DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Clinical trials for DEPRESSIVE DISORDER, TREATMENT-RESISTANT explained in plain language.
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New hope for hard-to-treat depression? fast-acting drug HNK enters human trial
Symptom relief Recruiting nowThis study tests whether a drug called HNK can quickly improve symptoms in people with major depression that hasn't gotten better with standard treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depres…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: National Institute of Mental Health (NIMH) • Aim: Symptom relief
Last updated May 01, 2026 15:59 UTC
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New nasal spray offers hope for Treatment-Resistant depression
Symptom relief Recruiting nowThis study is testing whether esketamine nasal spray can help Korean adults whose depression has not improved with other treatments. About 47 participants will receive the spray and be monitored for 4 weeks to see if their depressive symptoms get better. The goal is to find a new…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE4 • Sponsor: Janssen Korea, Ltd., Korea • Aim: Symptom relief
Last updated May 01, 2026 15:58 UTC
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New Helmet-Style brain zaps may beat standard coil for stubborn depression
Symptom relief Recruiting nowThis study tests whether a deep brain stimulation method (using a helmet-like coil) works better than the standard figure-eight coil for people whose depression hasn't improved with medication. About 152 adults will receive 20 sessions over 4 weeks, with follow-up visits at 30, 6…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: Centre Hospitalier Henri Laborit • Aim: Symptom relief
Last updated May 01, 2026 15:57 UTC
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Text messages boost brain therapy for stubborn depression?
Symptom relief Recruiting nowThis study looks at whether adding a text-message support program (Text4Support) to standard brain stimulation therapy (rTMS) can improve symptoms in people with treatment-resistant depression. About 200 adults who have not gotten better with at least two antidepressants will be …
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Apr 30, 2026 15:49 UTC
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Can faster brain zaps beat daily sessions for Late-Life depression?
Symptom relief Recruiting nowThis study tests whether giving multiple brain stimulation treatments each day (accelerated) works better than one daily session for depression in people aged 60 and older. All 280 participants will receive active treatment, but some get the accelerated schedule and others the st…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Symptom relief
Last updated Apr 29, 2026 15:15 UTC