DEPRESSION IN ADOLESCENCE

This study is testing whether a yoga program can help ease depression symptoms in teenagers, compared to group cognitive-behavioral therapy (CBT). Researchers will recruit 96 teens aged 12-18 with elevated depressive symptoms across two sites in Boston and Columbus. Participants …

This study tests a group therapy program called TAG TEAM for trans and gender diverse teens aged 12-17. The program helps them understand and cope with stress from discrimination and rejection. Researchers will compare the program to a waitlist to see if it reduces anxiety, depre…

This study tests whether a sleep-focused therapy can improve depression in teenagers whose body clocks are out of sync with their wake-up time. Researchers will enroll 200 adolescents with depression and delayed sleep phase. The therapy aims to realign their internal circadian rh…

This study tests whether combining mindfulness meditation with real-time brain scan feedback can help teens with depression. Researchers will train 90 adolescents aged 13-18 to control brain circuits linked to rumination (repetitive negative thinking). The goal is to see if this …

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study is recruiting 160 depressed teens aged 14-21 to understand how stress affects inflammation and brain chemistry. Participants will undergo a mild stress test and then take either fluoxetine or escitalopram for 12 weeks. Researchers will track who responds to treatment a…

This study looks at how sleep duration and timing, along with stressful life events, are linked to depression and loss of interest in activities (anhedonia) in teenagers aged 14-18. Researchers will monitor 150 high school students using questionnaires, brain scans, and stress te…