SCHIZOAFFECTIVE DISORDER

This study tests whether valbenazine can reduce involuntary muscle movements in people with tardive dyskinesia who still have symptoms despite prior treatment. About 50 adults with schizophrenia, bipolar disorder, or major depression will take valbenazine for 24 weeks. The goal i…

This study tests magnetic seizure therapy (MST) as a gentler alternative to electroconvulsive therapy (ECT) for people with schizophrenia that hasn't improved with medication. About 80 adults with treatment-resistant schizophrenia or schizoaffective disorder will receive MST to s…

This study is testing whether the antipsychotic clozapine works better than risperidone for people with a specific brain-based subtype (Biotype-1) of psychosis. About 524 adults with schizophrenia, schizoaffective disorder, or bipolar I disorder with psychosis will take either cl…

This study looks at whether adding five extra services—like peer support, digital outreach, and family therapy—to standard coordinated specialty care helps people with early psychosis stay in treatment longer. About 350 participants will either receive standard care or the enhanc…

This study tests whether clozapine, a medication for schizophrenia, can lower the risk of violent acts better than usual antipsychotic treatments. About 280 adults with schizophrenia or schizoaffective disorder who have been violent in the past six months will take either clozapi…

This study tests a community-based cognitive remediation program for 160 adults with schizophrenia or schizoaffective disorder. Participants will do computer exercises and group sessions to improve memory, problem-solving, and social skills. The goal is to see if this helps them …

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce psychiatric symptoms in people recently diagnosed with bipolar I or schizoaffective disorder. Fifty adults aged 18-45 will follow the diet for 12 weeks alongside their usual care. T…

This study tests whether a prebiotic (a type of fiber that feeds good gut bacteria) can reduce inflammation and improve thinking and memory in people with schizophrenia or schizoaffective disorder. Researchers will enroll 60 adults who are stable on antipsychotic medication. The …

This pilot study explores whether physical activity in green outdoor spaces can reduce negative symptoms (like lack of motivation or social withdrawal) in people with schizophrenia more than indoor exercise. Researchers will compare the two settings in 45 adults aged 18-55. The g…

This study tests a smartphone-based program called mSITE that encourages social interaction for people with schizophrenia or related conditions. About 125 adults will use the app, which tracks conversations and prompts social activity. The goal is to reduce social withdrawal and …

This study tests a 12-week group program called Motivation Skills Training (MST) for 80 adults with schizophrenia or schizoaffective disorder. The program teaches skills to improve motivation, goal-setting, and daily functioning. Participants are compared to a group focusing on h…

This study tests whether a smartphone app called Kiso Mind is acceptable and helpful for people with schizophrenia or schizoaffective disorder. About 60 participants will either use the app plus their usual care, or just usual care, for 12 weeks. The goal is to see if the app is …

This study looks at whether safely stopping unnecessary anticholinergic drugs (like benztropine) can improve thinking, daily function, and quality of life in people aged 40-70 with schizophrenia or schizoaffective disorder. Participants will either continue their medication or gr…

This study is testing whether a daily synbiotic (probiotic plus prebiotic) supplement can reduce symptoms like hallucinations and social withdrawal in people with schizophrenia or schizoaffective disorder. Researchers will compare the supplement to a placebo in 68 adults who are …

This study tests a therapy called Targeted Cognitive Training (TCT) for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. TCT uses brain exercises to improve how the brain processes information, with the goal of boosting thinking skills and dai…

This study is testing a program called iTEST for people with schizophrenia or related disorders. The program combines daily brain-training exercises on a mobile device with coaching to help participants accurately judge their own abilities. Researchers want to see if this improve…

This study collects brain scans and thinking tests from 1,000 people with schizophrenia, schizoaffective disorder, and healthy volunteers. Researchers want to see how brain areas work differently during memory tasks. The goal is to better understand mental disorders, not to test …

This study looks at how attention and thinking strategies influence decision-making and brain activity in people with schizophrenia or schizoaffective disorder compared to healthy volunteers. Researchers will train participants to use a positive thinking strategy and then measure…

This study looks at whether a non-invasive brain stimulation technique called TMS can improve how quickly people with psychotic disorders (like schizophrenia or bipolar disorder) solve problems. About 95 participants will do thinking tasks and get brain scans before and after TMS…

This study tests whether a fast type of brain stimulation (accelerated TMS) can improve thinking and memory in people with schizophrenia or schizoaffective disorder who are already taking the medication clozapine. About 30 adults aged 18-50 will receive both real and fake stimula…

This study looks at 320 people who recently developed psychosis (like schizophrenia or bipolar I) to see if brain scans, eye-tracking, and genetics can predict who will get better with treatment. Participants attend four visits over a year, providing DNA, EEG, and MRI data. The g…