OBSESSIVE COMPULSIVE DISORDER (OCD)

This study tests whether deep brain stimulation (DBS) can help people with severe obsessive-compulsive disorder (OCD) who have not gotten better with medication or therapy. DBS uses a device implanted in the brain to send electrical pulses to areas linked to mood and anxiety. The…

This study tests whether a lifestyle program can help people with obsessive-compulsive disorder (OCD) become more active and lower their risk for heart disease and diabetes. Researchers will enroll 108 adults with OCD who are not very active. Participants will either receive the …

This study tests whether delivering cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 participants will be randomly assigned to one of three delivery methods. The goal is to find ways to make…

This study compares two ways to help adults with obsessive-compulsive disorder (OCD) find and keep jobs. All 40 participants will receive up to 12 sessions of a proven OCD therapy called exposure and response prevention. Half will also get extra job coaching (Individual Placement…

This study tests if a type of talk therapy called acceptance and commitment therapy (ACT) can help people with religiously focused obsessive-compulsive disorder (OCD). Ten adults will receive the therapy and report changes in their symptoms. The goal is to see if ACT reduces dist…

This study tests a new, non-invasive brain stimulation method called temporal interference (TI) to see if it can reduce obsessive-compulsive symptoms in people with OCD. 18 adults with moderate-to-severe OCD will receive the stimulation, and researchers will use brain scans to un…

This study tests whether a type of talk therapy called Exposure and Response Prevention (ERP) can improve daily functioning and quality of life in veterans with obsessive-compulsive disorder (OCD). About 160 veterans, half of whom also have PTSD, will receive either ERP or a cont…

This study tests a stepped care model for treating anxiety in children and teens aged 7-17. It starts with a low-intensity, parent-focused therapy and offers more intensive treatment only if needed. The goal is to make effective care more accessible and affordable for families in…

This study tests whether a quick, 5-day course of brain stimulation (called accelerated TMS) can reduce OCD symptoms in adults. Twenty participants will receive six sessions per day, targeting a specific brain area linked to OCD. Researchers will check symptom changes and side ef…

This study looks at how the brains of people with Obsessive-Compulsive Disorder (OCD) process fear and safety signals. Researchers will use brain scans and mild electrical stimulation to see if they can improve the brain's ability to unlearn fear. The goal is to better understand…

This study aims to find genetic markers that can predict which children and youth (ages 6-24) with depression, anxiety, or OCD may experience behavioral activation—a side effect like agitation or restlessness—when taking SSRI antidepressants. Researchers will analyze DNA from 160…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…

This study is collecting health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to better understand these illnesses and help…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers use brain scans, computer tasks, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to predict…

This pilot study tests whether low-intensity focused ultrasound can safely affect OCD symptoms. Ten adults with chronic OCD will receive single sessions of ultrasound to specific brain areas. Researchers will measure changes in symptom intensity and brain imaging to see if this a…