Brain training targets voices in schizophrenia

NCT ID NCT05299749

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether real-time fMRI neurofeedback can help people with schizophrenia who still hear voices despite medication. Participants learn to control their own brain activity while inside an MRI scanner, aiming to reduce the brain signals linked to auditory hallucinations. The trial will enroll 104 people and compare real feedback to a sham version.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

real-time fMRI neurofeedback

What this could lead to

If it works, this could offer a new, non-drug way to reduce distressing voices for people with schizophrenia who don't respond to medication.

What could go wrong

This is an early-stage study with a small number of participants. The effect may be small or not last long, and not everyone may benefit.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Hallucinations schizoaffective disorder schizophrenia Schizophrenia, Treatment-Resistant treatment-refractory schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Boston VA Healthcare System, Brockton

    RECRUITING

    Brockton, Massachusetts, 02301, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••