Texts and brain zaps: new combo for tough depression?
NCT ID NCT05570344
First seen Apr 26, 2026 · Last updated Jun 19, 2026 · Updated 10 times
Summary
This study tests whether adding a supportive text-messaging program (Text4Support) to repetitive transcranial magnetic stimulation (rTMS) improves depression symptoms more than rTMS alone. About 200 adults with treatment-resistant depression will be randomly assigned to one of two groups. The trial lasts 6 weeks of active treatment, with follow-ups at 1, 3, and 6 months.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Edmonton Mental Health Clinic
RECRUITINGEdmonton, Alberta, T6R 3P5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nova Scotia Health - Abbie J. Lane Memorial Building QEII Health Sciences Centre
RECRUITINGHalifax, Nova Scotia, B3H 2E2, Canada
Contact Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Repetitive transcranial magnetic stimulation (rTMS) and Text4Support (supportive text messages)
What this could lead to
If it works, this could point toward a more effective, low-cost way to ease depression symptoms in people who haven't responded to standard treatments.
What could go wrong
This is a small, early pilot trial, so results may not apply widely. Adding text messages may not provide extra benefit over rTMS alone, and the study is not designed to prove long-term effectiveness.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.