Washington University School Of Medicine

This early-stage study tests a personalized DNA vaccine for children and young adults (ages 12-25) whose central nervous system tumors have come back or not responded to treatment. The vaccine is custom-made based on each patient's tumor DNA to train the immune system to attack t…

This early-phase study tests a personalized cancer vaccine for people with bladder or stomach cancer who have tiny bits of tumor DNA still in their blood after surgery. The vaccine is made specifically for each person based on their tumor's unique markers. The goal is to see if i…

This early-phase study tests a new treatment called WS-CART-CS1 for people with multiple myeloma that has come back or not responded to at least three prior therapies. The treatment uses a patient's own immune cells, modified to target the CS1 protein found on myeloma cells. The …

This study compares standard wound care alone to standard care plus a collagen scaffold called Miro3D. The scaffold provides a structure that may help wounds heal better. The trial includes 70 adults with acute soft tissue wounds or chronic pressure ulcers. Researchers will measu…

This study tests if giving a higher dose of radiation directly to the prostate (called HDR brachytherapy) can better control early-stage prostate cancer without causing too many side effects. About 36 men with low- or favorable intermediate-risk prostate cancer will receive one o…

This study is for people with HPV-related throat cancer. After surgery, participants receive lower doses of radiation or chemo based on their risk level. The goal is to see if these gentler treatments can keep the cancer from coming back while causing fewer side effects. About 14…

This study tests if freezing a small, low-risk breast tumor (cryoablation) works as well as standard surgery (lumpectomy) to control the disease. About 120 women with early-stage breast cancer will be randomly assigned to one of the two treatments. The goal is to see if cryoablat…

This study tests whether tofersen, a drug already approved for a specific type of ALS, can help people with ALS who do not have the SOD1 gene mutation. About 30 adults will receive the drug via spinal injections over 24 weeks. Researchers will measure nerve damage markers in bloo…

This early-stage trial tests whether adding siltuximab to standard treatment is safe for lung transplant patients experiencing antibody-mediated rejection, a serious condition that often leads to organ failure. About 30 adults who are hospitalized for this rejection will receive …

This study looks at whether nerve transfer surgery can improve arm function and quality of life in people with high-level cervical spinal cord injuries (tetraplegia). About 30 adults aged 18-80 who have had a spinal cord injury for at least 6 months but less than 5 years will tak…

This study tests whether giving smokers a personalized treatment plan—based on their genes, health history, and other markers—helps them quit better than standard care. About 850 adult smokers and their doctors will take part. The goal is to see if this approach increases the use…

This early-phase study tests whether combining two drugs (ruxolitinib and abatacept) can prevent graft-versus-host disease and cytokine release syndrome in 41 adults receiving a half-matched stem cell transplant for blood cancers. The goal is to reduce dangerous immune reactions …

This study tests whether using a blood pressure cuff at home to briefly restrict blood flow (remote ischemic conditioning) can improve heart and blood vessel health in people with spinal cord injury. Twenty-four adults with SCI who are not physically active will try either a high…

This study tests whether adding choline to a special peanut-based food helps brain development in 1,500 severely malnourished children aged 6 to 59 months in Malawi. Children receive either standard therapeutic food or the same food with extra choline. The goal is to see if choli…

This early-phase trial tests a new drug (CA-4948) combined with standard chemotherapy and immunotherapy for people with untreated stomach, esophageal, or gastroesophageal junction cancer that cannot be removed by surgery. The study includes two groups: one for HER2-negative cance…

This study tests whether giving cancer patients a personalized quit-smoking plan—based on their genes, health history, and lab results—works better than standard care. About 112 patients and their doctors will take part. The goal is to see if more patients use stop-smoking medici…

This study tests a new way to choose pre-surgery treatment for postmenopausal women with stage II/III ER-positive, HER2-negative breast cancer. By using biomarkers, doctors aim to improve response and identify patients who may not need chemotherapy. The trial enrolls 81 participa…

This study tests whether adding the drug epacadostat to standard chemotherapy and radiation before surgery can improve outcomes for people with locally advanced rectal cancer. About 49 adults will take part. The goal is to find the best dose and see if the combination helps shrin…

This study tests whether adding a short course of radiation to the immunotherapy drug pembrolizumab can keep mucosal melanoma from returning after surgery. About 20 adults with this rare head and neck cancer will receive the combination. The goal is to improve local tumor control…

This study is testing whether statins, a common cholesterol-lowering drug, can help people with early blood disorders called CCUS and lower-risk MDS. These conditions can progress to more serious blood cancers or cause heart problems, and there are no approved treatments to impro…

This study tests whether adding two targeted drugs (defactinib and avutometinib) to a precise type of radiation therapy can help people with advanced pancreatic cancer live longer without their cancer growing. About 36 adults with advanced pancreatic cancer that cannot be removed…

This early-phase study tests an oral drug called PMD-026 in 18 adults with myelofibrosis, a rare bone marrow cancer. Participants must have already tried a JAK inhibitor without success. The main goals are to check safety, find the right dose, and measure changes in spleen size a…

This study tests whether adding palbociclib to cetuximab helps people with a specific type of advanced head and neck cancer live longer compared to cetuximab alone. Participants must have a CDKN2A gene change and their cancer must have worsened after prior immunotherapy. About 81…

This early-phase trial tests whether adding the drug emavusertib to standard chemotherapy and immunotherapy can help control advanced bile duct cancer. About 48 adults with untreated, advanced or metastatic biliary tract cancer will receive the combination. The main goal is to ch…

This study tests whether giving the drug DEC-C early can help people with myelodysplastic syndromes (MDS) who still have small amounts of cancer after a stem cell transplant. About 209 participants will be checked for leftover cancer cells using a special blood test. Those with d…

This study tests whether a very-low-carbohydrate (ketogenic) diet can help adults with type 1 diabetes achieve better blood sugar control. Researchers will monitor 58 participants using continuous glucose monitors and measure changes in insulin sensitivity. The goal is to see if …

This study is for premenopausal women with obesity and early-stage endometrial cancer or a precancerous condition. It tests whether adding a behavioral weight loss program to standard hormone therapy can help reverse the disease and allow women to keep their uterus and fertility.…

This study tests whether a very short course of radiation (5 treatments over 1 week) works as well as the standard 3-week course for people with breast cancer that has spread to nearby lymph nodes. The goal is to see if the shorter schedule causes fewer long-term side effects lik…

This study tests whether enasidenib can safely improve blood cell counts in people with clonal cytopenia of undetermined significance (CCUS) who have a specific IDH2 gene mutation. About 15 adults with unexplained low blood counts for at least 6 months will take the drug. The goa…

This study tests whether giving special 'memory-like' natural killer (NK) cells after a stem cell transplant can help control high-risk acute myeloid leukemia (AML) in children and adults. The NK cells come from the same donor as the transplant and are grown in a lab to be strong…

This early-phase study tests whether adding the experimental drug zanzalintinib to two approved immunotherapies (ipilimumab and nivolumab) is safe and effective for people with metastatic soft tissue sarcoma that has worsened after prior treatments. About 18 adults with certain s…

This study tests whether propranolol, a safe oral drug used for heart conditions and infant hemangiomas, can shrink Kaposi sarcoma tumors in adults. About 25 participants will receive propranolol to see if at least 45% respond. The goal is to find an affordable, low-toxicity trea…

This study compares two daily doses (24 mg vs 10 mg) of the drug lenvatinib in people with advanced thyroid cancer that no longer responds to radioactive iodine. The goal is to see if the lower dose causes fewer side effects while still controlling the cancer. About 34 participan…

This study tests a non-invasive device that stimulates a nerve in the ear to help patients in the NeuroICU recover from serious brain or spinal injuries. Researchers want to see if it reduces complications like infections, shortens hospital stays, and lowers medical costs. About …

This early-phase study tests whether the drug selinexor can help keep multiple myeloma under control after CAR-T cell therapy. About 20 adults with high-risk or hard-to-treat myeloma will take selinexor pills after their CAR-T treatment. The goal is to see if this maintenance app…

This study tests a personalized approach for people with newly diagnosed multiple myeloma who have had a stem cell transplant. After transplant, participants receive a drug called elranatamab as maintenance therapy, with the dose and duration guided by a sensitive blood test that…

This study tests a two-drug combination (polatuzumab vedotin plus rituximab) as a first treatment for a rare blood cancer that can occur after an organ or stem cell transplant. About 12 adults who have not had prior therapy will receive the drugs to see if the combo is safe and w…

This pilot study tests two approaches to help pregnant and postpartum people with substance use disorder stay in treatment. One approach screens for social needs like housing and childcare and connects patients to community support. The other offers small rewards for recovery-foc…

This study tests whether a specific chemotherapy combination (thiotepa and carmustine) followed by a stem cell transplant can prevent lymphoma from spreading to the brain in patients with high-risk diffuse large B-cell lymphoma. About 36 newly diagnosed patients who are at high r…

This study looks at whether a home blood pressure monitoring program can improve heart health for women in Nigeria who had high blood pressure during pregnancy. Researchers will work with 1,200 women at four hospitals to see if this approach leads to better blood pressure control…

This study tests whether tirzepatide, a drug used for diabetes, can heal the small bowel in people with Crohn's disease whose inflammation hasn't improved with standard treatments. About 60 adults aged 18-80 with active Crohn's in the ileum will receive the drug and be monitored …

This study looks at whether it is possible and acceptable to start hepatitis C treatment during pregnancy for women who have used drugs in the past or currently. About 50 pregnant adults will take the medication glecaprevir-pibrentasvir and be followed for about a year. The goal …

This early-phase study tests whether a diabetes medicine called dapagliflozin is safe and tolerable when taken for four weeks before prostate removal surgery in men with localized prostate cancer. About 24 men with intermediate- to high-risk prostate cancer will take the drug dai…

This early-phase study tests a new drug, zanzalintinib, combined with standard chemotherapy (paclitaxel) in people whose high-grade uterine or endometrial cancer has come back. The main goal is to find the safest and most effective dose of the combination. Researchers will also m…

This study is testing a procedure called cryoablation, which uses extreme cold to freeze and destroy breast cancer tumors. It is for people who cannot have surgery due to medical reasons or personal choice. Researchers will follow 100 participants to see how safe the freezing tre…

This study tests a new drug, zunsemetinib, combined with the chemotherapy capecitabine in people with a common type of advanced breast cancer (HR+/HER2-) that has spread to the bones. The goal is to see if the combination is safe and can slow cancer growth. About 152 participants…

This study is for children under 21 with severe non-cancerous diseases like sickle cell disease or bone marrow failure. It tests a bone marrow transplant from a partially matched family donor to see if it can control the disease. The goal is to measure how well the donor cells ta…

This study tests whether adding milk fat globule membrane (MFGM) to a standard therapeutic food helps improve brain development and reduces death, hospitalization, or persistent malnutrition in 1,600 children aged 6-59 months with severe acute malnutrition in Sierra Leone. Childr…

This early-phase study tests whether a diabetes drug called dapagliflozin is safe to add to standard treatment for children with brain or solid tumors that have come back or not responded to therapy. About 20 children will take the drug alongside their usual care. The goal is to …

This early-phase trial tests whether adding an experimental drug (MK2 inhibitor) to standard chemotherapy (mFOLFIRINOX) can better control metastatic pancreatic cancer. About 51 adults with untreated advanced disease will participate. The main goal is to find the safest dose and …

This study works with community health centers to help doctors prescribe a guideline-recommended asthma treatment called SMART (Single Maintenance and Reliever Therapy). The program provides training, feedback, and educational tools to clinicians. Researchers will measure if this…

This study looks at whether a simple blood test can help doctors decide if a patient's current treatment is working or if they should switch to a different therapy early. It involves 65 people with a common type of advanced breast cancer (HR+ HER2-). The goal is to improve how lo…

This study tests if a custom mouthpiece (mandibular advancement device) can effectively treat severe obstructive sleep apnea in adults who cannot use a CPAP machine and did not benefit from a nerve stimulation implant. Researchers will measure how well the device reduces breathin…

This early-stage study tests a long-acting immune booster called NT-I7 in 24 people with relapsed or refractory large B-cell lymphoma who have already received CAR T-cell therapy. The goal is to see if NT-I7 can safely help CAR T-cells grow and stay active longer, potentially imp…

This study tests a program to help people aged 55 and older return home safely after a stroke. Half of the 520 participants will get a stroke education program, while the other half will receive help modifying their home environment. The goal is to reduce disability and avoid adm…

This early-phase trial tests whether combining two drugs, zanzalintinib and eribulin, is safe and can help people with advanced liposarcoma or leiomyosarcoma live longer without their cancer growing. About 18 adults whose cancer has worsened after prior treatments will receive th…

This study tests a new way to deliver radiation for locally advanced cervical cancer by giving brachytherapy (internal radiation) earlier and using fewer, larger doses of external radiation. The goal is to see if this shorter schedule reduces long-term bowel and bladder side effe…

This study tests whether adding the drug azeliragon to standard chemoradiotherapy can help the immune system fight glioblastoma, an aggressive brain cancer. About 12 adults with newly diagnosed glioblastoma will receive either standard treatment alone or standard treatment plus a…

This study tests a new drug (TTI-101) combined with targeted radiation for people with pancreatic cancer that cannot be removed by surgery right away. The goal is to see if this combination is safe and helps control the cancer for longer. About 18 adults will take part in this ea…

This study tests an experimental drug called CUE-101 in 30 people with a type of throat cancer caused by HPV16. The drug is given before standard treatments like surgery or chemoradiation to see if it safely boosts the body's immune response against the cancer. Researchers will m…

This study tests whether dapagliflozin, a drug used for diabetes, can slow the progression of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 70 adults aged 50 and older with this condition will take the drug for 12 month…

This early-phase study tests a new treatment for people with advanced melanoma that has stopped responding to standard immunotherapy. It combines specially trained natural killer cells (either from the patient or a donor) with two drugs, nivolumab and relatlimab, to boost the imm…

This early-phase study tests whether a low-dose radiation and chemotherapy combination can safely prepare multiple myeloma patients with kidney problems for CAR T cell therapy (Carvykti). Standard prep often excludes these patients due to kidney risks. The study enrolls 16 adults…

This study tests whether a daily ketone ester drink can reduce liver fat and improve blood sugar control in adolescents and young adults (ages 18-25) with obesity and a fatty liver condition called MASLD. Participants are randomly assigned to drink either a ketone ester or a plac…

This study is testing a less intense stem cell transplant for people with non-cancerous blood, immune, or metabolic disorders. The goal is to see if a milder preparation before transplant helps the donor cells take hold with fewer severe side effects. About 220 participants will …

This study tests whether a sleep aid called lemborexant can reduce levels of amyloid and tau proteins in the blood, which are linked to Alzheimer's disease. Researchers will give the drug or a placebo to 201 healthy adults aged 65 and older. The goal is to see if improving sleep …

This study is testing a new way to do stem cell transplants for children with certain blood cancers. The method uses a special technique to remove certain cells from the donated stem cells, which may lower the risk of complications. Up to 50 children will take part to see if this…

This study tests whether a structured exercise program can improve heart health and body composition in wheelchair users. About 108 adults who use wheelchairs will take part in weekly exercise sessions. The goal is to find safe and effective ways to help wheelchair users get enou…

This study is for people with small cell lung cancer that has returned after initial treatment. It tests a new drug called cirtuvivint added to standard chemotherapy, aiming to shrink tumors and delay cancer growth. About 42 adults will participate to find the best dose and see h…

This study compares two different ways of giving the chemotherapy drug 5-FU to people with advanced head and neck cancer that has already been treated with platinum and immunotherapy. The goal is to see if a shorter, more frequent dosing schedule works better or has fewer side ef…

This study tests a new drug called ONT01 combined with standard chemotherapy (gemcitabine and nab-paclitaxel) for people with metastatic pancreatic cancer that has worsened after initial treatment. The goal is to see if ONT01 can reprogram immune cells in the tumor to make the ch…

This study tests whether taking zanzalintinib after initial chemotherapy can help keep high-grade neuroendocrine tumors from growing or coming back. About 32 adults with this aggressive cancer will receive the drug and be monitored for progression and survival. The goal is to see…

This early-phase study tests whether adding a drug called mosunetuzumab after a stem cell transplant is safe and doable for people with aggressive B cell lymphoma that has come back or not responded to prior treatments. Mosunetuzumab is an engineered antibody that helps the body'…

This study is testing a new endorectal device that combines ultrasound and photoacoustic imaging to better see rectal tumors. The goal is to accurately tell if a patient's cancer has completely responded to pre-surgery treatment, which could help some patients avoid unnecessary s…

This study looks at whether giving women at-home HPV self-test kits can help more people get screened for cervical cancer. Researchers will compare different ways of distributing the kits and track how many people return them and follow up on results. The goal is to find the best…

This study tests a new method called sonobiopsy that uses ultrasound to release DNA from brain tumors into the blood, making it easier to detect without surgery. Researchers will enroll 40 adults with suspected glioblastoma to see if this approach can identify tumor mutations fro…

This study aims to see if a special PET/MRI scan (18F-DOPA) can accurately find small, treatable spots in the pancreas that cause hyperinsulinism—a condition where the body makes too much insulin, leading to dangerously low blood sugar. About 100 patients who have not improved wi…

This study tests whether the sleep medication suvorexant can slow the buildup of amyloid plaques in the brain, a key sign of Alzheimer's disease. Researchers will compare blood and spinal fluid samples from 200 healthy adults aged 65 and older who take either the drug or a placeb…

This study tests a music-inspired program called Music4Health to help prevent high blood pressure and stroke in Nigeria. It involves about 1,400 youth (ages 14-24) and their caregivers (ages 40+). The program uses community-designed music and campaigns to improve blood pressure, …

This study explores whether mindfulness training can help prevent cognitive decline in Latino adults aged 65 and older, a group at higher risk for Alzheimer's disease. Researchers will measure brain activity and thinking skills in 60 participants before and after mindfulness prac…

This study tests a drug called remternetug to see if it can prevent or slow Alzheimer's disease in people who have a genetic mutation that almost guarantees they will develop it. The trial involves 280 adults who do not yet have symptoms. Researchers will use brain scans and spin…

This study tests a program called HARP that helps people with physical disabilities find and remove fall hazards in their homes. Researchers will enroll 80 adults aged 45-64 in St. Louis who have had a disability for at least 5 years and have fallen or feel unsteady. Half will ge…

This study tests whether new drugs can prevent or slow Alzheimer's disease in people who have a gene mutation that almost guarantees they will develop it. About 280 adults with this genetic risk will receive either the study drug or a placebo. The goal is to see if the drugs can …

This study works with over 1,200 young people aged 14-24 in Nigeria to make HIV self-testing and prevention services more available and long-lasting. Researchers will compare standard program delivery with an enhanced version that includes community input and planning. The goal i…

This study compares two ways to help people stop smoking and lower their cancer risk. About 5,000 adults who smoke and get care at participating clinics will be assigned to either a program that uses personalized nudges or standard quit-focused care. The goal is to see which appr…

This study tests a combination program to help adolescent girls and young women (ages 15-24) at high risk of HIV in Uganda start and stick with PrEP, a daily pill that prevents HIV. The program includes HIV education, support from peers who have used PrEP, and financial help like…

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of strong painkillers (opioids) needed after the operation. About 70 adults with broken jaw or midface bones will be randomly assigned to receive either the nerve …

This study tests a new approach to help people with Parkinson's disease who have mild thinking or memory problems. Instead of brain games, participants learn practical strategies from an occupational therapist to handle everyday challenges like remembering tasks or staying focuse…

This early-phase trial tests a special proton radiation technique called GRID for people with large, hard-to-treat tumors that cause symptoms. The goal is to see if this approach is safe and can provide better symptom relief than standard palliative radiation. The study enrolls 2…

This study tests whether rivastigmine, a drug used for Alzheimer's, can help people with delirium caused by anticholinergic poisoning (e.g., from certain medications or plants). About 42 participants aged 10 and older with severe agitation will receive either rivastigmine or a pl…

This study tests whether a low or moderate dose of propofol, a sleep-inducing drug, combined with brief therapy for insomnia can improve deep sleep and reduce depression in adults aged 60 and older. Seventy participants will receive two propofol infusions and several therapy sess…

This study tests whether a specific sequence of position changes can help people with prolonged labor deliver faster and with fewer complications. About 82 participants with slow labor will be randomly assigned to either the position-change circuit or standard care. The goal is t…

This study tests whether the drug fluvoxamine, typically used for depression, can help prevent delirium (sudden confusion) in older adults after non-heart, non-brain surgery. About 46 people will take the drug before and after surgery to see if it reduces risk. The goal is to imp…

This study looks at two treatments for people with moderate-to-severe obstructive sleep apnea who cannot use a CPAP machine. One treatment is a custom mouthpiece that moves the jaw forward, and the other is a small implanted device that stimulates a nerve to keep the airway open.…

This study tests whether taking potassium nitrate (a natural salt similar to compounds in beets) can improve muscle power and exercise ability in people with heart failure. 75 adults with reduced heart function will receive either the supplement or a placebo daily for 6 weeks. Re…

This study looks at whether giving oxytocin (a hormone that helps contractions) during the pushing stage of labor can shorten delivery time and lower the chance of C-sections or other complications. It involves 400 first-time mothers with a single baby who are at least 37 weeks p…

This study compares two phone-delivered programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25–65 years o…

This study tests a new 8-week group program called PEEPS for women aged 18-48 with endometriosis-related chronic pelvic pain. Participants join weekly sessions combining education, peer support, and integrative care. The goal is to see if this approach reduces how much pain inter…

This study tests if exposure to bright blue light can lower inflammation and organ damage in people with serious infections like pneumonia, infected joints, or abdominal infections. 144 adults will be assigned to either blue light or standard hospital light for 3 days. Researcher…

This study tests whether a combination of two nasal sprays (oxymetazoline and a corticosteroid) works better than the steroid spray alone for people with long-term nasal blockage that hasn't improved with standard treatment. About 80 adults who have tried steroid sprays without s…

This study tests a smartphone app called Enhearten designed to reduce self-stigma in pregnant women and new mothers (up to 12 months postpartum) who have a substance use disorder. The app provides real-time support to help them stick with addiction treatment and feel less judged.…

This study is testing whether a combination of social media outreach and a smartphone app can help teens and young adults quit vaping. Participants will be recruited through social media, screened by an online chatbot, and then use a mobile app designed to support vaping cessatio…

This study compares two different skin cuts used during trigger finger surgery to see which one helps patients recover better. About 200 adults with trigger finger will be randomly assigned to get either a straight cut along the finger or a cut across the palm crease. Researchers…

This pilot study tests whether giving the anti-inflammatory drug Ketorolac before placing a ureteral stent can reduce pain and discomfort in kidney stone patients. About 36 adults undergoing stent placement will be randomly assigned to receive the drug or a placebo. The goal is t…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms in pregnant women starting treatment for opioid use disorder. About 40 participants will use the patch during the required withdrawal period before switching to standard under-the-tongue buprenorphine. …

This study looks at how blood flow and metabolism affect brain development in children with sickle cell anemia. Researchers will use MRI scans to measure brain blood vessel function and compare results between children with sickle cell and healthy children. The goal is to underst…

This early-phase study is testing a new imaging agent called [64Cu]-RYM2 to see if it can safely and accurately detect enzyme activity (MMP) in abdominal aortic aneurysms (AAA). Researchers will compare scans from healthy volunteers and AAA patients scheduled for surgery. The goa…

This study looks at whether watching an animated video before DIEP flap breast reconstruction helps patients understand the procedure and feel less anxious. About 300 adults scheduled for surgery will take surveys before and after watching the video, and again after recovery. The…

This study looks at how electroconvulsive therapy (ECT) changes sleep patterns and brain communication in people with depression that hasn't improved with other treatments. Researchers will measure brain activity during sleep and wakefulness in 50 participants. The goal is to und…

This study aims to find better ways to measure myofascial pain, a common type of muscle pain. Researchers will use MRI and other imaging tools to look at muscle tissue in 100 adults with neck or shoulder pain. The goal is to identify imaging markers that can track how well treatm…

This study is testing whether a mild electrical stimulation of a nerve in the ear can reduce brain injury and inflammation after a stroke caused by a blocked large artery. Researchers will measure markers of brain damage and inflammation in the blood of 65 participants. The goal …

This study looks at whether giving mothers extra oxygen during labor when the baby's heart rate is concerning actually improves baby health. About 2,100 women with full-term, single-baby pregnancies will be randomly assigned to receive either oxygen or regular room air. The goal …

This study is testing a digital tool called PREVENT that helps doctors and patients work together to improve heart health. It is for low-income, rural patients with obesity who are at risk for heart disease. The tool shows patient information and suggests personalized goals for h…

This study looks at how spinal cord stimulation combined with training can change nerve pathways in people with spinal cord injuries. Researchers will measure brain-to-muscle signals and reaction times in 120 participants to understand improvements in movement. The goal is to lea…

This study tests a new tool called 'Let's Get REAL' that helps children and teens with serious blood disorders or cancers take part in decisions about their stem cell transplant or cellular therapy. About 60 youth aged 8-17 and their parents will try the tool and report if it is …

This study looks at two different training programs for doctors and health workers at community health centers. The goal is to see which training helps patients lose weight better and get more people to use weight management services. About 6,200 adults and youth on Medicaid will…

This study aims to understand how the tumor's surroundings change during chemoradiotherapy for locally advanced cervical or pancreatic cancer. Researchers will collect tissue samples, blood, and imaging data from 60 participants before, during, and after treatment. The goal is to…

This study compares a continuous heart-monitoring patch with standard electrocardiograms (ECGs) in 60 adults receiving drugs that can cause dangerous heart rhythms. Participants have leukemia or solid tumors and are starting medications like arsenic trioxide, capecitabine, or rib…

This study follows 700 adults who carry a gene mutation for early-onset Alzheimer's. Researchers use blood tests, spinal taps, brain scans, and memory tests to find early warning signs. The goal is to predict who will develop Alzheimer's, not to test a treatment.

This study tests a new electronic health record tool called Cancer Care Companion for parents of children recently diagnosed with cancer. The tool helps parents track and share medical information with their care team. Researchers want to see if parents find the tool useful and e…

This study looks at how social media use and feelings of rejection affect the mental health of girls aged 10-11. Researchers will track 250 girls over time to see how puberty and social media experiences influence each other. The goal is to better understand these connections, no…

This study tests a computer system that helps doctors decide which surgery patients need blood prepared before their operation. The goal is to make sure blood is ready for those who need it, while avoiding unnecessary preparation that wastes blood and money. About 50 patients hav…

This study tests whether a wellness program is practical and helpful for older Black patients who feel depressed or anxious before surgery. Researchers will enroll 50 people aged 60 and older who are scheduled for surgery at certain hospitals. The goal is to see if patients join …

This study looks at how proton beam radiation affects thinking and learning in children with brain tumors. Researchers will test memory and other mental skills before treatment and then yearly for up to five years. The goal is to understand how factors like age and tumor location…

This study looks at why some inflammation in the brain stays active even after treatment for relapsing-remitting multiple sclerosis. Researchers will use brain scans and spinal fluid tests to compare different types of inflammation. The goal is to better understand the disease, n…

This study tests whether an AI tool can create a personalized list of questions for people with lymphoma or multiple myeloma to ask during their doctor appointments. About 40 participants will use the AI-generated list before a follow-up visit, and researchers will measure how co…

This study tests a new tool called HPARSS that helps doctors identify childhood cancer survivors at risk for hearing and vision problems from past treatments. About 146 children aged 7-17 who finished cancer therapy 6 months to 2 years ago will take part. The goal is to make sure…

This study looks at how the immune system responds to flu and COVID-19 infections. Researchers will collect blood, saliva, and nasal samples from 300 people over 6 months to track antibody levels. Some participants may also have a lung wash procedure. The goal is to understand ho…

This study looks at how the FluMist nasal spray vaccine and the standard flu shot trigger immune responses in the nose, blood, and lungs. About 30 healthy adults aged 18-40 will receive one of the two FDA-approved flu vaccines. Researchers will measure antibodies before and 14 da…

This study is for people with spinal cord injury who have some movement in their legs. Researchers are testing a non-invasive method to stimulate the spinal cord through the skin, using different settings to better target specific muscles. The goal is to improve how well people c…

This study looks at whether a campaign called Pink & Pearl can help more women who are at risk for lung cancer get screened. About 5,500 women getting mammograms at Christian Hospital will be part of the campaign, which provides information and nurse support to encourage lung can…

This study looks at why some people with Parkinson's disease develop dementia. Researchers will use brain scans, memory tests, and spinal fluid analysis in 320 participants to find different types of dementia. The goal is to identify those at risk and understand the underlying ca…

This study looks at 86 pregnant people whose water breaks before 37 weeks (PPROM). It compares two ways doctors check the cervix: a digital exam (using a gloved finger) versus a speculum exam. The goal is to see if one method leads to a longer time before delivery and fewer infec…

This study aims to see if proteins in the blood can predict who will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 older adults, some with mild forgetfulness or dementia, and track their cognitive health over time. The goal is to develop and valida…

This study tests whether adding exercise to a common weight-loss medication helps preserve muscle mass and physical function in people with obesity. Forty participants will be followed for two years, including after stopping the drug. The goal is to understand the best way to mai…

This study is testing a blood test that looks for tiny bits of cancer DNA (called ctDNA) to find if a tumor is coming back earlier than usual scans. Researchers will follow 100 people with various cancers, plus healthy volunteers, to see if the test helps predict cancer growth or…

This study looks at how children aged 9 to 17 with juvenile arthritis experience pain. Researchers will use heat, cold, and pressure tests along with questionnaires to measure pain sensitivity. They will also collect saliva, blood, or joint fluid samples to study immune and hormo…

This study looks at how massage affects brain connections in newborns. Researchers will give daily massages to half of the 80 babies in the study and compare their brain scans to those who did not receive massage. The goal is to see if massage changes how different parts of the b…

This study uses MRI brain scans to investigate a newly discovered brain network, called SCAN, in people with Parkinson's disease and healthy volunteers. Researchers want to see if this network is disrupted in Parkinson's and how it connects to brain areas affected by the disease.…

This study tests a new radioactive tracer called [18F]-FZTA to see if it can detect inflammation in the brain using a PET scan. Researchers will compare brain scans of 80 healthy adults and people with Multiple Sclerosis. The goal is to better understand inflammation in MS, not t…

This study looks at whether a special campaign called Pink & Pearl can encourage more women who are getting mammograms to also get screened for lung cancer. About 279 women aged 50-80 who smoke or used to smoke will take part. Researchers will track how many women complete the lu…

This study is testing a special dye (called a radiotracer) that can be seen on a PET scan. The dye sticks to certain inflammatory cells in the lungs. Researchers want to see if this dye can help them spot and measure inflammation in people with lung diseases like fibrosis. About …

This study uses a special PET-MR scan to look at plaque buildup in the neck arteries of 80 people who have narrowing but no symptoms. The goal is to see if the scan can predict who is at higher risk for a stroke or mini-stroke. Participants will be followed for up to 18 months to…

This study aims to improve a mobile app called Wysa for Chronic Pain by testing different types of in-app notifications. Researchers want to see which notifications help people aged 45 and older with chronic pain, depression, or anxiety use the app more. Participants will use the…

This pilot study tests a caregiver-reported suicide-risk screener for children ages 4-7 in a behavioral health center. Researchers will ask clinicians and caregivers for feedback to see if the screener is practical and helpful. The goal is to catch suicidal thoughts early in youn…

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake and aware while paralyzed on a breathing machine in the emergency department. About 3,090 adults on ventilators will…

This study looks at genetic markers on breast cancer cells before and after chemotherapy. Researchers want to see how these markers change and whether they can predict if the cancer will come back. About 300 adults with stage II–IV breast cancer will take part. The goal is to bet…

This study looks at whether a new whole genome test called ChromoSeq can find genetic changes in people with myelodysplastic syndrome (MDS) as well as current standard tests. About 60 adults with MDS or suspected MDS will take part. The goal is to see if ChromoSeq is reliable and…

This study looks at how brain tumors and their treatments affect thinking skills in children aged 4 to 18. Researchers will use brain scans and thinking tests to find early signs of future cognitive problems. The goal is to better predict which children may need extra support aft…

This study tests whether a 16-week text-messaging program can help people with spinal cord injury better manage secondary health issues like pain, bladder problems, and emotional distress. About 40 adults with spinal cord injury will receive health tips via text and complete surv…

This study looks at how blood flow and oxygen use in the brain change as children grow, especially in those with sickle cell disease or at risk of stroke. Researchers will use MRI scans and sometimes a special mask to measure how well blood vessels expand. The goal is to learn wh…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial help resources. Researchers want to see if using the tool reduces financial stress and helps patients feel more confident talking about…

This study looks at whether the types of bacteria living in your gut are linked to the severity and recovery of Complex Regional Pain Syndrome (CRPS), a chronic pain condition. Researchers will compare stool samples from 140 adults with CRPS and their household members. No treatm…

This early study tests whether the oral drug DSP-0390 can reach brain tumor tissue in people with IDH-mutant glioma who are scheduled for surgery. About 20 participants will take the drug for two weeks before their tumor is removed, and blood samples will be taken to measure drug…

This study looks at how tiny changes in blood cells, called clonal hematopoiesis, relate to aging and heart disease in people 50 and older. Researchers will check for these mutations in 2,000 adults and follow them over time to see if they raise the risk of blood cancer, heart pr…

This study creates a worldwide database for people with malignant peripheral nerve sheath tumors (MPNST), a rare cancer often linked to the genetic condition neurofibromatosis type 1. Researchers will collect medical records, tumor samples, and genetic data from over 1,000 partic…

This study looks at whether a blood test called DiviTum, which measures a protein linked to cancer growth, can help doctors decide if they can safely delay routine scans for people with advanced breast cancer. About 55 patients starting standard treatment will be followed. The go…

This study builds a worldwide registry for people with Wolfram syndrome, a rare genetic disorder causing diabetes, vision loss, and hearing problems. Researchers will collect health information and blood samples from up to 5,000 participants to track how the disease progresses ov…

This study looks at why very low-carb (ketogenic) diets can cause high cholesterol in some normal-weight adults. Researchers will enroll 100 healthy people, identify those whose cholesterol spikes on the diet, and measure how their bodies make and remove cholesterol-carrying part…

This study looks at different types of parathyroid tumors in people with hyperparathyroidism (high calcium levels). Researchers will analyze tumor samples from 839 patients to see how tumor type relates to disease severity and surgical outcomes. The goal is to better understand t…

This study is testing a new 3D imaging device called SkinScan3D to see if it can take better pictures of Kaposi sarcoma skin lesions than standard 2D photos. The goal is to measure the height and volume of lesions, which may help doctors detect treatment response earlier. About 3…

This study looks at whether giving children in Ghana a daily peanut-based school meal can improve school attendance and reduce dropouts. About 6,700 kids aged 5 to 17 will take part. One group gets the peanut meal, while the other gets a local rice or millet flour meal, and resea…

This study looks at whether a new whole genome sequencing test called ChromoSeq can find more genetic changes in people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) than current tests. Researchers will compare ChromoSeq results with standard genetic testing…

This study follows 117 teenagers ages 12-17 who are overweight or at risk for type 2 diabetes. Researchers use brain scans and thinking tests to see how obesity, insulin resistance, and blood sugar changes affect brain structure and memory over time. The goal is to understand whi…

This study looks at inflammation in brain tumors using a special PET scan called [C-11]-CS1P1. About 104 adults with brain cancer that hasn't been treated with radiation will get two scans over two years. Researchers want to see how inflammation patterns relate to MRI results, tr…

This study explores how nitrous oxide (laughing gas) changes brain connections related to emotion and depression. About 50 people—half with treatment-resistant depression and half healthy—will inhale the gas or a placebo and get brain scans. The goal is to understand how the drug…