Can mindfulness and brain scans lift teen depression?
NCT ID NCT05617495
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether combining mindfulness meditation with real-time brain scan feedback can help teens with depression. Researchers will train 90 adolescents aged 13-18 to control brain circuits linked to rumination (repetitive negative thinking). The goal is to see if this approach reduces depression symptoms by changing how the brain works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mindfulness-based real-time fMRI neurofeedback
What this could lead to
If it works, this could point toward a new brain-training method to ease depression symptoms in teens.
What could go wrong
This is an early study with only 90 participants, so results may not apply to everyone. The technique requires an MRI scanner, which is expensive and not widely available.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Northeastern University
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Email: •••••@•••••
Contact