DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Clinical trials for DEPRESSIVE DISORDER, TREATMENT-RESISTANT explained in plain language.
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Helmet vs coil: which brain zaps beat stubborn depression?
Symptom relief Recruiting nowThis study tests two non-invasive brain stimulation methods for people with depression that hasn't improved with medication. 152 adults will receive either standard rTMS (using a figure-8 coil) or deep rTMS (using a helmet-like coil) for 20 sessions over 4 weeks. Researchers will…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: Centre Hospitalier Henri Laborit • Aim: Symptom relief
Last updated Jun 16, 2026 22:22 UTC
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New nasal spray offers hope for Treatment-Resistant depression
Symptom relief Recruiting nowThis study tests whether esketamine nasal spray can reduce depression symptoms in Korean adults whose depression has not improved with other treatments. About 47 participants will receive the spray and be monitored for 4 weeks. The main goal is to see if their depression scores i…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE4 • Sponsor: Janssen Korea, Ltd., Korea • Aim: Symptom relief
Last updated Jun 16, 2026 12:51 UTC
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New hope for Treatment-Resistant depression: Fast-Acting drug trial launches
Symptom relief Recruiting nowThis study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: National Institute of Mental Health (NIMH) • Aim: Symptom relief
Last updated Jun 15, 2026 19:04 UTC
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Can faster brain zaps beat daily sessions for Late-Life depression?
Symptom relief Recruiting nowThis study tests whether giving multiple brain stimulation sessions each day works better than one daily session for treating depression in people aged 60 and older. All 280 participants will receive active treatment, but some get an accelerated schedule and others get the standa…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Symptom relief
Last updated Jun 12, 2026 12:06 UTC
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Texts and brain zaps: new combo targets tough depression
Symptom relief Recruiting nowThis study tests whether adding a text-message support program (Text4Support) to standard repetitive transcranial magnetic stimulation (rTMS) therapy improves outcomes for people with treatment-resistant depression. About 200 adults who have not responded to at least two antidepr…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 11, 2026 12:10 UTC
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New hope for tough depression? drug trial targets Non-Responders
Symptom relief Recruiting nowThis study tests a new medicine called ACP-211 in 153 adults with major depression who didn't get better with at least two antidepressants. The goal is to see if ACP-211 reduces depression symptoms more than a placebo over 28 days. Participants must be 18-65 and currently on a st…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: ACADIA Pharmaceuticals Inc. • Aim: Symptom relief
Last updated Jun 08, 2026 13:13 UTC
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Ketamine's brain chemistry trick may lift depression fast
Symptom relief Recruiting nowThis study tests whether a single dose of intravenous ketamine can rapidly reduce symptoms in adults with treatment-resistant depression. Researchers will measure changes in key brain chemicals (GABA and glutamate) using brain scans and blood tests. 30 participants will receive e…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 01, 2026 18:07 UTC
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Laughing gas scans could unlock depression secrets
Knowledge-focused Recruiting nowThis study looks at how nitrous oxide (laughing gas) changes brain connections in people with hard-to-treat depression compared to healthy volunteers. About 50 participants will get either the gas or a placebo and have their brains scanned with MRI. The goal is to understand how …
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE1 • Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 11, 2026 12:09 UTC