Mouth device offers new hope for sleep apnea patients who Can't use CPAP

NCT ID NCT07132307

Recruiting now Disease control Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a custom mouthpiece (mandibular advancement device) for people with moderate to severe obstructive sleep apnea who cannot tolerate CPAP and have not improved with a nerve stimulation implant. Researchers will measure if the device reduces breathing pauses during sleep. The trial involves 30 adults and uses home sleep tests to check results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mandibular advancement device (MAD) - ProSomnus Sleep Device
What this could lead to: If it works, this could offer a new treatment option for people with severe sleep apnea who have not been helped by other therapies.
What could go wrong: This is a small, early study with only 30 people. The device may not work for everyone, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTRUCTIVE SLEEP APNEA

Contacts and locations

Locations

Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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