University Of California, Los Angeles

This study aims to compare two different, already FDA-approved, artificial discs used to replace a damaged disc in the neck. The goal is to see which design—one with more constrained movement versus one with less—leads to better outcomes for patients with neck pain and nerve prob…

This study is testing whether combining psilocybin (the active compound in 'magic mushrooms') with talk therapy can help people with depression. Researchers will enroll 50 adults with major depression to compare two different therapy approaches alongside two psilocybin sessions. …

This study compares remote video training to traditional in-office visits for teaching people with low vision how to use magnifiers and vision apps for daily tasks like reading. It also tests if small Bluetooth sensors attached to magnifiers can detect when patients stop using th…

This UCLA study is testing whether drinking pomegranate juice daily for 8 weeks can help people with mild-to-moderate ulcerative colitis. Researchers want to see if the juice reduces gut inflammation, improves quality of life, and changes the mix of gut bacteria. The study involv…

This pilot study is testing a new smartphone app designed to help teens with obesity manage their weight. The app is based on a theory that suggests replacing unhealthy eating habits with positive coping behaviors. Researchers will enroll 38 adolescents to test the app's usabilit…

This study is testing a new system to help people with HIV stick to their medication schedule. It uses a special pill with a tiny sensor that sends a signal when swallowed. If a dose is missed, the system alerts a care team who can quickly check in and help with any life challeng…

This study is testing a new AI tool that predicts which patients with chronic diseases are likely to have high medical costs. The goal is to see if offering these patients extra support from a nurse care manager can help them stay healthier and avoid hospital visits. Researchers …

This study is testing whether a 12-week brain training program can help young people who are at high risk for developing psychosis. Participants will either do fun, computer-based thinking exercises or receive standard mental health support. The goal is to see if the training imp…

This study is testing a coaching program for teachers and school staff to help them better manage challenging behaviors in autistic children. It involves 373 participants and aims to see if this training is effective and if schools can keep using these methods long-term. The goal…

This study compares two anesthesia approaches during emergency stroke surgery to remove blood clots. Researchers want to see if slightly increasing carbon dioxide levels during anesthesia helps maintain better blood flow to the brain during the procedure. The trial involves 90 st…

This study is testing a new system to match community college students with anxiety or depression to the right level of mental health care. It will compare a standard method based on symptoms to a more personalized method that also considers life stress, background, and other fac…

This study is testing a new support package designed to help people living with HIV in Malawi stay on their medication when they need to travel. It will involve 400 people who are starting or restarting treatment. The program includes special counseling, a support hotline, and tr…

This study aims to understand how a smoking cessation medication called cytisinicline affects the brain's response to smoking triggers. Researchers will give 64 daily smokers either the medication or a placebo for 2-3 weeks, then use brain scans to see how their brains react to v…

This pilot study aims to test if a hybrid closed-loop insulin pump system can help adults with poorly controlled Type 1 diabetes. It will enroll 40 diverse participants from Los Angeles who are not currently using an insulin pump. The main goal is to see if a larger trial is feas…

This study is testing whether focused ultrasound stimulation can help patients recover consciousness after severe traumatic brain injury. Researchers will compare real ultrasound treatment to a sham procedure in 60 patients who have been in a disorder of consciousness for more th…

This study is testing a custom-modified stent graft to treat dangerous aortic aneurysms in patients who are too high-risk for traditional open surgery. Doctors will modify the stent during the procedure to fit each patient's unique anatomy and preserve blood flow to vital organs.…

This UCLA study is testing whether a non-invasive brain stimulation technique can help improve memory in people with mild-to-moderate Alzheimer's disease. Researchers will use a device that delivers magnetic pulses to a specific brain area to see if it's safe, tolerable, and show…

This study is testing a support program designed to help transgender women in Vietnam better prevent and manage HIV. The program includes individual counseling, group support sessions, and social events. Researchers will compare outcomes for 80 participants who receive the full p…

This study is testing whether a non-invasive brain stimulation technique can help people who have both major depression and chronic pain. It will involve 54 adults who haven't gotten enough relief from standard medications. Participants will receive 30 sessions of magnetic stimul…

This UCLA study is testing whether gentle electrical or magnetic stimulation of the spinal cord can help improve bladder function in men with spinal cord injuries. The research aims to see if this non-invasive approach can help people urinate more normally and reduce the need for…

This study is testing whether having a peer support worker—someone who has personally recovered from addiction—in the emergency room helps people with substance use disorders get connected to treatment and social services. Researchers will follow 400 people for 6 months to see if…

This UCLA study is testing a new method to reduce fear in people with specific phobias, like fear of spiders or snakes. Using a brain scanner, researchers aim to unconsciously train the brain to be less fearful, avoiding the distress of repeatedly facing the feared object. The st…

This study is testing whether a specific combination of probiotic supplements can help adults with obesity manage their weight and food-related behaviors. Researchers will compare the probiotic against a placebo (a dummy pill) in 100 participants, while everyone also follows stan…

This UCLA study is testing whether a gentle, focused ultrasound can help people with severe, treatment-resistant anxiety. The ultrasound targets a deep part of the brain called the amygdala, which is involved in fear and anxiety. Researchers will compare real ultrasound treatment…

This study tests a new approach to help people who received a liver transplant from a living donor safely stop taking lifelong anti-rejection drugs. These drugs prevent organ rejection but have serious side effects. Researchers will use a short course of radiation and medication,…

This study is testing a smartphone app designed to help people with HIV stay on their medication and keep their appointments, which is key to controlling the virus. It will follow 1,000 people who are struggling with treatment or at risk of their virus becoming detectable again. …

This UCLA study is testing a personalized, non-invasive brain stimulation treatment for people who still have symptoms like headaches, dizziness, fatigue, and brain fog months after a concussion. Researchers will use MRI scans to map each person's brain and then apply magnetic pu…

This UCLA study is checking if a single 25mg dose of psilocybin (the active compound in 'magic mushrooms') is safe for people trying to quit cocaine. Ten participants with cocaine addiction will take the capsule in a supervised lab setting while researchers monitor their heart ra…

This study is testing whether adding a home-based video therapy program to standard stroke care helps people recover arm function better than standard care alone. About 200 adults who had a stroke 3-5 months ago will be randomly assigned to either do the video therapy plus their …

This study is testing a weight loss program delivered through a smartphone app and phone coaching for young people who are obese after a stem cell transplant. It aims to see if this convenient, at-home approach can help them lower their BMI and improve their health. The 4-month p…

This study is testing whether a daily natural supplement can improve the health of blood vessels and reduce markers in the blood linked to aging and future heart disease. Healthy adults will take the supplement for six weeks while researchers measure changes in specific blood mar…

This early-stage study is testing the safety and feasibility of a spinal cord stimulator implant for people with severe neck injuries who depend on a ventilator to breathe. The device is placed in the neck and sends electrical signals intended to help reactivate the breathing mus…

This study is testing whether a specific low-calorie, anti-inflammatory diet combined with regular walking can help reduce body fat and improve heart health markers in men with advanced prostate cancer who are on hormone therapy. It will compare how 70 men—35 African American and…

This study is testing a new system to help surgeons better plan and perform operations for a serious pregnancy condition called placenta accreta. It involves 60 pregnant patients at high risk for the condition. The goal is to see if using a specific classification method during s…

This study compares two ways to create a dialysis access point for people with kidney failure. Researchers want to see if a newer, less invasive procedure (using devices inserted through the skin) works as well as traditional open surgery. They will enroll 90 patients who qualify…

This study is testing a new flexible support program called CHOICE for people in Malawi living with HIV who have stopped taking their medication. The program lets participants choose how and where they receive support services over time, based on their changing needs. Researchers…

This study is testing if a mindfulness program can help high-achieving high school students from diverse backgrounds who are under a lot of stress. The researchers want to see if learning mindfulness skills can reduce the negative health effects, like anxiety and physical strain,…

This study is testing whether a program led by experienced local mothers can help pregnant women in South Africa reduce alcohol use and stick to their HIV prevention or treatment medications. The program involves one-on-one supportive conversations with trained 'mentor mothers' w…

This study is testing a faster, personalized version of a non-invasive brain stimulation treatment for people hospitalized with severe depression. Researchers want to see if they can safely give 25 treatments over just five days, using a person's unique brain rhythm to potentiall…

This study is testing whether taking prebiotic supplements for 8 weeks can improve the mix of gut bacteria and help control symptoms in people with ulcerative colitis. Researchers will enroll 70 adults with active symptoms and track changes in their gut health and inflammation ov…

This study is testing whether taking vitamin B1 (thiamine) capsules for three months can improve brain function and mood in adults with type 2 diabetes. Researchers believe many people with diabetes are low in this vitamin, which might harm the brain's protective barrier. The tri…

This early-stage study is testing a new approach for people who have already received a kidney transplant from a well-matched family donor. Researchers want to see if giving patients stem cells from the same donor, after a special preparation treatment, can teach their immune sys…

This study is observing adults with cystic fibrosis who have ongoing sinus problems. It aims to see if sinus surgery helps more than medication alone. Researchers will track changes in lung function, hospital stays, and quality of life over time.

This UCLA study is testing whether targeted magnetic brain stimulation can help people with Borderline Personality Disorder better manage their emotions and reduce impulsive behaviors. The research will involve 30 participants who will receive either real or placebo brain stimula…

This study aims to create a simple checklist to help doctors decide which blunt trauma patients truly need a CT scan of their abdomen and pelvis. By carefully checking for specific signs and symptoms, the goal is to safely identify patients at very low risk of serious injury who …

This study is testing a new, tampon-sized scanning device that uses light to measure pelvic muscle health. Researchers want to see if this tool can help doctors more accurately diagnose myofascial pelvic pain, a common but often overlooked condition that causes chronic pain. The …

This study is testing a support program for men recently released from jail or prison who are at risk for HIV and substance use problems. The program uses trained peer mentors, a smartphone app, and small incentives to help participants get HIV prevention medication (PrEP), testi…

This study is testing a special online program designed to help college students at risk for type 2 diabetes. It aims to see if a tailored, digital version of a proven diabetes prevention program can help students lose weight and improve their health. The program focuses on reach…

This study aims to get more children vaccinated against HPV, a virus that causes thousands of cancers each year. Researchers are testing two different training programs for doctors and their clinics to see which is better at helping them recommend and deliver the first dose of th…

This study is testing if an injection into the knee soon after an ACL tear can prevent the development of osteoarthritis later in life. Researchers are comparing a drug called anakinra against a placebo (saltwater) injection in 32 active adults aged 18-35. The goal is to see if b…

This study compares two emergency care approaches for youth ages 13-24 who come to the emergency room with suicidal thoughts or behaviors. Researchers want to know if adding follow-up phone support after emergency care is better than emergency care alone at preventing suicide att…

This study is testing whether monthly penicillin injections during the third trimester of pregnancy can prevent syphilis infection in high-risk women and stop it from passing to their babies. Researchers will compare the injections to standard care in 500 pregnant women in Brazil…

This study is testing if a special back brace with built-in laser lights can help reduce chronic pain and improve wound healing for people who have had spinal fusion or decompression surgery. Researchers will compare the laser brace to a look-alike placebo brace. Participants wil…

This study is testing whether a new virtual reality training program can help improve mood and reduce symptoms in people with depression and low positive feelings. Researchers will compare two different VR programs over 7 weeks with 80 adult participants. The goal is to see if gu…

This study is testing a procedure called hemorrhoidal artery embolization (HAE) to see if it can reduce symptoms like bleeding from internal hemorrhoids. The procedure works by blocking the small arteries that supply blood to the hemorrhoids. Researchers at UCLA will enroll 22 ad…

This small, early-stage study is testing whether a non-invasive brain stimulation technique called rTMS can boost the benefits of Tai Chi for people with knee arthritis and depression. Researchers will compare two different rTMS stimulation patterns in 30 participants to see if t…

This study is testing whether freezing nerves near the surgical incision during a double lung transplant can help manage pain afterward. Doctors use a special cold probe during surgery to numb the area, hoping this reduces the need for strong opioid painkillers and helps patients…

This UCLA study is testing whether looking at pictures of supportive people can help reduce fear in adults with social anxiety. Researchers will compare how 100 participants (50 with social anxiety, 50 without) respond to fearful cues when paired with either a photo of someone th…

This study is testing a 6-week online mindfulness program designed to reduce stress and burnout in healthcare workers. 80 doctors from UCLA Health will either take the meditation course immediately or be placed on a waitlist. Researchers will measure stress, burnout, depression, …

This study is testing whether a specific nerve block can better control pain after hip replacement surgery. Researchers will compare the standard painkiller ropivacaine against a placebo (saltwater) injection in 80 patients. The main goal is to see if this nerve block reduces pai…

This study is testing whether online group discussions can improve the well-being of Black American women diagnosed with breast cancer. Researchers want to see if these sessions help reduce feelings of depression and fatigue. The trial will compare women who participate in four o…

This study is testing if a brief treatment to improve mood and reward processing can make standard exposure therapy more effective for people with social anxiety and a specific fear of public speaking. All 94 participants will receive exposure therapy, but first, they will be ran…

This study compares two programs to help college students sleep better. Researchers want to see if a 6-week mindfulness training course is more effective than a standard sleep education program. They will enroll about 240 UCLA students who report poor sleep and measure changes in…

This study is testing if a type of talk therapy can help veterans manage long-term pain. The therapy, called Emotional Awareness and Expression Therapy (EAET), helps people understand and express emotions linked to past trauma, which may reduce pain. Researchers are training ther…

This study is testing whether a special electrical stimulation device, used vaginally, can reduce chronic pelvic pain caused by tight muscles. It will compare the device's effects to standard care like education and stretching. The research also aims to see if nurses can deliver …

This study is testing whether an FDA-approved eye drop called Xiidra can help relieve eye dryness and discomfort in people with glaucoma. The discomfort is often caused by the multiple daily eye pressure medications these patients must use. Researchers will measure changes in eye…

This study is testing a sleep education program designed specifically for older Korean immigrants who have trouble sleeping. It aims to see if this culturally adapted approach is practical and can help improve sleep quality. The program is being compared to a simple information-o…

This study is testing whether a specific type of talk therapy (Cognitive Behavioral Therapy or CBT), when taught to therapists through weekly online expert coaching, works better than standard care for children with autism. It aims to help kids aged 6-14 who struggle with emotion…

This study is testing whether a minimally invasive procedure can reduce knee pain from osteoarthritis. The procedure, called genicular artery embolization (GAE), uses tiny particles to block abnormal blood flow thought to cause inflammation and pain in the knee. Researchers will …

This study is testing whether a specific voice therapy technique can reduce harmful pressure on the vocal cords to help heal injuries and improve voice quality. Researchers will measure pressure changes and scan the throat in 60 adults with vocal cord lesions before and after fou…

This study is testing whether a simple, private text message program can help UCLA students who have recently lost a loved one. About 126 students will be randomly assigned to either receive weekly supportive texts for a year or get a standard list of grief resources. Researchers…

This study aims to understand how and why critically ill patients lose muscle mass, a condition linked to frailty and poor recovery. Researchers will observe 250 adults in intensive care to identify factors that might be changed to help patients get stronger. The goal is to gathe…

UCLA researchers are studying how writing about personal experiences might influence brain function, stress levels, and body inflammation in healthy older adults. Participants aged 65+ will write weekly for six weeks and undergo brain scans and blood tests before and after the wr…

This study aims to understand how breathing secondhand smoke from hookah or aerosol from vaping affects blood vessel health in people who don't smoke. Researchers will measure blood pressure and blood flow in 12 healthy, non-smoking adults before and after brief exposures in a co…

This study is testing if a small change in appointment reminders helps patients arrive on time. Researchers are comparing two types of messages: one that shows just the appointment time, and another that shows an explicit 'arrive by' time set 15 minutes earlier. They will track w…

This study is testing whether summaries written by artificial intelligence (AI) can help patients understand their eye doctor's notes. About 460 adults receiving eye care will either get their standard medical notes or notes with an added AI summary written in plain language. Res…

This research study aims to identify brain patterns that might predict whether spinal cord stimulation will help people with chronic low back pain. Researchers will perform brain scans on 42 patients before they receive this standard pain treatment, then follow up two weeks later…

This study aims to understand how smoking high-strength cannabis affects feelings of pleasure and pain tolerance in people who use it regularly. Researchers will test 30 participants by having them smoke different strengths of cannabis, including a fake version, and measure their…

This study aims to understand if new, highly effective CF medications improve sinus health and the sense of smell in young children with cystic fibrosis. Researchers will follow 80 children, aged 2 to 8, for two years. They will compare kids taking the new medications to those wh…

This study aims to understand if CBD, a non-intoxicating cannabis component, can reduce the negative effects of THC, the main psychoactive compound in cannabis. Researchers will give controlled doses of THC and CBD to 30 regular cannabis users and measure their experiences, pain …

This study aims to understand how the community of bacteria in the gut and certain digestive chemicals are related to symptoms of Irritable Bowel Syndrome (IBS). Researchers will compare adults with IBS to healthy volunteers by having them follow a specific high-fat diet and prov…

This study is testing whether artificial intelligence (AI) can rewrite complicated medical consent forms into simpler language. Researchers want to see if people understand these AI-simplified forms better than traditional ones. The study involves older patients, medical research…

This study aims to better understand how young people (ages 9-19) with bipolar disorder respond to treatment over one year. Researchers at four US clinics will follow 80 youth and their families, providing standard care while tracking mood, family relationships, and quality of li…

This study aims to better understand several rare genetic conditions caused by changes in ASXL genes. Researchers will collect health information over time from about 200 people who have one of these disorders. The goal is to learn about the typical course of these diseases and h…

This University of California, Los Angeles study aims to understand how cannabis affects pain relief and addiction potential differently in men versus women. Researchers will recruit 160 adults who regularly use cannabis to test different cannabis strengths and measure pain respo…

This study aims to understand why some teens with severe anorexia urinate excessively when they start eating again in the hospital, which can delay recovery. Researchers will check if levels of a hormone called secretin are different in patients who have this problem compared to …

This study is testing if wearing a continuous glucose monitor (CGM) for just 24 hours right after giving birth can help predict a woman's long-term risk of developing type 2 diabetes. The research focuses on women who had diabetes during pregnancy (gestational diabetes). Research…

This study aims to understand why a spinal cord stimulator relieves chronic back pain for some people but not others. Researchers will use brain scans and other tests on 20 people who already use the device to see how their brain activity changes when it's on versus off. The goal…

This study aims to see if making small changes to the prescription screen in UCLA's electronic health record system can help doctors prescribe stomach acid medications (PPIs) more appropriately. The research will involve about 372 UCLA primary care doctors and will automatically …

This study aims to develop computer algorithms that can interpret brain and body signals to control assistive devices like robotic arms or wheelchairs. Researchers are testing these systems with 50 healthy volunteers who will wear non-invasive sensors while performing or imaginin…

This study aims to understand if looking at a picture of a supportive person can help people with social anxiety disorder 'unlearn' a fear response. Researchers will compare 50 healthy adults with 50 adults diagnosed with social anxiety. Participants will learn to associate an im…

This study aims to understand how sleep helps form and strengthen our memories. Researchers will record brain activity from epilepsy patients during sleep and test if gentle sounds or electrical pulses can influence what they remember. The goal is to learn more about the brain's …

This study aims to understand how smoked and edible THC affects people differently based on their age and sex. Researchers will measure pain relief, feelings of intoxication, and impairment in adults aged 18-65 who regularly use cannabis. The goal is to gather basic knowledge abo…

This study is testing whether a special web app that uses interactive stories and a relatable character can help Latinas with anxiety or depression take the first step to get professional help. It will compare this story-based app to a standard app with informational videos and r…

This study aims to understand why people with schizophrenia often struggle with social connections by measuring how their brain waves sync with others during simple tasks. Researchers will compare 100 people—some with schizophrenia and some without—while they draw and tap fingers…