Custom brain exercises show promise for schizophrenia thinking skills

NCT ID NCT04554121

Completed Symptom relief Sponsor: Columbia University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether personalizing cognitive training based on a person's early auditory processing ability improves thinking and daily function in schizophrenia. 194 adults with schizophrenia or schizoaffective disorder were assigned to either a tailored program (Brain Basics) or standard cognitive training (Brain Training). The goal was to see if matching the exercises to each person's auditory strengths and weaknesses leads to better outcomes in verbal learning and functional capacity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cognitive remediation therapy (computer-based brain exercises plus group discussions)
What this could lead to: If successful, this approach could lead to more effective cognitive training for people with schizophrenia, improving memory and daily living skills.
What could go wrong: This is a completed study, but the intervention is behavioral and effects may be modest. Results may not apply to all patients or settings.

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Conditions

The condition(s) this trial relates to.

Psychotic Disorders schizoaffective disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOAFFECTIVE DISORDER SCHIZOPHRENIA

Contacts and locations

Locations

Heights Hill Clinic

Brooklyn, New York, 11217, United States
Institute for Community Living

Brooklyn, New York, 11207, United States
Laurel House

Stamford, Connecticut, 06902, United States
Manhattan Psychiatric Center 125th Street Clinic

New York, New York, 10027, United States
Mapleton Mental Health Services

Brooklyn, New York, 11230, United States
Pibly Residential Programs Inc.

The Bronx, New York, 10461, United States
Rockland Psychiatric Center

Orangeburg, New York, 10962, United States
The Bridge, Inc.

New York, New York, 10025, United States
Williamsburg Clinic

Brooklyn, New York, 11206, United States

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