Washington University School Of Medicine

This early-stage trial tests a personalized cancer vaccine for people with bladder or stomach cancer who still have tiny amounts of cancer DNA in their blood after surgery. The vaccine is made from unique proteins in each person's tumor and aims to train the immune system to find…

This study tests a personalized DNA vaccine for children and young adults (ages 12-25) with central nervous system tumors that have come back or not responded to treatment. The vaccine is made from each patient's unique tumor DNA to train the immune system to fight the cancer. Th…

This early-phase trial tests whether adding the experimental drug zanzalintinib to two immunotherapy drugs (ipilimumab and nivolumab) is safe and can shrink tumors in people with metastatic soft tissue sarcoma. About 18 adults who have already tried 1 to 3 prior treatments will r…

This study tests a mobile health app called uMAT-R, designed to help Black adults recover from opioid or stimulant use and manage depression or anxiety. Participants are recruited from community treatment centers and use the app to track substance use and mental health symptoms. …

This phase 2 trial tests whether tofersen, a drug already approved for a specific type of ALS, can help people with ALS who do not have the SOD1 gene mutation. Thirty adults will receive the drug via spinal injections over 24 weeks. Researchers will measure changes in nerve damag…

This study tests two experimental drugs, CTX-009 and CTX-471, in people whose glioblastoma has returned after standard treatment. The goal is to see if these drugs are safe and can help control the tumor or extend survival. About 54 participants will receive either CTX-009 alone …

This pilot study looks at two strategies to help pregnant and postpartum people with substance use disorder stay in treatment. One strategy screens for social needs like housing or childcare and connects patients to support. The other offers rewards for recovery-supportive behavi…

This study tests a combination of a vaccine targeting the CMV virus (PEP-CMV) and an immunotherapy drug (nivolumab) in children and young adults with certain aggressive brain tumors, including diffuse midline glioma and medulloblastoma. The goal is to see if this approach is safe…

This early-stage trial tests whether adding a drug called NT-I7 (a lab-made immune booster) can help CAR-T cells survive longer in people with multiple myeloma that has come back or stopped responding to treatment. About 52 participants who are already getting standard CAR-T ther…

This early-phase study tests whether dapagliflozin, a diabetes medicine, is safe for children with brain or solid tumors that have come back or not responded to other treatments. About 20 children will receive the drug alongside standard care. The goal is to check for side effect…

This study tests whether the drug selinexor can safely extend the benefits of CAR-T cell therapy in people with high-risk multiple myeloma that has returned after other treatments. About 20 participants will take selinexor pills after their CAR-T infusion. The goal is to see if t…

This study looks at whether starting hepatitis C treatment during pregnancy is feasible and acceptable for women who have used drugs. Fifty pregnant adults with hepatitis C will take glecaprevir-pibrentasvir daily for 56 days. Researchers will track how well participants stick to…

This study tests tirzepatide, a drug used for diabetes, in 60 adults with Crohn's disease who have active inflammation in the small bowel despite other treatments. The goal is to see if tirzepatide can heal the gut lining better than switching to another standard biologic therapy…

This early-phase trial tests whether adding zanzalintinib to the chemotherapy drug eribulin can help control advanced liposarcoma and leiomyosarcoma better than eribulin alone. About 18 adults whose cancer has worsened after prior treatments will receive the combination. The main…

This early study tests whether adding the drug azeliragon to standard chemoradiotherapy can help the immune system fight glioblastoma, an aggressive brain cancer. About 12 adults with newly diagnosed glioblastoma will receive either standard treatment or standard treatment plus a…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study tests whether adding a drug called pembrolizumab to a special type of radiation therapy can help prevent mucosal melanoma from returning after surgery. About 20 people with this rare head and neck cancer will receive the combination. The goal is to see if this approach…

This early-phase trial tests a drug called TTI-101 combined with a precise type of radiation (SBRT) in 18 people with pancreatic cancer that is borderline resectable or locally advanced. The goal is to see if the combination is safe and can improve how long patients live without …

This study tests whether enasidenib, a drug that blocks a faulty IDH2 protein, can safely improve blood cell counts in people with clonal cytopenia of undetermined significance (CCUS). CCUS causes low blood counts and raises the risk of blood cancers. The trial enrolls 15 adults …

This early-phase study tests an oral drug called PMD-026 in 18 adults with myelofibrosis, a type of bone marrow cancer. Participants must have already tried a JAK inhibitor without success. The main goals are to check safety, find the best dose, and see if the drug can shrink the…

This study tests whether adding palbociclib to cetuximab helps people with a certain genetic type of head and neck cancer live longer than cetuximab alone. Participants must have HPV-unrelated cancer with a CDKN2A gene change that has worsened after prior immunotherapy. About 81 …

This study is for people with metastatic pancreatic cancer that has worsened after initial treatment. It tests a new drug, ONT01, combined with standard chemotherapy (gemcitabine and nab-paclitaxel) to see if it can reprogram immune cells in the tumor to fight cancer better. Abou…

This early-phase trial tests whether adding a drug called NT-I7 after standard CAR T-cell therapy can help the immune cells work better and last longer in people with relapsed or refractory large B-cell lymphoma. About 24 participants will receive NT-I7 after their CAR T treatmen…

This study is for people with HPV-related throat cancer. After surgery, patients receive lower-than-standard doses of radiation and sometimes chemotherapy, based on their risk level. The goal is to keep cancer from coming back while reducing side effects like weight loss. About 1…

This study is testing a procedure called cryoablation, which uses extreme cold to freeze and destroy breast cancer tumors. It is for people who cannot have surgery due to medical reasons or personal choice. Researchers will follow 100 participants to see how safe the freezing tre…

This study tests whether giving special 'memory-like' natural killer (NK) cells after a stem cell transplant can help prevent relapse in children and adults with high-risk acute myeloid leukemia (AML). The NK cells come from the same donor as the transplant and are boosted in the…

This study tests an experimental drug called CUE-101 in 30 people with HPV16-positive throat cancer. The drug is given before standard treatments like surgery or chemoradiation to see if it safely boosts the body's immune cells to fight the cancer. Researchers will monitor side e…

This study tests whether the sleep medication lemborexant (Dayvigo) can reduce levels of amyloid-beta and tau proteins in the blood and spinal fluid of older adults. These proteins are linked to Alzheimer's disease. The trial will enroll 201 healthy volunteers aged 65 and older, …

This early-phase trial tests whether adding an experimental MK2 inhibitor (zunsemetinib) to standard chemotherapy (mFOLFIRINOX) can better control metastatic pancreatic cancer. About 51 adults who have not had prior treatment for advanced disease will participate. The main goals …

This early-stage trial is testing a new type of CAR-T cell therapy, called WS-CART-CS1, in 25 people with multiple myeloma that has come back or not responded to at least three prior treatments. The therapy targets a protein called CS1 found on myeloma cells. The main goals are t…

This study compares two ways of giving the chemotherapy drug 5-FU to people with head and neck cancer that has spread or come back after prior treatments. One group gets the drug over two days every two weeks, the other over four days every three weeks. The goal is to see which s…

This early-phase trial is testing a new targeted drug called CA-4948 combined with standard chemotherapy and immunotherapy for people with advanced stomach, esophageal, or gastroesophageal junction cancer that cannot be removed by surgery. The study will enroll 42 participants an…

This early-phase trial tests whether two drugs, ruxolitinib and abatacept, can prevent graft-versus-host disease (GVHD) and cytokine release syndrome in people receiving stem cell transplants from half-matched donors. About 41 adults with blood cancers will take these drugs aroun…

This study tests a new drug, zunsemetinib, combined with standard chemotherapy (capecitabine) in people with a common type of advanced breast cancer (HR+/HER2-) that has spread to the bones. The goal is to see if the combination is safe and can slow down the cancer or reduce bone…

This phase 2 trial tests whether adding two drugs (defactinib and avutometinib) to targeted radiation therapy can help people with advanced pancreatic cancer live longer without their cancer growing. About 36 participants with borderline resectable or locally advanced pancreatic …

This study compares two alternative treatments for moderate-to-severe obstructive sleep apnea in people who cannot use a CPAP machine: a custom mouthpiece (mandibular advancement device) and a surgically implanted nerve stimulator (hypoglossal nerve stimulation). Researchers will…

This study tests a personalized approach for people with newly diagnosed multiple myeloma who have had a stem cell transplant. After transplant, participants receive the drug elranatamab as maintenance therapy, with the dose and duration guided by a sensitive blood test (MRD test…

This phase II trial is testing whether using specific genetic tests (Ki67 and Oncotype DX) can help doctors choose the best treatment before surgery for women with a common type of breast cancer (ER-positive, HER2-negative). The study includes 81 postmenopausal women with stage I…

This study tests whether statins, common cholesterol-lowering drugs, can reduce inflammation and slow the progression of two blood disorders: CCUS and lower-risk MDS. These conditions can lead to more serious blood cancers or heart problems, and there are no approved treatments t…

This phase II trial tests whether propranolol, a cheap and widely available blood pressure medicine, can shrink Kaposi sarcoma tumors in adults. The study enrolls 25 people with measurable lesions, including those with HIV. Researchers hope for a 45% response rate with fewer side…

This early-phase trial tests a new drug called emavusertib added to standard chemotherapy and immunotherapy for people with untreated advanced bile duct cancer. The goal is to see if the combination is safe and to find the best dose. About 48 participants will be enrolled.

This study tests a home blood pressure monitoring program for 1,200 women in Nigeria who had high blood pressure during pregnancy. The program includes patient education, home BP monitors, follow-up care, and free medication if needed. Researchers want to see if this approach lea…

This study is testing a milder type of stem cell transplant for people with non-cancerous blood, immune, or metabolic disorders. The goal is to safely get donor cells to grow in the patient's body while reducing harsh side effects. About 220 participants will receive a reduced-in…

This study tests whether a simple, home-based technique called remote ischemic conditioning can improve heart health in people with spinal cord injury. Participants will use a blood pressure cuff to briefly restrict blood flow to an arm, then release it, repeating this several ti…

This study tests whether giving a two-drug combination (decitabine and cedazuridine, or DEC-C) early can prevent myelodysplastic syndromes (MDS) from coming back after a stem cell transplant. About 209 adults with MDS who have tiny amounts of cancer cells left after transplant wi…

This study tests whether adding choline to a peanut-based therapeutic food improves cognitive development in 1,500 Malawian children aged 6-59 months with severe acute malnutrition. Half get standard food, half get food with extra choline. All also receive amoxicillin. The goal i…

This study compares two doses of the drug lenvatinib (24 mg vs 10 mg daily) in 34 people with advanced thyroid cancer that no longer responds to radioactive iodine. The goal is to see if the lower dose causes fewer side effects while still controlling the cancer. Participants tak…

This study tests whether a very-low-carbohydrate (ketogenic) diet can safely improve blood sugar control in adults with type 1 diabetes. Researchers will enroll 58 people and measure changes in blood sugar levels and insulin sensitivity. Participants will follow the diet for a pe…

This study tests a custom mouthpiece (mandibular advancement device) for people with moderate to severe obstructive sleep apnea who cannot tolerate CPAP and have not improved with a nerve stimulation implant. Researchers will measure if the device reduces breathing pauses during …

This study tests a new way to do stem cell transplants for children with blood cancers like leukemia. It uses a half-matched family donor and removes certain immune cells from the donated cells to lower risks. The goal is to see if this method is safe and helps the child's body a…

This early-stage study tests a new conditioning regimen (low-dose total body irradiation plus cyclophosphamide) before CAR T therapy (cilta-cel) in 16 multiple myeloma patients with impaired kidney function. The goal is to see if this approach is safe and feasible for patients wh…

This study tests whether giving a higher dose of radiation directly to the prostate (via HDR brachytherapy) can better control early-stage prostate cancer without causing too many side effects. About 36 men with low- or favorable intermediate-risk prostate cancer will receive one…

This study looks at whether nerve transfer surgery can improve arm function and quality of life in people with high-level cervical spinal cord injuries (tetraplegia). Thirty participants will receive standard nerve transfer surgery and be followed for up to 4 years. The goal is t…

This study compares a freezing technique called cryoablation to standard lumpectomy surgery in people with low-risk, early-stage breast cancer. The goal is to see if freezing the tumor offers similar disease control with fewer complications and better quality of life. About 120 p…

This study tests whether adding the drug epacadostat to standard chemoradiation helps treat locally advanced rectal cancer before surgery. About 49 adults with stage 2 or 3 rectal cancer will receive short-course radiation, chemotherapy, and epacadostat. The goal is to find the b…

This study tests two programs for people recovering from a stroke who are leaving inpatient rehab to go home. Half of the 520 participants will get a standard stroke education program, while the other half will get a program that helps modify their home environment. The goal is t…

This study tests whether giving smokers a personalized quit plan based on their genes, health history, and biomarkers helps more people stop smoking than standard advice. About 850 smokers and their doctors from primary care clinics will take part. The goal is to see if tailored …

This study tests whether a community-based exercise program can improve heart health in wheelchair users. Researchers will measure changes in fitness and body composition. The goal is to find safe, effective ways for wheelchair users to get enough physical activity to reduce hear…

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This study tests whether adding a behavioral weight loss program to standard hormone therapy helps premenopausal women with obesity and early endometrial cancer or precancer keep their uterus and fertility. About 96 women will receive either the weight loss program plus hormone t…

This study tests a program to help doctors at community health centers prescribe a recommended asthma treatment called SMART (Single Maintenance and Reliever Therapy). The program includes training, feedback, and educational tools for both doctors and patients. Researchers will m…

This phase 2 trial compares a new ultra-short radiation schedule (5 sessions over 1 week) to the current standard (15-16 sessions over 3 weeks) for women with node-positive breast cancer. The goal is to see if the shorter course is just as effective at controlling cancer while ca…

This study looks at whether giving the drug oxytocin during the second stage of labor (when the cervix is fully open and the baby is being pushed out) can shorten delivery time and reduce the need for C-sections or vacuum/forceps. Researchers will study 400 first-time mothers wit…

This early-stage trial tests a drug called siltuximab in 30 lung transplant patients who are experiencing antibody-mediated rejection, a serious condition that often leads to transplant failure. The drug is added to standard rejection treatment to see if it is safe and tolerable.…

This study tests a new way to deliver radiation for locally advanced cervical cancer by giving brachytherapy (internal radiation) earlier and using fewer, larger doses of external radiation. The goal is to see if this faster schedule reduces long-term bowel and bladder side effec…

This study tests whether adding a new drug called cirtuvivint to standard chemotherapy can help people with small cell lung cancer that has come back after initial treatment. About 42 adults whose cancer has progressed after at least one prior therapy will receive the combination…

This study tests whether dapagliflozin, a drug used for diabetes, can slow the progression of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 70 adults aged 50 and older with this condition will take the drug for 12 month…

This study tests whether adding milk fat globule membrane (MFGM) to a standard therapeutic food helps brain development and reduces death or hospitalization in 1,600 severely malnourished children aged 6-59 months in Sierra Leone. Children receive either the MFGM-enriched food or…

This study tests whether a blood test measuring thymidine kinase activity (TKa) can help doctors decide early if a patient's breast cancer treatment is working. Patients with HR+ HER2- metastatic breast cancer start standard therapy with a CDK4/6 inhibitor and endocrine therapy. …

This phase 2 trial tests whether the drug zanzalintinib, taken as a maintenance therapy after initial chemotherapy, can help delay cancer progression in people with high-grade neuroendocrine neoplasms. About 32 participants will receive the drug and be monitored for how long thei…

This early-phase study tests a new drug called zanzalintinib combined with standard chemotherapy (paclitaxel) in people with recurrent high-grade uterine or endometrial cancer. The main goal is to find the safest and most effective dose of the combination. About 36 participants w…

This study tests whether a daily ketone ester drink can reduce liver fat and improve how the body handles sugar in adolescents and young adults with obesity and a fatty liver condition called MASLD. Forty participants will be randomly assigned to receive either the ketone drink o…

This study tests a non-invasive device that gently stimulates a nerve in the ear to help patients with serious brain or spinal cord injuries recover in the intensive care unit. Researchers want to see if it reduces complications like infections, the need for a breathing tube, and…

This study looks at whether adding exercise to a common weight-loss drug (semaglutide) can prevent muscle loss and keep people physically strong. Researchers will follow 40 adults with obesity for two years, tracking muscle mass, strength, and function. They will also see what ha…

This early-phase trial tests a new combination treatment for people with advanced melanoma that has worsened despite standard immunotherapy. The treatment uses specially trained natural killer cells (either from the patient or a healthy donor) along with two immunotherapy drugs, …

This early-phase trial is testing a new radioactive imaging agent called 64Cu-LLP2A to see if it can safely and clearly show blood cancers like multiple myeloma and lymphoma on PET/CT scans. The study includes healthy volunteers and patients with these cancers, including those wh…

This study tests a new radioactive tracer called 18F-Fluselenamyl for PET scans to safely detect amyloid plaques in the brain, a hallmark of Alzheimer's disease. Researchers will compare it to an existing tracer in 60 healthy volunteers and people with mild cognitive impairment o…

This study tests a new technique called sonobiopsy that uses focused ultrasound to release DNA from brain tumors into the bloodstream, making it easier to detect and analyze the tumor's genetic makeup through a simple blood test. The goal is to improve diagnosis and treatment pla…

This early-phase study tests a radioactive tracer called Cu-DOTA-ECL1i that binds to certain inflammatory cells in the lungs. Researchers will use PET scans to see how the tracer spreads in people with fibrotic lung disease, comparing it to CT scans and clinical status. The goal …

This study looks at whether giving women at-home kits to test for HPV (a virus that can cause cervical cancer) makes it easier for them to get screened. About 100 women who are overdue for screening will receive a kit and be asked to return a sample by mail. Researchers will comp…

This study is testing a new device that combines ultrasound with photoacoustic imaging to look at rectal tumors. The goal is to see if it can more accurately tell whether a patient's cancer has completely responded to pre-surgery treatment. If it works, doctors could avoid operat…

This study is testing whether a special PET/MRI scan using 18F-DOPA can accurately locate small, overactive areas in the pancreas that cause too much insulin (hyperinsulinism). The goal is to help doctors decide if surgery can remove just the problem spot, potentially curing the …

This study tests whether taking the sleep medication suvorexant (Belsomra) nightly for two years can slow the buildup of amyloid plaques in the brain, a hallmark of Alzheimer's disease. Researchers will enroll 200 healthy adults aged 65 and older with no signs of dementia. The go…

This study explores whether mindfulness training can help prevent cognitive decline in Latino adults aged 65 and older, a group at higher risk for Alzheimer's disease. Researchers will measure brain activity and thinking skills in 60 participants before and after mindfulness prac…

This study tests a new approach to prevent lymphoma from spreading to the brain in patients at high risk. Participants receive a stem cell transplant using drugs that better reach the brain. The goal is to see if this treatment is safe and feasible for 36 adults with newly diagno…

This study tests whether the drug remternetug can prevent or slow the buildup of harmful proteins in the brains of people who have a genetic mutation that almost always causes early-onset Alzheimer's. About 280 participants will receive either the drug or a placebo every 12 weeks…

This study tests a drug called remternetug in people who have a strong genetic risk for Alzheimer's but do not yet have symptoms. The goal is to see if the drug can prevent or slow the buildup of harmful proteins in the brain. About 280 participants will receive either the drug o…

This study compares two ways to help people stop smoking and lower their cancer risk. About 5,000 adults who smoke and visit a participating clinic will be assigned to either a program that uses personalized reminders and support (ELEVATE-S) or standard quit-focused care (ELEVATE…

This study is testing a home hazard removal program (HARP) adapted for people with physical disabilities. 80 adults aged 45-64 who have had a disability for at least 5 years and live in St. Louis will be randomly assigned to either the program or a waitlist. The program involves …

This study enrolls 600 adolescent girls and young women (ages 15-24) at high risk of HIV in Uganda. Participants are randomly assigned to one of three groups: HIV risk reduction sessions alone, sessions plus peer support, or sessions plus peer support and a matched savings accoun…

This study tests whether a mild electrical clip on the ear (called vagus nerve stimulation) can help people recover better after spine surgery for a condition called cervical myelopathy. The trial will include 36 adults with moderate to severe myelopathy who are scheduled for dec…

This study tests whether rivastigmine, a drug used for Alzheimer's, can quickly calm agitation and confusion caused by poisoning from medications that block certain nerve signals. About 42 people aged 10 and older with this type of delirium will receive either rivastigmine or a p…

This study tests whether an AI-generated personalized question prompt list (GPT-QPL) can help people with lymphoma or multiple myeloma ask more useful questions during their outpatient appointments. Researchers will create tailored question lists for 40 patients using ChatGPT, th…

This study tests a new approach to help people with early Parkinson's disease who have mild memory or thinking problems. Instead of brain games, participants learn practical strategies from an occupational therapist to handle everyday challenges like remembering tasks or staying …

This study tests whether a daily capsule of potassium nitrate (KNO3) can improve leg muscle power and overall exercise capacity in people with heart failure. 75 adults with reduced heart function will take either KNO3 or a placebo for 6 weeks. Researchers will measure changes in …

This study tests whether fluvoxamine, a drug used for depression, can help prevent delirium (sudden confusion) in older adults after non-cardiac surgery. About 46 people having elective surgery that requires at least a 2-day hospital stay will take part. The main goal is to see i…

This study is testing whether a social media and smartphone app program can help teens and young adults who vape to cut back or quit. Participants will be recruited through social media, screened by a chatbot, and given a mobile app with tailored tips and encouragement. The goal …

This study compares two different skin cuts used during trigger finger surgery to see which one helps patients recover better. About 200 adults with trigger finger will be randomly assigned to get either a straight cut along the finger or a cut across the palm crease. Researchers…

This study tests a wellness program designed for Black patients aged 60 and older who are scheduled for surgery and have symptoms of depression or anxiety. The program includes up to 10 remote sessions before and after surgery, with optional faith-based counseling and family invo…

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which one better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, have H…

This pilot study tests whether a specific sequence of maternal position changes (a 'circuit') can improve outcomes for women whose labor is progressing slowly. 82 participants with prolonged labor will be randomly assigned to either the circuit or standard care. The study will me…

This study tests a new type of radiation called proton GRID for people with large tumors (at least 4.5 cm) that cannot be removed by surgery or have spread. The goal is to safely relieve symptoms like pain. About 24 adults will receive three radiation treatments, and researchers …

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of opioids patients need after surgery. 70 adults with facial fractures will be randomly assigned to receive either the nerve block or a placebo. The goal is to se…

This study tests whether exposure to bright blue light can reduce inflammation and organ damage in people hospitalized with serious infections like pneumonia, infected joints, or abdominal infections. Participants will be randomly assigned to receive either blue-enriched light or…

This study is testing a new tool called the Cancer Care Companion, which is accessed through a patient portal. Parents of children recently diagnosed with cancer will use it for 3 months to complete educational tasks, surveys, and read patient stories. The goal is to see if the t…

This study tests an 8-week group program called PEEPS for people with endometriosis-related chronic pelvic pain. Participants attend weekly sessions with others and get education and support, in addition to their usual care. The goal is to see if this approach reduces how much pa…

This pilot study is testing whether a single injection of ketorolac (Toradol), given just before ureteral stent placement, can reduce pain and inflammation afterward. About 36 adults undergoing kidney stone surgery will be randomly assigned to receive either ketorolac or a placeb…

This study tests a digital app called Enhearten designed to reduce self-stigma in pregnant and postpartum women with substance use disorder. The app provides just-in-time support to help women feel less judged and stay on track with addiction treatment. Researchers will compare t…

This study tests whether a personalized approach to smoking cessation helps cancer patients quit. Researchers will use patients' clinical, genetic, and biomarker information to create tailored treatment plans. The study involves 112 participants and compares this precision treatm…

This study tests whether a low or moderate dose of propofol, a sleep-inducing drug, combined with brief behavioral therapy for insomnia, can improve sleep and depression symptoms in adults aged 60 and older with treatment-resistant depression. Seventy participants will receive tw…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This study tests whether using two over-the-counter nasal sprays together—oxymetazoline (Afrin) and budesonide (Rhinocort)—works better than steroid spray alone for people with chronic nasal obstruction that hasn't improved with standard treatment. About 80 adults who have tried …

This study will test a new 3D imaging device called SkinScan3D to see if it can measure Kaposi Sarcoma skin lesions more accurately and consistently than the current manual method. Researchers will compare the two methods in 300 adults with confirmed Kaposi Sarcoma who are starti…

This study explores whether a computer algorithm can analyze resting-state MRI scans taken before surgery to predict how long a person with glioblastoma multiforme (a type of brain cancer) might survive. The goal is to see if the algorithm can accurately classify patients as shor…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial resources. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it helps them feel more …

This study is testing a new tool called HPARSS that helps doctors identify childhood cancer survivors at risk for hearing or vision problems. The tool uses a patient's past cancer treatments to flag who needs screening. Researchers will see if this approach leads to more kids get…

This study explores whether using ChatGPT to create personalized educational materials helps patients better understand their breast reconstruction options before surgery. Participants scheduled for a breast reconstruction consultation are randomly assigned to receive either Chat…

This study is testing whether a new genetic test called ChromoSeq can quickly and accurately classify leukemia in children and young adults. Researchers will collect blood or bone marrow samples from 60 participants at diagnosis and compare the test results to standard methods. T…

This study looks at how depression and very early (preclinical) Alzheimer's disease affect driving habits in adults aged 65 and older who still drive regularly. Participants will have their driving tracked with a GPS device and undergo brain scans to measure Alzheimer-related pro…

This study tests a new radioactive tracer called [11C]-CS1P1 to see if it can detect inflammation in the brains of people with Alzheimer's disease. Researchers will compare brain scans from 80 older adults—some healthy and some with memory problems—to see if the tracer lights up …

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. The goal is to see if the tool is easy to use and helpful for families. About 60 …

This study tests a new device that tracks a patient's breathing and position during radiation therapy for cancers in the chest or upper abdomen. The goal is to see if the system can help deliver treatment more accurately without needing backup methods. About 20 adults who require…

This study looks at two different training programs for doctors and health workers at community health centers. The goal is to see which training helps patients lose weight better and get more people to use weight management services. About 6,200 adults and youth on Medicaid will…

This study looks at whether a campaign called Pink & Pearl can increase lung cancer screening among women who are already getting mammograms. Researchers will track how many eligible women get screened and what factors help or hinder the process. About 279 women aged 50-80 with a…

This long-term study follows 700 adults who carry a rare genetic mutation that causes early-onset Alzheimer's. Researchers collect blood, spinal fluid, brain scans, and cognitive tests to find biomarkers that signal the disease before memory loss begins. The goal is to improve ea…

This study looks at 2,000 adults aged 50+ to see if certain blood cell mutations are tied to aging and heart disease, beyond just getting older. Researchers will compare blood and mouth cells to find mutations and track health over time. The goal is to understand these mutations'…

This phase 2 study is collecting tumor samples from 839 people with hyperparathyroidism who are having parathyroid surgery. Researchers want to see if the genetic makeup of the tumors (whether they are monoclonal or polyclonal) relates to how many glands are affected and how well…

This study uses brain imaging (PET scans) and memory tests to understand why some people with Parkinson's disease develop dementia. Researchers will follow 320 participants over several years, using scans to look for abnormal proteins and track thinking changes. The goal is to id…

This study follows 250 girls aged 10-11 to understand how social media use, rejection sensitivity, and puberty interact to affect mental health. Participants complete daily diaries and surveys over time. The goal is to identify risk factors for mental health problems, not to test…

This early phase 1 trial is testing an oral drug called DSP-0390 in 20 people with IDH-mutant gliomas who are scheduled for tumor removal surgery. The goal is to see how much of the drug gets into the brain tumor and blood, and whether it affects cholesterol-related pathways. Par…

This study is testing a mobile app called Wysa for Chronic Pain, designed to support people aged 45 and older who have chronic pain along with depression or anxiety. Researchers want to see if personalized in-app notifications can encourage people to use the app more often. Parti…

This study looks at how a newborn's brain is wired and whether daily massage can change it. Researchers will scan the brains of 80 babies, half of whom receive massage from their caregivers. The goal is to see if massage alters how different brain areas communicate.

This study will test whether computer-based thinking assessments are practical for children aged 4 to 21 with brain tumors who are receiving proton beam radiation therapy. Researchers will measure thinking skills before, during, and after treatment to see how radiation affects me…

This study looks at how nitrous oxide (laughing gas) changes brain connections in people with hard-to-treat depression compared to healthy volunteers. About 50 participants will get either the gas or a placebo and have their brains scanned with MRI. The goal is to understand how …

This observational study at Washington University will use special PET scans to look at ongoing inflammation in the brains of 25 people with relapsing-remitting multiple sclerosis. Researchers want to understand why inflammation persists even after standard treatment. Participant…

This study is testing a new radioactive tracer called [C-11]-CS1P1 that lights up inflammation in brain tumors during a PET scan. Researchers will scan 104 adults with primary or secondary brain cancers before and after treatment to see how inflammation patterns change. The goal …

This study uses advanced MRI scans to look at a newly discovered brain network, called SCAN, in people with Parkinson's disease and healthy volunteers. Researchers want to see if this network is linked to the movement problems in Parkinson's. The goal is to find a specific brain …

This study is testing whether a gentle electrical stimulation of a nerve in the ear (the vagus nerve) can reduce brain injury and inflammation after a severe stroke. Researchers will measure brain damage markers in the blood of 65 participants over a week. The goal is to see if t…

This study looks at how spinal cord stimulation combined with physical training can change the way nerves work in people with spinal cord injuries. Researchers will measure brain-to-muscle signals and reaction times in 120 participants to understand if these changes lead to bette…

This study tests a new 3D imaging device called SkinScan3D to see if it can take better pictures of Kaposi sarcoma (KS) skin lesions than standard 2D photos. KS lesions can change in height when they respond to treatment, which 2D photos miss. The study will enroll 30 adults with…

This study looks at why very-low-carb ketogenic diets can cause high cholesterol in some normal-weight people. Researchers will enroll 100 adults, identify those whose cholesterol spikes on keto, and measure how their bodies make and remove cholesterol-carrying particles. The goa…

This study is testing whether a new type of PET-MR scan can help predict stroke risk in people with significant narrowing of the carotid artery (the main artery in the neck) who have not yet had symptoms. Researchers will give participants an injection of a radioactive tracer and…

This early-phase study tests a new radioactive tracer called [64Cu]-RYM2 to see if it can safely and accurately detect enzyme activity in abdominal aortic aneurysms (AAA). Researchers will scan 28 people—some healthy volunteers and some AAA patients scheduled for surgery—to measu…

This study looks at how electroconvulsive therapy (ECT) affects brain connections and sleep in 50 people with treatment-resistant depression. Researchers will measure brain activity during sleep and wakefulness to understand how ECT works. The goal is to learn more, not to test a…

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake while paralyzed during emergency breathing support. About 3,090 adults on ventilators in emergency departments will …

This study tests whether a 16-week text-messaging program can help people with spinal cord injury better manage common health problems like pain, bladder issues, and stress. About 40 adults with spinal cord injury will receive texts with tips and support, and researchers will see…

This study tracks the immune response of 300 people with confirmed flu or COVID-19, comparing those who were recently vaccinated to those who were not. Participants provide blood, saliva, and nasal samples over 6 months, and some may opt for a lung fluid sample via bronchoscopy. …

This study is building a worldwide database of people with malignant peripheral nerve sheath tumors (MPNST), a rare cancer often linked to the genetic condition neurofibromatosis type 1. Researchers will collect medical records, tumor samples, and genetic data to find patterns th…

This study tests a computer system that helps doctors decide which patients need blood prepared before surgery. About 1 million patients in the US need blood transfusions during surgery each year, but often too much blood is prepared, leading to waste. The system uses patient dat…

This study looks at whether giving mothers extra oxygen during labor when the baby's heart rate is concerning actually improves baby health. About 2,100 women with full-term, single-baby pregnancies will be randomly assigned to receive either oxygen or regular room air. The goal …

This study looks at whether a campaign called Pink & Pearl can help more women get screened for lung cancer. About 5,500 women aged 50-80 who get mammograms at Christian Hospital will take part. Researchers will track how many complete lung cancer screening and how long it takes,…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This study is testing a non-surgical method of spinal cord stimulation to help people with spinal cord injury regain movement. Researchers want to see if adjusting the timing and strength of electrical pulses can target specific muscles more precisely. The study involves 48 adult…

This pilot study tests a caregiver-reported suicide-risk screener for children aged 4 to 7 in a behavioral health center. Researchers will interview clinicians to see if the screener is acceptable and useful. The goal is to improve early detection of suicidal thoughts and behavio…

This study aims to see if proteins in the blood can predict who will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 older adults, some with mild forgetfulness or dementia, and track their cognitive health over time. The goal is to develop and valida…

This study tests whether a blood test called DiviTum TKa can help doctors decide to order fewer scans and other tests for women with HR+ HER2- metastatic breast cancer. The trial will enroll 55 women starting a common first-line treatment. Doctors will fill out care plans before …

This study aims to find better ways to measure myofascial pain, a common type of muscle pain. Researchers will use MRI and other imaging tools to look at muscle tissue in 100 adults with neck or shoulder pain. The goal is to identify imaging markers that can track how well treatm…

This study looks at 86 pregnant women whose water breaks early (before 37 weeks). It compares two ways doctors check the cervix: a traditional speculum exam and a digital exam using fingers. The goal is to see if digital exams affect how long the pregnancy lasts before delivery. …

This study compares a continuous heart-monitoring patch with standard electrocardiograms (ECGs) in 60 adults receiving cancer drugs that can cause dangerous heart rhythm changes. The goal is to see if the patch detects problems more accurately and consistently. Participants will …

This study tests a new radioactive tracer called [18F]FZTA to see if it can spot inflammation in the brain using PET scans. Researchers will compare 80 people—some with Multiple Sclerosis and some healthy—to see if the tracer lights up differently in those with MS. The goal is to…

This study is building a worldwide registry for people with Wolfram syndrome, a rare genetic disorder causing diabetes, vision loss, and hearing problems. Researchers will track how the disease progresses over time and analyze participants' genetic information. The goal is to bet…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and memory tests to see which factors—like insulin resistance or inflammation—are most linked to changes in brain stru…

This study looks at whether a new whole genome test called ChromoSeq can find genetic changes in people with myelodysplastic syndromes (MDS) as well as current standard tests. About 60 adults with MDS will provide samples, and doctors will compare results. The goal is to see if C…

This study aims to understand how breast cancer cells change after chemotherapy by comparing genetic markers before and after treatment. Researchers will collect blood, breast tissue, and bone marrow samples from 300 people with stage II to IV breast cancer. The goal is to find m…

This study tests whether an animated video can improve understanding and reduce anxiety in 300 breast cancer patients scheduled for DIEP flap breast reconstruction. Patients will complete surveys before and after watching the video, and again after surgery. The goal is to see if …

This study looks at how brain tumors and their treatments affect thinking skills in children aged 4 to 18. Researchers will use brain scans and cognitive tests to find early signs of future cognitive problems. The goal is to better predict which children will recover and how to h…

This study is for people with cervical or pancreatic cancer who are scheduled to receive chemoradiotherapy. Researchers will collect tumor samples, blood, and imaging data before, during, and after treatment to see how the tumor environment changes over time. The goal is to learn…

This study looks at whether the bacteria in your gut are linked to the severity and recovery of Complex Regional Pain Syndrome (CRPS), a chronic pain condition. Researchers will compare gut microbiome samples from people with CRPS and their household members. They also aim to pre…

This study tests a digital tool called PREVENT that helps doctors and patients work together to improve heart health. It is for low-income, rural adults with obesity who are at risk for heart disease. The tool shows patient information and suggests personalized goals for healthy …

This study is testing a new whole genome sequencing approach called ChromoSeq for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Researchers want to see if ChromoSeq can find more genetic changes than current standard tests, and if it can be used in…

This study looks at how children aged 9-17 with juvenile idiopathic arthritis experience pain compared to healthy kids. Researchers will measure pain sensitivity using pressure and cold water tests, and collect information through questionnaires and samples. The goal is to uncove…

This study looks at how two FDA-approved flu vaccines—FluMist (a nasal spray) and the standard flu shot—trigger immune responses in healthy adults aged 18 to 40. Researchers will measure antibodies in the blood, nose, and lungs before and after vaccination. Some participants will…

This study aims to learn how blood flow and oxygen use in the brain change as children grow, especially in those with sickle cell disease who are at risk for stroke. Researchers will use MRI scans and have participants breathe in small amounts of carbon dioxide to see how well th…

This study looks at how blood flow and metabolism affect brain development in children with sickle cell anemia. Researchers will use MRI scans and a special mask to have participants breathe carbon dioxide, which helps measure how well brain blood vessels expand. The goal is to u…