A blood test for sleep apnea? MicroRNAs may hold the key

NCT ID NCT06189755

Recruiting now Diagnosis Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study investigates whether tiny molecules in the blood, called microRNAs, can serve as biomarkers for obstructive sleep apnea (OSA). Researchers will compare blood samples from people with moderate-to-severe OSA and those without the condition, before and after treatment with positive airway pressure (PAP) therapy. The goal is to develop a blood test that can identify OSA, reflect treatment effectiveness, and predict blood pressure response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Positive Airway Pressure (PAP) therapy
What this could lead to: If successful, this could lead to a simple blood test to diagnose sleep apnea and predict who will benefit most from treatment.
What could go wrong: The study is still in early stages, and the biomarkers may not prove accurate or specific enough for clinical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTRUCTIVE SLEEP APNEA

Contacts and locations

Locations

The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600
RECRUITING

Columbus, Ohio, 43221, United States
University of Iceland
RECRUITING

Reykjavik, Iceland
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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