University Of California, Los Angeles

This study investigates whether two medications—acetazolamide and eszopiclone—can improve sleep apnea outcomes when taken after soft palate surgery. The trial includes adults with moderate to severe obstructive sleep apnea who cannot use CPAP or oral appliances. Researchers will …

This study compares two methods for creating an arteriovenous fistula (AVF) in people with end-stage kidney disease who need dialysis. The newer endovascular method uses a needle through the skin, while the traditional surgical method requires an incision. Researchers will enroll…

This study tests whether a daily polyphenol supplement (like berry capsules) can slow cognitive decline in 300 older adults at risk for Alzheimer's. Participants take the supplement or a placebo for 12 months, providing blood, stool, and brain scans. The goal is to see if the sup…

This study compares two common blood pressure medications, labetalol and nifedipine, in 110 new mothers with postpartum hypertension. The goal is to see which drug controls blood pressure better and reduces the need for ongoing medication beyond six weeks after delivery. Particip…

This study tests whether low-intensity focused ultrasound (tFUS) can help people with severe traumatic brain injury who have not fully recovered consciousness. Researchers will compare real tFUS to a sham (fake) treatment in 60 participants, measuring changes in consciousness usi…

This early-stage study tests whether a special MRI scan (CEST-EPI) can help surgeons see and remove more aggressive brain tumor (glioblastoma) cells that standard scans miss. About 18 adults with newly diagnosed or recurrent glioblastoma will have surgery guided by this pH-sensit…

This study tests a new treatment for people who have had a stroke caused by a blood clot in the brain. A weak electrical current is applied through electrodes on the scalp to increase blood flow and protect brain tissue. The goal is to find the safest and most effective dose. The…

This study tests whether a 16-week ketogenic diet (low carbs, high fat, medium protein) can help teens aged 12–21 with bipolar disorder. Eighty participants will receive the diet plus standard medication, with coaching from dietitians and monthly checkups. Researchers will track …

This phase 2 trial tests whether injecting antibiotics directly into the tissue around chronic wounds helps them heal better than standard care alone. About 60 adults with non-healing wounds on their legs, arms, or trunk will either receive the antibiotic injections plus usual wo…

This study tests whether a drug called ferric citrate can lower a harmful protein (FGF23) in children aged 6–18 with moderate chronic kidney disease. About 160 kids will take either the drug or a placebo for 12 months. The goal is to see if the drug is safe and helps control kidn…

This study follows 100 men with prostate cancer who choose to have high-intensity focused ultrasound (HIFU) as their treatment. HIFU uses sound waves to heat and destroy cancer cells in a targeted area. Researchers will check if the cancer is gone at 6 and 18 months and track how…

This study tests whether cannabidiol (CBD), a compound from hemp, can help people who want to quit smoking reduce their cigarette use. 120 adults with tobacco use disorder will receive either CBD or a placebo twice daily for 56 days. Researchers will measure nicotine levels and c…

This study tests a program called Mentor Moms+ for pregnant women in South Africa who drink alcohol. Trained mentor mothers—women who have successfully reduced alcohol use while on HIV medication—provide one-on-one counseling sessions. The goal is to see if this approach helps wo…

This trial tests a gene therapy for children with ADA-SCID, a severe immune disorder often called 'bubble boy disease.' Doctors take the child's own blood stem cells, add a working gene, and return them via infusion. The goal is to restore immune function and improve survival. Th…

This study tests whether a probiotic (a mix of good bacteria) can help adults with obesity lose weight when combined with healthy lifestyle changes. About 100 people aged 18-50 with a BMI between 25 and 40 will take either the probiotic or a placebo for several weeks. Researchers…

This study tests whether a donor stem cell infusion can retrain the immune system to accept a liver transplant without lifelong anti-rejection drugs. Twelve adults who had a liver transplant from a matched living donor at least one year ago will receive the infusion after a mild …

This study tests whether taking a daily prebiotic supplement for 8 weeks can improve gut health and reduce inflammation in people with ulcerative colitis. Researchers will collect stool samples and track symptoms in 70 adults. The goal is to see if prebiotics can help manage the …

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or arthritis. Twenty adults aged 18 to 60 will be randomly assigned to receive either the Biomet Zimmer Mobi-C or Nuvasive Simplify implant. Researchers will mea…

This study aims to see if a hybrid closed-loop insulin pump (a smart insulin pump) can help adults with poorly controlled type 1 diabetes (A1c >8.5%) from diverse backgrounds. The study will enroll 40 participants from Los Angeles who do not currently use an insulin pump. The goa…

This study tests a system that uses a special pill bottle to track when HIV medication is taken. If doses are missed, the system alerts a care team to help address problems like food or housing issues. The goal is to help 110 adults in Los Angeles stick to their HIV treatment and…

This pilot study is testing a smartphone app with telephone coaching to help obese teenagers and young adults lose weight after a stem cell transplant. The study will enroll 20 participants aged 13 to 30 who are at least 100 days post-transplant. The goal is to see if the app can…

This study tests a support package for people with HIV in Malawi who start or restart antiretroviral therapy (ART). The package includes mobility counseling, a toll-free hotline, and multi-month medication dispensing. Researchers want to see if this approach is acceptable to pati…

This study compares two types of general anesthesia during emergency clot removal for stroke patients. The goal is to see which method better maintains blood flow to the brain and improves recovery. About 90 adults with severe stroke will take part at two hospitals in Los Angeles…

This study in Malawi tests a new approach for people with HIV who have stopped taking their medication. Instead of a one-size-fits-all plan, participants can choose from different services to fit their changing needs. The goal is to see if this flexible, client-driven care helps …

This study looks at whether a low-calorie, anti-inflammatory diet combined with walking can reduce heart disease risk factors in men with advanced prostate cancer who are on hormone therapy (ADT). Researchers will compare results between African American and non-Hispanic white me…

This study looks at whether specially modified stent grafts can safely treat complex aortic aneurysms (bulges in the main blood vessel) in people who are too high-risk for traditional open surgery. Researchers will track 50 patients to see how many have serious complications like…

This pilot study is testing whether drinking 8 ounces of pomegranate juice daily for 8 weeks can reduce gut inflammation and improve quality of life in people with mild-to-moderate ulcerative colitis. Researchers will also look at how the juice affects gut bacteria. The study inv…

This early-stage study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop taking lifelong anti-rejection medications. Ten adults with a well-functioning kidney from a matched living donor will receive a conditioning treatm…

This early study tests whether a spinal cord stimulator can safely help people with cervical spinal cord injuries breathe without a ventilator. Twelve adults who have been injured for at least a year and rely on a breathing machine will receive an implant and attend weekly sessio…

This study aims to help people living with HIV achieve and maintain viral suppression (low virus levels) using a smartphone-based program. It will enroll 1,000 adults who have trouble staying on treatment due to substance use, mental health issues, or other barriers. The program …

This study is testing a new device that uses near-infrared light to measure pelvic floor muscle fitness in women with myofascial pelvic pain, a condition that affects up to 26% of women. The goal is to create a simple, non-invasive diagnostic tool that could replace the need for …

This study tests whether giving penicillin shots to pregnant women at high risk for syphilis can prevent infection. Researchers in Rio de Janeiro will enroll 500 women and compare the shots to standard care. Participants receive monthly injections and tests during their third tri…

This study compares two strategies to help clinics increase HPV vaccination rates among children aged 9-17. One strategy provides online communication training for providers; the other adds a learning collaborative with performance feedback. The goal is to see which approach work…

This study tests a new way to prevent HIV by giving a long-acting injectable medication called lenacapavir through mobile health vans. It aims to reach 100 people in Los Angeles who are unhoused or unstably housed and face barriers to regular clinic visits. Participants receive t…

This study tests a program called Mobile Enhanced Prevention Support (MEPS) for people recently released from jail or prison who have substance use disorders. The program pairs participants with a peer mentor, offers cash incentives for using health services, and provides a smart…

This study tests whether injecting a drug called anakinra into the knee within two weeks of an ACL injury can prevent arthritis that often develops years later. Half of the 32 participants will receive the drug, and half will receive a placebo (salt water). Researchers will track…

This study tests an online diabetes prevention program for UCLA undergraduates who are at risk for type 2 diabetes. The program includes short online lessons and aims to help participants lose weight and improve quality of life. Researchers will compare results between those who …

This study tests a behavioral sleep program called Care2Sleep for people with Alzheimer's disease and their caregivers. The program includes sleep hygiene, activity, and light exposure. Researchers will compare it to a sleep education group to see if it improves sleep, health, an…

This study tests whether a home-based telerehabilitation program, using games, exercises, and video calls with therapists, can improve arm function and reduce disability in people who had a stroke 90-150 days ago. 202 participants will be randomly assigned to receive telerehabili…

This early-phase study tests whether low-intensity focused ultrasound (LIFU) can safely reduce tremors in people with essential tremor. Twenty adults will receive six non-invasive ultrasound sessions targeting a small brain area involved in movement. Researchers will measure trem…

This study tests whether a virtual reality training program can help people with depression and low positive affect feel more joy and motivation. 80 adults will be randomly assigned to either a reward-focused VR training or a neutral memory VR training for 7 weeks. The goal is to…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in older adults with mild cognitive impairment or subjective memory complaints. About 70 participants will be randomly assigned to receive either …

This study looks at whether giving children a nerve block before elbow fracture surgery can help control pain afterward and reduce the need for strong painkillers like oxycodone. About 90 children with a specific type of elbow fracture will be randomly assigned to receive either …

This study tests whether a low dose of buprenorphine (0.15 mg) can improve social motivation in 40 people with schizophrenia. Participants will take either the drug or a placebo and complete tasks that measure their drive to seek or avoid social interaction. The goal is to see if…

This study tests a non-invasive technique called Low Intensity Focused Ultrasound Pulsation (LIFUP) to see if it can safely increase brain activity and improve memory in people with mild cognitive impairment or mild Alzheimer's disease. Participants will receive ultrasound to a k…

This study tests whether a non-medication sleep program (CBT-I) can improve sleep, PTSD symptoms, and heart health in older adults with PTSD who still have sleep problems after PTSD therapy. About 167 veterans aged 50 and older will receive PTSD therapy first, then the sleep prog…

This study tests whether a device that delivers gentle electrical stimulation to the pelvic floor can reduce chronic pelvic pain in women. Sixty women with myofascial pelvic pain will either receive the device treatment or standard care (education and exercises). The goal is to s…

This study tests two approaches in public schools: a teacher-led program (RUBIES) to reduce challenging behaviors in autistic children, and a leadership strategy (HELM) to help schools keep using effective methods. About 373 teachers and students in grades K-5 will take part. The…

This study tests whether giving children acetaminophen (Tylenol) with ibuprofen (Advil) works as well as acetaminophen with oxycodone for pain after elbow fracture surgery. About 90 children with a specific type of elbow fracture will be randomly assigned to one of the two combin…

This study looks at whether doing a positive mood treatment before standard exposure therapy can improve outcomes for people with social anxiety and public speaking fears. About 94 adults with social anxiety disorder will first receive either a positive mood treatment or a relaxa…

This study tests a program called Reminder-Focused Positive Psychiatry (RFPP) for teens aged 11-15 with PTSD. The program helps teens reframe traumatic memories in a positive way. Researchers will compare RFPP to a general support group to see if it reduces PTSD symptoms and impr…

This study looks at whether Xiidra, an FDA-approved eye drop for dry eye, can reduce eye discomfort and dryness in people with glaucoma who are already using multiple eye drops to control eye pressure. About 75 participants will receive Xiidra as part of their standard care and b…

This early-stage study tests whether taking vitamin B1 (thiamine) daily for three months can improve brain function and repair the blood-brain barrier in adults with type 2 diabetes. Researchers will use brain scans, memory tests, and blood markers to compare results between the …

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can improve pain and depression in people with knee osteoarthritis. Thirty adults aged 50 and older with chronic knee pain and moderate to severe depression will receive rTMS while also ta…

This study tests whether a tailored mindfulness program can help high-achieving Black, Latinx, and Asian American students manage the hidden health costs of resilience. 504 students from 18 schools will be randomly assigned to either the mindfulness program or a study skills grou…

This study tests a sleep improvement program designed specifically for older Korean immigrants who have trouble sleeping. The program adapts standard sleep therapy to fit Korean culture and language. Researchers will measure sleep quality and gather feedback from 32 participants …

This study tests a new way to manage pain after a double lung transplant. Instead of relying only on strong pain medicines, doctors will use a cold-therapy probe during surgery to numb the nerves near the incision. The goal is to see if this method reduces the need for opioids an…

This study tests a personalized, noninvasive brain stimulation technique called TMS for people aged 18–65 with chronic symptoms after a mild concussion or traumatic brain injury. Symptoms like headache, dizziness, brain fog, and anxiety can last for months. Participants will rece…

This study tests a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) for veterans with chronic musculoskeletal pain. EAET helps people understand and express emotions linked to past stress or trauma, which may reduce pain. Researchers will train therap…

This study tests whether electromagnetic stimulation can safely improve bladder function in people with spinal cord injury. Researchers will enroll 24 men with complete motor paralysis who have used catheters for at least a year. Participants will receive non-invasive stimulation…

This study tests whether combining psilocybin (the active ingredient in magic mushrooms) with cognitive behavioral therapy can help people with major depression. Fifty adults aged 21-60 with current depression will receive two doses of psilocybin and either 12 sessions of CBT or …

This study compares cognitive behavioral therapy (CBT) with online expert coaching to usual care for children aged 6-14 with autism who struggle with anxiety, irritability, or emotional outbursts. About 100 children and 50 therapists will take part. The goal is to see if the coac…

This study tests a new, non-invasive treatment for people with generalized anxiety disorder who haven't gotten better with standard medications. The treatment uses low-intensity focused ultrasound to gently stimulate a deep brain area linked to anxiety, called the amygdala. 48 ad…

This study enrolls 1,000 community college students aged 18-40 who have depression or anxiety. Participants are randomly assigned to one of two decision-making methods that determine their level of care: self-guided online prevention, coach-guided online therapy, or clinician-del…

This study tests a procedure called hemorrhoidal artery embolization (HAE) for people with internal hemorrhoids who have not had success with other treatments or cannot have surgery. The procedure blocks certain arteries to reduce blood flow to the hemorrhoid tissue, aiming to im…

This study tests an online group program called Project SOAR Awakenings for Black American women diagnosed with breast cancer. The program uses small-group video chats to discuss culturally relevant topics and promote well-being. Researchers will compare participants' depression,…

This pilot study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can safely improve memory in people with mild-to-moderate Alzheimer's disease. The treatment targets the precuneus, a brain region important f…

This study tests whether a back brace with red laser diodes can reduce chronic lower back pain in people who had spinal fusion or decompression surgery 1 to 5 years ago. Half of the 80 participants will wear the active laser brace, and half will wear a sham brace that looks the s…

This study compares two types of counseling for young people aged 13-24 who come to the emergency room with suicidal thoughts or actions. One approach is a single session called SAFETY-A that involves the youth and their family, and the other adds extra follow-up support. Researc…

This pilot study tests a smartphone app called BrainWeighve that helps teens aged 14-21 with obesity lose weight by replacing overeating with healthier coping behaviors. The study enrolls 38 participants to test the app's feasibility and satisfaction over 4 months. It is an early…

This study tests a six-week mindfulness program called BEST (Building Emotional Strength Training) in 80 healthcare workers from UCLA Health. The program teaches loving-kindness, compassion, and other skills to reduce stress, depression, and burnout. Participants will fill out qu…

This study looks at how voice therapy works for people with vocal fold lesions (like nodules) caused by voice overuse. Researchers want to see if therapy reduces the pressure when vocal folds collide. 60 adults aged 18-40 with these lesions will be studied before and after voice …

This study tests whether computer-based cognitive training, combined with group therapy, can improve thinking skills and daily functioning in Tunisian youth at clinical high risk for psychosis. Fifty-four participants will either receive the cognitive training program or an enhan…

This study tests whether a text-based program called Help Texts can reduce grief and depression in college students who lost a loved one in the past year. About 126 UCLA students will either receive the texts twice a week for 12 months or get a list of grief resources. Researcher…

This study compares a 6-week mindfulness program to a sleep education class to see which better improves sleep in first- and second-year college students. About 240 students aged 18-22 who have trouble sleeping will participate. Researchers will track sleep quality, mood, and inf…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can reduce symptoms of borderline personality disorder (BPD). Up to 30 adults with BPD will receive either real or sham TMS over several weeks. Researchers will trac…

This study tests a new way to reduce fear in people with phobias (like spiders or snakes) without needing to consciously face what scares them. Using brain scans (fMRI), the method retrains the brain unconsciously, aiming to lower fear responses and make treatment less distressin…

This pilot study tests whether a faster, personalized version of transcranial magnetic stimulation (TMS) is safe and feasible for inpatients with major depressive disorder. Thirty participants will receive up to 25 TMS sessions over two weeks, with the frequency tailored to their…

This study compares telerehabilitation (remote training) to in-office care for adults with low vision who have received new magnification devices or assistive apps. Researchers will also use Bluetooth sensors to monitor if patients stop using their devices, aiming to provide time…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of major depression and chronic pain at the same time. Fifty-four adults with moderate depression and pain will receive 30 sessions of active rTMS over several weeks. Researchers …

This study investigates a technique called drug-induced sleep endoscopy (DISE) to examine the upper airway in adults with obstructive sleep apnea (OSA) who are considering surgery. Participants receive a mild sedative (propofol) to induce sleep, then a thin camera is passed throu…

This study looks at whether an artificial intelligence (AI) tool can predict if lung scarring (pulmonary fibrosis) will get worse over time. Researchers will analyze CT scans from 200 people with either idiopathic pulmonary fibrosis (IPF) or other types of interstitial lung disea…

This observational study is looking at 250 people who have had a stroke or mini-stroke due to narrowing of arteries in the brain. Researchers want to see if a specific platelet protein (FcγRIIa) and blood flow patterns on MRI can help predict who will have another stroke within a…

This observational study tests whether a non-invasive headband called fNIRS can measure brain activity in healthy adults and in people with disorders of consciousness, such as coma, after severe brain injury. Participants wear the headband while receiving gentle touch, listening …

This study tests a non-invasive brain stimulation technique called tDCS for depression. Researchers use MRI scans to see how the stimulation affects brain networks. 144 adults with depression will receive either real or sham tDCS while performing a memory task. The goal is to fin…

This study is recruiting 160 depressed teens aged 14-21 to understand how stress affects inflammation and brain chemistry. Participants will undergo a mild stress test and then take either fluoxetine or escitalopram for 12 weeks. Researchers will track who responds to treatment a…

This study follows 80 children aged 2-8 with cystic fibrosis to see how highly effective CF drugs (Kalydeco or Trikafta) impact sinus disease and sense of smell. Researchers will use MRI scans, smell tests, and quality-of-life surveys over two years. The goal is to understand whe…

This study explores whether artificial intelligence can simplify the language used in informed consent forms for clinical trials. Researchers will test AI tools like ChatGPT and NotebookLM to rewrite these forms and see if people understand them better. The study involves 230 par…

This study looks at whether using surgical mesh during breast reconstruction after mastectomy is safe and helpful. About 120 women will be randomly assigned to receive reconstruction with or without mesh. The goal is to compare complication rates and patient satisfaction to guide…

This study aims to understand the different reasons people with alcohol use disorder are motivated to drink. Researchers will give participants IV alcohol and ask them to press a button for more doses, while measuring mood, cravings, and thinking skills. The goal is to link these…

This study looks at whether adjusting the default prescription length for proton pump inhibitors (PPIs) in the electronic health record can reduce overprescribing. About 372 UCLA Health primary care doctors will participate, and the study will track how many extra pill days are p…

This study tests a program called TransAction to help transgender women in Ho Chi Minh City improve their HIV prevention and care. 80 participants will either join the full program (individual sessions, group support, and social events) or just social events. The goal is to see i…

This study follows 170 adults with cystic fibrosis and chronic sinusitis to see if sinus surgery improves lung function and quality of life compared to medical treatment alone. Participants either have surgery or continue with standard care. Researchers will track changes in brea…

This study looks at when to start a parent coaching program called JASPER Babble for infants who have an older sibling with autism, putting them at higher risk. About 140 babies will join at 6-8 months old and be randomly assigned to start coaching at 9, 12, or 15 months. Researc…

This UCLA study is looking for healthy adults aged 65 and older to see if writing about their experiences can affect their brain and body. Over 6 weeks, participants will write once a week and complete online surveys. They will also visit UCLA twice for brain scans, blood tests, …

This study aims to understand if cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will give 160 regular cannabis users either active cannabis or a placebo and measure their pain response, drug effects, and blood levels. The goal is to g…

This study looks at whether seeing a picture of a supportive person can help people with social anxiety feel less afraid. Researchers will compare 50 healthy adults and 50 adults with social anxiety disorder. Participants will learn to associate a neutral image with a mild electr…

This study tests whether seeing a picture of a supportive friend or family member helps people with social anxiety unlearn fear more effectively. Researchers will compare fear responses in 100 participants (50 with social anxiety, 50 healthy) after pairing threatening cues with e…

This pilot study is testing whether wearing a continuous glucose monitor (CGM) for just 24 hours after giving birth can help predict a woman's long-term risk of developing type 2 diabetes. The study involves 50 women who had gestational diabetes and will wear the CGM immediately …

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study looks at how spinal cord stimulators change brain activity in people with chronic low back pain. Researchers will use fMRI scans to compare brain connectivity when the device is on versus off. The goal is to find patterns that predict who will respond well to this trea…

This study explores why some teenagers with anorexia urinate excessively when they start eating again in the hospital. Researchers think a hormone called secretin might be involved. They will compare secretin levels in teens who urinate a lot versus those who don't, using one ext…

This study looks at whether telling patients to arrive 15 minutes before their appointment helps them show up on time. Researchers will compare two groups: one gets an explicit arrival time, the other just a reminder. Up to 300,000 adults with UCLA Health appointments in primary …

This study follows 80 youth aged 9 to 19 with bipolar disorder across four U.S. sites. Researchers will track mood symptoms, inflammation, and family conflict over 12 months to find what predicts better or worse outcomes. The goal is to create standardized tools and best-practice…

This study looks at whether brain activity synchronizes differently in people with schizophrenia during social interactions. Researchers will compare 100 participants—some with schizophrenia and some without—as they chat and do tasks together while wearing EEG caps. The goal is t…

This study follows 250 adults in the ICU to understand frailty and muscle wasting. Researchers will use ultrasound, blood tests, and questionnaires to track changes. The goal is to find factors that can be changed to improve recovery and reduce long-term disability.

This study looks at a program called Proactive Care, which gives personalized support to people with chronic diseases. The goal is to see if this help can reduce how often people need to go to the hospital. About 5,000 adults with high expected medical costs will be randomly chos…

This study tests a new way to classify placenta accreta during surgery, aiming to guide the best surgical approach. Researchers will follow 60 pregnant people at risk, using ultrasound before surgery and a classification system during the operation. The goal is to see if this sys…

This study is developing a decision tool to help doctors identify blunt trauma patients who can safely skip abdominal-pelvic CT scans, avoiding unnecessary radiation and expense. Researchers will collect data from 12,000 patients in the emergency department to find a set of clini…

This study looks at how age and sex influence the effects of THC, the main psychoactive ingredient in cannabis. Researchers will give smoked and oral THC to 103 adults aged 18-65 who use cannabis regularly. They will measure pain relief, intoxication, impairment, and how the body…

This study collects information from people with ASXL-related disorders (such as Bohring-Opitz syndrome) to better understand how these conditions progress and are managed. No new treatments are tested; instead, participants share their medical history and records through surveys…

This study is developing algorithms that decode brain and body signals to help people with paralysis control assistive devices like robotic arms, wheelchairs, or computer cursors. Fifty healthy participants will perform tasks while wearing non-invasive sensors such as EEG and EMG…

This study tests whether a choice-driven, interactive storytelling web app can help Latinas with anxiety or depression start mental health treatment. Seven hundred participants in Los Angeles and Orange County will either use the story-based app or a control webpage with standard…

This study looks at how CBD (a non-psychoactive cannabis compound) changes the effects of THC (the compound that makes you high). Researchers will give both substances to 30 regular cannabis users who are not seeking treatment. They want to see if CBD can reduce the abuse potenti…

This study looks at how gut bacteria and diet affect symptoms in people with irritable bowel syndrome (IBS). Researchers will measure bile acids, short-chain fatty acids, and gut microbes in stool samples from 72 adults with IBS and healthy volunteers after a controlled diet. Par…

This study tests whether the drug cytisinicline changes how the brain reacts to seeing smoking-related images in daily smokers who are not trying to quit. Sixty-four participants will receive either the drug or a placebo and undergo brain scans while watching videos of smoking an…

This study looks at how memories are processed during sleep by recording brain activity in epilepsy patients. Researchers will use gentle electrical and sound stimulation during sleep to see if it changes memory recall. The goal is to understand the brain's natural memory consoli…

This study looks at how smoking high-potency cannabis affects pain relief, feelings of being high, and drug levels in the blood. Researchers will test 30 near-daily cannabis users who are not seeking treatment. Participants will smoke either placebo, low-dose, or high-dose THC ca…

This study looks at whether having a specially trained peer recovery specialist in the emergency department helps people with substance use disorders connect to treatment and support services. Researchers will follow 400 adults who visit the ER for substance-related issues, compa…

This study looks at whether brain scans can help predict which people with chronic low back pain will get good pain relief from spinal cord stimulation (SCS). Researchers will scan the brains of 42 adults before they receive SCS as part of their normal care. They will then check …