SCHIZOAFFECTIVE DISORDER

This study tested a new approach to help people with schizophrenia get more out of cognitive training—a type of brain exercise. 68 adults with schizophrenia or schizoaffective disorder took part. The idea was to use a medication to enhance the effects of the training, aiming to i…

This study tested whether delivering mental health services by video (telehealth) helps young people with psychotic disorders stay engaged in care and avoid hospital stays better than standard in-person clinic visits. 74 people aged 16-35 with early psychosis took part. The goal …

This study compared two ways to help people with serious mental illness quit smoking: a smartphone app designed for them (Quit on the Go) versus standard care. 343 participants were followed for 6 months to see who stopped smoking, verified by a breath test. The goal was to find …

This study tested whether a higher dose of a long-acting injectable antipsychotic medication works better than the standard dose for people with schizophrenia or schizoaffective disorder. It involved 160 participants whose symptoms weren't well-controlled on their current medicat…

This study looked at how well valbenazine works for tardive dyskinesia, a condition causing uncontrollable movements often linked to psychiatric medications. Fifty-nine adults with schizophrenia, bipolar disorder, or major depression took valbenazine for up to 24 weeks. Researche…

This study tested whether luteolin, a natural substance found in celery and chamomile tea, can improve symptoms of schizophrenia. 85 adults with schizophrenia or schizoaffective disorder took luteolin or a placebo. The goal was to see if it helps with thinking, mood, and overall …

This study tested whether adding the drug memantine to a computer-based cognitive training program helps improve thinking and daily function in people with schizophrenia or schizoaffective disorder. 62 adults took part in a 13-week trial where some received memantine and others a…

This study tested an investigational medication called BXCL501 for calming agitation episodes in people with bipolar disorder, schizophrenia, or related conditions. 452 adults took either the drug or a placebo, and researchers measured changes in agitation levels and safety. The …

This study tested whether patients with schizophrenia or schizoaffective disorder could improve their awareness of their illness by watching a video of themselves recorded during a severe episode. 60 patients participated, with half watching the video after they stabilized. The g…

This study looked at how young adults aged 18-30 with early psychosis process information from their surroundings, compared to those without a psychiatric diagnosis. Participants completed computer-based tasks and cognitive training to measure changes in attention and decision-ma…

This study tested whether a smartphone app could passively track activity, sociability, and sleep in 87 veterans with serious mental illnesses like schizophrenia and bipolar disorder. The goal was to see if this data could help detect early warning signs of relapse. The study foc…

This study tested whether sending text message reminders helps young people (ages 14-35) with psychosis attend their first appointment at an early psychosis program after being seen in the emergency room. Researchers enrolled 186 participants and tracked whether they showed up fo…

This study tested whether customizing cognitive training based on a person's early auditory processing ability improves thinking and daily functioning in people with schizophrenia or schizoaffective disorder. 194 adults from community mental health centers were grouped by their a…

This study looked at how people aged 15-45 with early psychosis process information about their surroundings, compared to healthy young adults. Participants completed computer tasks while their brain activity was measured using EEG and MRI. The goal was to understand brain functi…

This study looked at how a natural brain chemical called kynurenic acid (KYNA) affects thinking and memory in people with schizophrenia. Researchers gave participants tryptophan (a common amino acid) to raise KYNA levels, then tested whether the supplement N-acetylcysteine (NAC) …

This study looked at how dopamine receptors in the brain work in people with schizophrenia compared to healthy volunteers. Researchers used special PET and MRI scans to measure two types of dopamine receptors. The goal was to better understand what causes schizophrenia, which cou…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. By understanding these conn…

This study looked at whether a program called NAVIGATE helps youth (ages 14-35) having their first episode of psychosis get better coordinated care. Researchers worked with 100 participants across Ontario to see if the program reduces hospital stays and ER visits. The goal was to…

This study tested a telehealth program called CRAFT-EP that helps families support a relative with early psychosis and substance use (like alcohol or cannabis). 65 family members took part. The goal was to see if the program improves family wellbeing, including depression and anx…

This study tested a training program called Collaborative Decision Skills Training (CDST) to help veterans with serious mental illness, like schizophrenia, work more closely with their doctors in making treatment decisions. The program involved 8 weekly group sessions, and resear…

This study tested whether special visual exercises could improve how people with schizophrenia see and process visual information. About 79 adults with schizophrenia or schizoaffective disorder took part. The training focused on two visual skills often affected by the condition: …

This study looked at how people aged 15-45 with early psychosis process information about their environment, compared to those without a psychiatric diagnosis. Researchers tested two types of cognitive training and measured changes in brain activity and task performance using com…

This study looked at whether family members or caregivers can help measure agitation in people with bipolar disorder or schizophrenia. 33 adults took a single dose of an experimental medicine, and researchers compared ratings from doctors, patients, and their family members. The …