Washington University School Of Medicine

This study tests a personalized DNA vaccine designed to help the immune system fight brain tumors that have come back or not responded to treatment. It involves up to 7 children and young adults aged 12 to 25. The main goals are to see if the vaccine is safe and can be made for e…

This early-stage trial tests a personalized cancer vaccine for people with bladder or gastroesophageal cancer who have tiny amounts of cancer still detectable after surgery. The vaccine is custom-made from each patient's unique tumor markers and aims to train the immune system to…

This study tests a home-based treatment called remote ischemic conditioning (RIC) for people with spinal cord injury. RIC uses a blood pressure cuff to briefly restrict blood flow, which may improve heart and blood vessel health. Researchers will compare different cuff types and …

This early-phase study tests a drug called mosunetuzumab given after a stem cell transplant for people with aggressive B cell lymphomas that have come back or not responded to treatment. Mosunetuzumab is an engineered antibody that helps the body's immune T cells find and kill ca…

This study tests whether adding the drug epacadostat to standard chemotherapy and radiation before surgery can improve outcomes for people with locally advanced rectal cancer. About 49 adults with stage 2 or 3 rectal cancer will take part. The goal is to find the best dose and se…

This study tests whether a very-low-carbohydrate (ketogenic) diet can safely improve blood sugar control in adults with type 1 diabetes. Researchers will compare the diet to usual care in 58 participants, measuring time in target blood sugar range and insulin sensitivity. The goa…

This early-phase study tests whether adding the drug azeliragon to standard chemoradiotherapy can help the immune system fight glioblastoma, an aggressive brain cancer. About 12 adults with newly diagnosed tumors will receive either standard treatment or standard treatment plus a…

This study tests whether adding two targeted drugs (defactinib and avutometinib) to a precise form of radiation therapy can help people with advanced pancreatic cancer live longer without their disease getting worse. About 36 adults whose cancer is locally advanced or borderline …

This study tests whether adding the immunotherapy drug pembrolizumab to a special type of radiation (hypofractionated radiotherapy) can better prevent mucosal melanoma from returning after surgery. About 19 adults with this rare head and neck cancer will receive the combination t…

This study looks at whether giving mothers extra oxygen during labor is safe and helpful for babies who show signs of distress on the heart monitor. About 2,100 women with a single, full-term pregnancy will be randomly assigned to receive either oxygen or regular air. The goal is…

This study is for people with a certain type of advanced breast cancer (HR+ HER2-). It uses a blood test to measure a marker called TKa early in treatment. If the marker doesn't drop enough, doctors may switch to a different therapy sooner. The goal is to see if this approach hel…

This early-phase trial tests whether combining two drugs—zanzalintinib and eribulin—is safe and can help people with advanced liposarcoma or leiomyosarcoma live longer without their cancer growing. About 18 adults whose cancer has worsened after at least one prior treatment will …

This early-stage trial tests a drug called siltuximab for lung transplant patients experiencing antibody-mediated rejection, a serious condition where the immune system attacks the new lung. The study involves 30 adults who are already receiving standard rejection treatment. The …

This study follows 100 breast cancer patients who cannot have surgery to see if freezing the tumor (cryoablation) is safe and helps control the disease. Participants get an ultrasound-guided freeze treatment instead of an operation. The goal is to track complications and long-ter…

This study tests whether adding an experimental drug called cirtuvivint to standard chemotherapy (irinotecan) can help people with small cell lung cancer that has come back after initial treatment. About 42 adults whose cancer has progressed after at least one prior therapy will …

This study tests two programs for people recovering from a stroke who are leaving inpatient rehab and going home. Half of the 520 participants (age 55+) will get a stroke education program, and the other half will get a program focused on making their home environment safer. The …

This study compares freezing breast tumors (cryoablation) to standard surgery (lumpectomy) in 120 women with low-risk, early-stage breast cancer. The goal is to see if freezing offers similar disease control with fewer complications and better quality of life. Participants will b…

This study tests a combination of two drugs (zunsemetinib and capecitabine) in people with a common type of breast cancer that has spread to the bones and cannot be cured. The goal is to see if the combo is safe and can slow cancer growth while also reducing bone damage. About 15…

This study tests an experimental drug called CUE-101 in 30 people with a specific type of HPV-positive throat cancer. The drug is given before standard treatments like surgery or chemoradiation to see if it safely boosts the body's immune cells to fight the cancer. Researchers wi…

This study tests whether giving cancer patients personalized recommendations to quit smoking—based on their genes, health history, and lab results—helps them stop more than standard care. About 112 patients and their doctors will take part. The goal is to see if this tailored app…

This study tests whether giving special immune cells (memory-like NK cells) after a stem cell transplant can help control high-risk acute myeloid leukemia (AML) in children and adults. About 68 participants will receive donor stem cells followed by these NK cells. The goal is to …

This study tests a new drug called ONT01 combined with standard chemotherapy for people with advanced pancreatic cancer that has worsened after initial treatment. The goal is to see if ONT01 can reprogram immune cells in the tumor to make the cancer more responsive to treatment. …

This study tests whether a stem cell transplant using thiotepa and carmustine can prevent lymphoma from spreading to the brain in high-risk patients. About 36 people with newly diagnosed diffuse large B-cell lymphoma who are at high risk for brain relapse will receive the transpl…

This early-phase trial tests whether adding an experimental MK2 inhibitor (zunsemetinib) to standard chemotherapy (mFOLFIRINOX) can better control metastatic pancreatic cancer. About 51 adults who have not had prior treatment for advanced disease will participate. The main goal i…

This study is for people with HPV-related throat cancer. After surgery, they receive lower doses of radiation or chemo than usual, based on their cancer's risk level. The goal is to see if this gentler approach can reduce side effects like weight loss while still preventing the c…

This study tests a non-invasive device that gently stimulates a nerve in the ear to help patients in the NeuroICU recover from serious brain or spinal cord injuries. Researchers will see if it reduces complications like infections and the need for a breathing tube, shortens hospi…

This early-phase study tests a new way to prepare the body for CAR T-cell therapy in people with multiple myeloma who also have kidney problems. Standard prep can be hard on the kidneys, so researchers are using a low dose of total body radiation plus a chemotherapy drug (cycloph…

This study tests a new way to give radiation for locally advanced cervical cancer. Instead of the usual 5-6 weeks of daily treatments, this approach gives a strong dose of internal radiation (brachytherapy) early, followed by fewer external beam sessions. The goal is to see if th…

This early-phase study tests whether two drugs, ruxolitinib and abatacept, can prevent graft-versus-host disease (GVHD) and cytokine release syndrome in 41 blood cancer patients receiving a half-matched stem cell transplant. The goal is to reduce dangerous immune reactions while …

This study tests whether a very short course of radiation (5 treatments over 1 week) works as well as the standard shorter course (15-16 treatments over 3 weeks) for people with breast cancer that has spread to lymph nodes. The goal is to see if the ultra-short course causes fewe…

This early-phase study tests a drug called NT-I7 (a long-acting immune booster) given after standard CAR T-cell therapy for people with relapsed or hard-to-treat large B-cell lymphoma. The goal is to see if NT-I7 is safe and can help CAR T-cells grow and last longer in the body, …

This early study tests whether a diabetes medicine called dapagliflozin is safe and tolerable when taken for four weeks before prostate cancer surgery. About 24 men with intermediate or high-risk localized prostate cancer will take the drug daily before their operation. Researche…

This study tests a new way to do stem cell transplants for children with blood cancers like leukemia. It uses a special method to remove certain cells from the donor's stem cells before transplant, aiming to reduce side effects and improve success. About 50 children will take par…

This study tests whether the drug selinexor can help keep multiple myeloma from coming back after CAR-T cell therapy. About 20 people with high-risk myeloma who have already had CAR-T will take selinexor pills. The goal is to see if this maintenance approach is safe and can lead …

This study tests whether a gentle nerve stimulation (applied to the ear) can reduce brain injury and inflammation after a stroke caused by a large blood clot. About 65 adults will either receive standard care or standard care plus the stimulation. Researchers will measure brain d…

This study tests a personalized approach for people with newly diagnosed multiple myeloma who have had a stem cell transplant. After transplant, participants receive a drug called elranatamab as maintenance therapy, with the dose and duration guided by a sensitive blood test that…

This study looks at whether starting hepatitis C treatment during pregnancy works well for women who have used drugs. About 50 pregnant women will take the medication glecaprevir-pibrentasvir and be followed for a year. Researchers will check how well they stick to the treatment …

This early-phase study tests whether dapagliflozin, a diabetes medicine, is safe for children with brain or solid tumors that have come back or not responded to standard treatments. About 20 children will receive the drug alongside their usual care. The goal is to check for side …

This early-phase study tests whether adding the drug zanzalintinib to two immunotherapy drugs (ipilimumab and nivolumab) is safe and effective for people with metastatic soft tissue sarcoma that has worsened after prior treatments. About 18 adults with certain sarcoma subtypes wi…

This study tests whether a daily ketone ester drink can reduce liver fat and improve blood sugar control in adolescents aged 18-25 with obesity and metabolic fatty liver disease (MASLD). Participants are randomly assigned to receive either the ketone drink or a placebo for 6 week…

This early-phase study tests whether specially trained natural killer (NK) cells, given with two immunotherapy drugs (nivolumab and relatlimab), are safe and can shrink tumors in people with advanced melanoma that stopped responding to standard checkpoint inhibitors. About 33 adu…

This study tests whether a lower dose of the drug lenvatinib works as well as the standard higher dose for people with advanced thyroid cancer that no longer responds to radioactive iodine. About 34 participants will be randomly assigned to take either 24 mg or 10 mg daily. The g…

This study tests whether the sleep aid lemborexant can lower levels of amyloid-beta and tau proteins in the blood—proteins linked to Alzheimer's disease. Researchers will enroll 201 healthy adults aged 65 and older. Participants will take either lemborexant or a placebo to see if…

This study tests whether adding choline to a special peanut-based food helps brain development in 1,500 severely malnourished children in Malawi, ages 6 months to 5 years. Half get standard food, half get food with extra choline. Researchers will measure thinking and motor skills…

This study tests two different schedules of the chemotherapy drug 5-FU in people with advanced head and neck cancer that has not responded to prior treatments. About 46 participants will receive the drug either over two days every two weeks or over four days every three weeks. Th…

This study tests a combination of two drugs, polatuzumab vedotin and rituximab, as a first treatment for a rare cancer called post-transplant lymphoproliferative disorder (PTLD) that can occur after an organ or stem cell transplant. The goal is to see if this combo is safe and wo…

This study works with community health centers to help doctors use a recommended asthma treatment called SMART (Single Maintenance and Reliever Therapy). The program includes training, feedback, and educational tools for both doctors and patients. The goal is to see if this appro…

This study is testing a milder stem cell transplant for people with non-cancerous diseases like metabolic disorders, sickle cell disease, and thalassemia. The goal is to safely get donor stem cells to grow in the patient's body while reducing harsh side effects. Up to 220 partici…

This study tests whether statins, a common cholesterol-lowering drug, can reduce inflammation and slow the worsening of two blood disorders: CCUS and lower-risk MDS. These conditions can progress to more serious blood cancers, and there are no approved treatments to improve survi…

This study tests if propranolol, a safe oral drug used for heart conditions, can shrink Kaposi sarcoma tumors in adults. About 25 participants with measurable skin lesions will take the drug and be monitored for response and side effects. The goal is to find a low-cost, accessibl…

This study tests whether adding milk fat globule membrane (MFGM) to ready-to-use therapeutic food (RUTF) helps brain development and reduces death, hospitalization, or persistent malnutrition in 1,600 children aged 6-59 months with severe acute malnutrition in Sierra Leone. Child…

This study tests whether enasidenib, a drug that blocks a faulty protein from a mutated IDH2 gene, can safely improve blood cell counts in people with clonal cytopenia of undetermined significance (CCUS). About 15 adults with unexplained low blood counts for at least 6 months and…

This study tests whether dapagliflozin, a drug used for diabetes, can slow the progression of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 70 adults aged 50 and older with non-foveal geographic atrophy will take the dr…

This early-phase study tests a new CAR-T cell therapy that targets a protein called CS1 on multiple myeloma cells. It is for patients whose cancer has returned or not responded to at least three prior treatments. The goal is to check the treatment's safety and see how well it con…

This study looks at whether a home blood pressure monitoring program can help pregnant women in Nigeria better control their blood pressure after having a hypertensive disorder of pregnancy. About 1,200 new moms from four hospitals in Abuja and Kano will take part. The goal is to…

This study is testing whether giving a higher dose of radiation directly to the prostate (called HDR brachytherapy) can better control early-stage prostate cancer. About 36 men with low- or favorable intermediate-risk prostate cancer will receive one of three dose levels. Researc…

This study looks at whether nerve transfer surgery can help people with high-level spinal cord injury (C1-C4) regain arm function and improve their quality of life. About 30 adults who have had a spinal cord injury for at least 6 months but less than 5 years will undergo standard…

This study tests whether adding palbociclib to cetuximab helps people with a specific genetic form of head and neck cancer live longer compared to cetuximab alone. Participants must have a CDKN2A gene change and their cancer must have grown despite prior immunotherapy. About 81 a…

This study tests a new way to choose pre-surgery treatment for postmenopausal women with stage II or III ER-positive, HER2-negative breast cancer. By using biomarkers, doctors hope to improve response and identify patients who may not need chemotherapy. The trial enrolls 81 parti…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms in pregnant women with opioid use disorder when starting treatment. About 40 participants will receive either the patch or standard care during the required withdrawal period before taking buprenorphine…

This study tests a new drug, zanzalintinib, combined with standard chemotherapy (paclitaxel) in people with recurrent high-grade uterine cancer. The goal is to find the safest and most effective dose and see if the combination can shrink tumors. About 36 participants will be enro…

This early-phase trial tests a new drug (CA-4948) combined with standard chemotherapy and immunotherapy for people with advanced stomach, esophageal, or gastroesophageal junction cancer that cannot be removed by surgery. The study aims to find the safest dose and check if the com…

This study tests a bone marrow transplant from a partially matched family donor for children under 21 with severe non-cancer diseases like sickle cell disease, bone marrow failure, or immune disorders. The goal is to see if the transplant can control the disease with fewer side e…

This study tests whether adding a collagen scaffold (Miro3D) to standard wound care helps acute and chronic wounds heal faster than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal is to …

This study tests whether tofersen, a drug already approved for a specific genetic form of ALS, can help people with ALS who do not have that gene mutation. About 30 adults will receive the drug via spinal injections over 24 weeks. Researchers will measure nerve damage markers, sa…

This early-phase trial tests whether adding the experimental drug emavusertib to standard chemotherapy and immunotherapy can improve outcomes for people with advanced bile duct or gallbladder cancer that has not been treated before. The study will enroll about 48 participants to …

This study looks at two ways to help pregnant and postpartum people with substance use disorder stay in treatment. One approach screens for social needs like housing or childcare and connects them to community help. The other offers small rewards for positive recovery actions. Th…

This study tests whether rivastigmine, a longer-acting drug, can prevent the return of delirium in people poisoned by substances that block muscarinic receptors. After initial control with physostigmine, 42 participants aged 10 and older will receive either rivastigmine or a plac…

This study tests whether adding a behavioral weight loss program to standard hormone therapy helps premenopausal women with obesity and early-stage endometrial cancer or precancer keep their uterus and fertility. About 96 women will receive either hormone therapy plus the weight …

This study tests whether a structured exercise program can improve heart health and fitness in wheelchair users. Researchers will enroll 108 adults who use a wheelchair and have a physical disability. Participants will take part in weekly exercise sessions, and their heart and bo…

This study tests whether giving smokers a personalized treatment plan—based on their genes, health history, and other markers—helps them quit better than standard care. About 850 adult smokers from primary care clinics will take part. The goal is to see if this tailored approach …

This study tests whether giving a drug combination (decitabine and cedazuridine, or DEC-C) early can prevent myelodysplastic syndromes (MDS) from coming back after a stem cell transplant. About 209 adults who have had a transplant and still have tiny amounts of cancer cells (meas…

This study tests whether the drug zanzalintinib, taken as a maintenance therapy after initial chemotherapy, can delay cancer progression in people with high-grade neuroendocrine neoplasms (aggressive tumors). About 32 participants will receive the drug and be monitored for how lo…

This study looks at whether giving women a simple at-home kit to test for HPV (the virus that can cause cervical cancer) makes it easier for those who are overdue for screening to get tested. About 100 women aged 25-65 who haven't had a Pap smear in 3 years will receive a self-co…

This study tests a new endorectal device that combines ultrasound and photoacoustic imaging to better diagnose rectal cancer and assess how well tumors respond to treatment. About 90 adults with rectal cancer who are scheduled for surgery will be imaged with this device. The goal…

This study tests sonobiopsy, a noninvasive technique that uses focused ultrasound to release tumor DNA into the bloodstream for easier detection. About 40 adults with suspected glioblastoma will undergo the procedure before standard surgery. The goal is to see if this method can …

This study tests a special PET/MRI scan (18F-DOPA) to find tiny, hidden spots in the pancreas that cause severe low blood sugar (hyperinsulinism) in children and adults who don't respond to medication. About 100 participants will get the scan before surgery to see if it can accur…

This study tests whether combining photoacoustic imaging with standard ultrasound can more accurately tell if an ovary is cancerous or benign. Researchers hope this will reduce the number of unnecessary surgeries for benign growths while catching more cancers early. About 310 wom…

This study works with over 1,200 young people aged 14-24 in Nigeria to make HIV self-testing and prevention services more available and long-lasting. Researchers will compare standard program delivery with enhanced strategies to see which helps community organizations keep offeri…

This study tests a drug called remternetug to see if it can prevent or slow Alzheimer's disease in people who have a gene mutation that causes the disease. About 280 adults with this high genetic risk will receive either the drug or a placebo. The goal is to stop harmful protein …

This study tests a program that helps people with physical disabilities make their homes safer to prevent falls. Researchers will enroll 80 adults aged 45-64 who have had a disability for at least 5 years and live in St. Louis. Half will get the home hazard removal program right …

This study tests three approaches to help 600 teen girls and young women (ages 15-24) at high risk of HIV in Uganda start and stick with PrEP, a daily pill that prevents HIV. Some participants get HIV risk education alone, others add peer support from PrEP users, and a third grou…

This study tests a music-inspired program called Music4Health to see if it can lower blood pressure and improve stroke awareness in Nigerian youth (ages 14-24) and their caregivers (ages 40+). About 1,400 participants will join as pairs. The program involves listening sessions an…

This study compares two ways to help people stop smoking and lower their cancer risk. About 5,000 adults who smoke will get either standard quit-smoking support or extra reminders and encouragement. The goal is to see which approach gets more people to use quit-smoking tools like…

This study tests whether the sleep aid suvorexant can slow the buildup of a protein called amyloid in the brain, which is linked to Alzheimer's disease. About 200 healthy adults aged 65 and older will take either the drug or a placebo for a period of time. Researchers will measur…

This study tests whether investigational drugs can prevent or slow the buildup of harmful proteins in the brain of people who carry a gene mutation that causes early-onset Alzheimer's. About 280 participants will receive either the study drug or a placebo. The goal is to see if e…

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, on stable …

This study tests if a custom mouthpiece (mandibular advancement device) can safely and effectively treat severe sleep apnea in people who cannot use a CPAP machine and whose nerve stimulation therapy did not work. About 30 adults will use the device at home and have their sleep b…

This study tests a special type of proton radiation called GRID for people with large or previously treated tumors that cannot be removed. The goal is to safely relieve symptoms like pain. About 24 adults will receive three radiation sessions. Researchers will check for side effe…

This study compares two different skin cuts used during trigger finger surgery to see which one helps patients recover better. About 200 adults with trigger finger will be randomly assigned to get either a straight cut along the finger or a cut across the palm crease. Researchers…

This study tests whether a sleep-inducing drug called propofol, given with brief behavioral therapy, can improve deep sleep and reduce depression in adults aged 60 and older whose depression has not responded to standard treatments. Seventy participants will receive two propofol …

This study tests whether taking potassium nitrate (a natural compound found in vegetables like beets) can improve leg muscle power and overall exercise ability in people with heart failure. Researchers will give 75 adults either the nitrate or a placebo daily for 6 weeks, measuri…

This study tests an 8-week group program called PEEPS for women aged 18-48 with endometriosis-related chronic pelvic pain. Participants join weekly group sessions and complete surveys about pain and quality of life. The goal is to see if the program reduces how much pain interfer…

This study tests a smartphone app called Enhearten designed to reduce self-stigma in pregnant women and new mothers (up to 12 months postpartum) who have a substance use disorder. About 152 participants will use the app, which provides real-time support to help them stick with ad…

This study looks at whether giving oxytocin (a hormone that causes contractions) during the pushing stage of labor can shorten delivery time and lower the need for C-sections or vacuum/forceps. About 400 first-time mothers with a single baby at full term will take part. The goal …

This early study looks at whether giving a single dose of Ketorolac (an anti-inflammatory) before placing a ureteral stent can reduce pain and discomfort after the procedure. About 36 adults with kidney stones who need a stent will be randomly assigned to receive the drug or a pl…

This study tests whether fluvoxamine, an antidepressant, can reduce the risk of delirium (sudden confusion) in older adults after non-cardiac surgery. About 46 people having elective surgery will take the drug or a placebo. The goal is to see if this approach is practical for a l…

This study tests whether a specific sequence of position changes can improve outcomes for people whose labor is progressing slowly. About 82 participants with prolonged labor will be randomly assigned to either the circuit of position changes or standard care. The goal is to see …

This study looks at two alternative treatments for people with moderate-to-severe obstructive sleep apnea who cannot use a CPAP machine. One treatment is a custom mouthpiece (mandibular advancement device) and the other is a surgically implanted nerve stimulator (hypoglossal nerv…

This study tests if exposure to bright blue light can reduce inflammation and organ damage in patients hospitalized with serious infections like pneumonia, infected joints, or abdominal infections. About 144 adults will be assigned to either blue light or standard hospital light …

This study tests whether using a common decongestant (oxymetazoline) together with a steroid nasal spray can better relieve chronic nasal blockage than the steroid spray alone. About 80 adults who haven't gotten enough relief from standard treatments will use the sprays daily for…

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of strong painkillers (opioids) needed after the operation. About 70 adults with broken jaw or midface bones will receive either the nerve block or a placebo. The …

This study tests whether a social media and mobile app program can help teens and young adults stop vaping. About 189 participants who vape and want to quit will use a smartphone app with a chatbot that gives personalized tips and support. The goal is to see if the app helps them…

This study uses a special PET-MR scan to look at plaque buildup in the carotid arteries of people who have narrowing but no symptoms. The goal is to see if the scan can predict who might have a stroke or need surgery later. Researchers will follow 80 adults for up to 18 months to…

This study looks at whether computer-based thinking tests are practical for children with central nervous system tumors who are receiving proton beam radiation therapy. Researchers will test children's memory, attention, and other thinking skills before treatment and then again 6…

This study looks at inflammation in brain tumors using a special PET scan called [C-11]-CS1P1. About 104 adults with brain cancer or tumors that spread to the brain will get two scans over two years. The goal is to see how inflammation patterns relate to MRI results, treatments, …

This study looks at whether a health campaign called Pink & Pearl can encourage more women who are at risk for lung cancer to get screened. About 279 women aged 50-80 who smoke or used to smoke will be invited to screening during their regular mammogram visit. Researchers will tr…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and thinking tests to see if factors like insulin resistance or inflammation are linked to changes in memory, processi…

This study creates a worldwide database for people with malignant peripheral nerve sheath tumors (MPNST), a rare cancer often linked to the genetic condition neurofibromatosis type 1 (NF1). Researchers will collect medical records, tumor samples, and imaging data from over 1,000 …

This study looks for early warning signs of Alzheimer's disease in people who carry a gene mutation that causes it. Researchers will use blood tests, brain scans, and memory tests to find biomarkers that predict who will develop the disease. The goal is to better understand and e…

This study is testing a new way to use electrical stimulation on the back to help people with spinal cord injury move their legs. The goal is to see if changing the timing and strength of the stimulation can target specific muscles better than current methods. 48 adults with chro…

This study aims to understand how electroconvulsive therapy (ECT) changes sleep patterns and brain communication in people with depression that hasn't improved with other treatments. Researchers will measure brain activity during sleep and wakefulness in 50 adults receiving ECT. …

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake and aware while paralyzed on a breathing machine in the emergency room. About 3,090 adults on ventilators will take …

This study looks at how the immune system reacts to influenza and COVID-19 in people with symptoms. Researchers will compare those who got a flu or COVID vaccine in the past year with those who did not. About 300 participants will provide blood, saliva, and nasal samples over 6 m…

This study tests whether a wellness program is practical and helpful for older Black patients who are about to have surgery and feel depressed or anxious. Researchers will enroll 50 people aged 60 and older to see how many join and complete the program. The goal is to learn if th…

This study tests a caregiver-reported suicide-risk screener for children aged 4 to 7 in a behavioral health center. Researchers want to see if the tool is practical and helpful for clinicians and families. The goal is to catch warning signs early and improve mental health care fo…

This study looks at whether a new, detailed DNA test called ChromoSeq can work as well as current tests for people with myelodysplastic syndromes (MDS), a bone marrow disorder. About 60 adults with MDS will give samples, and doctors will compare the results and fill out surveys. …

This study is testing a new tool called the Cancer Care Companion, which is built into the electronic health record system. The goal is to see if it helps parents of children with cancer better communicate with doctors and manage their child's care at home. About 40 parents will …

This study looks at how social media use and mental health affect each other in girls aged 10-11. Researchers want to understand how puberty and feeling rejected play a role. The study involves 250 girls and uses daily diaries and questionnaires to track their experiences.

This study looks at how massage affects brain connections in newborns. Researchers will give daily massages to half of the 80 babies in the study and compare their brain scans to those who did not get massages. The goal is to learn more about early brain development and how touch…

This study tests a computer system that helps doctors decide which surgery patients need blood prepared before their operation. The goal is to make sure blood is ready for those who truly need it, while avoiding unnecessary preparation that wastes blood and money. About 50 patien…

This study aims to improve a mobile app called Wysa for Chronic Pain, which supports people aged 45 and older who have chronic pain along with depression or anxiety. Researchers will test different types of in-app notifications to see which ones encourage people to use the app mo…

This study tests a new 3D imaging device called SkinScan3D to see if it can take better pictures of Kaposi sarcoma (KS) skin lesions than standard 2D photos. The goal is to capture the height and volume of lesions, which may help doctors detect treatment response earlier. About 3…

This study looks at how the body's immune system responds to two different flu vaccines: the FluMist nasal spray and the standard flu shot. Researchers will measure antibodies in the blood, nose, and lungs of 30 healthy adults aged 18 to 40. Some participants will also have a bro…

This study looks at genetic markers on breast cancer cells before and after chemotherapy. Researchers want to see how these markers change and which ones might predict if the cancer will come back. About 300 adults with stage II to IV breast cancer will take part. The goal is to …

This study is building a worldwide registry of people with Wolfram syndrome, a rare genetic disorder that causes diabetes, vision loss, hearing loss, and other problems. Researchers will collect medical history and genetic information from up to 5,000 participants to better under…

This study compares a continuous heart monitor patch to standard electrocardiograms (ECGs) in 60 patients taking medications that can cause dangerous heart rhythms. The goal is to see if the patch provides more accurate and timely detection of heart issues. Participants include p…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk about stem cell transplant and cellular therapy decisions. About 60 youth and their parents will try the tool, and researchers will measure if it is…

This study looks at how brain tumors and their treatments affect thinking skills in children aged 4 to 18. Researchers will use brain scans and cognitive tests to find early signs of future cognitive problems. The goal is to better predict which children will recover their thinki…

This study aims to find better ways to measure myofascial pain, a common type of muscle pain, using advanced imaging techniques like MRI and electrical sensors. Researchers will study 100 adults with neck or shoulder pain to see if these imaging tools can track how well treatment…

This study looks at how popular weight-loss drugs (GLP-1 receptor agonists) affect muscle mass and physical function in people with obesity, and whether adding exercise helps. Researchers will follow 40 participants for 2 years, measuring muscle, strength, and metabolism. They al…

This study tests a new PET scan tracer that sticks to certain inflammatory cells in the lungs. Researchers want to see if this tracer can help track inflammation in people with fibrotic lung diseases. About 110 adults who are either non-smokers or current smokers will get the tra…

This study looks at whether a special campaign called Pink & Pearl can help more women who are at risk for lung cancer get screened. About 5,500 women ages 50 to 80 who come for mammograms at Christian Hospital will be included. Researchers will track how many get referred and co…

This study is testing whether an AI tool can create a personalized list of questions for people with lymphoma or multiple myeloma to use during their doctor appointments. About 40 participants will use the AI-generated list and then report how confident they felt communicating an…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial help. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it reduces financial stress a…

This study aims to understand why very low-carb (ketogenic) diets can dramatically raise cholesterol in some normal-weight people. Researchers will enroll 100 healthy adults, identify those whose cholesterol spikes on the diet, and measure how their bodies produce and remove chol…

This study tests a new tool called HPARSS to help doctors identify childhood cancer survivors who may have vision or hearing problems from their past treatment. Researchers will see if the tool makes it easier for doctors to order the right screening tests. The goal is to catch t…

This study looks at why some people with Parkinson's disease develop dementia. Researchers will use brain scans, memory tests, and spinal fluid analysis on 320 participants to identify different types of dementia and find early warning signs. The goal is to better understand and …

This study compares two training programs for doctors and health workers at community health centers that serve Medicaid patients. The goal is to see which training helps patients lose more weight and get better access to obesity care. About 6,200 patients and their providers wil…

This study tests whether giving children a daily peanut-based school meal can improve attendance and reduce dropouts. About 6,700 kids aged 5-17 in rural Ghana will receive either the peanut meal or a local rice/millet flour. The goal is to see if a simple, nutritious snack can h…

This study looks at how blood flow and metabolism changes in the brain affect development in children with sickle cell anemia. Researchers will use MRI scans and a special mask to measure brain blood vessel function. The study includes 120 children aged 4-21, both with sickle cel…

This study looks at whether a new whole genome test called ChromoSeq can give doctors more detailed genetic information for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) than current tests. Researchers will compare ChromoSeq results to standard geneti…

This study is testing a digital tool called PREVENT that helps doctors and patients work together to improve heart health. It is for low-income, rural adults with obesity who are at risk for heart disease. The tool shows patient information and suggests personalized goals for hea…

This study looks at 86 pregnant people whose water broke early (before 37 weeks). Doctors want to know if using a finger exam (digital) is as safe as using a tool (speculum) to check the cervix. The main goal is to see if the type of exam changes how long the pregnancy lasts befo…

This study is looking at whether certain substances in the blood can help predict if someone will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 adults aged 60 and older, including those with and without memory issues, to see how well these blood ma…

This early-phase study tests a new radioactive tracer called [64Cu]-RYM2 in PET/CT scans to see if it can safely detect enzyme activity (MMP) in abdominal aortic aneurysms (AAA). Researchers will compare scans from 28 healthy volunteers and AAA patients scheduled for surgery. The…

This study tests whether a 16-week text-messaging program can help people with spinal cord injury better manage common health problems like pain, bladder issues, and stress. About 40 adults who have had a spinal cord injury for at least 3 months will receive texts with tips and s…

This early study tests an oral drug called DSP-0390 in 20 adults with IDH-mutant gliomas (a type of brain tumor) who are scheduled for surgery. Participants take the drug for about two weeks before their tumor is removed, allowing researchers to measure how much drug reaches the …

This study looks at how children with juvenile idiopathic arthritis (JIA) experience pain. Researchers will use heat, cold, and pressure tests along with questionnaires to measure pain sensitivity. The goal is to better understand the causes of pain in JIA, which could lead to im…

This study looks at people with relapsing-remitting multiple sclerosis to understand why abnormal inflammation in the brain continues even after treatment. Researchers will use brain scans and analyze spinal fluid to compare different types of inflammation. The goal is to learn m…

This study tests a new radioactive tracer called [18F]FZTA to see if it can spot inflammation in the brain using PET scans. Researchers will compare healthy adults and people with Multiple Sclerosis (MS) to see if the tracer lights up areas of inflammation. The goal is to better …

This study looks at whether the bacteria in your gut are linked to the severity and recovery of Complex Regional Pain Syndrome (CRPS), a chronic pain condition. Researchers will compare the gut microbiomes of 140 people with CRPS and their household members. The goal is to find p…

This study looks at how blood flow and oxygen use in the brain change as children grow, and how these changes might affect development. Researchers will use MRI scans and sometimes measure blood flow while participants breathe in extra carbon dioxide. The goal is to better unders…

This study looks at whether watching an animated video before DIEP flap breast reconstruction surgery helps patients understand the procedure better and feel less anxious. About 300 adults scheduled for this surgery will fill out surveys before and after watching the video, and a…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…

This study tests whether daily CT scans can help doctors see and protect the ovaries during pelvic radiation in women under 50 with various cancers. The goal is to keep radiation doses to the ovaries low enough to avoid early menopause and infertility. Ten participants will recei…

This study looks at different types of parathyroid tumors in women with primary hyperparathyroidism who are having surgery to remove the tumors. Researchers want to understand how common each tumor type is and how they affect treatment results. The goal is to gather information t…

This study looks at how nitrous oxide (laughing gas) changes brain connections in people with treatment-resistant depression compared to healthy volunteers. About 60 adults will have brain scans before and after breathing nitrous oxide or a placebo. The goal is to understand whic…

This study looks at whether a blood test called DiviTum, which measures a protein linked to cancer growth, can help doctors monitor women with advanced breast cancer. About 55 participants will be followed to see if the test results lead to fewer routine scans and blood tests. Th…

This study looks at how spinal cord stimulation combined with training changes the way nerves communicate in people with spinal cord injuries. Researchers will measure brain-to-muscle signals and reaction times in 120 participants to understand how these changes might improve mov…

This study aims to understand how the tumor's surroundings change during chemoradiotherapy for locally advanced cervical and pancreatic cancers. Researchers will collect tissue samples, blood, and imaging data from 60 participants before, during, and after treatment. The goal is …

This study looks at how radiation therapy for brain tumors (gliomas) affects thinking and memory. Researchers will use special brain scans (resting-state fMRI) and thinking tests to find which brain networks are most sensitive to radiation. About 96 adults with glioma will partic…

This study uses advanced brain scans to understand how Parkinson's disease affects brain connections. Researchers will compare brain activity in 120 people—some with Parkinson's and some without—to study a recently discovered brain network called SCAN. The goal is to learn if thi…