Teen depression study aims to predict who will respond to antidepressants
NCT ID NCT05329441
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is recruiting 160 depressed teens aged 14-21 to understand how stress affects inflammation and brain chemistry. Participants will undergo a mild stress test and then take either fluoxetine or escitalopram for 12 weeks. Researchers will track who responds to treatment and follow participants for 18 months to see how their depression changes over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help doctors predict which depressed teens will benefit from common antidepressants, leading to more personalized treatment.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear predictors, and results may not apply to all teens or treatments.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
Contact
Contact Phone: •••-•••-••••