decreases agitated behaviors, such as pac…

This study tests a culturally adapted decision aid for Chinese American family caregivers of people with moderate to advanced dementia who face feeding difficulties. The tool, called CMCFODA, provides information on tube feeding versus hand feeding and includes personalized coach…

This trial tests whether a single dose of clonidine, given during surgery, can reduce emergence agitation—crying, thrashing, and confusion—when infants wake from anesthesia. The study includes infants aged 3 to 12 months undergoing general anesthesia with sevoflurane. Half receiv…

This phase 3 trial tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults will receive either the drug combo or a placebo for 14 weeks. The main goal is to see if agitation symptoms improve, as…

This early-stage trial tests BXCL501, a dissolving film placed under the tongue, to quickly reduce agitation in children and teens aged 10-17 with schizophrenia or bipolar disorder. About 140 participants will receive either the drug or a placebo. The study measures changes in ag…

This study is developing and testing an online platform called LEND that shares personal stories from people with dementia and their carers. The goal is to see if these relatable narratives can boost wellbeing, confidence, and quality of life for both groups. The trial involves i…

This trial tests an experimental drug called LTX-001 in adults with schizophrenia who are experiencing a sudden worsening of symptoms. Participants stay in a research unit for about five weeks and receive either LTX-001 or a placebo. The main goal is to see if the drug is safe an…

This study tests whether a noninvasive brain stimulation technique called iTBS can improve working memory in people with early-stage schizophrenia. Researchers will use magnetic pulses and EEG to measure brain activity before and after stimulation. The goal is to see if iTBS can …

This study tests SloMo, a digital therapy that helps people with psychosis who fear harm from others. It combines face-to-face sessions with a mobile app to help users notice worries and slow down fast thinking. 150 participants across three NHS trusts will try the therapy, with …

This study tests whether a specialized speech therapy that focuses on word meanings can help people with mild-to-moderate semantic aphasia—a condition where brain damage impairs understanding and use of words. Participants first undergo a control period of standard language exerc…

This trial tests whether a smartphone app called AffectUs can help people with schizophrenia or schizoaffective disorder better recognize emotions and interpret social situations. Participants use the app for 10 weeks, five times a week, while continuing their usual treatment. Th…

This study tests a device called Neuclare that is placed on the head to see if it can temporarily improve planning and problem-solving skills in people with mild cognitive impairment or very early Alzheimer's disease. About 138 adults aged 55 to 90 who are already on memory medic…

This study tests a tool called HART that helps caregivers of people with Alzheimer's or related dementias find health apps suited to their needs. Fifteen family caregivers will use the tool for four weeks and provide feedback on how easy it is to use and whether it improves their…

This study tests whether a brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help ease depression in people with schizophrenia. Researchers will give up to 20 sessions of active or sham rTMS to 120 participants and use brain scans to see h…

This study tests a program that teaches family caregivers how to help their loved ones with mild to moderate dementia manage chronic pain. Researchers will work with 60 people (30 patients and their caregivers) to see if the training improves pain coping and quality of life. The …

This study is testing a new online exercise program made specifically for people with chronic brain injury. Researchers want to see if it helps them be more active and feel more confident about exercising. Sixty adults with chronic brain injury will take part; half will use the n…

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This study tests whether three months of flicker stimulation (using near-infrared light or visual occlusion glasses) can improve thinking, movement, and mood in healthy older adults and those with subjective cognitive decline. Sixty participants aged 65-89 will be assigned to dif…

This trial tests whether a non-invasive electrical stimulation applied to specific acupoints on the fingers can improve memory, attention, and decision-making in people who have had a stroke. Adults aged 35 to 80 with mild to moderate cognitive impairment after an ischemic stroke…

This study tests a new drug called roluperidone for treating negative symptoms of schizophrenia, like lack of motivation and social withdrawal. About 380 adults with schizophrenia will take the drug or a placebo for 12 weeks to see if symptoms improve. Then, for 40 more weeks, re…

This randomized trial tests whether a structured, personalized music program (MUSIC CARE©) can reduce care refusal during daily hygiene care in nursing home residents with dementia. Care refusal—resisting bathing, dressing, or medication—is common and stressful for both residents…

This trial tests whether a six-week online group program, combining cognitive behavioural therapy with family support, can help people with schizophrenia and their caregivers. Researchers will measure changes in symptoms, expressed emotion, and caregiver mood. The study includes …

This study tests the safety and tolerability of the drug Zunveyl in 150 adults aged 50 and older with mild to moderate Alzheimer's disease. Over 12 weeks, researchers will monitor side effects and whether the drug helps reduce neuropsychiatric symptoms like agitation or mood chan…

This study tests a new, non-invasive brain stimulation method called time interference stimulation (TIS) to see if it can improve thinking and memory problems in people with schizophrenia. Fifty adults aged 18-50 with schizophrenia will receive either real TIS or a fake (sham) tr…

This pilot study will test whether a non-invasive brain stimulation device called rTMS can improve cognitive function in adults aged 50 to 90 with mild to moderate memory problems. Eighty participants will receive six sessions of targeted magnetic pulses over three weeks. Researc…

This early-phase trial tests whether propranolol, a drug typically used for high blood pressure, can improve language abilities and reduce anxiety in older adults with primary progressive aphasia (PPA). PPA is a type of dementia that gradually impairs speech and language, and the…

This study tests whether a low-dose extended-release version of levetiracetam (AGB101) can reduce overactivity in the hippocampus, a brain region often overactive in early dementia. Sixty adults aged 50–80 with normal thinking skills will take the drug or a placebo for two weeks …

This study tests whether a 4-week mindfulness group therapy program, added to usual care, can reduce symptoms in 252 young people (ages 16-35) hospitalized for early psychosis. Participants are randomly assigned to either the mindfulness program plus standard treatment or standar…

This study tests whether letting a child aged 2 to 6 video chat with a parent on a tablet while being taken to the operating room can reduce agitation when they wake up from anesthesia. It compares live video interaction, watching a cartoon, and standard care in 150 children havi…

This study investigates whether complex rhythmic movement training, like dancing with new partners, can improve mobility and learning in people with Parkinson's disease or mild cognitive impairment. Researchers will compare how participants with Parkinson's, those with memory pro…

This study tests a program called SUPPORT, where trained peer specialists (fellow veterans) help veterans with serious mental illness (like schizophrenia or bipolar disorder) who are at high risk for suicide. Together, they create a personalized recovery plan that includes coping…

This study tests a 6-week web-based program designed to help family caregivers of people with dementia manage behavioral and psychological symptoms like agitation, anxiety, and sleep problems. The program includes educational modules, symptom tracking, and online support. Researc…

This study tests whether acetazolamide, a drug currently used for altitude sickness and glaucoma, can reduce positive symptoms (like hallucinations or delusions) in people with treatment-resistant schizophrenia. Sixty adults aged 18-55 who still have significant symptoms despite …

This study tests whether a safe, non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve working memory in people with dementia. The stimulation is timed to each person's brain waves, measured by EEG, to help brain regions communicate b…

This study tests whether recreational fishing (angling) can help people with schizophrenia feel better and improve their quality of life. Participants will take part in a structured fishing program alongside their usual care. Researchers will measure changes in symptoms, loneline…

This study tests whether a week of morning bright light therapy improves sleep, alertness, mood, and thinking in healthy university students. Participants use a 10,000-lux light box for 30 minutes each morning for one week, and their results are compared to a week with usual ligh…

This study tests whether giving magnesium before surgery can reduce emergence delirium—a state of confusion and agitation—in children aged 4 to 7 after adenotonsillectomy. Half the children receive magnesium by mouth before surgery, half receive it through an IV during surgery, a…

This study tests a four-week financial counseling and advocacy program for family caregivers of people with Alzheimer's or related dementias who are in early or middle adulthood. Participants receive financial coaching, self-advocacy support, and referrals, and researchers measur…

This Phase 3 trial tests whether the drug combination KarXT + KarX-EC can safely reduce psychosis symptoms (like hallucinations and delusions) in people with Alzheimer's disease. About 325 participants aged 55-90 will receive either the drug or a placebo. The study is currently r…

This study tests a head-mounted far-infrared therapy device in 40 people with mild-to-moderate Alzheimer's disease. The device is placed on specific points on the head and delivers gentle heat. Researchers will check if it is safe and whether it helps improve cognitive function, …

This study tests whether daridorexant, a sleep medication, can improve sleep in people with mild cognitive impairment or mild-to-moderate Alzheimer's disease who also have insomnia. Sixty-two participants will receive either the drug or a placebo for one month, and their sleep wi…

This study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive procedure using magnetic pulses, can improve short-term memory in people with early Alzheimer's disease. Forty participants will receive either real or sham rTMS over four weeks, then be …

This trial tests whether shining a specific type of near-infrared light on the forehead—called transcranial photobiomodulation (tPBM)—can improve attention and reduce impulsivity in adults with and without ADHD. Participants receive either active tPBM or a sham (fake) treatment f…

This study tests whether short, calming virtual reality (VR) sessions can safely reduce anxiety, agitation, and delirium in adult intensive care unit (ICU) patients. Thirty participants will watch nature-based VR content using a headset. The main goal is to see if this approach i…

This study tests a behavioral sleep program called Care2Sleep for people with Alzheimer's disease and their caregivers. The program includes sleep hygiene, activity, and light exposure. Researchers will compare it to a sleep education group to see if it improves sleep, health, an…

This study tests whether a virtual reality game can help older adults with mild cognitive disorders improve their inhibitory control—the ability to stop and think before acting. 48 participants will play the game either on a VR headset or a tablet for 20 minutes, twice a week for…

This study tests if shining a special light on the head (transcranial photobiomodulation) can improve memory and thinking in people with mild cognitive impairment. Forty participants will receive either real or fake light sessions for 12 weeks. Researchers will measure brain acti…

This study tests a web-based version of cognitive behavioral therapy for insomnia (CBT-I) in 60 family caregivers of people with dementia. Caregivers will complete four online sessions focused on sleep habits, relaxation, and changing unhelpful thoughts. The goal is to improve sl…

This study tests a non-invasive brain stimulation technique called temporal interference stimulation (TIS) to see if it can improve cognitive function in people with mild cognitive impairment or early Alzheimer's disease. Sixty participants will receive either real TIS or a sham …

This study tests whether training mental health professionals to deliver a short psychoeducational program (BREF) can reduce the burden on caregivers of people with schizophrenia or first psychotic episode. The trial will include 206 caregivers, comparing those who receive the pr…

This study tests an educational support group program for people with progressive aphasia (a language disorder caused by Alzheimer's or other dementias) and their carepartners. The program includes group education, support sessions, and communication skills training. Researchers …

This study explores whether group drumming or music listening can improve pain, stress, and brain function in people with early Alzheimer's, mild dementia, or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will attend weekly sessions while r…

This study tests whether giving melatonin at bedtime can help older ICU patients (55+) recover faster from hypoactive delirium, a state of confusion and low activity. Researchers will compare melatonin to a placebo in 190 patients, measuring how long delirium lasts and overall re…

This study tests a new drug called EI-1071 in 15 people with mild to severe Alzheimer's disease. The main goal is to see if the drug is safe and tolerable over 4 weeks. Researchers will also check if it reduces brain inflammation using special brain scans. Participants must have …

This study tests whether vortioxetine, an antidepressant known to boost thinking skills, can reduce the mental fogginess caused by the lung cancer drug lorlatinib. About 24 adults with advanced ALK-positive lung cancer who are already taking lorlatinib will receive vortioxetine. …

This study tests a training program for caregivers that helps them identify and address unmet needs of people with dementia living in long-term care facilities. The goal is to reduce behavioral and psychological symptoms like agitation and anxiety. About 120 residents will take p…

This study tests whether combining mental exercises (cognitive stimulation therapy) with physical activities (motor stimulation) can improve thinking and mobility in people with mild-to-moderate dementia. About 421 participants aged 65 and older will attend 14 sessions over 7 wee…

This study tests whether listening to personalized music enhanced with binaural beats (sound patterns that may influence brain waves) or spatialized (3D-like) audio can reduce behavioral and psychological symptoms of dementia, such as agitation and anxiety. Researchers will enrol…

This study tests a new live video program called Resilient Together for Dementia (RT-D) for couples where one partner has early-stage dementia. The program is designed to help both partners manage emotional distress after a recent diagnosis. The study will include 24 couples and …

This study tests whether combining a special walking exercise with mild electrical brain stimulation can improve thinking and walking in adults aged 65 and older who have memory or mobility problems. Participants will do walking tasks while receiving either real or fake brain sti…

This pilot study tests whether a device called Cereset Research can help caregivers of people with dementia who feel stressed, anxious, or have trouble sleeping. The device plays tones that echo the brain's own rhythms, aiming to improve heart rate variability and reduce stress. …

This study tests whether infliximab, an anti-inflammatory drug used for arthritis, can improve motivation and brain activity in people with schizophrenia who have high inflammation. Sixty adults with schizophrenia will receive either infliximab or a placebo, and researchers will …

This study tests whether a non-invasive brain-computer interface combined with 40Hz audio-visual stimulation can improve cognitive function in people with Alzheimer's disease. 90 participants will be randomly assigned to receive either fixed 40Hz stimulation, personalized closed-…

This study tests whether low-intensity ultrasound, aimed at the brain, is safe and could help with schizophrenia symptoms. Eighty adults with schizophrenia will receive the non-invasive treatment. Researchers will check safety and look for any improvements in mood, thinking, and …

This study tests two types of speech therapy for adults with mild-to-moderate primary progressive aphasia, a condition that slowly impairs language. Researchers will compare the therapies in 200 participants to see which better improves communication and reduces caregiver burden.…

This study tests whether bazedoxifene, a drug that mimics estrogen, can help reduce schizophrenia symptoms in women when added to their usual antipsychotic medication. 160 women aged 18-65 with schizophrenia or related disorders will receive either bazedoxifene or a placebo daily…

This study is testing whether a special flickering light therapy can improve memory and sleep in people with mild cognitive impairment or early Alzheimer's disease. About 120 participants will be randomly assigned to one of four light conditions and use the light at home for two …

This small pilot study is testing whether a single infusion of human mesenchymal stem cells can help control agitation, aggression, and other behavioral symptoms in people with moderate to severe Alzheimer's disease. The study involves 8 adults aged 55-90 who are already taking a…

This study tests a noninvasive device that gently stimulates a nerve in the ear to help people wake up faster after surgery. Researchers will also see if it reduces confusion and depression after the operation. The study involves 40 adults having lumbar spine surgery.

This study tests an online education program called iSupport-Korea, designed for family caregivers of people with dementia. About 160 caregivers will be randomly assigned to use the program or receive usual support, and researchers will track changes in their well-being and confi…

This study tests whether an app called Genus, which provides videos, exercises, and quizzes, can help people with knee osteoarthritis learn more about their condition and feel more confident in treatment decisions. About 204 adults over 50 who are waiting for a specialist appoint…

This study tests whether combining a non-invasive brain stimulation technique called accelerated iTBS with computerized cognitive training can help people with mild cognitive impairment (MCI). Fifty adults aged 60-85 will receive the brain stimulation and be randomly assigned to …

This study tests whether people with schizophrenia who hear voices that medication doesn't help can learn to quiet them using a special brain-training technique. Participants get real-time feedback from an fMRI scanner to help them shift their brain activity away from the halluci…

This study tests a programme called Mentis Plus+ Caregivers, designed to improve mental health for adults who care for a family member with dementia. The programme includes six modules that teach skills like self-control, problem-solving, and building relationships. Researchers w…

This study tests whether adding two check-in calls per week to standard cognitive behavioral therapy (CBT) improves quality of life for adults caring for a family member with dementia in rural Texas. Sixty caregivers will receive either individual CBT for 12-16 weeks or CBT plus …

This study tests whether online (telehealth) programs can reduce pre-death grief, burden, and stress in family caregivers of people with dementia. About 60 adult caregivers who speak English and have a mental health condition like anxiety or depression will take part. The goal is…

This study is testing an app called PancreasPlus for people with pancreatic cancer. The app helps patients track symptoms, get information, and communicate with their care team from home. Researchers want to see if using the app improves quality of life, reduces anxiety, and cuts…

This study tests whether learning music—rhythm, singing, and body movements—can improve attention and thinking in people with schizophrenia. About 120 adults with stable schizophrenia will take part. The goal is to see if music-based training is a more engaging and effective way …

This study tests whether playing specially designed somatosensory video games for 2 months can improve thinking skills in people with schizophrenia. The games train five cognitive functions like memory and attention using body movements. Researchers will enroll 84 stable patients…

This study tests a personalized home-based activity program for people with mild-to-moderate dementia who have behavioral and psychological symptoms. About 55 participants will receive either the activity program or routine care after leaving the hospital. The program involves fa…

This study explores whether intensive singing lessons can improve thinking, memory, and mood in people with early-stage Alzheimer's. Over 5 months, participants will take twice-weekly singing lessons with a personal teacher, then switch to once-a-month sessions. Researchers will …

This study tests whether a special light that flickers 40 times per second can help people with mild to moderate Alzheimer's disease. For 6 months, 62 participants will use the light device at home for 1 hour each day. Researchers will measure changes in brain activity, memory, a…

This study tests whether personalized virtual music therapy can boost memory and mood in people with mild cognitive impairment or early Alzheimer's disease. Sixty participants will receive two 30-minute online music therapy sessions each week for 8 weeks, led by a certified thera…

This study tests a 6-week group therapy program for adults with schizophrenia or related disorders. The therapy focuses on changing negative core beliefs (like feeling worthless or that others are dangerous) using compassion-focused techniques. The goal is to see if this approach…

This study tests whether adding tablet-based cognitive exercises to standard non-drug care (like better sleep and mobility) can reduce delirium in older adults. Sixty people aged 60+ in a subacute care unit will receive either standard care alone or standard care plus twice-daily…

This study looks at whether therapeutic cuddling (like kangaroo care or comfort holding) can help reduce pain, agitation, and delirium in children in the pediatric intensive care unit (PICU). About 112 children expected to stay in the PICU for more than 48 hours will be randomly …

This study tests a new type of transcranial magnetic stimulation (TMS) that targets three brain areas at once to help with negative symptoms of schizophrenia, like lack of motivation, emotion, or social interest. Researchers will enroll 64 people with first-episode schizophrenia …

This study is testing a virtual reality (VR) program called bWell to see if it is a practical and enjoyable way to help people with major depression who have trouble with thinking and memory. Forty adults aged 19-55 will either use the bWell cognitive training or experience VR sc…

This study tests whether a low dose of buprenorphine (0.15 mg) can improve social motivation in 40 people with schizophrenia. Participants will take either the drug or a placebo and complete tasks that measure their drive to seek or avoid social interaction. The goal is to see if…

This study tests whether estradiol patches can improve anhedonia (loss of pleasure) and psychosis symptoms that start during perimenopause. About 100 women aged 44-55 will receive either estradiol or a placebo patch for three weeks, plus a short course of progesterone. Researcher…

This pilot study explores whether a music-based dance program can improve thinking skills and physical function in adults aged 55 and older with mild cognitive impairment. The dance routines combine music, partner guidance, and spatial coordination to challenge memory and attenti…

This study tests whether a device that sends gentle magnetic pulses to specific brain areas can improve thinking and memory in older adults. It includes 20 people aged 65 to 84—half with mild dementia and half without. Participants receive either real or sham stimulation to see i…

This study tests whether adding a trauma-focused therapy called EMDR to usual care can help reduce trauma symptoms in people with schizophrenia spectrum disorders. Many people with these conditions have experienced trauma, which can make their illness worse, but trauma treatment …

This study looks at whether taking ETAS® daily for 12 weeks can improve memory, mood, and brain activity in healthy adults aged 60 to 80 who have mild memory complaints. Participants will be randomly assigned to receive either ETAS® or a placebo, and will undergo memory tests, br…

This study tests whether cognitive stimulation therapy (CST) delivered by trained volunteers can improve thinking and quality of life for people with mild to moderate dementia. 520 participants in Hong Kong will either receive 7 weeks of volunteer-led CST sessions or continue wit…

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with cognitive training, can improve thinking skills and mood in people with mild cognitive impairment or early dementia. Fifty participants will receive both real and placebo stimulation in…

This study tests a culturally adapted program called ACES for Black immigrant caregivers of people with dementia. The goal is to see if it helps reduce depression and caregiver burden, and improve quality of life over 3 months. About 150 care partners and their loved ones with de…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can improve thinking, memory, and other symptoms in people with long COVID. About 91 adults who have had cognitive problems for at least 3 months after a COVID infection will be ra…

This study tests whether taking caffeine for 30 weeks can slow down memory and thinking problems in people with early-to-moderate Alzheimer's disease. About 248 adults aged 50 and older will receive either caffeine pills or a placebo (dummy pill) to see if caffeine helps keep the…

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This study tests whether virtual reality brain games can help older adults who survived a stay in the intensive care unit (ICU) and had delirium. About 100 people aged 50 and older will use a VR headset at home to play memory and attention games for 4 weeks. The goal is to see if…

This study tests a new drug called NSC001 in 90 people with mild to moderate Alzheimer's disease. The drug is designed to activate a specific receptor in the brain (M1 muscarinic) that may help with memory and thinking. The main goal is to check if the drug is safe and tolerable,…

This study is testing a mobile app called Care Buddy that helps family caregivers of people with dementia find local services, support groups, and health information. About 210 caregivers in Singapore will use the app for two years. The goal is to see if the app reduces caregiver…

This study tests a non-invasive technique called Low Intensity Focused Ultrasound Pulsation (LIFUP) to see if it can safely increase brain activity and improve memory in people with mild cognitive impairment or mild Alzheimer's disease. Participants will receive ultrasound to a k…

This study tests a virtual reality program designed to help people with psychosis improve their thinking and social skills. The program was created with input from patients and doctors. Researchers will see if it is practical and helpful for daily life. The study involves 52 adul…

This study tests whether exercising before a mild brain stimulation session can improve memory in people with mild cognitive impairment linked to heart or blood vessel problems. 64 adults aged 50 and older will be randomly assigned to receive either real or sham brain stimulation…

This study compares two cognitive rehab programs for adults with long COVID who have mild to moderate brain fog. Both programs include computer games, in-lab training, and a mild nerve stimulation device worn on the ear. One group focuses on processing speed and work-related task…

This study tests whether Jing Si Herbal Tea, taken twice daily, can improve quality of life and sleep for people with dementia and their caregivers. Researchers will first test the tea's feasibility in 100 people with dementia, then conduct a larger placebo-controlled trial with …

This small pilot study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce apathy in people with dementia or mild cognitive impairment. Ten participants will receive rTMS, some also taking the medication methyl…

This study tests a brief, virtual cognitive remediation therapy (Action-Based Cognitive Remediation) for young people aged 16-30 with early psychosis who also misuse alcohol or cannabis. The therapy aims to improve thinking skills and reduce substance use. Researchers will enroll…

This study tests a 16-week partner exercise program called BUDPA for people with mild dementia and their family caregivers. The program involves group workouts and at-home practice, aiming to improve thinking, mood, and the relationship between the pair. Researchers will track 23…

This study aims to collect cognitive performance data from 1,000 healthy adults aged 18 to 100 using a fully digital, voice-recognition-based testing platform. Participants complete a one-time, 30-45 minute online assessment covering memory, language, attention, and problem-solvi…

This study looks at whether a drug called fampridine, which blocks potassium channels in the brain, can improve working memory in people with cocaine use disorder. Forty chronic cocaine users will receive either the drug or a placebo and then take memory tests. The goal is to und…

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases. Researchers will compare these scans to those from healthy volunteers to see if inflammation levels differ. The goal is to d…

This study aims to find the genetic causes of movement disorders and dementias by analyzing DNA from up to 12,000 participants, including patients and their family members. Researchers will collect blood or saliva samples and look for gene mutations linked to these conditions. Th…

This study tests a new radioactive tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers (patients and healthy older adults) to understand how inflammation relates to m…

This pilot study will compare the Clubhouse Model—a structured, community-based program where members work together to run the clubhouse—to standard outpatient care for adults with schizophrenia. Researchers will measure changes in thinking, daily functioning, and brain activity …

This study follows 600 people aged 55 to 85 with early, middle, or late-stage Alzheimer's disease for 12 months. Researchers will track changes in memory, daily activities, behavior, and traditional Chinese medicine symptom patterns. They will also observe whether those receiving…

This study uses yearly PET scans to track amyloid protein buildup in the brains of 400 adults aged 55 and older over 5 years. Participants are already part of the Baltimore Longitudinal Study of Aging. The goal is to see how these brain changes relate to memory loss and other thi…

This pilot study explores whether adding a digital health platform called Lōvu to standard prenatal care is practical and well-received by pregnant people. Participants use a Bluetooth scale, blood pressure cuff, and fetal Doppler that send data to their care team, alongside ment…

This study tests whether simple reminders—called nudges—sent to doctors and patients can increase the use of genetic testing for people with certain conditions like Parkinson's disease, ALS, or heart problems. The trial will compare different ways of prompting genetic testing, su…

This study looks at how chemotherapy for colon or rectal cancer affects thinking and memory. Researchers will track changes in brain function and blood proteins in 60 patients during and after treatment. The goal is to find tests that could identify who is at risk for 'chemo brai…

This study aims to understand brain changes in people with mild cognitive impairment (MCI) and Alzheimer's disease. Researchers will use MRI, EEG, cognitive tests, and blood and stool samples to find differences between healthy individuals and those with cognitive impairment. The…

This study uses advanced MRI (3T fMRI) to look at brain activity in people who have or will have deep brain stimulation (DBS) implants. DBS is a treatment for conditions like Parkinson's disease, tremor, and obsessive-compulsive disorder. The researchers will scan participants un…

This international observational study will follow 50,000 people with Alzheimer's disease or related dementias for many years. Researchers will collect real-world data from routine doctor visits to track how the disease progresses and how treatments are used and tolerated. The go…

This study aims to understand why people with Alzheimer's disease differ from each other and from healthy older adults. Researchers will use advanced brain imaging (7T MRI), brain wave recordings (EEG), and blood and stool samples to look for patterns that might reflect different…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This study uses a special PET scan to measure amyloid plaques in the brains of 160 people with Alzheimer's disease. Researchers want to see how these plaques relate to race and heart health risks. Participants are already part of a larger Alzheimer's study at the University of Al…

This study tests whether a short video-based training program, called the ICU Delirium Playbook, can improve how intensive care unit (ICU) nurses understand and recognize delirium—a sudden confusion that affects many critically ill patients. Nurses at one hospital will complete q…

This study tests a 9-session program called Changing Lives and Changing Outcomes-9 for people with serious mental illness who have been involved with the legal system. The program is designed to help participants understand their mental health better and reduce their chances of f…

This study uses a special PET scan to measure a harmful protein called tau in the brains of 160 people with Alzheimer's disease. Researchers want to see how tau buildup relates to a person's thinking abilities, race, and heart health risks. Participants are already part of a larg…

This study investigates whether people who recently had a stroke (within 21 days) can learn new arm movements using a rehabilitation robot called REAplan. Researchers will compare their learning ability with healthy individuals and those who had a stroke long ago. The goal is to …

This study looks at whether brain activity synchronizes differently in people with schizophrenia during social interactions. Researchers will compare 100 participants—some with schizophrenia and some without—as they chat and do tasks together while wearing EEG caps. The goal is t…

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-…

This study looks at older adults hospitalized for heart, lung, or orthopedic issues to see how many also have undiagnosed mild cognitive impairment or dementia. Participants take a memory test at admission, and those with possible problems get a full brain evaluation and a follow…

This study looks at whether family members can help identify delirium—a sudden confusion that can occur during serious illness—in adult ICU patients. Family members will complete a short assessment after visiting, while nurses continue their usual screening. Researchers will comp…

This study tests whether a non-invasive electrical brain stimulation technique called TES-TI can temporarily alter sleep spindles—brain rhythms often reduced in schizophrenia. Researchers will apply the stimulation during sleep in 20 people (half with schizophrenia spectrum disor…

This study is testing whether a special PET imaging tracer, [18F]PI-2620, can detect tau protein buildup in the brains of people with Parkinson's disease, including those with a genetic form linked to the LRRK2 gene. About 60 participants will undergo high-resolution brain scans …

This early-stage study is testing an experimental drug called LY3439539 in 30 people with mild-to-moderate Alzheimer's disease. The main goal is to see if the drug changes certain proteins in the spinal fluid that are linked to Alzheimer's. Participants will receive the drug thro…

This study uses a special PET scan tracer, [18F]MH.MZ, to measure serotonin 2A receptors in the brains of people with neurodegenerative diseases like Parkinson's. Researchers want to see if these receptors differ between patients with psychosis and healthy people of the same age.…

This study looks at whether successfully treating moderate-to-severe sleep apnea can improve memory and reduce biological markers linked to Alzheimer's disease in older adults. About 200 cognitively healthy people aged 55-85 will either receive immediate sleep apnea treatment or …

This study will put 56 healthy adults aged 25-60 through 27 hours of sleep deprivation and alcohol consumption (to a 0.08% BAC) in a lab over 110 hours. Researchers will measure how these stressors affect thinking, movement, and brain scans. The goal is to better predict and mana…

This study looks at whether the immune system's T-cells react differently in people with Parkinson's disease or Alzheimer's disease compared to healthy older adults. Researchers will collect blood samples from 120 participants—30 with Parkinson's, 30 with Alzheimer's or mild cogn…

This study follows people with several types of spinocerebellar ataxia (SCA) — rare genetic diseases that cause balance, coordination, and speech problems — to learn how these conditions change over time. Researchers will collect blood samples, perform neurological exams, and use…

This study is testing whether a program delivered remotely (by video or phone) that combines exercise and dementia caregiving support is practical and helpful for older adults with Down syndrome and their caregivers. About 40 participants will take part. The goal is to see if the…

This study records brain activity from electrodes placed in the brains of epilepsy patients while they perform memory tasks. Researchers aim to understand how brain cells work together to hold and use information in the short term. The goal is to find new ways to diagnose and tre…

This study explores whether using physical actions, imagined movements, or videos can improve memory in people with early-stage Alzheimer's disease. Researchers will compare recall in 80 older adults (some with Alzheimer's, some healthy) after they watch videos of daily activitie…

This long-term study follows people with or at genetic risk for frontotemporal lobar degeneration (FTLD), a group of brain disorders that cause changes in behavior, language, and movement. Researchers will use brain scans, memory tests, and blood samples to measure how the diseas…

This study investigates repetitive behaviors—like repeating words or actions—in people with Alzheimer's disease. Researchers want to understand how common these behaviors are, what types occur, and whether they are linked to memory problems or lack of awareness of the condition. …

This study investigates whether markers of inflammation in the blood could serve as diagnostic or severity biomarkers across several psychiatric conditions, including bipolar disorder, schizophrenia, and depressive episodes with psychotic features. Researchers will collect blood …

This study is testing whether a smartphone app can help predict the risk of developing Alzheimer's disease. Researchers will collect health data like weight, blood pressure, and blood sugar from people with mild cognitive concerns. An artificial intelligence model will analyze th…

This study investigates whether reduced sensitivity to social rewards contributes to social anhedonia—a lack of pleasure from social interactions—in people who have recently experienced their first episode of psychosis. Participants, aged 18 to 35, will undergo brain scans while …

This study tests a new way to monitor muscle activity during electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. It compares a standard arm tourniquet method with a newer, potentially less painful technique. The goal is to see if the new method wor…

This study tests a digital tool called CGM ASSIST that combines a continuous glucose monitor with easy-to-read displays. The goal is to help people with Alzheimer's or dementia and diabetes, along with their caregivers, better understand blood sugar levels and make informed decis…

This study follows 5,000 people with mild cognitive impairment or mild-to-moderate dementia living at home in Bavaria, along with their family caregivers. Researchers collect detailed information on health, daily function, care needs, and quality of life over several years. The g…

This observational study asks whether older patients placed under isolation precautions in the hospital are more likely to develop delirium or experience cognitive decline. Researchers will compare isolated patients aged 70 and older with similar non-isolated patients, tracking d…

This study is testing whether a risk score can predict which older adults will experience confusion or memory problems after a common urological procedure. Researchers will follow 150 patients aged 65 and older undergoing transurethral resection, using cognitive tests before and …

This study is testing whether a non-invasive eye scan called optical coherence tomography (OCT) can help track neurological diseases like multiple sclerosis, Alzheimer's, Parkinson's, and migraine. Over two years, researchers will measure the thickness of retinal layers in 840 pa…

This study is testing whether proteins in the blood can accurately diagnose Alzheimer's disease and predict how quickly it will progress. Researchers will follow 2,000 adults with memory complaints for five years, collecting annual blood samples. The goal is to find a less invasi…

This study investigates whether early-detection programs for psychosis can reduce the time people live with untreated symptoms and whether that leads to better long-term functioning. Researchers will follow adults newly diagnosed with schizophrenia-spectrum disorders in two Danis…

This study observes how three standard pain-control methods—opioids given through a vein, epidural, or nerve block—affect how quickly patients aged 65 and older get out of bed after major surgery. Researchers track time to first sit, stand, or walk, along with pain levels, confus…

This study investigates whether immune inflammation in the blood and brain is linked to brain structure, function, and symptoms in people with schizophrenia. Researchers will follow 200 participants for three months, collecting clinical data, brain scans, and biological samples. …

This study investigates how a person's genetic makeup influences their response to cannabis, including risk for addiction and psychosis. Healthy adults aged 21-60 receive either a very low or medium dose of THC (the active ingredient in cannabis) or a placebo intravenously. Resea…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these connections. The goal is to…

This study uses advanced PET scans and blood tests to examine brain inflammation and white matter damage in people with corticobasal syndrome, a rare movement and thinking disorder. Researchers will compare these brain changes across different subtypes of the condition and agains…

This study investigates whether microRNAs found in brain-derived particles in the blood can serve as biomarkers for schizophrenia. Researchers will compare blood samples from 80 people recently diagnosed with first-episode schizophrenia and 80 healthy volunteers, tracking changes…

This study looks at how alcohol and substance use affect people with severe mental illnesses like schizophrenia and bipolar disorder. Researchers compare those who also have substance use problems with those who do not, measuring things like hospitalizations, medication needs, em…

This study investigates paradoxical lucidity—brief, unexpected episodes of mental clarity—in people with end-stage dementia. Researchers will use caregiver diaries and video EEG monitoring to capture and analyze these rare events. The goal is to create a standard definition and m…

This study investigates whether digital biometrics and blood-based markers can help detect, predict, and track delirium in older adults admitted to the intensive care unit (ICU). Participants wear a digital device to collect data like activity and heart rate, and provide blood sa…

This study follows older adults (ages 70-95) who have memory concerns but no dementia, tracking them for up to 5 years to see who develops Alzheimer's. Researchers use brain scans, EEG, eye movement tests, and memory assessments to spot early warning signs. The goal is to better …

This study tests whether cameras, motion sensors, and other monitors can automatically detect signs of pain, delirium, and physical decline in critically ill patients. Researchers will collect video, movement, noise, light, and vital sign data from 400 adults in the ICU. The goal…

This study looks at whether brain wave patterns, measured by EEG, can help explain why some children become confused and agitated after waking up from anesthesia (emergence delirium). Researchers will monitor children aged 2 to 8 who are having eye surgery under general anesthesi…

This study uses special PET scans to measure brain inflammation and tau protein buildup in people with different forms of Alzheimer's disease, including those with memory, vision, or language problems. Researchers aim to understand how inflammation relates to other brain changes …

This study investigates how fluid drains from the brain to lymph nodes in the neck, a connection that may be important for clearing waste linked to Alzheimer's disease. Researchers will inject a fluorescent dye into the meningeal space of recently deceased organ donors and track …

This study looks at whether older adults with prediabetes have lower brain energy use and slower thinking compared to those with normal blood sugar. It also tests if a single dose of a ketone supplement can improve brain energy and processing speed. Twenty participants will under…

This study aims to enroll 50,000 adults aged 45 and older in France to test for a gene called APOE, which is linked to Alzheimer's risk. Participants provide a saliva sample at home and complete online questionnaires. The goal is to build a large registry of genetic and health da…

This study aims to create a risk score that uses information from electronic medical records to predict the chance of developing dementia within 5, 9, or 13 years in older adults with depression. Researchers will analyze data from 44 participants aged 50 and older who have a depr…

This study examines whether a person's personality traits before they got sick are linked to the thinking and behavior problems seen in certain brain disorders. Researchers will ask caregivers about the patient's personality from the 10 years before the illness started. The goal …

This study aims to create a 'patient library' by collecting blood, stool, and hair samples from 250 people aged 15 to 30 who have had a first psychotic episode or are at high risk. Researchers will track their mental health over 10 years using the CAARMS test. The goal is to bett…

This study looks at how differences in the NOTCH2NLC gene affect the symptoms and course of neuronal intranuclear inclusion disease (NIID), a rare inherited brain disorder. Researchers will follow 12 members of one family, including those with NIID, gene carriers without symptoms…

This study follows 178 people who had a first episode of psychosis to see how early treatment choices and relapses affect their thinking, daily life, and mental health over 20 years. Participants attend one interview to assess symptoms, thinking skills, and functioning. The goal …

This study aims to find the best way to deliver preventive health screenings to people in underserved and rural areas. It will compare different methods, such as interactive health reports, mobile screening units, and even droid-assisted screenings, to see which improves health e…

This study looks at whether people aged 70 and older experience changes in thinking skills, like attention and processing speed, after same-day hip or knee replacement surgery. About 48 participants will take a short cognitive test before surgery and again on the first and sevent…

This study looks at how certain brain cells (cholinergic neurons) change with age in adults with Down syndrome, and how that relates to Alzheimer's disease risk. Researchers will use brain scans and EEGs to measure these changes in 30 adults aged 18-55 who do not have dementia. T…

This study aims to help 25,000 young people aged 12-29 who are at high risk for psychosis reach out for help sooner. Researchers will use online screening and personalized digital messages to encourage them to schedule assessments and connect with local clinics. The goal is to re…

This study looks at early changes in mitochondria (the energy centers of cells) and metabolic markers in blood cells of people with Alzheimer's or related dementias. Researchers will compare these measures between those with and without Alzheimer's to find clues about how the dis…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study aims to create a French-language memory task that can be used during brain scans to measure source-monitoring—the ability to remember where information came from. Researchers will test the task on 120 people, including those with schizophrenia and healthy volunteers. T…

This study collects a small sample of tissue from inside the nose to learn how the sense of smell changes in people with Alzheimer's. Researchers will compare samples from healthy volunteers and those with early or mild Alzheimer's. The goal is to understand the biology behind sm…

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study looks at brain activity in 100 adults with epilepsy who already have electrodes implanted for seizure monitoring. Researchers will record brain signals while participants answer questionnaires and perform memory and impulse-control tasks. The goal is to find links betw…

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study looks at how depression and very early (preclinical) Alzheimer's disease affect driving habits in adults aged 65 and older who still drive regularly. Participants will have their driving tracked with a GPS device and undergo brain scans to measure Alzheimer-related pro…

This study will follow 1,200 people with schizophrenia in Shanghai for up to 5 years. Researchers will track symptoms, aggression, and other mental health changes to understand how the disease progresses. The goal is to build a long-term database and biobank to improve future car…

This study uses a special PET scan to look at tau protein buildup in the brain and see if it relates to memory and thinking problems. Researchers will study 900 adults, some with normal memory and some with mild dementia. The goal is to better understand Alzheimer's disease, not …

This study uses brain scans (PET and MRI) to find early signs of Alzheimer's disease in 650 adults with normal cognition or early-stage symptoms. Participants receive special tracers that highlight amyloid and tau proteins in the brain. The goal is to understand how these biomark…

This study tests a new radioactive tracer called [11C]-CS1P1 to see if it can detect inflammation in the brains of people with Alzheimer's disease. Researchers will compare brain scans from 80 older adults—some healthy and some with memory problems—to see if the tracer lights up …

This study looks at whether changes in movement, like how fast you can tap your fingers, can help detect early signs of dementia. Researchers will study 200 people, some with mild cognitive impairment (MCI) and some healthy, using a special glove to measure finger movements. The …

This study looks at how older adults who worry about their memory may use extra brain power to stay mentally sharp. Researchers will give a medication that temporarily affects a brain chemical to see how attention networks respond. The goal is to understand these compensatory bra…

The CROWN-I study is an observational research project involving 160 people with Alzheimer's disease or mild cognitive impairment. Participants will provide samples and undergo assessments over time to help researchers understand the molecular and genetic features that distinguis…

This observational study is recruiting 600 participants to improve detection and understanding of dementia with Lewy bodies (DLB). Researchers will collect clinical data, brain scans, and spinal fluid samples from people with early symptoms like hallucinations or movement problem…

This study looks at brain activity during sleep in people with early-course schizophrenia compared to healthy individuals. Researchers will play soft tones during deep sleep using a wearable headband to see if it can strengthen sleep-related brain waves and improve memory. The go…

This large nationwide study in China will track nearly 10,000 people with Alzheimer's disease to measure the financial and emotional burden on patients and their caregivers. Researchers will collect data on medical expenses, care costs, and lost income. The goal is to fill gaps i…

This study is testing whether subtle changes in how people speak can predict who will develop schizophrenia. Researchers will record and analyze free speech from 215 young people aged 15-30 who are at ultra-high risk for psychosis. By using computer programs to detect semantic an…

This study tests a program to help doctors in psychiatric clinics prescribe medications for alcohol use disorder to patients who also have serious mental illness. The program uses an external facilitator to work with clinic staff and overcome barriers to prescribing. The goal is …

This study looks at why people with Alzheimer's disease may move more slowly. Researchers will use brain MRI scans and simple reaction time tests in 155 participants with mild cognitive impairment or early dementia. The goal is to link brain lesions to attention-related motor slo…

This study investigates whether abnormal insulin action in the brain contributes to cognitive and metabolic problems in schizophrenia. Twenty participants (some with schizophrenia, some healthy) will receive either intranasal insulin or a placebo before a PET scan that measures b…

This study is collecting blood samples and questionnaires from 1,100 people with bipolar disorder or schizophrenia. Researchers are looking for links between genetics, inflammation, and a dormant virus called HERV-W. The goal is to find new biomarkers and pave the way for future …

This study follows 20 people from families with a genetic risk for frontotemporal dementia (FTD), including those already diagnosed and those at risk. Over five years, researchers will track changes in health and brain function to better understand how the disease develops. The g…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This study is creating a new computer-based cognitive assessment to help detect Alzheimer's disease in its earliest stages. Researchers are working with memory nurses and older adults to design the test and a training course for nurses. 120 older adults with memory concerns will …

This study looks at whether special brain cells called tanycytes play a role in Alzheimer's disease and frontotemporal dementia. Researchers will measure hormone levels in blood and spinal fluid from 102 participants to see if these cells help control metabolism and hormone signa…

This study aims to find genes that increase the risk of developing Alzheimer's disease. Researchers are recruiting 10,000 people, including those with Alzheimer's and their family members, from all ethnic backgrounds. By analyzing DNA, they hope to discover new genetic clues that…

This study looks at how much pain people feel after a cardiac arrest while they are in the intensive care unit. Researchers will track pain using special scales, even in patients who are unconscious or on a breathing machine. The goal is to understand how pain affects recovery, s…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This study looks at how sleep problems before heart surgery might impact recovery in 144 adults. Researchers will collect blood and stool samples before and after surgery to measure changes in metabolism, inflammation, and gut bacteria. The goal is to understand why poor sleep le…

This study is for adults with depression who have recently attempted suicide. It tests a group program that teaches emotion regulation and values to improve daily functioning and prevent future suicide attempts. Researchers will also measure thinking skills, quality of life, and …

This early-phase study is testing the safety and how the body handles a new oral drug called AS-S603, which is being developed to treat Alzheimer's disease. The trial involves 88 healthy volunteers, including Korean and Caucasian adults and Korean elderly people. Participants wil…

This study is a national registry for people with adrenoleukodystrophy (ALD), a rare genetic disorder. Researchers will collect medical records and survey data from up to 1,000 patients and their families over time to understand how the disease progresses. The goal is to find bet…

This study looks at 240 adults aged 40-60 to see if being overweight or obese in midlife is linked to early signs of Alzheimer's in the brain. Participants will have metabolic tests and brain scans (MRI and PET) to measure inflammation, brain shrinkage, and protein buildup. The g…

This study explores how the brain recognizes and remembers places, using virtual tours and brain recordings in people with epilepsy. Researchers aim to map the brain regions critical for spatial memory, so surgeons can avoid them during epilepsy surgery. Over 600 participants, in…

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…

This study uses brain imaging (PET scans) and memory tests to understand why some people with Parkinson's disease develop dementia. Researchers will follow 320 participants over several years, using scans to look for abnormal proteins and track thinking changes. The goal is to id…

This study compares swallowing function in older adults with and without Alzheimer's disease. Researchers will also survey caregivers to understand the burden of swallowing issues. Participants will undergo tests of swallowing, coughing, and muscle strength. The goal is to learn …

This study looks at how to measure cardiorespiratory fitness in people with severe mental illness, such as schizophrenia or bipolar disorder. Researchers will compare three different fitness tests in 50 patients and 25 healthy volunteers. The goal is to find a simple, accurate wa…

This study tests new methods to improve how dementia clinical trials are run. Researchers want to see if a combined score of thinking and daily function can better measure treatment effects. They will also check if blood proteins can predict who responds to the Alzheimer's drug d…

This study is testing a new, non-invasive ultrasound technique called Tissue Pulsatility Imaging (TPI) to measure tiny brain movements. Researchers will compare these measurements in 300 people with mild versus major cognitive disorders. The goal is to see if brain pulse patterns…

This study looks at how people with schizophrenia-spectrum disorders update their beliefs after treatment for persecutory delusions. Researchers will use therapy, brain scans, and learning tasks to see if treatment changes how the brain responds to uncertainty. The goal is to bet…

This study is testing a mobile app called Wysa for Chronic Pain, designed to support people aged 45 and older who have chronic pain along with depression or anxiety. Researchers want to see if personalized in-app notifications can encourage people to use the app more often. Parti…

This study aims to help 25,000 young people ages 12-29 who may be at risk for psychosis get connected to care sooner. Researchers will use online screening and text-based coaching to understand different types of help-seekers and test which digital strategies work best. The goal …

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This study looks at whether low oxygen levels during sleep after hip fracture surgery are linked to delirium (sudden confusion) in patients over 70. Researchers will monitor 70 participants in the hospital to see if nighttime hypoxia increases the risk of complications like infec…

This study looks at whether treating depression with a common antidepressant (escitalopram) can change brain and blood markers linked to Alzheimer's disease. Researchers will compare the drug to a placebo in 60 adults aged 60 and older who have major depression but no memory prob…

This study is testing whether a non-invasive electrical stimulation technique can improve working memory, attention, and thinking skills in healthy older adults and those with mild cognitive impairment. The stimulation targets deep brain structures without surgery, using special …

This study at Mayo Clinic looks at two different types of Progressive Apraxia of Speech, a condition that makes it hard to speak clearly. Researchers will use brain scans, speech assessments, and thinking tests in 47 adults to better tell these types apart. The goal is to improve…

This study looks at how social and emotional thinking skills relate to everyday behavior in people with Alzheimer's disease and similar conditions. Researchers will give 120 participants tests of social cognition and ask their study partners to complete behavior checklists. They …

This study looks at whether simpler hearing aid settings work better for older adults with Alzheimer's dementia or mild memory problems. Researchers will test two different hearing aid programs in 20 participants to see which one helps them understand speech in noisy settings and…

This study records brain activity from epilepsy patients who already have electrodes implanted for seizure monitoring. While they perform thinking tasks like memory and attention games, researchers watch how different brain areas talk to each other. The goal is to better understa…

This study uses a special PET scan tracer called [11-C]OMAR to measure cannabinoid receptors in the brain. Researchers will compare healthy volunteers to people with schizophrenia, cannabis dependence, PTSD, opioid use disorder, and other conditions. The goal is to understand how…

This study tests a 4-week training program for assisted living staff (nurses, administrators, and coordinators) to improve palliative care for residents with dementia. The goal is to increase advance care planning discussions and reduce caregiver burnout. About 792 participants f…

This study tests whether a training program for volunteers aged 50 and over can improve their knowledge about dementia, confidence in caregiving, and quality of life. Participants either receive 80-90 hours of BrainLive Coach training or just educational materials. The goal is to…

This study aims to find genetic factors that increase the risk of developing dementia before age 70. Researchers will analyze DNA from 1,000 participants, including people with memory concerns or dementia and their healthy family members. The goal is to better understand how gene…

This study looks at whether the drugs used to keep you asleep during breast surgery can cause confusion or memory problems afterward. Researchers will test 200 women's thinking before and after surgery using simple puzzles and questions. The goal is to see if certain drug levels …

This study tests whether eating walnuts daily for a week can improve thinking and memory in adults who feel their memory is slipping. Participants will eat either walnuts or a white chocolate bar each day, then switch after a break. Researchers will measure brain function and gut…

This study tests whether cinematic virtual reality (VR) is more effective than traditional lectures for teaching medical students about geriatric care. One hundred students at Ohio University will be randomly assigned to either VR training or a lecture. The VR group will experien…

This study creates a registry of brain scans, thinking tests, and blood samples from 1,000 people with schizophrenia, schizoaffective disorder, or no mental illness. Researchers use MRI to compare brain activity and connections between groups while performing memory tasks. The go…

This study tests whether improving sleep with a special headband and doing mild exercise twice a week can lower biological markers linked to dementia. Thirty adults with mild memory or thinking problems will use the DREEM 2 headband for sleep therapy and follow a guided exercise …

This study looks at how well people with frontotemporal dementia or Alzheimer's disease can recognize emotions in others and how aware they are of their own performance. Researchers will ask 34 participants (ages 50-80) to complete computer tasks and confidence ratings. The goal …

This study follows 650 people with early Parkinson's disease or a sleep condition called idiopathic REM sleep behavior disorder (iRBD). Researchers use brain scans, heart tests, and fluid samples to track changes over time. The goal is to better understand how these conditions de…

This study looks at slow brain waves during sleep and wakefulness in 90 people: young adults, healthy seniors, and early-stage Alzheimer's patients. Researchers will measure these waves and test memory and attention. They will also play sounds during sleep to see if it boosts mem…

This study compares two online training programs for assisted living staff who care for people with dementia. One program is a self-paced web course called essentiALZ; the other adds a virtual mentoring group called Project ECHO. Researchers will track changes in staff knowledge,…

CAPTURE ALS is a long-term study that collects health data and biological samples from 150 people with ALS and related conditions. The goal is to create a shared resource for researchers worldwide to better understand the disease and develop new treatments. No experimental drugs …

This study follows 500 people with early Alzheimer's who are receiving anti-amyloid antibody therapy (like lecanemab) in routine care. Researchers will compare their cognitive decline to historical data and track side effects. The goal is to learn how well these drugs work in the…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study looks at how tau protein buildup in the brain may cause psychotic symptoms like delusions in Alzheimer's disease. Researchers will use PET scans and MRI to compare brain changes in Alzheimer's patients with and without psychosis, as well as healthy older adults. The go…

This study tests whether a video camera and artificial intelligence can accurately measure delirium severity in ICU patients over 50. Researchers will compare the camera data with standard bedside assessments. The goal is to create a passive digital marker that works automaticall…

This study follows nearly 3,000 people, including healthy adults and those with memory or movement problems, to learn how brain diseases like Alzheimer's and Parkinson's develop. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve ear…

This study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…

This study is testing whether neighborhood pharmacies can help identify older adults with early memory problems and guide them to the right support. Over 1,000 participants aged 60 and older will take a digital memory test at their pharmacy. If the test shows concerns, the pharma…

This study is watching 400 children under 16 who are having planned surgery. Researchers will use a special brain wave test (EEG) to see if they can predict which kids will wake up confused or agitated (emergence delirium). The goal is to better understand why this happens and ho…

This study looks at 100 older adults with normal pressure hydrocephalus (NPH) to find out why some get better after a shunt surgery and others do not. Researchers will use brain scans, blood tests, and wearable monitors to check for nerve damage and signs of dementia. The goal is…

This study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…