Could a mouthpiece replace the CPAP machine for sleep apnea?
NCT ID NCT03924817
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This registry study follows 500 adults with obstructive sleep apnea who are prescribed a mandibular advancement device (MAD) — a dental appliance worn at night to keep the airway open. Researchers will track how the device is prescribed, how often patients actually use it, and whether it improves breathing and sleep-related quality of life after three months. The goal is to better understand which patients might benefit from this alternative to CPAP therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mandibular advancement device (a dental appliance worn at night to hold the lower jaw forward and keep the airway open)
- What this could lead to
- If successful, this could help identify which patients with obstructive sleep apnea benefit most from a mandibular advancement device, offering an alternative to CPAP machines.
- What could go wrong
- This is an observational registry, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by patient selection and adherence, and the device may not work for everyone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ruhrlandklinik Essen
Essen, North Rhine-Westphalia, 45239, Germany
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Schlaf- und Beatmungszentrum Blaubeuren
Blaubeuren Abbey, Badden-Württemberg, 89143, Germany
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Universitätsklinikum Regensburg - Klinik für Innere Medizin II
Regensburg, 93053, Germany
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Zentrum für Schlafmedizin Dr. Warmuth
Berlin, State of Berlin, 12683, Germany
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