Cutting unneeded meds may boost brain power in schizophrenia

NCT ID NCT06562608

First seen Feb 13, 2026 · Last updated May 10, 2026 · Updated 10 times

Summary

This study looks at whether safely stopping unnecessary anticholinergic drugs (like benztropine) can improve thinking, daily function, and quality of life in people aged 40-70 with schizophrenia or schizoaffective disorder. Participants will either continue their medication or gradually stop it under medical supervision, and be followed for 6 months with brain scans and cognitive tests. The goal is to see if reducing these drugs leads to better brain connectivity and mental performance.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UPMC Western Psychiatric Hospital/University of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

    Contact

    Contact

    Contact Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.