DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Clinical trials for DEPRESSIVE DISORDER, TREATMENT-RESISTANT explained in plain language.
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New hope for depression that Won't respond to current medications
Disease control Recruiting nowThis study is testing whether an experimental medication called ACP-211 can help adults with major depressive disorder who haven't gotten better with standard antidepressant treatments. Researchers will compare ACP-211 against a placebo (inactive pill) to see if it reduces depres…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: ACADIA Pharmaceuticals Inc. • Aim: Disease control
Last updated Apr 22, 2026 15:58 UTC
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Can faster brain zaps beat daily therapy for late-life depression?
Symptom relief Recruiting nowThis study tests whether giving multiple brain stimulation sessions per day works better than one session per day for treating depression in people aged 60 and older. About 280 participants will receive active treatment, but some get the accelerated version and some get the stand…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Symptom relief
Last updated May 17, 2026 00:31 UTC
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New drug HNK shows promise for Treatment-Resistant depression in early trial
Symptom relief Recruiting nowThis study tests a new drug called (2R,6R)-HNK to see if it can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with thei…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: National Institute of Mental Health (NIMH) • Aim: Symptom relief
Last updated May 15, 2026 12:07 UTC
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Text messages boost brain therapy for stubborn depression?
Symptom relief Recruiting nowThis study looks at whether adding a text-message support program (Text4Support) to repetitive transcranial magnetic stimulation (rTMS) helps people with treatment-resistant depression more than rTMS alone. About 200 adults who have not gotten better with at least two antidepress…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: University of Alberta • Aim: Symptom relief
Last updated May 15, 2026 11:56 UTC
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New study tests helmet vs. coil for stubborn depression
Symptom relief Recruiting nowThis study compares two non-invasive brain stimulation methods—standard rTMS (using a figure-8 coil) and deep rTMS (using an H-shaped helmet)—to see which works better for people with treatment-resistant depression. About 152 adults will receive 20 sessions over 4 weeks, plus fol…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: Centre Hospitalier Henri Laborit • Aim: Symptom relief
Last updated May 12, 2026 13:43 UTC
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New nasal spray offers hope for Treatment-Resistant depression
Symptom relief Recruiting nowThis study tests how well esketamine nasal spray works for Korean adults with depression that hasn't improved with other treatments. About 47 participants will use the spray and be monitored for 4 weeks. The main goal is to see if their depression symptoms get better, as measured…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE4 • Sponsor: Janssen Korea, Ltd., Korea • Aim: Symptom relief
Last updated May 12, 2026 13:43 UTC
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Ketamine shows promise for Hard-to-Treat depression in new brain study
Symptom relief Recruiting nowThis study tests whether a single dose of intravenous ketamine can rapidly reduce depression symptoms in 30 adults with treatment-resistant depression. Researchers will measure changes in key brain chemicals (GABA and glutamate) using brain scans and blood tests. The goal is to u…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated May 05, 2026 11:55 UTC