Can a simple therapy ease OCD in veterans? new trial aims to find out

NCT ID NCT05240924

Recruiting now Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a type of talk therapy called Exposure and Response Prevention (ERP) can improve daily functioning and quality of life in veterans with obsessive-compulsive disorder (OCD). About half of the 160 participants also have post-traumatic stress disorder (PTSD). The therapy involves 8-16 sessions where veterans learn to face their fears without performing compulsive rituals. The goal is to see if ERP works better than usual care for this group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Exposure and Response Prevention (ERP) therapy
What this could lead to: If successful, this could provide an effective, evidence-based therapy option for veterans with OCD, including those who also have PTSD.
What could go wrong: This is a relatively small trial (160 participants) and the therapy may not work for everyone. It is also limited to veterans in specific VA settings, so results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Compulsive Behavior obsessive-compulsive disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMORBID POST-TRAUMATIC STRESS DISORDER AND OCD OBSESSIVE COMPULSIVE DISORDER (OCD)

Contacts and locations

Locations

Asheville VA Medical Center, Asheville, NC
RECRUITING

Asheville, North Carolina, 28805-2576, United States
Durham VA Medical Center, Durham, NC
RECRUITING

Durham, North Carolina, 27705-3875, United States
East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
RECRUITING

East Orange, New Jersey, 07018, United States
Fayetteville VA Medical Center, Fayetteville, NC
RECRUITING

Fayetteville, North Carolina, 28301-3856, United States
Hampton VA Medical Center, Hampton, VA
RECRUITING

Hampton, Virginia, 23667, United States
Hunter Holmes McGuire VA Medical Center, Richmond, VA
RECRUITING

Richmond, Virginia, 23249-0001, United States
James J. Peters VA Medical Center, Bronx, NY
RECRUITING

The Bronx, New York, 10468-3904, United States
Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WA
RECRUITING

Walla Walla, Washington, 99362-3975, United States
Michael E. DeBakey VA Medical Center, Houston, TX
RECRUITING

Houston, Texas, 77030-4211, United States
Michael E. DeBakey VA Medical Center, Houston, TX
RECRUITING

Houston, Texas, 77030-4211, United States
Northport VA Medical Center, Northport, NY
RECRUITING

Northport, New York, 11768-2200, United States
Ralph H. Johnson VA Medical Center, Charleston, SC
RECRUITING

Charleston, South Carolina, 29401-5703, United States
Salem VA Medical Center, Salem, VA
RECRUITING

Salem, Virginia, 24153-6404, United States
Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC
RECRUITING

Salisbury, North Carolina, 28144, United States
Spokane VA Medical Center, Spokane, WA
RECRUITING

Spokane, Washington, 99205-6185, United States
VA NY Harbor Healthcare System, New York, NY
RECRUITING

New York, New York, 10010-5011, United States
VA Roseburg Healthcare System, Roseburg, OR
RECRUITING

Roseburg, Oregon, 97471, United States
VA Southern Oregon Rehabilitation Center and Clinics, White City, OR
RECRUITING

White City, Oregon, 97503, United States
VA Western New York Healthcare System, Buffalo, NY
RECRUITING

Buffalo, New York, 14215-1129, United States

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