University Of California, Los Angeles

This study tests two simple methods to help doctors talk to parents about the HPV vaccine and make it easier for kids to get it. About 100,000 children ages 9 to 17 from up to 72 doctor's offices will take part. The goal is to see which method works best to increase vaccination r…

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or degenerative disc disease. Twenty adults aged 18-60 who have not improved with non-surgical care will be randomly assigned to receive one of the two implants.…

This study is testing whether a probiotic supplement can help adults with obesity lose weight by changing gut bacteria. One hundred participants will take either the probiotic or a placebo for several weeks. The goal is to see if this safe, easy-to-take option can support weight …

This study follows 80 youth aged 9-19 with bipolar disorder to understand what affects their symptoms over a year. Participants receive medication management and talk therapy, and complete interviews and questionnaires. The goal is to improve diagnosis and treatment for young peo…

This study is tracking 100 men with prostate cancer who choose to receive a treatment called high-intensity focused ultrasound (HIFU). HIFU uses sound waves to heat and destroy cancer cells in a targeted area. The goal is to see how well the treatment works at removing the cancer…

This study looks at whether taking prebiotics (a type of fiber) can improve gut health and reduce symptoms in people with ulcerative colitis, a form of inflammatory bowel disease. About 70 adults with active symptoms will take a prebiotic supplement for 8 weeks. Researchers will …

This study tests a new treatment for people who have had a stroke caused by a blood clot. A weak electrical current is applied through electrodes on the scalp to increase blood flow to the brain and protect at-risk tissue. The goal is to find the safest and most effective dose. T…

This study tests a program to help transgender women in Ho Chi Minh City improve their HIV prevention and care. Participants will attend counseling sessions, skill-building groups, and social events. The goal is to see if this support helps them stay healthy, whether they are HIV…

This study tests a daily oral supplement made from natural ingredients and L-citrulline to see if it can improve blood vessel function and reduce markers of aging and heart disease risk. Healthy adults aged 18 and older will take the supplement for 6 weeks. Researchers will measu…

This study compares two types of general anesthesia during emergency clot removal for stroke patients. The goal is to see which method better maintains blood flow to the brain and improves recovery. About 90 adults with severe stroke will take part at two hospitals in Los Angeles…

This study looks at whether a calorie-controlled, anti-inflammatory diet combined with walking can reduce heart disease risk factors in men with advanced prostate cancer who are on hormone therapy (ADT). The researchers want to see if African American men respond differently than…

This study is testing a program where trained 'mentor mothers' from the community provide one-on-one support to pregnant women who drink alcohol. The goal is to help them reduce drinking and improve their use of HIV prevention (PrEP) or treatment (ART). About 100 pregnant women i…

This study tests whether injecting antibiotics into the skin around chronic wounds helps them heal better than standard care alone. About 60 adults with non-healing wounds on their arms, legs, or trunk will either receive the injections plus usual wound care, or usual care only. …

This study tests whether smartphone tools can help 1000 people with HIV who struggle to keep the virus under control. It focuses on those facing extra challenges like drug use, mental health issues, or living in rural areas. The goal is to improve medication adherence and viral s…

This study is testing whether a 16-week ketogenic diet (low carb, high fat) is safe and helpful for teens and young adults (ages 12-21) with bipolar disorder who are also taking standard medications. Researchers will track mood, thinking skills, and metabolic health to see if the…

This study tests a new approach for people with HIV who have stopped taking their medication. Instead of a one-size-fits-all plan, participants can choose which services they receive and how. The goal is to see if this flexibility helps more people achieve viral suppression after…

This early-stage study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop taking lifelong anti-rejection medications. Ten adults with a well-functioning kidney from a matched living donor will receive the infusion after a …

This study tests a new MRI technique that spots acidic areas around glioblastoma tumors, which may contain cancer cells not visible on standard scans. About 18 adults with newly diagnosed or recurrent glioblastoma will have surgery guided by this method to safely remove more tumo…

This study tests a gene therapy for infants and children with a rare, life-threatening immune disorder called ADA-SCID. Doctors take the child's own blood stem cells, add a working ADA gene in the lab, and return them to the body. The goal is to restore immune function and improv…

This study compares a new, less invasive method to create dialysis access (endoAVF) with traditional surgery (surgAVF) in 90 adults with end-stage kidney disease. The goal is to see how many patients qualify for each method and track outcomes like blood flow and usability. The ne…

This pilot study is testing a smartphone app with telephone coaching to help teens and young adults (ages 13-30) who are overweight or obese after a stem cell transplant. The goal is to see if the app can help them lose weight and improve their health. The study will enroll 20 pa…

This study tests a new approach to help liver transplant recipients stop taking toxic anti-rejection drugs for good. Twelve adults who received a liver from a living donor at least one year ago will get a donor stem cell infusion after a mild radiation and antibody treatment. The…

This study tests a support package for people with HIV in Malawi who are starting or restarting antiretroviral therapy. The package includes counseling, a hotline, and multi-month medication dispensing to help patients stay on treatment even when they travel or move. Researchers …

This study tests whether a drug called ferric citrate can lower a hormone linked to heart and kidney damage in children with chronic kidney disease. About 160 kids aged 6-18 will take either the drug or a placebo for 12 months. The goal is to see if the drug safely improves miner…

This study looks at how safe and effective custom-made stents are for treating certain types of aortic aneurysms (bulges in the main artery). About 50 people who are too high-risk for traditional open surgery will receive these stents. Researchers will track serious complications…

This early study tests the safety of implanting a spinal cord stimulator in people with neck-level spinal cord injuries who rely on ventilators to breathe. The goal is to see if the device can help them breathe more on their own. The study involves 12 adults who are at least one …

This study tests whether a hybrid closed-loop insulin pump can help adults with poorly controlled type 1 diabetes (A1c >8.5%) manage their condition more easily. The trial focuses on diverse patients from Los Angeles who are not currently using an insulin pump. Researchers want t…

This study tests a system that uses a special pill bottle to track when HIV medication is taken. If doses are missed, the system alerts a care team who can help with things like food, housing, or transportation. The goal is to see if this approach helps 110 adults with HIV take t…

This study aims to develop a non-invasive device that uses light to measure pelvic floor muscle fitness, helping doctors diagnose myofascial pelvic pain (MPP) more easily and accurately. Researchers will test the device on 110 women with chronic pelvic pain to see if it can repla…

This study tests a tailored online program to help 80 UCLA undergraduates at risk for type 2 diabetes lose weight and improve health. Participants will take short weekly lessons over 9 months, with some receiving the full program and others getting general wellness materials. The…

This study tests a program called MEPS that uses a mobile app, peer mentors, and incentives to help people recently released from jail access HIV prevention (like PrEP), STI testing, and substance use treatment. About 300 people across three California counties will take part. Th…

This study is testing whether giving a drug called anakinra into the knee soon after an ACL tear can prevent arthritis from developing years later. About half of people with an ACL injury get arthritis within 10–20 years, even after surgery. The trial will enroll 32 active adults…

This study tests a new way to prevent HIV by giving a long-acting injectable medication called lenacapavir to people who are unhoused or unstably housed in Los Angeles County. A mobile health van brings the shots directly to shelters, encampments, and community centers. The goal …

This study tests whether giving penicillin to pregnant women at high risk for syphilis can prevent infection. About 500 women in Rio de Janeiro will receive either penicillin or routine care during their third trimester. The goal is to protect both mother and baby from congenital…

This study looks at older adults (50+) with PTSD and ongoing insomnia. After a talk therapy for PTSD, those with remaining sleep issues will get a non-drug sleep program. Researchers will check if this improves sleep, PTSD symptoms, heart health markers like blood pressure, and q…

This study tests whether a gentle, non-invasive ultrasound technique called LIFUP can increase brain activity in a memory-related area and improve memory in people with mild cognitive impairment or mild Alzheimer's. About 144 participants will receive focused ultrasound to the en…

This study looks at whether doing a positive mood treatment before exposure therapy can improve outcomes for people with social anxiety and public speaking fears. About 94 adults with social anxiety disorder will be randomly assigned to either a positive mood treatment or a relax…

This study tests a personalized, noninvasive brain stimulation treatment (TMS) for people aged 18-65 with persistent symptoms after a mild concussion or brain injury, such as headache, dizziness, brain fog, or anxiety. Participants will receive either active or sham TMS over 10 s…

This study tests whether a series of online group discussions, called Project SOAR Awakenings, can help Black American women with breast cancer feel less depressed and fatigued and improve their overall well-being. About 90 women will be randomly assigned to either join four smal…

This study tests whether gentle electrical stimulation of the spinal cord can help improve bladder function in men with spinal cord injury. The goal is to increase urine flow and volume, making catheterization easier. The trial involves 24 men who have been injured for at least a…

This study tests whether a 6-week mindfulness program (MAPs) or a sleep education class can improve sleep quality in first- and second-year UCLA students who have trouble sleeping. About 240 participants will wear sleep trackers, answer surveys, and give blood samples to measure …

This study compares remote training (telerehabilitation) to in-person visits for teaching people with low vision how to use magnifiers and visual apps for daily tasks like reading. It also tests whether Bluetooth sensors can detect when patients stop using their devices, so help …

This study is testing a smartphone app designed to help teenagers with obesity lose weight. The app is based on the idea that replacing unhealthy eating habits with healthy coping skills can lead to weight loss. About 38 teens aged 14-21 will try the app and provide feedback on h…

This study looks at two ways to manage pain in children after surgery for a broken elbow. One group gets a standard painkiller plus a common anti-inflammatory, while the other gets the same painkiller plus a narcotic. The goal is to see if the non-narcotic option works just as we…

This study tests a non-invasive technique called focused ultrasound to stimulate a deep brain region (the thalamus) in people who have been in a coma or minimally conscious state for over a month after a severe brain injury. The goal is to see if this can safely improve their lev…

This study compares two proven emergency care methods for teens and young adults (ages 13-24) who come to the ER with suicidal thoughts or actions. The goal is to see which approach better prevents suicide attempts and helps them start mental health treatment. Researchers will fo…

This study tests whether a special belt with laser lights can reduce long-term back pain in people who had spinal fusion or decompression surgery. About 80 adults who have had back pain for over 3 months after surgery will wear either a laser belt or a normal brace. Researchers w…

This study tests whether cannabidiol (CBD) can help people who want to quit smoking reduce their cigarette use. Researchers will give 120 adults either CBD or a placebo twice daily for 56 days, and measure nicotine levels, cravings, and withdrawal symptoms. The goal is to find a …

This study tests whether a non-invasive brain stimulation technique called rTMS can improve both depression and chronic pain symptoms. Fifty-four adults with moderate-to-severe major depressive disorder and pain will receive 30 treatments over several weeks. Researchers will trac…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in older adults with mild cognitive impairment or subjective memory complaints. About 70 participants will be randomly assigned to receive either …

This study looks at whether a program called Help Texts, which sends weekly text messages about grief and coping, can help bereaved college students feel better. About 126 UCLA students who lost a loved one in the past year will either get the texts right away or wait 6 months. R…

This study tests a faster version of repetitive transcranial magnetic stimulation (rTMS) for people hospitalized with major depression who haven't improved with standard treatments. Researchers will personalize the stimulation frequency for each participant and deliver 25 session…

This study looks at two ways to decide the best treatment for anxiety and depression in 1,000 community college students. Participants will be placed into one of three care levels: self-guided online help, coach-guided online therapy, or care from a clinician. The goal is to see …

This study tests a brain stimulation technique called rTMS to see if it can reduce knee arthritis pain and depression in older adults. Thirty volunteers aged 50 and older with chronic knee pain and moderate to severe depression will receive rTMS along with Tai Chi. The goal is to…

This study tests a new method that uses brain scans (fMRI) to reduce fear of spiders or snakes without the person having to consciously face them. The treatment works by reinforcing changes in the brain's fear center (amygdala) while the participant is unaware. The goal is to low…

This study tests whether a special nerve block (QL block) can reduce pain and the need for strong painkillers after hip replacement surgery. About 80 adults having planned hip replacement will take part. Researchers will measure pain levels and how quickly patients can stand up a…

This study tests a program called Reminder-Focused Positive Psychiatry (RFPP) for teens aged 11-15 with PTSD. The program uses telehealth sessions to help teens cope with trauma reminders and improve well-being. Researchers will compare RFPP to a control group and measure changes…

This study tests a 6-week mindfulness program designed to reduce stress, depression, and burnout in healthcare workers. Eighty doctors from UCLA Health will learn practices that build compassion, kindness, and calmness. Researchers will measure changes in stress levels, mood, and…

This study tests whether taking vitamin B1 (thiamine) capsules can repair the blood-brain barrier and improve thinking and mood in adults with type 2 diabetes. About 52 participants will have brain scans, memory tests, and blood work at UCLA over two visits, three months apart. T…

This study looks at whether a very low dose of buprenorphine, a drug used for opioid addiction and depression, can boost social motivation in 40 adults with schizophrenia. Many people with this condition struggle with wanting to connect with others or avoiding social situations, …

This study tests a new virtual reality training designed to help people with depression and low positive affect feel more joy and pleasure. 80 adults will be randomly assigned to either the VR reward training or a memory training control group for 7 weeks. The goal is to see if t…

This pilot study tests whether drinking one cup of pomegranate juice daily for 8 weeks can lower gut inflammation and improve quality of life in 30 adults with mild-to-moderate ulcerative colitis. Researchers will also check how the juice affects gut bacteria. Participants must f…

This study tests a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) on people with mild-to-moderate Alzheimer's disease. The goal is to see if targeting a deep brain area (the precuneus) is safe and can help improve memory. Parti…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can reduce symptoms of borderline personality disorder (BPD). Up to 30 adults with BPD will receive either real or sham (fake) stimulation over several weeks. The go…

This study tests whether gentle ultrasound waves aimed at a deep brain area (the amygdala) can reduce anxiety in adults with generalized anxiety disorder who haven't gotten better with standard medications. Forty-eight participants will receive either real or fake ultrasound trea…

This study tests whether combining psilocybin (the active ingredient in magic mushrooms) with cognitive behavioral therapy (CBT) is a safe and helpful treatment for depression. Fifty adults with major depression will receive two doses of psilocybin and either 12 sessions of CBT o…

This study tests a sleep improvement program made specifically for older Korean immigrants who have trouble sleeping. The program adapts standard sleep therapy to fit Korean culture and language. Researchers will check if the program is practical and helps improve sleep quality i…

This study tests whether adding a home-based telerehabilitation program to usual care helps people with arm weakness after a stroke. About 202 participants who had a stroke 90-150 days ago will be randomly assigned to either receive telerehabilitation plus usual care or usual car…

This study looks at whether Xiidra, a drug already approved for dry eye, can reduce eye discomfort in people with glaucoma who use multiple eye drops. About 75 participants will receive Xiidra as part of their normal care, and researchers will track changes in eye staining, dryne…

This study looks at whether cytisinicline, a drug used to help people quit smoking, can change how the brain responds to seeing smoking-related images. 64 daily smokers who are not trying to quit will take either the drug or a placebo and have their brain activity measured with a…

This study tests whether fun computer-based brain exercises can help Tunisian youth at high clinical risk for psychosis improve their thinking skills and daily functioning. 54 participants will either do cognitive training or receive standard care for 12 weeks. The goal is to see…

This study looks at whether giving children a nerve block in the arm before elbow fracture surgery can reduce pain and the need for opioid painkillers afterward. About 90 children with closed elbow fractures will be randomly assigned to receive either the nerve block or standard …

This study tests a new way to manage pain after a double lung transplant. Instead of relying mainly on strong painkillers like opioids, doctors will use a cold probe during surgery to numb the nerves near the incision. The goal is to see if this method lowers the need for opioids…

This study tests a device that uses gentle electrical pulses to relax pelvic floor muscles in women with chronic pelvic pain. About 60 women will receive either standard care (education and exercise) or the electrical stimulation, delivered by a nurse or a doctor. The goal is to …

This study tests a procedure called hemorrhoidal artery embolization (HAE) for people with internal hemorrhoids who have not had success with other treatments or cannot have surgery. HAE blocks the blood supply to the hemorrhoid tissue to reduce symptoms, especially bleeding. Abo…

This study compares two ways to help children aged 6-14 with autism who struggle with emotions like anxiety and irritability. Half of the therapists get weekly online expert coaching on a special therapy (CBT), while the other half use usual care plus self-guided materials. The g…

This study looks at how voice therapy works for people with vocal fold lesions (like nodules) caused by voice overuse. Researchers want to see if specific exercises actually lower the pressure when vocal cords collide. 60 adults aged 18-40 with these lesions will be studied befor…

This study is testing whether a type of talk therapy can help veterans manage long-term pain. The therapy, called Emotional Awareness and Expression Therapy (EAET), helps people understand and express emotions linked to past trauma. Researchers are training therapists at up to se…

This study looks at whether cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will give cannabis to 160 people who already use it and measure their pain response, drug effects, and blood levels. The goal is to understand sex-based differ…

This study looks at whether having a trained peer recovery specialist in the emergency room helps people with substance use disorders connect to treatment and support. Researchers will follow 400 adults who visit the ER for substance-related issues, comparing those who work with …

This study looks at the best age (9, 12, or 15 months) to start a special coaching program for infants who have a higher chance of developing autism because they have an older sibling with autism. About 140 infants from low-income families in Los Angeles will be monitored and som…

This study tests whether artificial intelligence can create easy-to-understand summaries of eye doctor notes. About 460 adults receiving eye care will either get standard notes or notes with an AI-generated plain language summary. Participants will answer surveys right after thei…

This study looks at how CBD (a non-psychoactive cannabis compound) changes the effects of THC (the part that makes you high). Researchers will give both substances to 30 regular cannabis users (ages 21-55) who are not seeking treatment. They will measure drug effects, pain relief…

This study looks at whether telling patients to arrive 15 minutes before their appointment helps them show up on time. Researchers will compare this to just asking patients to come early without a specific time. The goal is to improve clinic flow and make visits smoother for ever…

This study looks at whether wearing a continuous glucose monitor (CGM) for just 24 hours after giving birth can help predict a woman's risk of developing type 2 diabetes later in life. It involves 50 women who had gestational diabetes during pregnancy. The goal is to see if this …

This study aims to develop algorithms that can help people with paralysis control assistive devices like robotic arms or wheelchairs using their brain and body signals. Healthy participants will wear non-invasive sensors (such as EEG or muscle activity monitors) and perform or im…

This study explores whether artificial intelligence can simplify the complex language used in informed consent forms for clinical research. Researchers will test AI-generated simplified versions with 230 participants, including older adults, doctors, and ethics committee members.…

This study looks at whether brain scans can help predict which people with long-term low back pain will respond well to spinal cord stimulation (SCS). Researchers will scan the brains of 42 adults before they receive SCS as part of their normal care, then check their pain levels …

This study aims to create a checklist of simple clinical signs that can identify blunt trauma patients who do not need a CT scan of their abdomen or pelvis. By studying 12,000 patients, researchers hope to find a set of criteria that is 98% accurate in ruling out serious injuries…

This study looks at how a person's age and sex affect their response to THC, the main active ingredient in cannabis. Researchers will give THC by smoking or by mouth to 103 adults aged 18-65 who already use cannabis weekly or monthly. The goal is to measure pain relief, feelings …

This study looks at how smoking high-potency cannabis affects pain relief and feelings of being high. Researchers will test 30 near-daily cannabis users who are not trying to quit. They will compare results when people smoke as usual and after a short break from cannabis.

This study looks at a hormone called secretin in teenagers with anorexia who are being fed in the hospital. Some of these teens urinate a lot, which can delay their recovery. Researchers want to see if secretin levels differ between those who urinate excessively and those who don…

This study is testing a new system to classify placenta accreta during surgery. The goal is to help doctors better plan the operation and improve outcomes for pregnant people. About 60 participants will be followed before, during, and after surgery to see if the new classificatio…

This study follows 250 adults in the intensive care unit (ICU) to learn why some become frail and lose muscle. Researchers will track hospital stays, falls, and readmissions to find factors that can be changed. The goal is to identify targets for future treatments to help patient…

This study watches how newer cystic fibrosis (CF) medicines impact sinus disease and sense of smell in children aged 2 to 8. Researchers will use MRI scans, smell tests, and quality-of-life surveys over two years. The goal is to understand if these treatments help with sinus and …

This study looks at high-achieving Black, Latinx, and Asian American high school students who succeed despite stress. Researchers want to see if mindfulness training can reduce the physical and mental health problems that often come with this kind of resilience. About 504 student…

This study looks at how spinal cord stimulators affect the brains of 20 adults with chronic low back pain. Researchers will use fMRI scans to compare brain activity when the stimulator is on versus off. The goal is to find patterns that predict who will benefit most from this tre…

This study looks at how brain activity syncs up between two people during social interactions, aiming to understand why social connection is harder for those with schizophrenia. About 100 participants—half with schizophrenia and half without—will have their brain waves recorded w…

This study looks at whether using surgical mesh during breast reconstruction after mastectomy is safe and helpful. About 120 women will be randomly assigned to receive reconstruction with or without mesh. The goal is to understand if the mesh, which is commonly used but not FDA-a…

This study looks at two ways to improve support for autistic children in schools. First, it tests a program where teachers learn special techniques to help reduce challenging behaviors. Second, it tests a strategy to help school leaders keep these techniques in use over time. Abo…

This study looks at whether a special care program can help people with chronic diseases stay healthier and out of the hospital. About 5,000 adults with high expected medical costs will either get the program right away or be placed on a waitlist. Researchers will compare how man…

This study looks at how gut bacteria and diet relate to irritable bowel syndrome (IBS). Researchers will measure substances in stool from people with IBS and healthy volunteers after a special diet. The goal is to understand what causes IBS symptoms, not to test a treatment. Abou…

This study collects information from people with rare genetic conditions caused by changes in the ASXL1, ASXL2, or ASXL3 genes. Researchers want to understand how these disorders progress over time and how they are currently managed. Up to 200 participants will share their medica…

This study compares two web-based apps to see which one better helps Latinas with anxiety or depression start mental health treatment. One app uses an interactive story with a character who gives treatment advice, while the other provides standard information and resources. The g…

This study looks at how memories are formed and strengthened during sleep. Researchers will record brain activity from epilepsy patients who already have electrodes placed for medical reasons. They will also use sounds or mild electrical pulses during sleep to see if they can imp…

This study explores whether seeing a picture of a supportive person can help people with social anxiety unlearn fear more effectively. Researchers will compare the fear response of 100 participants (50 with social anxiety, 50 healthy) after pairing threatening cues with images of…

This study looks at whether changing the default number of pills in electronic prescription forms can help doctors prescribe fewer unnecessary acid-reducing medications (PPIs). About 372 UCLA primary care doctors will take part. The goal is to see if a simple computer adjustment …

This UCLA study is looking for healthy adults aged 65 and older to see if writing about their experiences can affect their brain and body. Over 6 weeks, participants will write once a week and complete online questionnaires. They will also visit the UCLA campus twice for a brain …

This study looks at whether seeing a picture of a supportive person can help people with social anxiety feel less afraid. Researchers will show participants either a photo of someone they trust or a stranger while they learn to associate a neutral image with a mild electric shock…

This study looks at whether sinus surgery improves lung function and quality of life in adults with cystic fibrosis who also have chronic sinusitis. About 170 participants will be followed, including some who have surgery and some who receive only medical treatment. The goal is t…

This study looks at why people aged 21 to 65 with alcohol use disorder feel motivated to drink. Researchers will use questionnaires and a controlled alcohol infusion to see how reward-seeking, emotions, and thinking skills affect drinking behavior. The goal is to better understan…