Could two common drugs boost sleep apnea surgery success?

NCT ID NCT05953610

Recruiting now Disease control Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study investigates whether two medications—acetazolamide and eszopiclone—can improve sleep apnea outcomes when taken after soft palate surgery. The trial includes adults with moderate to severe obstructive sleep apnea who cannot use CPAP or oral appliances. Researchers will measure changes in the apnea-hypopnea index to see if the drugs help address underlying causes like unstable breathing control or low arousal threshold.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Acetazolamide and Eszopiclone
What this could lead to: If successful, this could point toward a combined surgical and medication approach to better control obstructive sleep apnea in people who cannot tolerate standard treatments like CPAP.
What could go wrong: This is a Phase 2 study with a moderate number of participants, so results may not apply to everyone. The drugs may cause side effects or not improve outcomes as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTRUCTIVE SLEEP APNEA

Contacts and locations

Locations

UCLA Santa Monica Medical Center
RECRUITING

Santa Monica, California, 90401, United States
UCLA Westwood
NOT_YET_RECRUITING

Westwood, Los Angeles, California, 90095, United States

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