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Can faster brain zaps beat depression in seniors?

NCT ID NCT06854367

Recruiting now Symptom relief Sponsor: Centre for Addiction and Mental Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving multiple sessions of magnetic brain stimulation each day works better than the usual one-session-per-day approach for treating depression in people aged 60 and older. About 280 participants will receive active treatment, with some getting the accelerated schedule and others the standard schedule. The goal is to see which method improves mood more quickly and effectively.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
theta burst stimulation (a type of magnetic brain stimulation)
What this could lead to
If it works, this could point toward a faster, more effective treatment for depression in older adults.
What could go wrong
This is an early-stage comparison study, not a final test. The accelerated schedule may not be more effective, and some people may not respond or may experience discomfort from the stimulation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

depressive disorder Depressive Disorder, Treatment-Resistant major depressive disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION - MAJOR DEPRESSIVE DISORDER DEPRESSIVE DISORDER, TREATMENT-RESISTANT LATE LIFE DEPRESSION (LLD) MOOD DISORDERS

Contacts and locations

Locations

  • Centre for Addiction and Mental Healh

    RECRUITING

    Toronto, Ontario, M6J 1H1, Canada

  • Sunnybrook Health Sciences Centre

    RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

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