Can the immune system hold the key to treating resistant mental illness?

This study is looking for biological markers in the body that might predict how well people with treatment-resistant psychiatric disorders—like schizophrenia, depression, bipolar disorder, OCD, and catatonia—respond to new treatments. Researchers will collect blood, stool, cerebrospinal fluid, and skin samples from 700 participants, along with symptom assessments, to see if inflammation or other immune signals are linked to treatment outcomes. The goal is to pave the way for more personalized and effective treatments for people who haven't found relief with standard therapies.