Could a daily probiotic help tame schizophrenia?

NCT ID NCT04226898

Recruiting now Disease control Sponsor: Sheppard Pratt Health System Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a daily synbiotic supplement (a mix of probiotics and prebiotics) can reduce symptoms of schizophrenia when taken alongside standard antipsychotic medications. Researchers are enrolling 68 adults with schizophrenia or schizoaffective disorder who have ongoing symptoms. Half will get the supplement, half a placebo, and changes in symptoms and thinking will be measured over several weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: synbiotic supplement (Probio-Tec ABCG)
What this could lead to: If it works, this could point toward a simple, safe add-on treatment to help control schizophrenia symptoms.
What could go wrong: This is a small, early-phase trial (68 people) testing a supplement, not a new drug. The effect may be small or no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Psychotic Disorders schizoaffective disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOAFFECTIVE DISORDER SCHIZOPHRENIA

Contacts and locations

Locations

Sheppard Pratt Health System
RECRUITING

Batlimore, Maryland, 21285, United States

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