OBSTRUCTIVE SLEEP APNEA

This study investigates whether two medications—acetazolamide and eszopiclone—can improve sleep apnea outcomes when taken after soft palate surgery. The trial includes adults with moderate to severe obstructive sleep apnea who cannot use CPAP or oral appliances. Researchers will …

This study is testing a device called the Genio® System for people with moderate to severe obstructive sleep apnea who cannot use CPAP machines. The device is implanted and stimulates the tongue to keep the airway open during sleep. Researchers will track how well it reduces brea…

This study looks at whether using a CPAP machine for sleep apnea after a heart procedure (catheter ablation) can help prevent atrial fibrillation from coming back. About 658 adults with both conditions will be randomly assigned to use CPAP for a year or receive usual care. The go…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This study tests a new medicine, maridebart cafraglutide, for adults with obstructive sleep apnea who are overweight or obese and already use a CPAP machine. The goal is to see if the drug can reduce breathing pauses during sleep and help with weight loss over 52 weeks. About 250…

This phase 3 trial tests whether maridebart cafraglutide, a drug that may help with weight loss, can reduce sleep apnea episodes in 250 adults who are overweight or obese and not using a breathing machine. Participants receive either the drug or a placebo for 52 weeks. The main g…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …

This study tests a culturally tailored sleep program for Latino couples where one partner has sleep apnea and is starting CPAP therapy. The program includes three telehealth sessions teaching sleep skills and support strategies. Researchers want to see if it improves CPAP use and…

This study tests a non-surgical laser treatment for people with obstructive sleep apnea who still have breathing problems even after using a dental mouthpiece. The laser aims to stiffen the soft palate and tongue to keep the airway open during sleep. Researchers will enroll 528 a…

This study tests whether acetazolamide, a cheap and well-tolerated diuretic, can help people with obstructive sleep apnea who cannot use a CPAP mask. Sixty adults with moderate to severe sleep apnea will receive either the drug or a placebo for 4 weeks each. Researchers will meas…

This study looks at whether a structured program to find and treat obstructive sleep apnea can reduce the amount of time people with atrial fibrillation have an irregular heartbeat. About 209 adults with AF will use a home sleep test device and a Fitbit smartwatch to track their …

This study compares two alternative treatments for moderate-to-severe obstructive sleep apnea in people who cannot use a CPAP machine: a custom mouthpiece (mandibular advancement device) and a surgically implanted nerve stimulator (hypoglossal nerve stimulation). Researchers will…

This study tests whether a custom mouthpiece called EVO can safely treat severe obstructive sleep apnea. About 49 adults with severe sleep apnea will use the device, which moves the jaw forward to keep the airway open. The goal is to see if it reduces breathing pauses by at least…

This study tests a custom mouthpiece (mandibular advancement device) for people with moderate to severe obstructive sleep apnea who cannot tolerate CPAP and have not improved with a nerve stimulation implant. Researchers will measure if the device reduces breathing pauses during …

This study looks at whether lifestyle changes (diet and exercise) plus CPAP therapy can reduce eye pressure in people with glaucoma, sleep apnea, and obesity. Forty participants will be split into two groups: one gets CPAP alone, the other gets CPAP plus lifestyle changes. The ma…

This study compares personalized surgery guided by a special camera during sleep (DISE) to standard tonsil and adenoid removal for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and standard surgery …

This study tests a custom mouthpiece called OrthoApnea NOA for obstructive sleep apnea, a condition where breathing stops and starts during sleep. Researchers want to see if it can reduce breathing pauses by at least half, to fewer than 5 per hour. They will compare new patients …

This phase 3 trial tests an injectable drug called HRS9531 in 140 obese adults with moderate-to-severe obstructive sleep apnea who already use a breathing machine (PAP). The study aims to see if the drug reduces the number of breathing pauses during sleep and helps with weight lo…

This study tests a lung-protective technique during surgery for women with obstructive sleep apnea (OSA) undergoing total laparoscopic hysterectomy. The approach uses ultrasound to guide lung recruitment maneuvers, aiming to reduce postoperative lung complications like collapsed …

This early study tests a new device called MAGNAP for people with moderate to severe obstructive sleep apnea who cannot tolerate CPAP machines. The device is surgically implanted in the neck and works with an external magnetic brace to keep the airway open during sleep. The study…

This study works with 300 Native American elders aged 50 and older who have sleep apnea and a PAP machine. It tests if adding motivational interviews and text messages to usual care helps them use their machine more often. The goal is to improve sleep apnea control and possibly l…

This study tests a device called the Restora Serene System, which uses mild electrical pulses to stimulate nerves in the neck during sleep. The goal is to keep the airway open in people with obstructive sleep apnea who cannot use a CPAP machine. Twenty adults will be enrolled to …

This study tests whether using a CPAP machine at night can help people with severe uncontrolled asthma who also have obstructive sleep apnea. Researchers will compare asthma control, lung function, and quality of life between those who receive CPAP plus lifestyle advice and those…

This study is testing a new, smarter algorithm for CPAP machines used to treat obstructive sleep apnea. The algorithm automatically adjusts air pressure to keep the airway open during sleep. Researchers will compare the new algorithm to the current one in 80 adults who already us…

This study tests whether artificial intelligence can predict the best treatment for each person with obstructive sleep apnea (OSA). It also checks if a smartphone app helps people stick with mouth and throat exercises. About 300 adults with OSA will be assigned to CPAP, surgery, …

This study looks at whether treating obstructive sleep apnea (OSA) early with a positive airway pressure (PAP) device can improve outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive PAP therapy…

This study compares a personalized surgical approach using sleep endoscopy to standard tonsil removal in 240 children aged 2-17 with small tonsils and moderate-to-severe obstructive sleep apnea. The goal is to see if tailoring surgery to each child's specific airway blockages imp…

This registry follows 225 adults with moderate-to-severe obstructive sleep apnea who receive the Inspire hypoglossal nerve stimulation implant. The device is for people who cannot use CPAP, the standard treatment. Researchers will measure how well it reduces breathing pauses duri…

This early-phase trial is testing whether dronabinol, a synthetic form of THC, can reduce the severity of obstructive sleep apnea. 120 adults with moderate to severe sleep apnea will take the drug for two weeks. Sleep studies before and after treatment will measure changes in bre…

This registry follows 1,000 people with obstructive sleep apnea who have received the Inspire implant, a device that stimulates nerves to keep the airway open during sleep. Researchers will track how well the device works over time and how consistently patients use it, using rout…

This study looks at whether using a positive airway pressure (PAP) machine to treat obstructive sleep apnea can help people recover better after an ischemic stroke. About 360 participants who have had a stroke and have moderate to severe sleep apnea will be randomly assigned to r…

This early-phase study will test whether a device that stimulates the phrenic nerve can help treat moderate-to-severe obstructive sleep apnea in 50 Latin American adults. Participants will undergo sleep studies and a procedure to map their airway collapse. The goal is to see if t…

This study tests whether a sleep medication called eszopiclone can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. About 250 adults with a new sleep apnea diagnosis will receive either eszopiclone or a placebo f…

This study tests whether a type of light therapy called photobiomodulation can help people with obstructive sleep apnea tolerate their CPAP machine better. About 30 adults who currently use CPAP but have trouble with it will receive the light treatment. The goal is to see if it l…

This study looks at whether endoscopic sinus surgery can improve sleep in people with chronic sinusitis and nasal polyps. Researchers will measure sleep quality before and after surgery in 30 participants. The goal is to see if removing polyps and opening blocked sinuses helps wi…

This study tests whether extra support—like a health pamphlet, a video, and motivational counseling—helps people with obstructive sleep apnea use their mandibular advancement appliance (a mouth guard) more consistently. Fifty-six adults (age 40+) with sleep apnea will be randomly…

This study tests whether doing specific mouth and tongue exercises can help people with obstructive sleep apnea who cannot use a CPAP machine. Forty-five adults will be randomly assigned to real exercises, sham exercises, or unsupervised exercises for 10 weeks. The main goal is t…

This study tests whether eating a whole food plant-based diet for 8 weeks can reduce daytime sleepiness and improve sleep apnea severity. Researchers will measure changes using a sleepiness questionnaire and a home sleep test. The study involves 40 adults with sleep apnea who are…

This study tests a special nasal airway device (ssNPA) in 40 children with weak throat muscles and obstructive sleep apnea, including those with Down syndrome. The device is designed to keep the airway open during sleep without needing surgery. Researchers will measure how well i…

This early-phase study tests whether a combination of two drugs—atomoxetine and DAW2022—can reduce the severity of obstructive sleep apnea (OSA) in 18 adults with moderate-to-severe OSA. The goal is to find a better-tolerated alternative to current treatments by measuring breathi…

This study tests a mobile app called OurSleepKit that coaches couples to work together on CPAP therapy for obstructive sleep apnea. 360 newly diagnosed patients and their partners will use the app for 6 months. Researchers will measure how many hours per night the patient uses CP…

This study tests a new device called DidgeriTU, which works like a didgeridoo to strengthen breathing muscles, in 76 adults with mild-to-moderate obstructive sleep apnea. Participants will use the device or a sham (fake) device for 3 months and take sleep tests to see if it reduc…

Many people with obstructive sleep apnea still feel very sleepy during the day even after using a CPAP machine. This study tests a device called tPBM, which shines red and near-infrared light on the scalp to change brain activity. Researchers will measure brain blood flow and sle…

This study tests whether wearing bright light therapy glasses can reduce daytime sleepiness and depressive symptoms in people with obstructive sleep apnea who still feel tired despite using their CPAP machine. Sixty participants will wear the glasses for four weeks of active trea…

This Mayo Clinic study tests a smartphone app called SleepWell24 to help people with obstructive sleep apnea use their CPAP machine for at least 6 hours a night, 6 nights a week. The app connects to a smart plug and a Fitbit to track CPAP usage, sleep time, and activity. Research…

This study looks at whether trained community health workers can motivate people with moderate-to-severe sleep apnea to use their breathing machines (PAP) more regularly. About 48 adults who have never used PAP before will receive either motivational coaching or standard care. Th…

This study tests whether brief, mild low-oxygen breathing sessions can improve blood vessel function, lower blood pressure, and reduce tiredness in people with obstructive sleep apnea. Researchers will enroll 60 adults aged 30-60 who are newly diagnosed and not yet using CPAP. Th…

This study compares how satisfied people with moderate to severe obstructive sleep apnea are with a standard CPAP machine (Airsense 10) versus a portable one (Air-Mini). Fifty adults who are new to CPAP will try both devices and rate their satisfaction. The goal is to see if the …

This study tests whether bexagliflozin, a drug used for diabetes, can reduce the severity of obstructive sleep apnea in overweight or obese adults. Over 6 months, participants will take either the drug or a placebo and undergo sleep tests and body scans. The goal is to see if the…

This study tests a 12-month telehealth program that combines healthy eating, exercise coaching, and remote pulmonary rehab for 400 overweight veterans with both COPD and obstructive sleep apnea. Participants use a Fitbit and app to track progress, with the goal of improving physi…

This study tests a device called FreeO2 that automatically adjusts oxygen levels during noninvasive breathing support. It includes 10 patients with COPD flare-ups or after weight-loss surgery. The goal is to see if the device keeps oxygen in a safe range better than manual adjust…

This study looks at whether special mouth and throat exercises can improve sleep apnea by strengthening the muscles that keep the airway open. Thirty adults with sleep apnea will use myofunctional therapy devices for three months. Researchers will measure muscle pressure in the t…

This study will test new methods to measure how sleep apnea affects the heart. Researchers will follow 270 adults with moderate to severe sleep apnea who use CPAP, mouth devices, or nerve stimulation. The goal is to see if these new metrics can better predict heart problems than …

This study looks at whether stimulating two nerves in the neck (the ansa cervicalis and hypoglossal nerve) can help people with obstructive sleep apnea. Researchers will measure how the airway changes during sleep in 100 adults. The goal is to understand if combining these stimul…

This pilot study at Tulane University is testing whether obstructive sleep apnea (OSA) can cause scarring (fibrosis) in the heart's upper chambers, even in people without atrial fibrillation. Researchers will use a special MRI with contrast dye to measure scarring in 60 adults wi…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart. Researchers will compare people with one or both conditions and test two breathing treatments—a special mask that helps breathing at night and extra oxygen—to see which may impro…

This study looks at whether a quality-of-life questionnaire (OSA-18) can help parents of children with mild obstructive sleep apnea make treatment decisions. About 130 parents of children aged 3-12 with mild sleep apnea will take the survey. The goal is to see if the survey reduc…

This study looks at older veterans who have both sleep apnea and COPD, a combination called 'overlap syndrome.' Researchers want to see if having both conditions worsens thinking and memory more than having just one. They will also test whether using a breathing machine (CPAP) pl…

This study looks at the connection between high blood pressure and obstructive sleep apnea (OSA) using heart rate variability (HRV), a simple heart monitoring method. Researchers will track 100 adults with high blood pressure who are at risk for OSA, using heart monitors and slee…

This study looks at two different sedative drugs used during a sleep endoscopy procedure in children with obstructive sleep apnea. The goal is to see if one drug causes more airway collapse than the other, and whether the collapse patterns can predict if sleep apnea will continue…

This study will explore whether sleep apnea makes multiple sclerosis worse. Researchers will collect sleep studies, MRIs, and lab results from 800 adults with MS to see if there is a link. The goal is to better understand how sleep problems might affect the brain and overall heal…

This study is testing new ResMed mask systems in 500 adults who already use CPAP for obstructive sleep apnea. Researchers will track how often the mask is used, how well it seals, and how comfortable it feels. The goal is to confirm the masks work well in everyday life.

This study looks at whether having obstructive sleep apnea (OSA) might help protect the body from damage during surgery to fix a large blood vessel (aortic aneurysm). The idea is that the short, repeated drops in oxygen from sleep apnea might train the body to handle the stress o…

This study is following 1,000 people in Korea who have symptoms of sleep apnea, like loud snoring or feeling very tired during the day. The goal is to learn more about the condition and how well patients stick with breathing machine therapy. Participants will have sleep tests and…

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth sores in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No treatment is given; the goal i…

This study looks at 30 six-month-old infants with Down syndrome to see if their sucking patterns are linked to the severity of obstructive sleep apnea (OSA). Researchers will measure sucking bursts and compare them to sleep study results. The goal is to find a simple way to scree…

This study looks at whether children with a narrow upper jaw (transverse orthodontic deficiency) are more likely to have obstructive sleep apnea. Researchers will compare sleep test results from 102 children aged 6 to 16, some with and some without this jaw issue. The goal is to …

This study checks tongue strength in 78 children with suspected obstructive sleep apnea. Researchers use a device to measure tongue pressure during pushing and swallowing. They compare results to healthy kids to see if weak tongue muscles are linked to sleep problems.

This study looks at whether obstructive sleep apnea (OSA) changes how the body processes fat. Researchers will compare fat metabolism in 100 adults with and without sleep apnea using glucose tests. No treatment is given; the goal is to better understand how OSA might affect energ…

This study looks at people with interstitial lung disease (ILD) and obstructive sleep apnea (OSA) to learn more about these conditions. Researchers will collect medical data, lung samples, and sleep test results from 70 participants. The goal is to find better ways to diagnose an…

This study tests whether a tongue-stimulating device (hypoglossal nerve stimulation) for obstructive sleep apnea can improve how the body handles blood sugar and lower heart risks. About 30 overweight or obese adults who cannot use a CPAP machine will wear a continuous glucose mo…

This study looks at whether a night of disrupted sleep can lead to extra heartbeats or atrial fibrillation the next day. Researchers will ask 100 adults with sleep apnea to either use or not use their sleep device on different nights, then monitor their heart rhythms. The goal is…

This study looks at how sleep issues and sleep apnea might affect thinking, memory, and daily life in people who had COVID-19. Researchers will follow 200 veterans for up to a year, testing their brain function, sleep quality, and exercise ability. The goal is to find out if trea…

This study looks at how doctors currently screen and treat obstructive sleep apnea in children with Down syndrome at one hospital. By reviewing past records of 30 children, researchers hope to create a standard care plan that can be used across France. The goal is to improve brea…

This study looks at whether men and women with untreated obstructive sleep apnea (OSA) have different blood pressure control systems. Researchers will measure blood pressure, artery stiffness, and nerve activity in 60 adults aged 20-70. The goal is to understand sex-specific risk…

This study aims to create a computer tool that uses MRI scans to predict which surgery will work best for children with obstructive sleep apnea (OSA). About 120 children with persistent OSA after tonsil and adenoid removal will be enrolled. The tool simulates airflow in the airwa…

This study reviews medical records of 200 children with obstructive sleep apnea who had tonsil surgery. Researchers want to find out how often breathing problems happen after surgery, especially in children with obesity, Down syndrome, or other health issues. The goal is to bette…

This study will follow 7,000 people with obstructive sleep apnea to see how different forms of the condition relate to long-term health. Researchers will use sleep tests, health records, and additional lab work to find patterns. The goal is to better understand sleep apnea and it…

This study aims to uncover the clinical features and molecular mechanisms behind obstructive sleep apnea (OSA). Researchers will analyze blood, saliva, and urine samples from 500 participants to build a multi-omics database. The goal is to identify biomarkers and treatment target…

This study looks at how a device that stimulates the nerve to the tongue (hypoglossal nerve) changes the way the upper airway collapses during sleep in people with obstructive sleep apnea. Researchers will use a sleep endoscopy and sleep study data to compare collapse patterns be…

This study looks at whether the way people make decisions about effort can predict how well they stick with CPAP therapy for obstructive sleep apnea. Researchers will test memory, planning, and decision-making in 64 adults before and after starting CPAP. The goal is to understand…

This study looks at whether successfully treating moderate-to-severe sleep apnea can improve memory and reduce biological markers linked to Alzheimer's disease in older adults. About 200 cognitively healthy people aged 55-85 will either receive immediate sleep apnea treatment or …

This study looks at how the amount of air in your lungs affects throat collapse during sleep in people with obstructive sleep apnea (OSA). Researchers will use a special camera to watch the throat while patients are sedated, and try changing lung volume with a chest device or nec…

This study looks at whether using a CPAP machine for obstructive sleep apnea can also help people with chronic pain. Researchers will follow 80 adults newly diagnosed with sleep apnea who are starting CPAP therapy. Participants will fill out pain and sleep questionnaires at the s…

Researchers at Mayo Clinic are studying 600 Somali-American adults to understand how common obstructive sleep apnea is and how it affects heart health. Participants will have sleep tests, blood pressure monitoring, and glucose testing. The goal is to learn about unique risk facto…

This study compares two ways of adjusting a nerve stimulator implant (Inspire system) for obstructive sleep apnea. Currently, patients need an overnight sleep study to fine-tune the device. Researchers want to see if a daytime sleep study works just as well. The trial will enroll…

This study follows 65 adults with obstructive sleep apnea to see how three weeks of CPAP therapy changes their thinking skills, blood markers of brain health, and emotional well-being. Participants complete memory and attention tests, give blood samples, and fill out questionnair…