Gene hunt aims to prevent SSRI agitation in children

NCT ID NCT06763081

Recruiting now Knowledge-focused Sponsor: University of Manitoba Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study is looking for genetic markers linked to a side effect called behavioral activation—feeling overly excited or agitated—that can happen when children and youth take SSRI antidepressants for depression, anxiety, or OCD. Researchers will collect DNA from 160 participants aged 6 to 24 in Manitoba and compare those who had the side effect to those who didn't. The goal is to find a set of genes that could one day help doctors choose safer medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors predict which kids might have bad side effects from common antidepressants, making treatment safer.
What could go wrong: This is an observational study, not a treatment trial. It may not find clear genetic markers, and results might not change practice for years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression Drug-Related Side Effects and Adverse Reactions major depressive disorder mood disorder obsessive-compulsive disorder psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIDEPRESSANT DRUG ADVERSE REACTION ANXIETY DISORDERS BEHAVIORAL ACTIVATION MAJOR DEPRESSION MAJOR DEPRESSIVE DISORDER OBSESSIVE COMPULSIVE DISORDER (OCD)

Contacts and locations

Locations

Shared Health Facilities
RECRUITING

Winnipeg, Manitoba, R3C 3H8, Canada
University of Manitoba College of Pharmacy
RECRUITING

Winnipeg, Manitoba, R3E 0T5, Canada

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