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Can a short exercise program stop antipsychotic weight gain?

NCT ID NCT06740890

Recruiting now Disease control Sponsor: New York State Psychiatric Institute Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study tests whether adding a four-week aerobic exercise program to a new antipsychotic medication (olanzapine-samidorphan) can prevent the early weight gain often seen with these drugs. Thirty adults with schizophrenia, schizoaffective disorder, or bipolar disorder will take the medication for eight weeks and exercise for the first four weeks. The main goal is to see if participants gain less weight than expected.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Olanzapine-samidorphan plus aerobic exercise
What this could lead to
If successful, this approach could help prevent the rapid weight gain often caused by antipsychotic medications, improving long-term health outcomes.
What could go wrong
This is a small, early-phase study with only 30 participants, so results may not apply broadly. The exercise program is short (4 weeks), and weight gain prevention may not persist.

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Conditions

The condition(s) this trial relates to.

bipolar disorder bipolar I disorder bipolar II disorder Motor Activity Psychotic Disorders schizoaffective disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER I OR II BIPOLAR DISORDER NOS SCHIZOAFFECTIVE DISORDER SCHIZOPHENIA DISORDER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • New York State Psychiatric Institute

    RECRUITING

    New York, New York, 10032, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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