Laughing gas may reveal new clues about Tough-to-Treat depression

NCT ID NCT02994433

First seen May 03, 2026 · Last updated May 03, 2026

Summary

This study looks at how nitrous oxide (laughing gas) changes brain connections in people with treatment-resistant depression compared to healthy volunteers. About 60 adults will have brain scans before and after breathing nitrous oxide or a placebo. The goal is to understand which brain circuits are involved, not to test a new treatment.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DEPRESSIVE DISORDER, MAJOR are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.