Better brain zaps: new study tests precision targeting for depression treatment

NCT ID NCT03851380

Completed Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This study tests whether using MRI to guide transcranial magnetic stimulation (TMS) works better than the usual scalp-based method for treating depression. It involves 54 participants, including those with treatment-resistant depression and others with COVID-related distress. The goal is to improve targeting accuracy and measure changes in quality of life and functioning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES)
What this could lead to: If successful, this could make TMS therapy more effective for depression by improving how doctors target the right brain areas.
What could go wrong: This is a small, early-stage study focused on targeting accuracy, not a large trial testing a new treatment. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

combat disorder Depression depressive disorder Depressive Disorder, Treatment-Resistant major depressive disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID STRESS DEPRESSION DEPRESSIVE DISORDER, TREATMENT-RESISTANT PTSD - POST TRAUMATIC STRESS DISORDER

Contacts and locations

Locations

VA Palo Alto Health Care System, Palo Alto, CA

Palo Alto, California, 94304-1207, United States

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