One-Day brain zaps: a new hope for stubborn depression?

This trial tests whether a single day of accelerated transcranial magnetic stimulation (TMS) can reduce depressive symptoms in adults with treatment-resistant depression. Participants are randomly assigned to receive one of two active TMS protocols—targeting the precuneus or the left dorsolateral prefrontal cortex—or a sham (inactive) treatment. The study compares changes in depression scores over four weeks to see if either active approach outperforms the placebo-like sham.