Teen depression study aims to predict who will respond to antidepressants
NCT ID NCT05329441
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is recruiting 160 depressed teens aged 14-21 to understand how stress affects inflammation and brain chemistry. Participants will undergo a mild stress test and then take either fluoxetine or escitalopram for 12 weeks. Researchers will track who responds to treatment and follow participants for 18 months to see how their depression changes over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors predict which depressed teens will benefit from common antidepressants, leading to more personalized treatment.
- What could go wrong
- This is an observational study, not a treatment trial. It may not find clear predictors, and results may not apply to all teens or treatments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
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