Could two common drugs boost sleep apnea surgery success?
NCT ID NCT05953610
First seen Jul 01, 2026 · Last updated Jul 01, 2026
Summary
This study investigates whether two medications—acetazolamide and eszopiclone—can improve sleep apnea outcomes when taken after soft palate surgery. The trial includes adults with moderate to severe obstructive sleep apnea who cannot use CPAP or oral appliances. Researchers will measure changes in the apnea-hypopnea index to see if the drugs help address underlying causes like unstable breathing control or low arousal threshold.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Acetazolamide and Eszopiclone
What this could lead to
If successful, this could point toward a combined surgical and medication approach to better control obstructive sleep apnea in people who cannot tolerate standard treatments like CPAP.
What could go wrong
This is a Phase 2 study with a moderate number of participants, so results may not apply to everyone. The drugs may cause side effects or not improve outcomes as hoped.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UCLA Santa Monica Medical Center
RECRUITINGSanta Monica, California, 90401, United States
Contact
Contact
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UCLA Westwood
NOT_YET_RECRUITINGWestwood, Los Angeles, California, 90095, United States
Contact
Contact