DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Clinical trials for DEPRESSIVE DISORDER, TREATMENT-RESISTANT explained in plain language.
Never miss a new study
Get alerted when new DEPRESSIVE DISORDER, TREATMENT-RESISTANT trials appear
Sign up with your email to follow new studies for DEPRESSIVE DISORDER, TREATMENT-RESISTANT, keep track of the ones that matter, and come back to a personal dashboard instead of checking manually.
By submitting, you agree to our Terms of use
-
New nasal spray could help those with stubborn depression
Disease control Recruiting nowThis study tests esketamine nasal spray in 47 Korean adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants will use the spray themselves twice a week for 4 weeks. The main goal is to see if depressive symptoms improve, me…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE4 • Sponsor: Janssen Korea, Ltd., Korea • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
-
New hope for Treatment-Resistant depression: Fast-Acting drug trial launches
Symptom relief Recruiting nowThis study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: National Institute of Mental Health (NIMH) • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
-
New hope for tough depression? drug trial targets Non-Responders
Symptom relief Recruiting nowThis study tests a new medicine called ACP-211 in adults with major depression who haven't gotten better with standard antidepressants. About 153 people will receive either the drug or a placebo for 28 days. The main goal is to see if ACP-211 reduces depression symptoms more than…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: ACADIA Pharmaceuticals Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 13:05 UTC
-
Texts and brain zaps: new combo for tough depression?
Symptom relief Recruiting nowThis study tests whether adding a supportive text-messaging program (Text4Support) to repetitive transcranial magnetic stimulation (rTMS) improves depression symptoms more than rTMS alone. About 200 adults with treatment-resistant depression will be randomly assigned to one of tw…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
-
Can faster brain zaps beat depression in seniors?
Symptom relief Recruiting nowThis study tests whether giving multiple sessions of magnetic brain stimulation each day works better than the usual one-session-per-day approach for treating depression in people aged 60 and older. About 280 participants will receive active treatment, with some getting the accel…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
-
New Helmet-Style brain stimulation may beat standard treatment for resistant depression
Symptom relief Recruiting nowThis study tests whether a newer 'deep' magnetic stimulation helmet works better than the standard coil for people with depression that hasn't improved with medication. 152 adults will receive 20 sessions over 4 weeks and be followed for 90 days. The goal is to see which method r…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: Centre Hospitalier Henri Laborit • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
-
Laughing gas scans could unlock depression secrets
Knowledge-focused Recruiting nowThis study looks at how nitrous oxide (laughing gas) changes brain connections in people with hard-to-treat depression compared to healthy volunteers. About 50 participants will get either the gas or a placebo and have their brains scanned with MRI. The goal is to understand how …
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE1 • Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
-
Ketamine study probes brain chemistry for depression clues
Knowledge-focused Recruiting nowThis study tests how a single dose of intravenous ketamine changes brain chemicals like GABA and glutamate in people with treatment-resistant depression. Thirty adults will receive either ketamine or a placebo, and researchers will measure brain activity and depression symptoms. …
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC