OBSTRUCTIVE SLEEP APNEA

This study tracks 225 adults with moderate to severe obstructive sleep apnea who receive the Inspire hypoglossal nerve stimulator. The device is implanted and stimulates a nerve to keep the airway open during sleep. The goal is to see how well it reduces breathing pauses and how …

This study looks at whether a structured program to find and treat obstructive sleep apnea can reduce the amount of time people with atrial fibrillation spend in an irregular heart rhythm. About 209 adults with AF will use a home sleep test and a Fitbit smartwatch to monitor thei…

This study looks at how a nerve-stimulation device (hypoglossal nerve stimulation) changes the way the upper airway collapses in people with obstructive sleep apnea. Researchers will use a sleep endoscopy and a new non-invasive method to measure collapse before and after one year…

This study looks at how well a custom mouthpiece called OrthoApnea NOA helps people with obstructive sleep apnea (OSA). OSA causes breathing to stop and start during sleep, and some people find the standard CPAP machine uncomfortable. The NOA mouthpiece may be a simpler option. R…

This study tests whether artificial intelligence can predict the best treatment for each person with obstructive sleep apnea (OSA), and whether a smartphone app helps people stick with mouth and throat exercises. Researchers will use data from 300 adults to develop and validate t…

This study tests a new drug, maridebart cafraglutide, for adults with obstructive sleep apnea who are overweight or obese and not using a breathing machine (PAP therapy). Over 52 weeks, researchers will measure if the drug reduces breathing pauses during sleep and helps with weig…

This study tests a new drug, maridebart cafraglutide, in 250 adults with obstructive sleep apnea who are overweight or obese and already use a breathing machine (PAP therapy). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss over 52 …

This early study tests a new magnetic device (Magnap) for obstructive sleep apnea. It involves a small implant and an external brace to keep the airway open during sleep. The study includes 10 adults who cannot tolerate CPAP therapy and aims to see if the device is safe and usabl…

This study compares personalized surgery guided by a special camera during sleep (DISE) to standard tonsillectomy for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and standard surgery often fails. …

This study tests a nerve-stimulation therapy for people with moderate-to-severe obstructive sleep apnea (OSA) who cannot use standard treatments like mouthpieces or breathing machines. Researchers will enroll 50 Latin American adults to see how well the therapy works compared to …

This study tests a new, smarter algorithm for CPAP machines that automatically adjusts air pressure to treat obstructive sleep apnea. About 80 adults who already use a ResMed CPAP will try the new algorithm for up to 8 weeks. Researchers will check if the new algorithm reduces br…

This study tests whether using a PAP machine (a device that helps keep your airway open during sleep) can improve recovery after a stroke. Researchers will enroll 360 people who have had an ischemic stroke and also have moderate to severe obstructive sleep apnea. Participants are…

This study tests whether a personalized surgery guided by a sleep endoscopy works better than standard tonsil removal for children aged 2-17 with small tonsils and moderate-to-severe obstructive sleep apnea. About 240 children will be randomly assigned to one of the two surgeries…

This study tests if a smartphone app called SmartWell24 can help people with obstructive sleep apnea use their CPAP machine for at least 6 hours a night, 6 nights a week. Researchers will track CPAP usage and quality of life in 40 adults newly diagnosed with sleep apnea. The goal…

This study tests whether community health workers can help people with moderate-to-severe sleep apnea stick to using their breathing machines at night. About 48 adults who have never used a PAP machine before will receive either motivational coaching from a health worker or stand…

This study looks at whether a sleep medication (eszopiclone) can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. Researchers will study 250 adults with a new sleep apnea diagnosis. The goal is to see if raising …

This study tests whether a custom mouthpiece called EVO can safely and effectively treat severe obstructive sleep apnea. About 49 adults with severe sleep apnea will use the device for 6 months. The goal is to see if it reduces breathing pauses by at least half and keeps them bel…

This study looks at whether lifestyle changes can help control glaucoma in people who also have obstructive sleep apnea and obesity. Researchers will measure eye pressure, sleep quality, and body measurements in 40 participants. The goal is to see if simple lifestyle corrections …

This study tests a small device that stimulates nerves in the neck to keep the airway open during sleep. It is for adults with moderate to severe sleep apnea who cannot use a CPAP machine. The goal is to see if the device is safe and improves breathing. About 20 people will take …

This study tests a culturally tailored program that uses motivational interviewing and text messages to help Native American elders use their sleep apnea machines consistently. About 300 participants aged 50 and older from three Northern Plains Reservations will either receive st…

This study explores whether brief, mild drops in oxygen (mild intermittent hypoxia) can improve heart and blood vessel function and reduce fatigue in people with obstructive sleep apnea. About 60 adults aged 30-60 with newly diagnosed, untreated sleep apnea will receive this trea…

This study tests whether dronabinol, a drug similar to a compound in marijuana, can help people with obstructive sleep apnea. About 120 adults with moderate to severe sleep apnea will take the drug for two weeks. Sleep tests before and after treatment will measure if their breath…

This study tests if a custom mouthpiece (mandibular advancement device) can safely and effectively treat severe sleep apnea in people who cannot use a CPAP machine and whose nerve stimulation therapy did not work. About 30 adults will use the device at home and have their sleep b…

This study tests whether a type of light therapy called photobiomodulation can help people with obstructive sleep apnea use their CPAP machine more comfortably. About 30 adults who currently use CPAP but have trouble tolerating it will receive the light treatment. The goal is to …

This study tests whether wearing bright light therapy glasses can reduce daytime sleepiness and depression in people with obstructive sleep apnea who still feel tired despite using their CPAP machine. About 60 participants will wear the glasses for four weeks with active light an…

This study looks at whether eating a whole food plant-based diet can improve sleep apnea and reduce daytime sleepiness. Researchers will measure changes in sleepiness and breathing pauses during sleep in 40 adults. Participants must have mild to moderate sleep apnea and daytime s…

This study looks at whether treating sleep apnea early can improve long-term outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive sleep apnea treatment right away or be placed on a waitlist. The…

This study looks at whether giving extra support and advice helps people with obstructive sleep apnea use their mouthpiece more regularly. About 56 adults aged 40 and older will be split into two groups: one gets routine care, the other gets additional support. Researchers will t…

This study tests a low-cost pill called acetazolamide for people with moderate to severe sleep apnea who cannot tolerate a CPAP mask. Sixty adults will receive either the drug or a placebo for 4 weeks each, and researchers will measure sleep quality, memory, and quality of life. …

This study tests a 12-month telehealth program for 400 veterans with COPD, sleep apnea, and overweight. Participants get a self-directed lifestyle plan, supervised exercise sessions, and optional weight management medication. The goal is to improve physical quality of life and re…

This study compares how satisfied people are with two different CPAP machines for treating moderate to severe obstructive sleep apnea. About 50 adults will try both a standard home machine and a smaller portable one. The goal is to see which device users prefer and how well each …

This study tests a new device called DidgeriTU for people with mild-to-moderate obstructive sleep apnea. The goal is to see if it can reduce breathing pauses during sleep. Participants will use either the real device or a fake one for 3 months and complete sleep tests and questio…

This study is for people with chronic sinusitis and nasal polyps who have trouble sleeping. Researchers want to see if endoscopic sinus surgery can improve sleep quality, especially deep sleep. Thirty adults will have their sleep measured before and three months after surgery to …

This study tests whether doing specific throat and mouth exercises can help people with obstructive sleep apnea who cannot tolerate the standard CPAP machine. Researchers will enroll 45 adults and randomly assign them to supervised exercises, unsupervised exercises, or a sham (fa…

This study tests a new light-based treatment called transcranial photobiomodulation (tPBM) for people with obstructive sleep apnea who still feel sleepy even after using their CPAP machine. Researchers will measure changes in brain blood flow and sleepiness scores in 22 adults. T…

This study looks at two alternative treatments for people with moderate-to-severe obstructive sleep apnea who cannot use a CPAP machine. One treatment is a custom mouthpiece (mandibular advancement device) and the other is a surgically implanted nerve stimulator (hypoglossal nerv…

This study tests a mobile health program for couples to help people with sleep apnea stick with their CPAP machine. About 360 newly diagnosed patients and their partners will get tips and resources on their phones for 6 months. The goal is to see if this support improves nightly …

This study looks at whether using a CPAP machine at night can improve asthma control in adults with severe, hard-to-control asthma and obstructive sleep apnea. Researchers will measure asthma symptoms and lung function in 138 participants over time. The goal is to see if treating…

This study tests a special nasal tube (ssNPA) that stays in place without tape or ties, designed to help children with weak throat muscles breathe easier during sleep. About 40 children with obstructive sleep apnea and conditions like Down syndrome will try the device overnight. …

This early-phase study tests whether a combination of two drugs, atomoxetine and DAW2022, can reduce the severity of obstructive sleep apnea (OSA). Researchers will monitor 18 adults with moderate-to-severe OSA overnight to see if the drugs lower breathing interruptions and impro…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea. About 668 participants will use PAP therapy and be tested on memor…

This study looks at whether obstructive sleep apnea (OSA) is linked to problems with how the body processes fat. Researchers will compare fat metabolism in 100 adults with and without sleep apnea using a glucose test. The goal is to understand how fat tissue releases substances t…

This study looks at how common sleep apnea is in Somali-American adults and how it affects their heart health. Researchers will compare 600 Somali, African, Asian, and European participants to find genetic and physical risk factors. The goal is to better understand sleep problems…

This study looks at two different sedatives used during a sleep endoscopy procedure in children with obstructive sleep apnea. The goal is to see if one drug causes more airway collapse than the other, and whether the collapse patterns can predict which children will still have sl…

This study looks at whether a treatment called hypoglossal nerve stimulation (HGNS) for obstructive sleep apnea can improve how the body processes sugar and lower heart risks. About 30 overweight or obese adults who cannot use a CPAP machine will take part. Researchers will measu…

This study looks at older veterans who have both sleep apnea and COPD, a combination called Overlap Syndrome. Researchers want to see if having both conditions causes more problems with memory, attention, and daily life than having just one. They will also test whether treating s…

This study reviews medical records of 200 children with obstructive sleep apnea who had tonsil or adenoid surgery. Researchers want to see how often breathing problems happen after surgery, especially in children with obesity, Down syndrome, or other health issues. The goal is to…

This study looks at whether children with a narrow upper jaw are more likely to have obstructive sleep apnea (OSAHS). Researchers will compare 102 children aged 6-16 who have this jaw issue to those with other dental problems. The goal is to find a simple, early warning sign that…

This study looks at how the amount of air in your lungs affects throat collapse during sleep in people with obstructive sleep apnea (OSA). Researchers will use a special camera to watch the throat while patients are sedated, and they will either use a chest ventilator or neck ele…

This study looks at how well new ResMed masks work for people with obstructive sleep apnea. About 500 adults who already use a CPAP machine will try the new masks at home. Researchers will track sleep data, mask leaks, and comfort to see if the masks perform well in everyday use.

This study looks at whether obstructive sleep apnea (OSA) causes scarring (fibrosis) in the heart's upper chambers, even in people without atrial fibrillation. Researchers will use special MRI scans to measure scarring in 60 adults with different severities of OSA. The goal is to…

This study looks at a nerve in the neck called the ansa cervicalis, which controls muscles that may help keep the airway open during sleep. Researchers will measure the nerve's size and shape in 50 adults having neck surgery for head and neck cancer. They will also test how much …

This study explores whether sleep apnea makes multiple sclerosis (MS) worse. Researchers will collect sleep tests, MRI scans, and lab results from 800 adults with MS to see if there is a link. The goal is to understand how sleep apnea might affect MS symptoms and brain changes. N…

This study follows 1,000 people who have the Inspire System implanted for obstructive sleep apnea. Researchers will collect data from routine clinic visits to see how well the device works over time and how consistently patients use it. No extra tests or treatments are required b…

This study aims to create a computer tool that predicts which surgery will work best for children with obstructive sleep apnea (OSA) who still have breathing problems after tonsil and adenoid removal. Researchers will use MRI scans and airflow simulations to model each child's un…

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth ulcers in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No new treatments are tested; th…

This study looks at how sex affects the way the body controls blood pressure in people with untreated obstructive sleep apnea. Researchers will measure blood pressure, artery stiffness, and nerve activity in 60 adults aged 20-70. The goal is to understand differences between men …

This study will follow 7,000 people with obstructive sleep apnea to see how different sleep patterns relate to future health problems. Researchers will use sleep tests, health records, and additional exams like lung function and memory tests. No new treatments are being tested; t…

This study looks at why people with obstructive sleep apnea often struggle to stick with CPAP therapy, the standard treatment. Researchers will test 64 adults to see if their decision-making style—specifically how much effort they're willing to put in for a reward—predicts poor C…

This study looks at whether a daytime sleep test works as well as an overnight one for adjusting the Inspire device, which treats obstructive sleep apnea. About 110 adults who already have the Inspire implant will take part. The goal is to see if daytime testing can save time and…

This study looks at 30 infants with Down syndrome who are 6 months old. Researchers want to see if the way babies suck (non-nutritive sucking) is linked to how severe their sleep apnea is. The goal is to find a simple way to screen for sleep apnea early, so babies can get help so…

This study looks at 65 adults with obstructive sleep apnea to see how three weeks of breathing therapy (ventilotherapy) changes their thinking skills, blood markers linked to brain health, and overall well-being. Participants will take thinking tests, give blood samples, and answ…

This study looks at how using a CPAP machine for sleep apnea affects chronic pain. About 80 adults newly diagnosed with sleep apnea will fill out pain questionnaires before starting CPAP and again at 3 and 6 months. Researchers want to see if better CPAP use leads to less pain, a…

This study looks at whether successfully treating moderate-to-severe sleep apnea can improve memory and reduce biological markers linked to Alzheimer's disease in older adults. Researchers will compare a group that receives immediate sleep apnea treatment (using CPAP, oral applia…

This study aims to better understand obstructive sleep apnea (OSA) by looking at the clinical features and molecular makeup of 500 patients. Researchers will collect blood, saliva, and urine samples to build a multi-omics database and track patients for at least one year. The goa…

This study looks at whether a night of poor sleep can trigger heart rhythm problems like atrial fibrillation (AFib) in people with sleep apnea. About 100 adults with a sleep apnea device will wear a heart monitor for 14 days. Researchers will compare days after good sleep versus …

This study looks at tongue muscle function in children with suspected obstructive sleep apnea (OSA). Researchers will measure tongue pressure and movement in 78 children referred for sleep testing and compare them to healthy children. The goal is to find out if weak tongue muscle…

This study looks at how sleep problems and sleep apnea might affect thinking, memory, and daily life in people who had COVID-19. Researchers will follow 200 veterans to measure sleep quality, brain function, and exercise ability. The goal is to find out if treating sleep issues c…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart and blood vessels. Researchers will compare 240 adults aged 40-79 who have one or both conditions. They will also test if using a breathing machine at night or extra oxygen can im…

This study looks at whether having obstructive sleep apnea (OSA) might protect the body from damage during surgery to repair a large blood vessel (aortic aneurysm). The idea is that the short, repeated drops in oxygen from sleep apnea might train the body to handle the stress of …

This study looks at how doctors currently screen and treat obstructive sleep apnea (OSA) in children with Down syndrome. By reviewing past medical records of 30 children, researchers hope to create a simple guide to improve care. The goal is to help these children get better slee…

This study looks at whether stimulating two nerves in the neck (the ansa cervicalis and hypoglossal nerve) can help people with obstructive sleep apnea. Researchers will measure changes in the airway and breathing during sleep in 100 adults. The goal is to understand if adding st…