DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Clinical trials for DEPRESSIVE DISORDER, TREATMENT-RESISTANT explained in plain language.
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Can a Parkinson's drug boost brain function in depressed seniors?
Disease control CompletedThis study tested whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers gave 79 participants either levodopa or a placebo for three weeks. The goal was to see if boosting dopamine could he…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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Better brain zaps: new study tests precision targeting for depression treatment
Disease control CompletedThis study tests whether using MRI to guide transcranial magnetic stimulation (TMS) works better than the usual scalp-based method for treating depression. It involves 54 participants, including those with treatment-resistant depression and others with COVID-related distress. The…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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New nasal spray could help those with stubborn depression
Disease control CompletedThis study tests esketamine nasal spray in 47 Korean adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants will use the spray themselves twice a week for 4 weeks. The main goal is to see if depressive symptoms improve, me…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE4 • Sponsor: Janssen Korea, Ltd., Korea • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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Experimental depression drug aims to help when standard meds fail
Disease control CompletedThis study tests whether a new drug called AVP-786 can help people with major depressive disorder who have not gotten enough relief from standard antidepressants. Participants take AVP-786 or a placebo alongside their current antidepressant for 10 weeks. The main goal is to see i…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc. • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC