Columbia University

This study tests whether a small wireless sensor placed in the pulmonary artery can help doctors better manage medications for people with heart failure and a leaky mitral valve. The sensor constantly measures pressure inside the heart, giving doctors real-time data to adjust tre…

This study tests a device called Barostim that is implanted in the body to stimulate blood pressure sensors, which may help the heart work better. It involves 58 adults with heart failure who are already on the best available medications. The goal is to see if the device improves…

This study tests whether giving iron supplements to teens with iron deficiency before scoliosis surgery can reduce the need for blood transfusions and improve thinking and physical recovery afterward. About 275 participants aged 10-26 will receive either iron pills or a placebo f…

This study tests a combination of two drugs, venetoclax and dexamethasone, in people with a rare blood disorder called AL amyloidosis that has come back or not improved after treatment. The trial includes 53 adults with a specific genetic marker (t(11;14)). The goal is to find th…

This early-phase study is testing a new drug called 131I-apamistamab, which combines an antibody with radioactive iodine, to prepare people with severe sickle cell disease for a bone marrow transplant. The goal is to find the smallest effective dose that allows the donor stem cel…

This study is testing whether a portable gluten-detection device, combined with regular telemedicine check-ins with a dietitian, can improve gut healing in adults newly diagnosed with celiac disease. Two hundred participants will use the technology and receive expert guidance to …

This early-stage trial tests whether specially grown immune cells from a donor can safely help transplant patients fight off viral infections that standard treatments can't control. The cells target Epstein-Barr virus, cytomegalovirus, adenovirus, and BK virus. Up to 36 adults wh…

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This study investigates whether certain genetic variations influence how much weight people lose when taking the FDA-approved weight loss drug Contrave (naltrexone/bupropion). Over 40 weeks, 120 adults with obesity will first follow a calorie-restricted diet for 12 weeks, then ad…

This study tests whether a heart rehab program that combines telehealth sessions at home with some clinic visits helps more people stick with it and improve their fitness compared to the standard all-clinic program. About 250 adults who had a heart attack or related condition in …

This study will give HEPA air cleaners to 55 children (ages 7-18) with asthma living in low-income housing in East Harlem, NYC. Researchers will measure indoor air pollution and track asthma attacks, lung function, and airway inflammation over a year. The goal is to see if a simp…

This study looks at whether radiofrequency ablation (RFA) can safely shrink thyroid nodules that are not clearly cancerous. RFA uses a tiny needle to deliver heat directly to the nodule. Researchers will review medical records from 50 adults to see how much the nodules shrink and…

This study tests whether a program to improve sleep can help lower blood pressure in adults. Two hundred people with high blood pressure and poor sleep will either get standard heart health advice or a sleep improvement program with coaching and tips. The goal is to see if better…

This study looks at using radiofrequency ablation (RFA) — a procedure that uses heat to destroy cancer cells — for small papillary thyroid cancers. Researchers will follow 50 adults who chose RFA over surgery to see how well it works and how safe it is. The goal is to offer a les…

This study tests four approaches to help adults with drug-resistant tuberculosis and HIV stick to their treatments. Participants receive either standard care, counseling, phone reminders via a special pill bottle, or both counseling and reminders. The goal is to see which method …

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study tests a program to help people with early-stage breast cancer take their hormone therapy and heart medications as prescribed. Participants receive a pharmacist review, training on using a patient portal, and a reminder app. The goal is to see if this support improves m…

This study tests whether pouring tranexamic acid (TXA), a drug that helps blood clot, directly into the surgical wound during spine surgery can reduce bleeding and the need for blood transfusions. About 252 adults with spinal injuries or deformities will be randomly assigned to r…

This study tests whether a treatment called photopheresis can improve early-stage cutaneous T-cell lymphoma (a type of skin lymphoma). Normally used for advanced disease, researchers want to see if using it earlier helps clear skin lesions. About 74 adults with stage IA to IIA my…

This study tests whether a patch made from donated placental tissue can help rotator cuff tears heal better after surgery. Half of the 120 participants will get the patch along with standard repair, and the other half will get standard repair alone. An MRI one year later will che…

This study tests whether adding sleep health coaching to a diet and exercise program can improve heart health, especially blood pressure. About 150 adults with high blood pressure from underserved NYC neighborhoods will take part. The program includes sleep education, a Fitbit tr…

This study tests whether a team of community health workers, social workers, and nurses can help stroke survivors who face social challenges like food or housing insecurity. The team visits participants at home starting within 72 hours of hospital discharge, offering referrals, c…

This study compares the usual surgery for thumb arthritis to a newer procedure that implants donated tissue at the base of the thumb. Researchers will track hand function and pain in 200 adults for one year after surgery. The goal is to see if the new approach leads to better rec…

This study tests whether customizing the nutrients in donor breast milk helps preterm babies (born at 30 weeks or earlier, weighing under 3.3 pounds) grow better than standard fortification. Fifty infants will be randomly assigned to receive either standard or targeted fortificat…

This early-phase trial is testing whether giving intestinal transplant patients stem cells from their organ donor can safely allow them to take less immunosuppression medication. The goal is to reduce the high risk of infections and cancers caused by these drugs. Six participants…

This study tests whether shining a special red light on eggs and embryos during IVF can help them develop better. As women age, their egg cells have less energy, which can make fertilization and embryo growth harder. The light treatment, called photobiomodulation, aims to boost t…

This study looks at 128 people with advanced heart failure who have a HeartMate3 heart pump. All take warfarin to prevent clots, and half will also stop taking aspirin. The goal is to see if skipping aspirin lowers the risk of serious bleeding without raising the chance of danger…

This study tests a mobile app called WiseApp along with a smart pill dispenser to help Spanish-speaking people with HIV take their medication regularly. About 248 participants from New York City and the Dominican Republic will use the app for 12 months. The goal is to see if the …

This study tests whether a same-day HPV screening and treatment approach can help prevent cervical cancer in women living with HIV in the Dominican Republic. 600 women will be randomly assigned to either the new same-day method or standard care. The goal is to see if more women c…

This study tests whether adding the immunotherapy drug cemiplimab to standard chemotherapy can shrink advanced bile duct tumors enough for surgery. About 20 adults with locally advanced, inoperable bile duct cancer will receive the combination treatment. The main goal is to see h…

This study looks at whether offering hereditary cancer screening alongside standard prenatal genetic tests is practical and acceptable. About 1000 pregnant or preconception patients will be offered both tests. The goal is to see how many complete the cancer screening and how they…

This pilot study tests whether using artificial intelligence to adjust radiation plans daily can better target tumors while sparing healthy organs in people with locally advanced anal cancer. Twenty participants will receive standard radiation over six weeks, but each day's plan …

This study tests a short, scripted conversation between doctors and Black adults with uncontrolled asthma. The goal is to help patients and doctors make decisions together about asthma medicines. Researchers will enroll 400 adults at community health centers to see if this approa…

This study tests whether keeping a consistent daily routine—like eating and sleeping at the same times—can improve blood sugar control and reduce body fat in people with pre-diabetes. Researchers will enroll 34 adults and ask half to follow a fixed schedule for 12 weeks. The goal…

This early study tests whether focused ultrasound can safely open the blood-brain barrier in children with progressive diffuse midline glioma (DMG), a rare and aggressive brain tumor. Ten children aged 4–21 will receive oral etoposide chemotherapy after ultrasound treatment to al…

This study is testing whether taking a low-dose aspirin (81 mg) daily for three weeks after giving birth can improve blood vessel function in women who had severe preeclampsia. About 100 women will be randomly assigned to receive either aspirin or a placebo. The main goal is to s…

This phase 1 trial is testing the long-term safety of imatinib (Gleevec), a drug already approved for leukemia, in 20 women with lymphangioleiomyomatosis (LAM), a rare cystic lung disease. Participants will take either imatinib or a placebo twice daily for 6 months, with regular …

This study tests whether giving intravenous iron to teens with iron deficiency before spinal fusion surgery can lower their need for blood transfusions. About 120 participants aged 10-19 will receive either IV iron or a placebo. The goal is to see if correcting iron levels improv…

This study tests whether a newer drug, letermovir, is safer and more effective than the standard valganciclovir for preventing CMV infection in heart transplant recipients. About 150 moderate- to high-risk adults will be enrolled. The main focus is on reducing side effects like l…

This phase 2 trial tests whether adding an experimental drug (fianlimab) to standard chemotherapy plus immunotherapy can help people with muscle-invasive bladder cancer avoid bladder removal. About 36 adults will receive either the standard combo or the standard plus fianlimab. T…

This study looks at tissue removed during back surgery to find early signs of a heart condition called ATTR cardiac amyloidosis. Researchers will test spine samples from 1,663 older adults for abnormal protein deposits. If found, participants will get further heart tests to confi…

This study looks at whether taking multiple saliva samples over time can better detect Barrett's esophagus, a condition where the lining of the food pipe changes and can raise the risk of cancer. About 275 adults who have had or will have an endoscopy will provide saliva samples.…

This study tests a new contrast agent called Gadopiclenol (Elucirem) for MRI scans of the prostate. The goal is to see if it makes aggressive prostate cancers stand out more clearly, helping doctors decide who needs a biopsy. About 150 men scheduled for a prostate MRI will receiv…

This study tests whether a mobile app plus virtual peer support can help young men who have sex with men (ages 16–25) start and stick with PrEP, a daily pill that prevents HIV. The app provides sexual health information and connects users with a peer navigator who can guide them …

This study tests a mobile health program called WINGS+PrEP for women who have experienced heavy drinking, partner violence, and involvement with the criminal legal system. The program provides information about PrEP (a daily pill that prevents HIV) and offers support sessions. Re…

This study tests whether showing a simple pictograph (a picture symbol like a rainbow or lion) in the electronic health record helps doctors and nurses avoid placing orders for the wrong baby in the NICU. Over 6,000 newborns and their clinicians at three hospitals will be randoml…

This study tests whether a mobile app called MyPEEPS can reduce new HIV infections among 3,200 high-risk young men who have sex with men and non-binary individuals aged 16-29. Participants use the app to learn safer sex strategies and are compared to a standard care group. The tr…

This study tests a 6-month virtual nutrition education program (PEDALL) to prevent overweight and obesity in children and teens with acute lymphoblastic leukemia (ALL) during maintenance chemotherapy. The program is offered in English and Spanish to 376 participants aged 5-21. Re…

This study tests whether community health workers can help people at higher risk for colorectal cancer get screened and adopt healthier habits. About 880 adults aged 45 and older who are not up-to-date with screening will be assigned to either a health worker-led program or usual…

This study looks at how to help cisgender women and transgender individuals, especially Black and Latinx communities, start and stick with PrEP—a daily pill that prevents HIV. Researchers will give personalized feedback to participants based on their adherence. The goal is to und…

This early-phase trial tests a new nasal ointment called TOR-582, which contains sirolimus, in 27 adults with hereditary hemorrhagic telangiectasia (HHT) who have frequent nosebleeds. Participants apply the ointment inside their nostrils twice daily for 12 weeks, with different s…

This study tests whether pairing electrical stimulation of the brain's hand area with stimulation of a wrist nerve can improve hand and arm function in adults with hemiplegic cerebral palsy (hCP). Researchers will measure changes in muscle responses and dexterity tasks like movin…

This study tests a small, non-invasive device that gently stimulates a nerve in the ear (taVNS) to see if it is safe and tolerable for people with persistent symptoms after Lyme disease treatment. The trial will enroll 24 adults who still have symptoms like fatigue or pain months…

This study tests a new way to treat brain fog in people with post-treatment Lyme disease. Participants will play computer-based thinking games at home while receiving either real or fake brain stimulation (tDCS) for 4 weeks. Researchers will check if the active stimulation improv…

This study tests whether combining mindfulness meditation with real-time brain scan feedback can help teens with depression. Researchers will train 90 adolescents aged 13-18 to control brain circuits linked to rumination (repetitive negative thinking). The goal is to see if this …

This study is testing whether giving parents extra face-to-face education about pain management helps reduce their child's pain after day surgery. Researchers will compare two groups of children ages 1-6: one group's parents receive additional teaching, while the other gets stand…

This study compares a new FDA-approved suction device (EXSALTA) to standard suctioning in 30 preterm and term infants who are on breathing tubes. The goal is to see if the new device causes smaller changes in heart rate, oxygen levels, and brain oxygen levels during suctioning. E…

This study is testing a device called MyHand 2 that helps people who have had a stroke use their affected hand better. The device is worn on the hand and assists with movement. Researchers want to see if it is easy to use and helpful for daily tasks. The study involves 60 adults …

This study looks at whether a simple home-based walking program can boost memory, thinking skills, and brain structure in older adults (over 55) who have both chronic kidney disease and mild cognitive impairment. Over 6 months, participants will either walk regularly or receive h…

This study tests a new therapy called AMBET (Acceptance- and Mindfulness-Based Exposure Therapy) for treating PTSD in people who survived a cardiac arrest. About 90 adults will be randomly assigned to either AMBET or a standard talk therapy (PCT) for 12 weeks. Researchers will tr…

This study tests a device called Discogen that uses low-intensity ultrasound to treat pain from a herniated disc. About 40 adults with leg or back pain will receive either the real treatment or a sham (fake) treatment. The goal is to see if the device safely reduces pain and impr…

This study tests a simple tool called iHeart DepCare to help people with heart disease who also feel depressed. About 200 adults will either get usual care or extra support and guidance to start depression treatment. The goal is to see if the tool helps more patients get the ment…

This study is testing a wearable robotic hand orthosis called MyHand-SCI for people with C6-C7 spinal cord injury. The device is designed to assist with hand and finger movement. Researchers will enroll 40 participants to evaluate how usable and helpful the device is. The goal is…

This study looks at whether eating pistachios can improve sleep in middle-aged adults who don't sleep well. 28 people will eat either pistachios or a similar snack for a while, and researchers will measure sleep quality, movement during sleep, and a sleep-related hormone. The goa…

This study tests a device called VibraCool that uses cooling and vibration to reduce pain after ACL knee surgery. The goal is to see if it can lower pain scores and help people stop taking opioid pain pills sooner. About 130 adults who had ACL reconstruction will use the device a…

This study tests a game-like iPad program called cognitive control training (AKL-T01) in 60 children aged 8–12 with obsessive-compulsive disorder (OCD). For 4 weeks, kids play the game 25 minutes a day, 5 days a week, to improve focus and self-control. Researchers will check if t…

This study tests a 12-week group therapy program called Motivation Skills Training for people with schizophrenia or schizoaffective disorder. The goal is to see if it improves motivation, goal attainment, and quality of life compared to a control group focused on healthy behavior…

This study tests whether doing crossword puzzles can help people with mild cognitive impairment (MCI) keep their thinking skills sharp. Researchers will compare doing 4 puzzles per week, 1 puzzle per week, or health education. The goal is to see if puzzles can slow memory decline…

This study is testing whether a special gel called StrataCTX can help people with skin reactions from cutaneous T-cell lymphoma (CTCL) or cancer treatments use less steroid cream. Steroid creams can have side effects when used a lot, so finding an alternative is important. The st…

This pilot study tests whether training obstetric clinicians in trauma-informed care can improve mental health and mother-child bonding in pregnant women who experienced childhood abuse. Sixty first-time mothers in Buenos Aires will receive care from trained providers, and resear…

This study tests a special neck brace designed to help children with cerebral palsy improve their head and neck control. The brace uses sensors, springs, and small motors to support and gently guide head movements during training. Researchers will enroll 30 children and measure c…

This study compares robotic-assisted total knee replacement to the standard manual procedure in 86 adults aged 40-85 with severe knee arthritis. Participants will receive the same knee implant, but one group's surgery is guided by a robotic system. Researchers will measure pain, …

This study aims to help 25,000 young people aged 12-29 who are at high risk for psychosis reach out for help sooner. Researchers will use online screening and personalized digital messages to encourage them to schedule assessments and connect with local clinics. The goal is to re…

This early-phase study tests whether pairing brain stimulation with spinal cord stimulation can strengthen the signals that control hand muscles. Researchers will study healthy volunteers, people with spinal cord injury, and those with cervical myelopathy. The goal is to understa…

This study follows 800 people with thumb arthritis to find out which treatments—surgical or non-surgical—work best for pain relief and hand function. Participants continue their usual care, and researchers track their progress over time. The goal is to learn what helps most, not …

This study is collecting prostate cancer tissue from 16 men with metastatic prostate cancer to analyze the tumor microenvironment—the cells and structures around the tumor. Researchers will use advanced genetic and molecular tests to understand how the immune system interacts wit…

This study tests a program called Youth-Nominated Support Team for Probation (YST-P) for teens aged 12-17 who are on probation and have suicidal thoughts or behaviors. The program connects them with supportive adults to reduce suicide risk and encourage them to get mental health …

This study follows 1,400 children and teens (ages 3-21) in Southern Europe with acute lymphoblastic leukemia or certain brain tumors. Researchers will track their diet, lifestyle, and quality of life over time to see how these factors relate to treatment side effects and survival…

This study tests a smartphone app designed to help African American and Spanish-speaking patients recognize warning signs of pregnancy-related death. Participants choose symptoms they are having and get advice on when to call a doctor or go to the emergency room. The goal is to s…

This study is a registry that collects information from 1,000 men with prostate cancer who receive focal therapy using high-intensity focused ultrasound (HIFU) or irreversible electroporation (IRE). No new treatment is given—researchers simply record patient details, disease feat…

This study looks at two treatments for non-cancerous thyroid nodules: surgery and radiofrequency ablation. Researchers will track how much the nodules shrink, changes in thyroid hormone levels, and quality of life. About 100 adults with benign nodules will participate, and the go…

This study looks at whether genome sequencing (reading nearly all of a baby's genes) should be used more routinely during pregnancy, even when ultrasounds look normal. Researchers will compare this test with current standard prenatal testing in over 1,000 families to see if it fi…

This study aims to understand how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medi…

This study tests a program to help people safely stop taking long-acting injectable HIV prevention (PrEP). It will enroll 30 HIV-negative adults who are considering stopping or have stopped their PrEP shots. The program includes personalized coaching and, for some, monthly drug l…

This study tests a new way to stimulate the brain and a nerve in the arm at the same time to encourage the spinal cord to adapt and improve hand movement. It involves 20 healthy adults who will receive non-invasive stimulation while researchers measure muscle responses. The goal …

This study looks at whether giving extra cash to pregnant women and new moms in Appalachia helps their babies grow better and improves the mothers' mental health. About 1,250 women will be randomly assigned to receive either a higher or lower amount of cash support. Researchers w…

This study looks at what happens when people sleep only a few hours on weekdays but catch up on weekends. Researchers want to see if this pattern harms blood sugar, blood pressure, and body fat compared to getting enough sleep every night. The study involves 72 adults aged 18 to …

This study aims to find genes that increase the risk of developing Alzheimer's disease. Researchers are recruiting 10,000 people, including those with Alzheimer's and their family members, from all ethnic backgrounds. By analyzing DNA, they hope to discover new genetic clues that…

This study looks at 150 patients who are unresponsive after a brain bleed (intracerebral hemorrhage). Researchers use EEG to detect hidden brain activity when patients are asked to imagine moving. The goal is to see if this activity can predict who will regain consciousness and h…

This study looks at how a mother's stress during pregnancy might affect her baby's brain and behavior. By comparing IVF pregnancies where the baby is genetically related to the mother versus those where the baby is not (using donor eggs), researchers can tell if stress effects ar…

This study is trying to figure out what makes someone more likely to develop multiple sclerosis (MS). Researchers are looking at a mix of genetic, environmental, and immune factors in 5,000 people in the US, including relatives of MS patients and others at higher risk. The goal i…

This study is looking at whether the brains and spinal cords of adults with cerebral palsy shrink or change over time, which might explain why some people lose function as they age. Researchers will collect and compare past and new MRI scans from 30 adults with CP across the U.S.…

This study looks at how stress and social support might influence preterm birth in 200 pregnant women, especially among Black and Hispanic women who face higher risks. Researchers will measure stress levels, immune responses, and cellular energy (mitochondria) to understand why s…

This study looks at how tired people with spinal muscular atrophy (SMA) feel during daily activities while taking the drug nusinersen. Researchers will use a new questionnaire called the SMA EFFORT to measure this fatigue. The goal is to better understand fatigue in SMA and see i…

This study looks for three common BRCA gene mutations in 100 Ashkenazi Jewish people with pancreatic cancer. By understanding how often these mutations occur, researchers hope to improve early screening and prevention for at-risk family members. Participants provide a sample and …

This study aims to help 25,000 young people ages 12-29 who may be at risk for psychosis get connected to care sooner. Researchers will use online screening and text-based coaching to understand different types of help-seekers and test which digital strategies work best. The goal …

This study aims to find genetic factors that increase the risk of developing dementia before age 70. Researchers will analyze DNA from 1,000 participants, including people with memory concerns or dementia and their healthy family members. The goal is to better understand how gene…

This study uses ultrasound imaging to measure how quickly the stomach empties after feeding in healthy newborns and infants. Researchers will watch the stomach shrink back to its starting size after babies drink clear liquids, breast milk, or formula. The goal is to learn normal …

This study tests a new device called transcranial interference stimulation (tIS) in 10 healthy adults. The goal is to see if it is safe and can change brain activity related to recognizing emotions in faces. If it works, this approach might one day help people with conditions lik…

This study tests a training program for entire HIV clinics to reduce stigma and improve well-being for both patients and staff. About 1,000 people from 5 clinics in the US South will take part. The training includes interactive sessions for all staff and aims to change clinic pol…

This study tests whether artificial intelligence (AI) can help cardiologists read echocardiograms (heart ultrasounds) more quickly and consistently. Researchers will give AI analysis to doctors in real time as they review heart images from 50 participants with valve disease. The …

This study is testing different combinations of how often and for how long people should interrupt prolonged sitting to improve blood pressure and blood sugar. Over 300 adults will take part in a 9-hour lab visit where they sit and take short walking breaks at various frequencies…

This study looks at how common COVID-19 is among healthcare workers by testing for antibodies in their blood. It also checks their mental and emotional health during the pandemic. About 1,000 workers from NewYork-Presbyterian will take part. The goal is to learn how to better pro…

This early-stage trial is testing whether a one-week course of diazoxide can reduce the production of new fat in the liver. The study involves 25 adults with obesity, insulin resistance, and fatty liver disease. Participants will take either the drug or a placebo and undergo bloo…

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This study is testing whether special insoles worn inside shoes can measure how well children with Duchenne muscular dystrophy (DMD) or spinal muscular atrophy (SMA) walk. About 106 participants, including healthy children, will wear the insoles during walking tests and in daily …

This study looks at ways to reduce the overuse of mammograms in women aged 75 and older, where screening may not be helpful. Researchers will test a strategy that helps doctors and patients make more informed decisions about mammograms. About 500 women and their doctors will take…

The PREDICT study is creating a registry and biospecimen bank for people with pancreatic disease or at high risk for pancreatic cancer. Researchers will collect blood, tissue, urine, and other samples from 1,000 participants to study the causes and biology of the disease. This is…

This study tests a wearable device and smartphone app that track how often and how tightly teens with scoliosis wear their brace. Researchers want to see if giving patients and their families real-time feedback on brace use improves compliance. About 87 adolescents with scoliosis…

This study looks at whether a structured physical activity program can improve thinking and learning in children who had heart surgery. Researchers will compare these children to those having other surgeries and healthy kids. The goal is to see if exercise helps with memory, atte…

This study is testing how growth hormone and liraglutide (a diabetes drug) affect appetite, energy use, and blood sugar in healthy adults and those with growth hormone deficiency. Forty participants will receive each treatment or placebo for 21 days, with blood tests and body mea…

This observational study looks at how structural racism—like unequal access to resources—might affect brain structure and decision-making in Puerto Rican teens aged 11 to 14. Researchers will compare teens living in New York and Puerto Rico using interviews and brain scans. The g…

This study looks at whether a summer research program helps high school students build confidence in science and feel like scientists. About 180 students from Upper Manhattan and the South Bronx will work in neuroscience labs over 8 months. Researchers will track changes in stude…

This study is testing whether educational videos and brochures can help Spanish-speaking Latinx patients with breast or prostate cancer better understand their radiation therapy and clinical trials. About 194 participants will watch videos or read brochures, then answer questions…

This study looks at whether taking atorvastatin (a statin) for 4 weeks can lower inflammation in the blood vessels of adults with obstructive sleep apnea who are already using CPAP therapy. Researchers will measure specific markers of inflammation and blood clotting. The goal is …

This study looks at how anxiety affects the brain in people with alcohol use disorder during early and long-term abstinence. Researchers will use fMRI scans and the medication disulfiram (Antabuse) to help participants stay sober. They aim to understand the brain circuits linked …

This study aims to find the genetic causes behind certain allergic and immune system disorders. Researchers will collect blood, saliva, and tissue samples from up to 10,000 people of all ages, along with some family members. No treatments are given; the goal is simply to learn mo…

This study is creating a large registry and tissue bank for people with mitochondrial disorders. Researchers will collect medical information and samples from up to 1,000 participants, including those diagnosed with or suspected to have a mitochondrial disease. The goal is to gat…

This study is developing a platform called CAMERA that uses wristband sensors and smartphone data to predict anxiety and memory states in people with epilepsy. Researchers will monitor 40 patients in the hospital to see how brain, body, and behavior signals relate. The goal is to…

This study uses a small button-like device worn on the thigh to measure how active people with neuromuscular diseases are over a week, every 6 months for 3 years. Participants also do a walking test and answer questionnaires. The goal is to better understand activity patterns, no…

This study follows 300 people who carry a specific mitochondrial DNA mutation (m.3243A>G) that can cause symptoms like migraines, seizures, and hearing loss. Researchers will use brain scans, muscle tests, and cognitive assessments to track how the disease progresses over time. N…

This study aims to reduce deaths from maternal sepsis, a leading cause of death in new mothers in the U.S. Researchers will create and test a safety bundle in four hospitals, involving over 33,000 birthing people. The goal is to see if the bundle helps diagnose and treat sepsis f…

This study follows 80 adults with PiMZ alpha-1 antitrypsin deficiency and mild-to-moderate COPD over three years. Researchers will use CT scans and blood tests to measure lung density changes and look for biomarkers that could be used in future treatment trials. No new treatment …

This study enrolls family members of people with inherited ALS who do not yet have symptoms. Participants receive genetic counseling and testing, and are followed yearly to track when and how symptoms might appear. The goal is to gather information that could one day lead to trea…

This study uses brain scans to understand why some people feel lonely even when they have friends. Researchers will look at how the brain represents feelings of connection and isolation. The goal is to find better ways to help people who feel lonely. The study needs 248 adults wh…

This study follows 106 adults with hypoparathyroidism for three years to see how the disease affects organs like the kidneys and brain. Researchers will measure kidney function and look for calcium buildup in the kidneys and brain using optional CT scans. The goal is to better un…

This study aims to identify genes that make a person more likely to develop congenital diaphragmatic hernia (CDH), a birth defect where the diaphragm doesn't form properly. Researchers will collect DNA samples from 3,000 people with CDH or a family history of it, along with their…

This study aims to understand how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide, which stops the pancreas from making insulin. Researchers will then measure their fasting blood su…

This study explores how electrical stimulation of the spinal cord can help people with cervical spinal cord injury regain arm and hand function. Researchers will place electrodes on the spinal cord during surgery and test different stimulation patterns. The goal is to find the be…

This study tests a program called Free Time for Wellness (FT4W) designed to help low-income mothers in New York City become more physically active. About 630 mothers with young children will take part. The program addresses common barriers like lack of time and resources, and res…

This study follows about 800 people who have recovered from COVID-19 to learn how long the virus can stay in different parts of the body, such as the nose, stool, semen, and breast milk. Researchers will also track how the immune system responds and look for any long-term health …

This study collects and stores tissue samples from people with cutaneous T-cell lymphoma (CTCL) and healthy volunteers. Researchers will use these samples to study how T cells change in CTCL. No treatment is given—the goal is to gather information for future research. Up to 400 p…

This study is testing whether a special nutrition shake (Ensure Surgery Immunonutrition) can improve gut health and reduce inflammation in heart failure patients awaiting LVAD surgery. Researchers will give the shake to 50 hospitalized patients before their operation and track ch…

This study follows 1,000 people who have certain genetic changes (hnRNP and others) that may cause developmental delays, autism, seizures, or muscle problems. Researchers collect medical records, school reports, and questionnaires to see how these gene variants affect behavior, t…

This study aims to find rare genetic changes that lead to severe obesity starting before age 6. Researchers will enroll 500 children and adults who had a very high BMI (above the 99th percentile) at a young age. Participants will answer health questions, have a brief physical exa…

This study looks at children with ROHHAD syndrome, a rare condition that causes rapid weight gain and breathing problems. Researchers will take blood samples to create special cells in the lab and study their genetic activity. The goal is to understand what goes wrong in the body…

This study looks at whether using a 3D-printed model of a child's heart helps surgeons plan a procedure to place a mechanical pump (VAD) in children with congenital heart disease and heart failure. About 36 children weighing over 3 kilograms will take part. The goal is to see if …

This study looks at how eating lots of ultra-processed foods (like packaged snacks and sugary drinks) affects the calories your body absorbs. Twenty adults with overweight or obesity will eat either a diet where 80% of calories come from ultra-processed foods or one where only 20…

This study will use genome sequencing on dried blood spots from 100,000 newborns to screen for rare genetic conditions that are not part of routine newborn screening. Families can choose to learn about treatable conditions or those with treatments in development. The goal is to s…

This study looks at how eating and sleeping at mismatched times (like shift workers do) affects weight regulation. Researchers will track 42 adults with overweight or obesity, measuring energy use, body composition, and brain responses to food. The goal is to understand whether a…