Sound waves aimed at brain may ease OCD

NCT ID NCT07558148

Recruiting now Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This pilot study tests whether low-intensity focused ultrasound (LIFU) can safely target brain areas linked to obsessive-compulsive disorder (OCD). Ten adults with chronic OCD will receive single sessions of ultrasound to up to three brain regions. Researchers will measure changes in symptoms and brain activity using scans and surveys. This is an early safety and feasibility study, not a treatment trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-intensity focused ultrasound (LIFU)
What this could lead to: If successful, this could help identify brain targets for future non-invasive OCD treatments.
What could go wrong: This is a very small, early pilot study with only 10 participants. It is not designed to test treatment effectiveness, only safety and target engagement. Results may not lead to a therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSESSIVE COMPULSIVE DISORDER (OCD)

Contacts and locations

Locations

University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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