SCHIZOAFFECTIVE DISORDER

This study tested whether delivering specialized early psychosis care via video calls (telehealth) works as well as standard in-clinic visits. It involved 74 young adults (ages 16-35) with recent-onset psychotic disorders. Over 12 months, researchers compared how often participan…

This study tested if adding a drug called memantine to a brain training program could help people with schizophrenia or schizoaffective disorder. Researchers wanted to see if this combination could improve thinking skills, reduce symptoms, and help with daily activities better th…

This study tested if sending supportive text messages could help young people with psychosis get from the emergency room to their first follow-up appointment. Researchers enrolled 186 young adults (ages 16-29) to see if reminders and check-ins via text improved attendance at that…

This study tested if a very low dose of amphetamine could make computer-based brain training more effective for people with schizophrenia or schizoaffective disorder. 68 participants completed up to 30 hours of training, with half receiving the medication and half receiving a pla…

This study tested a family training program delivered by video call. It aimed to help family members support a relative who is experiencing early psychosis and using substances like alcohol or cannabis. The goal was to see if the program improved family wellbeing and helped the r…

This study tested whether higher doses of a long-acting injectable antipsychotic medication (risperidone) work better than standard doses for people with schizophrenia or schizoaffective disorder whose symptoms aren't well controlled. 160 participants who hadn't responded well to…

This study tested whether customizing a brain training program (called Cognitive Remediation) could improve thinking skills and daily function for people with schizophrenia or schizoaffective disorder. Researchers first tested participants' basic hearing processing and then assig…

This study tested whether a smartphone app designed specifically for people with serious mental illness could help them quit smoking better than standard advice. Over 300 participants with conditions like schizophrenia, bipolar disorder, or depression were randomly assigned to us…

This study tested whether the drug valbenazine could improve daily life for people with tardive dyskinesia (TD), a condition causing uncontrollable movements often linked to certain mental health medications. For 24 weeks, 59 adults with TD and conditions like schizophrenia or bi…

This study tested a medication called BXCL501 to see if it could safely and effectively calm episodes of agitation when used at home by adults with schizophrenia or bipolar disorder. In the second part of the trial, 452 participants used the medication as needed over 12 weeks at …

This study tested whether watching a video of themselves recorded during a difficult period could help people with schizophrenia or schizoaffective disorder better recognize and understand their illness. Sixty patients were randomly assigned to either watch their own video after …

This study tested whether special computer exercises could help improve vision problems common in people with schizophrenia. Researchers worked with 79 adults who have schizophrenia or schizoaffective disorder, having them complete visual training tasks targeting contrast sensiti…

This study tested whether luteolin, a natural compound found in foods like celery and chamomile tea, could help improve symptoms and thinking problems in people with schizophrenia. For 12 weeks, 85 participants with schizophrenia or schizoaffective disorder took either luteolin c…

This study tested a new training program called Collaborative Decision Skills Training (CDST) for veterans with conditions like schizophrenia or severe depression. The goal was to teach veterans skills to help them work more closely with their doctors on treatment plans. Research…

This study tested whether two types of visual brain training could improve thinking skills in young adults with early psychosis. Researchers enrolled 152 people aged 18-30, including those with conditions like schizophrenia and those without any psychiatric diagnosis. The study w…

This study aimed to understand how computer-based brain training affects thinking skills and brain activity in people with early psychosis. It involved 100 participants, including people with conditions like schizophrenia and healthy volunteers, who completed about 10 hours of tr…

This large, completed study aimed to understand the genetic and brain function factors behind schizophrenia and related disorders. Researchers compared patients, their siblings, and healthy volunteers to identify genes that might increase risk and affect thinking skills. The goal…

This study aimed to understand how a brain chemical called KYNA affects thinking and memory in people with schizophrenia. Researchers gave 88 participants a dietary supplement (tryptophan) to increase KYNA, and then tested if another supplement (NAC) could block its effects. They…

This study aimed to understand how the brain processes information in people with early psychosis. Researchers measured brain activity in 277 participants, including those with and without a diagnosis, while they played computer games. The goal was to see if differences in brain …

This study tested a smartphone app designed to help veterans with serious mental health conditions track their own well-being. The app passively collects data on phone use, movement, and sleep patterns, which may act as warning signs for worsening symptoms. Researchers aimed to s…

This study aimed to better understand how brain chemistry differs in people with schizophrenia. Researchers used special brain scans (PET and MRI) to measure dopamine receptors in 283 participants, including healthy volunteers and people with schizophrenia. The goal was to gather…