Mood disorder

This study tests whether taking probiotics daily for 3 months can reduce symptoms of anxiety and depression in 60 adults with mild-to-moderate conditions. Participants will receive either probiotics, a placebo, or the antidepressant escitalopram. Researchers will measure changes …

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with multiple treatments. Researchers will implant a device that sends electrical pulses to a specific brain area. The trial includes 100 adults and compares active s…

This Phase 3 study tests whether KarXT, a combination of two drugs, can safely reduce manic symptoms in people with Bipolar-I disorder. About 274 participants hospitalized for mania will receive either KarXT or a placebo. The main goal is to see if KarXT improves scores on a stan…

This study tests whether adding KarXT to standard mood stabilizers (lithium, valproate, or lamotrigine) helps control manic episodes in people with bipolar I disorder. About 424 adults hospitalized for mania will receive either KarXT or a placebo for 5 weeks. The main goal is to …

This study compares IV iron to oral iron pills for treating moderate anemia after a C-section. The goal is to see if better iron levels can reduce the risk of postpartum depression. About 2,860 women will take part, and their mood will be checked 8 weeks after delivery.

This study tests whether adding the drug brenipatide to standard treatment can delay the return of bipolar symptoms compared to a placebo. About 400 adults with bipolar I or II will self-inject the study drug or placebo for at least 6 months. The main goal is to see how long it t…

This study investigates whether ketamine, given as four intravenous infusions over two weeks, can reduce depression and alcohol cravings in adults who have both conditions. Participants are already in inpatient addiction therapy and are randomly assigned to receive either ketamin…

This study tests a talk therapy called CETA for 300 mothers in a low-income area of Lima, Peru. The therapy aims to reduce depression, anxiety, and stress, and improve parenting and children's well-being. Another 300 mothers receive standard support. Researchers will follow famil…

This phase 3 study is testing the long-term safety of KarXT, a new drug for managing mania in people with bipolar I disorder. About 450 participants, including those who completed earlier studies and new volunteers, will take KarXT along with standard mood stabilizers like lithiu…

This study tests deep brain stimulation (DBS) in 20 people with severe depression that hasn't improved with other treatments. The device delivers electrical pulses to a brain region called the subcallosal cingulate, which may reset mood circuits. Researchers will record brain sig…

This study tests whether a combination of physical activity, cognitive training, and dietary supplements can reduce depression symptoms and prevent memory or thinking problems in people with Major Depressive Disorder (MDD). Researchers will enroll 120 adults aged 50-80 who have M…

This study tests a short counseling program (about 4 sessions) designed to help pregnant and postpartum women in Cape Town, South Africa, keep taking their daily HIV-prevention pill (PrEP). Many women stop PrEP due to depression or trauma from violence. The program uses cognitive…

This study tests whether valbenazine can reduce involuntary muscle movements (tardive dyskinesia) in adults who still have symptoms while taking or after stopping another similar drug. About 50 people with schizophrenia, bipolar disorder, or major depression will take valbenazine…

This study tests whether adding a new drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms. About 1000 adults with major depression who are already on stable medication will receive either brenipatide or a placebo as a shot, p…

This pilot study is testing whether combining cognitive behavioral therapy (CBT) with guided exercise can improve blood sugar control, reduce depression, and boost quality of life in Black men with type 2 diabetes. Eighty participants will receive 8 sessions of CBT, with half als…

This study tests a program called iCHART, designed to help teens aged 12-18 who have depression or suicidal thoughts. The program connects them to mental health care and safety planning. Researchers hope it will reduce suicide-related events by 50% compared to usual care.

This study tests esketamine nasal spray in 47 Korean adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants will use the spray themselves twice a week for 4 weeks. The main goal is to see if depressive symptoms improve, me…

This early study tests if deep brain stimulation (DBS) is safe and effective for people with severe depression that hasn't improved with other treatments. Twenty adults will have a device implanted in their brain and be monitored for five years. The device will be turned on and o…

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This study tests whether a combination drug called OLZ/SAM (olanzapine plus samidorphan) causes less weight gain than olanzapine alone in teenagers with schizophrenia or bipolar I disorder. About 220 teens aged 10-17 will take either the combo or olanzapine for 52 weeks. The main…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This study tests whether using a person's genetic information to guide medication choices leads to better recovery for people with mood, anxiety, or psychotic disorders. Over 2,500 participants will receive either standard care or personalized medication advice based on their gen…

This trial tests a program called WeCare, which combines problem-solving therapy with support for taking HIV medication. It is designed for men who have sex with men (MSM) in South Africa. The study will enroll 60 participants to see if the program reduces depression and anxiety,…

This study tests a non-invasive brain stimulation method (temporal interference stimulation) aimed at improving metabolism in people with stable bipolar disorder who also have obesity. Researchers will measure changes in key metabolic molecules like GLP-1. The study enrolls 70 ad…

This study tests whether screening for social needs like housing and food access, combined with referrals to community resources, can improve chronic disease outcomes for patients of color. Researchers will track blood pressure, cholesterol, blood sugar, depression, and asthma co…

Stanford University is studying whether the drug pramipexole can help people with depression, and if its effects depend on specific brain circuits. Sixty adults with recent depressive symptoms will take pramipexole for 8 weeks, then taper off over 2 weeks. The study uses brain im…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests whether adding melatonin (a natural sleep hormone) to standard treatment can help stabilize daily mood swings in people with bipolar disorder. Two hundred adults with bipolar disorder will take either a melatonin capsule or a placebo every day for six months. The…

This study compares clozapine and risperidone in people with schizophrenia, schizoaffective disorder, or bipolar I disorder with psychosis. Researchers want to see if a specific brain biotype (Biotype-1) responds better to clozapine. About 320 participants will be randomly assign…

This study tests a combined therapy for mothers with PTSD who are already receiving child welfare prevention services. The treatment blends skills to manage emotions and trauma with parent-child interaction coaching. Researchers will track changes in PTSD, depression, parenting b…

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study tests a smartphone app called Aviva that delivers a type of therapy (Brief Cognitive Behavioral Therapy) to service members who have had recent suicidal thoughts or attempts. The goal is to see if the app reduces suicidal thinking and behavior better than standard care…

This study compares methotrexate alone versus methotrexate plus the antidepressant escitalopram in 40 adults with moderate to severe psoriasis and depression or anxiety. Over six months, researchers will measure skin improvement and mental health changes to see if the combination…

This study tests a long-acting injection of cariprazine given once a month, instead of daily pills, for people with schizophrenia, bipolar I disorder, or major depression. The trial involves 24 clinically stable adults and will check safety, side effects, and how well the drug wo…

This study tests whether reducing the frequency of rTMS sessions can maintain the antidepressant effect in people with treatment-resistant depression who already responded to daily rTMS. 75 participants will receive either standard maintenance, clustered, or sham rTMS over 6 mont…

This study tests a program called Enhanced Friendship Bench that combines problem-solving therapy with HIV support for pregnant women in Malawi who have HIV and depression. About 400 women will take part to see if the program reduces depression symptoms and helps them stay in HIV…

This study tests a gamified mobile health app designed to reduce suicide risk in adults with mental disorders after they leave the hospital. Researchers will enroll 640 participants in Shenzhen, China, and use game-like features to encourage treatment adherence and follow-up visi…

This study tests whether a 16-week ketogenic diet (low carbs, high fat, medium protein) can help teens aged 12–21 with bipolar disorder. Eighty participants will receive the diet plus standard medication, with coaching from dietitians and monthly checkups. Researchers will track …

This study compares a new crystallized lithium (AL001) to standard lithium carbonate in 20 people with bipolar I disorder. Participants take each drug for 14 days and undergo MRIs and blood tests to measure how lithium enters the brain and body. The goal is to see if AL001 is saf…

This study tests a 9-session program called MILAP for young married women (ages 15-24) in Nepal who have experienced intimate partner violence. The program involves the woman, her husband, and her mother-in-law, aiming to reduce depression, violence, and PTSD. 900 participants wi…

This study tests an experimental drug called ALN-SNCA in 46 people with early Parkinson's disease. The drug is designed to lower levels of a harmful protein, alpha-synuclein, in the brain. The main goal is to check if the drug is safe and tolerable, and to see how it moves throug…

This study tests a small brain implant for people with severe depression that hasn't improved with standard treatments. The device is placed under the skull and stimulates a mood-related brain area. Researchers will track changes in depression and thinking skills over one year in…

This study is testing a digital app called QbMobile that measures attention, impulsivity, and activity levels through two 10-minute tests. Researchers want to see if the app can help distinguish ADHD from conditions like bipolar disorder, autism, depression, and anxiety. About 30…

This study tests a new iPhone app called Senseye DT that uses artificial intelligence to diagnose Post-Traumatic Stress Disorder (PTSD) in adults. Participants will use the app while it records video of their face, and the AI looks for signs of PTSD. The goal is to see if the app…

This pilot study tests a depression prevention program called Brief Interpersonal Psychotherapy-Adolescent Skills Training (B-IPT-AST) for teens aged 13-17 with mild symptoms. The program includes 6 sessions (4 group, 2 individual) and is compared to usual services. Researchers w…

This study tests whether taking part in racial justice activism can prevent depression and reduce physical stress in Black and Latinx young people aged 15-20. Researchers will measure mood, stress hormones, and health markers over two years. The goal is to see if activism can be …

This study is testing a short, 6-session group program called Resilience Training for Teens. The goal is to see if it can help high school students who have mild symptoms of depression, anxiety, or unusual feelings avoid developing more serious mental illnesses. The study will in…

This study tests a simple writing exercise for new mothers who had a stressful childbirth. In the days after giving birth, participants write about their experience for 15 minutes a day for three days. The goal is to see if this can prevent post-traumatic stress disorder (PTSD) a…

This study looks at whether the ROSE program, which has been shown to prevent about half of postpartum depression cases in women at higher risk, can work for all new mothers. Researchers will enroll 2,320 pregnant women from a large health system in Detroit to see if offering the…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests a parenting program designed to help Hispanic teens who are gay, lesbian, or bisexual. The goal is to see if the program can prevent or reduce drug use and symptoms of depression by improving family support and reducing stress. About 306 teens and their parents w…

This study tests whether a 4-week Resilience Training program can prevent serious mental illness in college students who already have mild psychotic experiences. 192 students aged 18-30 will be randomly assigned to either Resilience Training or a general Life Skills program. The …

This study tests a school-based program to prevent depression and suicide in teenagers attending special education schools in the Netherlands. About 236 students with mild depressive symptoms will either receive a cognitive behavioral therapy group training or be monitored. Teach…

This study tests a therapy called Positive Affect Treatment (PAT) to see if it can prevent depression in teenagers aged 12-16 who have experienced two or more adverse childhood events. The therapy involves 15 weekly sessions focused on building positive emotions and coping skills…

This study tests a new way to train mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. The training uses online modules, live coaching, and a buddy system where new mentors learn from experienced ones. About 96 teens age…

This study looks at whether cognitive-behavioral therapy (CBT), exercise training, or both can help prevent type 2 diabetes in teenage girls who are at risk. The researchers want to see if these approaches lower stress, improve mood, boost physical activity, and reduce insulin re…

This study tests whether a mindfulness-based sleep program for pregnant women with insomnia can prevent depression during and after pregnancy. Researchers will enroll 500 women and compare the program to standard care. The goal is to improve sleep and reduce the risk of perinatal…

This study tests an experimental oral drug called CYB003 in 220 adults with major depressive disorder. Participants receive either CYB003 or a placebo alongside their usual treatment. The goal is to see if CYB003 safely reduces depression symptoms better than placebo.

This study tests a smartphone app designed to help teenagers aged 14-18 who self-harm and are not currently in therapy. The app teaches coping skills and connects them with support through a friendly chatbot. The goal is to see if the app is easy to use and helps reduce self-inju…

This study tests a program called CAPABLE Transplant, where an occupational therapist, nurse, and handy worker visit people at home over 4 months. The goal is to help kidney transplant candidates who are currently inactive on the waitlist become active again, and to improve their…

This study tests a group therapy program called the Unified Protocol for adults with emotional disorders such as anxiety, depression, and related conditions. The program teaches skills like emotional awareness, flexible thinking, and facing fears. Researchers want to see if it im…

This study tests two digital mindfulness programs—one live over Zoom and one self-paced app—to see if they can reduce depression in younger breast cancer survivors. It includes 402 women diagnosed at or before age 50 who finished cancer treatment at least 6 months ago and have el…

This study tests whether a four-session mindfulness class (Primary Care Brief Mindfulness Training) can help veterans reduce symptoms of anxiety, depression, and PTSD compared to a problem-solving class. The classes are designed for primary care settings and focus on meditation, …

This study tests whether yoga-based exercises can help veterans with schizophrenia, schizoaffective disorder, or bipolar 1 disorder improve their ability to function in daily life—like socializing, working, and managing leisure activities. About 112 veterans will be randomly assi…

This study tests whether a mobile app with short weekly exercises can help first-time parents manage emotions and reduce depression during pregnancy. About 572 expectant mothers and fathers in Singapore will use the app or receive standard care. Participants will also wear a Fitb…

This study tests whether a specially designed bright light can improve cognitive problems like memory and attention in people with major depressive disorder. 120 adults with depression and cognitive issues will receive either the bright light or a dim red placebo light for four w…

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with ps…

This study tests whether using the soundBrilliance app—which combines enhanced music, natural visuals, and spoken guidance—can help people aged 13 and older manage anxiety, depression, and stress. Over 12 weeks, participants use the app at least 4 days per week and report their m…

This study tests whether clemastine, a common antihistamine, can improve brain white matter and make antidepressants work better for adults over 60 with depression. Eighty participants will receive either clemastine or a placebo alongside their antidepressant. The goal is to see …

This study explores whether a type of talk therapy called behavioral activation, delivered via video call, can help older adults who are involved with Adult Protective Services due to neglect or self-neglect. The therapy aims to reduce depression and apathy, and improve daily act…

This study tests whether wearing a headset that delivers a flickering 60Hz white light for 30 minutes a day can help ease depression symptoms. Adults with major depressive disorder will use the device at home for three weeks. Researchers will measure how well people stick with th…

This study tests a new online therapy platform called Teleo, designed specifically for children with anxiety or mood disorders. Researchers want to see if kids are more engaged during therapy sessions on Teleo compared to standard video calls. About 156 children will take part, a…

This phase 3 study is testing an oral drug called DT120 (related to LSD) against a placebo in 165 adults with major depressive disorder. Participants will take the drug or placebo for 12 weeks, followed by a 40-week period where everyone can receive DT120. The main goal is to see…

This study tests whether a noninvasive brain stimulation technique called tDCS can reduce depression in people with multiple sclerosis. Participants use a headband-like device at home for 30 minutes a day over 30 days, while listening to mindfulness meditation. Half receive real …

This small study tests if a non-invasive device that stimulates the brain during sleep can increase deep sleep in adults with depression. Researchers want to see if better deep sleep helps with memory, thinking, and mood. Participants wear a headband and activity tracker at home …

This study tests whether cariprazine (Vraylar) can safely ease depressive episodes in teens aged 10-17 with bipolar I disorder. Around 380 participants will receive either the drug or a placebo for 6 weeks, with dose adjustments based on response. The goal is to see if the drug i…

This study tests whether a chatbot that uses motivational interviewing can help college students with anhedonia (loss of interest or pleasure) feel more emotional arousal. Eighty participants will interact with the chatbot or a control version, and their brain activity will be sc…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This study tests whether a chatbot that uses motivational interviewing can help college students with anhedonia (loss of interest or pleasure) update their beliefs in a more positive way. 80 participants will interact with the chatbot or a control version over several sessions. T…

This study is testing whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with mindfulness-based therapy can help people with PTSD. Thirty adults with PTSD will receive psilocybin along with either standard support or extra mindfulness training…

This study is testing whether a single session that combines two types of brain stimulation (TMS and tACS) with psychotherapy can safely and feasibly help people with major depression that hasn't improved with standard treatments. The researchers will enroll 30 adults aged 18-70 …

This pilot study tests whether a peer support program can help young adults (ages 18-27) recently discharged from a psychiatric hospital. Participants get one-on-one and group meetings with trained Peer Support Specialists and recovery organizations, while a comparison group rece…

This Phase 3 trial is testing whether an experimental drug called NBI-1065845 can help reduce depression symptoms in adults who haven't responded well to standard antidepressants. About 200 participants will take either the drug or a placebo alongside their current antidepressant…

This study tests whether adding magnesium vitamin B6 to usual treatment can reduce depression, anxiety, and stress in people experiencing their first episode of bipolar I disorder. Forty adults aged 18-50 will take either the supplement or a placebo three times daily for four wee…

This study tests whether a chatbot that uses motivational interviewing can improve how people with anhedonia (loss of interest or pleasure) respond to social rewards. Eighty college students with elevated depression and anhedonia will interact with the chatbot regularly over a pe…

This study tests a program called ACT Together for parents of children with disabilities. The program includes six online lessons and weekly phone coaching sessions with a trained therapist. It teaches skills to handle stress and difficult emotions. Researchers want to see if the…

This study tests an experimental drug called RAP-219 for people with bipolar I disorder who are currently experiencing a manic episode. About 250 participants will receive either RAP-219 or a placebo daily for 21 days. Researchers will measure changes in manic symptoms using a st…

This study tests whether using a genetic test to guide antidepressant dosing helps teens aged 12-17 with anxiety or depression. About 452 teens will be randomly assigned to either gene-guided dosing or standard dosing. The goal is to see if the genetic approach leads to more remi…

This study tests whether a type of talk therapy called behavioral activation (BA) can help treat depression in older adults who have survived cancer. Participants will receive BA or supportive psychotherapy remotely via video or phone over 10 weeks. The goal is to see if BA reduc…

This Phase 3 study is testing the long-term safety of an experimental drug called NBI-1065845 (TAK-653) in 850 adults with major depressive disorder who haven't gotten enough relief from standard antidepressants. Participants take the drug alongside their usual antidepressant for…

This study looks at whether using a weighted blanket during intravenous cancer treatment can help lower anxiety, stress, and depression, and improve comfort. About 152 adults with solid cancers who are starting their first IV therapy will be randomly assigned to receive either a …

This study is testing the safety and tolerability of an experimental drug called ABBV-932 for people with bipolar I or II disorder who are currently in a depressive episode. About 200 adults will take the drug as capsules for 26 weeks, with regular check-ups and tests to monitor …

This study tests an internet-based cognitive behavioural therapy (ICBT) program designed specifically for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of depression, anxiety, or posttraumatic stress. Participants choose their leve…

This study tests a behavioral program called InSTILL for nursing home residents who feel stressed or depressed. Twenty participants will attend six sessions to learn life management and emotion regulation skills. The main goal is to see if the program is practical and well-liked,…

This pilot study tests whether adding brief guided mindfulness exercises (via a smartphone app) between sessions of accelerated brain stimulation (aiTBS) is feasible and acceptable for people with major depression. Twenty adults already receiving aiTBS as standard care will pract…

This study tests a smartphone app called VoiceLove that lets mothers of babies in the NICU record voice messages for their infant. Researchers want to see if using the app helps reduce symptoms of postpartum depression compared to standard care. About 150 mothers will take part, …

This study tests a program called Parenting STAIR Modular (PSTAIR-M) for military-connected mothers who have experienced trauma and have young children aged 2-10. The program helps mothers manage PTSD and depression symptoms while improving their parenting skills. Researchers wil…

This study tests whether eating only during an 8-hour window each day (time-restricted eating) can help people with bipolar disorder who are overweight and depressed lose weight and improve their mood. Forty adults will be randomly assigned to either follow this eating pattern fo…

This study tests a 10-session LGBTQ-affirmative cognitive behavioral therapy (CBT) delivered via telehealth to sexual minority women who drink heavily and have anxiety or depression. Researchers will compare it to standard LGBTQ-affirmative therapy to see if it better reduces hea…

This study tests whether using a gentle brain stimulation device (tDCS) twice a day at home can help people with depression who are not on medication. Thirty participants will be split into three groups: one gets real stimulation, one gets a sham (placebo) device, and one waits w…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce depression symptoms in people who have had a heart attack or related heart problem and a stent placed. About 120 adults will use the device at home for 8 weeks, and their mood…

This Phase 1 study is testing the safety and brain effects of DMT, a psychedelic drug, in 60 adults with depression and healthy volunteers. Participants receive low or medium doses of DMT, THC, or a placebo, and researchers monitor mood, anxiety, and brain activity. The goal is t…

This study compares two drugs, pramipexole and escitalopram, to treat major depression in people with HIV. Some participants also have mild memory or thinking problems. The goal is to see which medication is safer and more effective at easing depression symptoms. About 186 adults…

This study tests whether adding poverty alleviation (like financial support) to group talk therapy helps low-income rural women in Bangladesh with depression more than therapy alone. Six hundred women aged 18-45 with depression and economic hardship will be randomly assigned to e…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

This study tests whether adding a probiotic (Lactobacillus crispatus) to the antidepressant sertraline helps reduce depression symptoms more than sertraline alone in teens aged 12-18 with major depressive disorder. Sixty participants will take either the probiotic or a placebo fo…

This study looks at whether adding a magnesium supplement (magnesium bisglycinate) to standard antidepressant medication can help adults with major depression feel better. About 84 people aged 18-65 who are already on a stable antidepressant will receive either the supplement or …

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study tests an experimental drug, icalcaprant, for adults with major depressive disorder who are currently having a depressive episode. About 195 participants will take either the drug or a placebo daily for 6 weeks. Researchers will measure changes in depression symptoms an…

This study compares two ways to treat depression in cancer survivors: a mobile app called Moodivate that tracks activities and mood, and 8 sessions of telehealth therapy with a mental health provider. About 45 adults who have had cancer and currently feel depressed will take part…

This study tests a non-invasive brain stimulation technique called tACS to treat anhedonia (loss of interest or pleasure) in people aged 60 and older with major depression. Eighty participants will receive either real or sham stimulation over two weeks, with follow-up at three mo…

This study tests whether adding multi-strain probiotics to the antidepressant sertraline helps teenagers aged 12-18 with major depression feel better than sertraline alone. Over 8 weeks, 120 participants will take either the combination or sertraline with a placebo. Researchers w…

This study tests whether starting a structured exercise and education program within a month of a pulmonary embolism (a blood clot in the lungs) can prevent long-term problems like poor quality of life, shortness of breath, and reduced physical ability. About 160 hospitalized pat…

This study looks at whether a low dose of ketamine, given as an IV infusion, can quickly improve depressive symptoms in adults who have been in the intensive care unit (ICU) for at least 6 days. About 50 participants will receive either ketamine or a placebo on two days in a row.…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce pain and depression in people with fibromyalgia. About 36 adults with chronic pain, some also depressed, will receive either real or sham (fake) rTMS to two brain areas. Researchers will tr…

This study tests a new parent group program for teens aged 12-17 with autism who also have anxiety or depression. The program teaches parents skills to support their teen's mental health. Researchers will see if the program is practical and helpful for families.

This study tests a smartphone app that shares stories from teens who have overcome suicidal thoughts. The goal is to see if these stories help other at-risk teens feel less suicidal and more connected. The study involves 46 adolescents in The Bronx who have had recent suicidal th…

This study is testing whether a yoga program can help ease depression symptoms in teenagers, compared to group cognitive-behavioral therapy (CBT). Researchers will recruit 96 teens aged 12-18 with elevated depressive symptoms across two sites in Boston and Columbus. Participants …

This study tests whether a non-invasive brain stimulation technique called tDCS can help adults with Down syndrome who have depression with catatonia (a state of being unresponsive or stuck). 62 participants will receive either real or fake (sham) tDCS for 15 sessions over 5 days…

This study tests whether hemp-derived CBD (with or without THC) can help older adults (60+) who use cannabis for pain, anxiety, depression, or sleep problems. Over 8 weeks, 385 participants will take either CBD+THC, CBD alone, or a placebo. The goal is to see if CBD can reduce sy…

This study tests whether combining a brain stimulation technique called rTMS with a computer-based thinking exercise (CBM) can reduce negative thinking and depressive symptoms in people with mild-to-moderate depression. About 180 adults will receive either real or fake rTMS, and …

This study tests whether vortioxetine, an antidepressant known to boost thinking skills, can reduce the mental fogginess caused by the lung cancer drug lorlatinib. About 24 adults with advanced ALK-positive lung cancer who are already taking lorlatinib will receive vortioxetine. …

This study tests whether a coaching program combined with a decision aid can help Black patients with long-term muscle and joint pain and depression use non-drug treatments like physical therapy or counseling. 304 patients will be randomly assigned to either the coaching program …

This study tests a new medicine called ACP-211 in adults with major depression who haven't gotten better with standard antidepressants. About 153 people will receive either the drug or a placebo for 28 days. The main goal is to see if ACP-211 reduces depression symptoms more than…

This Phase 3 trial tests whether adding seltorexant (a drug that targets sleep) to standard antidepressants can improve mood and sleep in adults with major depression and insomnia who haven't fully responded to their current antidepressant. About 752 participants will receive eit…

This study tests a new drug called seltorexant for people with major depression who also have trouble sleeping. About 600 adults will receive either the drug or a placebo to see if it improves mood and sleep. The goal is to find a new treatment option that targets both depression…

This study tests whether listening to personalized music enhanced with binaural beats (sound patterns that may influence brain waves) or spatialized (3D-like) audio can reduce behavioral and psychological symptoms of dementia, such as agitation and anxiety. Researchers will enrol…

This study tests a sleep-focused program (TranS-C) plus bright light therapy in 90 teens aged 12-18 with moderate to severe depression and sleep problems. Half get the full program with a sleep therapist and light glasses; the other half just track their sleep. The goal is to see…

This study is testing a smartphone app called Vira, combined with health coaching, to help teens aged 12-18 who are dealing with depression and loss of interest in activities. The goal is to see if this approach can increase enjoyment and reduce the risk of suicide. Participants …

This study looks at whether two different exercise programs can help reduce depression in people with multiple sclerosis (MS) who also have major depressive disorder. Researchers will enroll 146 adults aged 18 to 64. One group will do a structured exercise program, while the othe…

This study tests if reading a personal narrative book, in addition to standard care, can help women of childbearing age manage anxiety, depression, and negative thinking before a hysterectomy. About 156 women will either receive standard information or also read a book. The goal …

This study tests whether the drug KarXT can reduce symptoms of mania in people with Bipolar I disorder who are currently hospitalized for a manic episode. About 274 participants will receive either KarXT or a placebo for 3 weeks while staying in the hospital. The main goal is to …

This study tests whether a nasal spray containing esketamine, given alongside standard care, can rapidly reduce symptoms of major depression and suicidal thoughts in adolescents. About 258 teens with acute suicidal ideation or behavior will receive either esketamine or a psychoac…

This study tests a workplace-based program designed to help low-wage hospital service workers manage depression and become more physically active. Ten participants will receive remote counseling, work coaching, social needs support, and text message encouragement. The goal is to …

This Phase 2 trial tests whether TNX-102 SL, a tablet taken under the tongue at bedtime, can improve depression symptoms in adults with moderate to severe major depressive disorder. About 360 participants will receive either the drug or a placebo nightly for 6 weeks. Researchers …

This study compares group-based Acceptance and Commitment Therapy (ACT) to standard individual therapy for young people aged 16-25 with depression, anxiety, or stress. About 212 participants will be randomly assigned to either group ACT or individual therapy. The goal is to see i…

This study tests whether a single dose of psilocybin, given with psychological support, can improve depression in people with Parkinson's disease. Sixty adults aged 40 to 80 with mild to moderate Parkinson's and depressive symptoms will receive either a low or high dose of psiloc…

This study tests whether a brief, culturally adapted form of behavioral activation therapy, delivered by psychologists in primary care clinics, can reduce depressive symptoms in adults. 96 participants with depression will receive the therapy and be compared to usual care. The st…

This study tests an 8-week social engagement program for seniors who have recently left Adult Protective Services after experiencing elder abuse or self-neglect. The program pairs each senior with a trained student volunteer who makes weekly calls to reduce loneliness and depress…

This study tests an experimental drug called azetukalner in 450 adults with moderate-to-severe major depression. Participants take the drug or a placebo daily for 6 weeks to see if it reduces depression symptoms like low mood and loss of pleasure. The goal is to find a new treatm…

This study tests whether brief cognitive behavioral therapy (CBT) can help people hospitalized for depression or anxiety. About 204 patients will receive CBT sessions during their stay. The goal is to see if this therapy reduces symptoms and improves daily functioning.

This study looks at whether a visual rehabilitation program can ease anxiety and depression in people with advanced age-related macular degeneration (AMD). Twenty-two participants will attend five group sessions over 60 days, learning skills like coin recognition, using voice ass…

This study tests a smartphone app called AMP-C that teaches people to notice and enjoy positive events. The goal is to see if it can reduce depression and cannabis use in adults who struggle with both. Eighty participants will either use the app or just track their symptoms. The …

This study tests whether giving flumazenil, a drug that reverses the effects of benzodiazepines, right before electroconvulsive therapy (ECT) can reduce cognitive side effects like memory loss in hospitalized patients with depression. About 145 participants will either continue t…

This study tests a new type of transcranial magnetic stimulation called theta burst stimulation (TBS) to see if it can reduce suicidal thoughts in adolescents aged 12-18 with major depressive disorder. Participants receive TBS over 10 days and are followed for one year. The goal …

This Phase 3 trial tests whether a daily pill called azetukalner can safely reduce depression in people with bipolar I or II disorder. About 400 adults currently in a depressive episode will take either the drug or a placebo for 6 weeks. Researchers will measure mood changes usin…

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical activity, mood, and thinking in women veterans aged 18-45. Participants will play VR games that involve movement, and researchers will track changes in depression, anxiety, and PT…

This study looks at how Behavioral Activation (BA) therapy affects the brains of depressed teenagers. 136 teens aged 15-17 with depression will receive up to 16 therapy sessions focused on increasing rewarding activities. Researchers will use brain scans (fMRI) to see if BA thera…

This study looks at whether riding a stationary bike while using virtual reality can improve mood and thinking skills. Researchers will compare the effects in 200 adults (ages 18-65) who are inactive, with or without depression symptoms. Participants will exercise on a cycle ergo…

Researchers at Yale University are testing whether a smartphone app called Caravan Wellness can improve quality of life, reduce stress, and ease symptoms of anxiety and depression. The app offers short mindfulness and light exercise modules like yoga and meditation. The study wil…

This study tests a modified version of dialectical behavior therapy (DBT) for people with anxiety or depressive disorders. Researchers will enroll 250 adults across two medical centers and randomly assign them to receive the adapted DBT or standard care. The goal is to see if thi…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with incurable cancer. Participants will receive a pharmaceutical-grade psilocybin along with guided discussions to help them ga…

This study tests a culturally adapted cognitive-behavioral therapy (CBT) program for Venezuelan migrants in Lima, Peru, who struggle with anxiety, depression, or PTSD. The intervention is delivered remotely by trained lay providers over 6 to 12 weekly sessions. The goal is to see…

This phase 2 trial tests whether DT-101 can ease depression symptoms in adults with major depressive disorder who are already on antidepressant medication. About 118 participants will receive either DT-101 or a placebo, and researchers will track changes in depression scores over…

This study tests whether a new oral drug called zelquistinel can reduce depression symptoms in adults with major depressive disorder. Participants take one tablet weekly for 6 weeks and have their depression severity checked at each clinic visit. The trial compares the drug again…

This study looks at two different ways to reach out to lung cancer patients who may need help with anxiety or depression. The goal is to see which method gets more people to start a telehealth counseling program. About 30 adults being treated for lung cancer at Penn Medicine will…

This pilot study tests a mobile game called Change My Story, designed to help young people (ages 16-24) living with HIV who also have depression. The game uses a choose-your-own-adventure format to teach coping skills, and is combined with problem-solving therapy. Researchers wil…

This study tests two behavioral treatments—cognitive behavioral therapy (CBT) and mindfulness—to help people with traumatic brain injury (TBI) sleep better and feel less stressed. 360 veterans and service members with mild to moderate TBI, insomnia, and PTSD symptoms will receive…

This study tests an accelerated version of a brain stimulation treatment called iTBS for depression. Instead of daily sessions over weeks, patients receive 30 short sessions in just 5 to 14 days. Researchers will track mood changes over six months to see if this faster approach w…

This study tests whether inhaling DMT, a psychedelic drug, can quickly reduce symptoms of major depression and suicidal thoughts. 140 adults with moderate-to-severe depression will receive either a high or low dose of DMT in two puffs. Those not improved after a week can get an e…

This study tests a noninvasive device that gently stimulates a nerve in the ear to help people wake up faster after surgery. Researchers will also see if it reduces confusion and depression after the operation. The study involves 40 adults having lumbar spine surgery.

This study tests a non-invasive device that uses electrical fields to gently stimulate deep brain areas, aiming to improve depression in people with bipolar disorder. Researchers will compare the real device to a sham version in 160 adults. They will also use brain scans to under…

This study tests a smartphone app called Matter Neuroscience that uses neurofeedback from brain scans to help people with mild to moderate depression better understand positive emotions. Researchers will enroll 240 adults to see if the app is safe and effective at reducing depres…

This study tests a new oral drug called zelquistinel to see if it can reduce symptoms of major depressive disorder in adults. About 164 people aged 18 to 64 will take either the drug or a placebo once a week for 6 weeks. Researchers will measure changes in depression severity usi…

This pilot study tests whether MRI-guided repetitive transcranial magnetic stimulation (rTMS) is safe and feasible for treating depression in 45 adolescents aged 12-18. Participants are randomly assigned to receive either targeted brain stimulation, standard stimulation, or a sha…

This study looks at whether adding a peer support program (WoVeN) to a self-help version of Cognitive Processing Therapy (CPT) helps women veterans with PTSD feel better and improve their mental well-being. About 100 women who have served in the U.S. military and have PTSD sympto…

This study tests whether using a smartphone meditation app (Healthy Minds Program) for 8 weeks can reduce depression symptoms in teens aged 14-19. 200 participants with elevated depression scores will be randomly assigned to either the meditation app or a hydration tracking app. …

This study compares two types of talk therapy—CBASP and Behavioral Activation—for adults with long-lasting depression that hasn't improved with other treatments. About 396 inpatients will receive 16 weeks of one therapy to see which works better and why. The goal is to find more …

This study compares a standard mobile cognitive behavioral therapy (CBT) program to a personalized version that teaches skills faster. About 100 adults aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app for 20 minutes, twice a week, for six weeks. The …

This study looks at whether orthopaedic surgeons can safely screen for depression in patients recovering from a broken bone and offer treatment with common antidepressants like Prozac or Cymbalta. About 100 adults who score at least 5 on a depression questionnaire will be offered…

This study tests whether a fast, non-invasive brain stimulation method called iTBS can help women with post-partum depression. About 40 new mothers will receive up to 10 or 12 sessions per day over 5-6 days. The goal is to see if the treatment is practical, well-tolerated, and re…

This study tests a communication coaching program for adolescent and young adult cancer survivors (ages 18-35) who have finished treatment at least a year ago. Participants complete online sessions and AI coaching to improve how they talk with peers. The goal is to see if the pro…

This study tests an accelerated form of transcranial magnetic stimulation (TMS) for people with major depression that hasn't improved with medication. Over five days, 35 adults will receive multiple sessions of targeted brain stimulation. Researchers will track changes in depress…

This study is testing a mobile app called MAYA that teaches cognitive behavioral therapy (CBT) skills to help older adults manage anxiety and depression. About 60 participants aged 40 and older with an anxiety or depressive disorder will use the app for at least 20 minutes, twice…

This study tests whether a daily medication called vortioxetine can safely reduce depression symptoms in Japanese teenagers aged 12 to 17 with major depressive disorder. About 180 participants will receive either the drug or a placebo for 14 weeks, with follow-up for 4 more weeks…

This study tests a mobile app called Moodivate that helps people with incurable cancer track their daily activities and mood, and suggests new activities to improve their mood. About 279 participants will be randomly assigned to use the app or receive usual care for 8 weeks, with…

This study tests whether watching augmented reality (AR) health education videos can help reduce anxiety and depression in women after breast cancer surgery. 60 female patients will be randomly assigned to receive either standard education alone or standard education plus AR vide…

This study tests whether using a mindfulness app for 15 minutes a day over two weeks, plus a storytelling workshop, can improve wellbeing in STEM graduate students at the University of Wisconsin-Madison. Researchers will measure changes in depression, anxiety, stress, sleep, and …

This study compares two brain areas for treating depression with a gentle electrical current (tDCS). Fifty adults with depression will receive stimulation to either the DLPFC or DMPFC. Researchers will measure changes in mood and emotional regulation to see which target works bet…

This study tests whether four intravenous ketamine infusions over two weeks can reduce suicidal thoughts in 36 adults with major depression. Participants will also have two MRI brain scans to see if changes in brain structure relate to symptom improvement. The goal is to both tre…

This study tests whether a daily snack rich in plant chemicals and fibre can ease perimenopause symptoms like hot flushes, mood changes, and sleep problems. Twenty women aged 40-55 who are not on hormone therapy will eat either the special snack or a placebo for several weeks, th…

This Phase 2 trial tests LV232, a new capsule for major depressive disorder, in 400 adults aged 18-65. Participants are randomly assigned to receive one of two doses of LV232, the active comparator escitalopram, or a placebo for 8 weeks. The main goal is to find the best dose and…

This study compares two behavioral approaches to see which works better for improving mood, sleep, and reducing suicide risk in adults aged 55 and older with depression. Participants will complete interviews, questionnaires, and wear a sleep tracker for 8 weeks. The goal is to fi…

This study tests a new drug called SPT-300 in 360 adults with major depressive disorder, with or without anxiety. Participants will receive either the drug or a placebo for 6 weeks to see if it reduces depression symptoms. The goal is to find a safe and effective new treatment op…

This study is testing whether adding small amounts of human coaching, email reminders, or text messages to a meditation app can help people with depression and anxiety feel better. About 688 adults with elevated symptoms will use the Healthy Minds Program app for four weeks. Rese…

This study tests whether bright light therapy can help reduce excessive daytime sleepiness in people with Prader-Willi syndrome. About 50 participants will receive either bright light or a dim placebo light. The goal is to see if the therapy improves alertness, mood, and behavior…

This study tests whether a noninvasive magnetic stimulation technique called TMS can improve symptoms in people with major depressive disorder. Researchers will target a brain region involved in emotion and reward processing. The study will enroll 80 adults with moderate to sever…

This study is testing whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people with non-small cell lung cancer who also have major depression. Ten participants will receive psilocybin in a controlled setting along with cou…

This study tests whether a structured emotional intelligence (EI) training program can improve mental health and reduce anxiety and depression among secondary school teachers and students in Dhaka, Bangladesh. The program teaches skills like self-awareness, self-management, socia…

This study tests an experimental drug called icalcaprant for treating depression in people with bipolar I or II disorder. About 195 adults will take either the drug or a placebo daily for 6 weeks. Researchers will measure changes in depression symptoms and watch for side effects.

This study tests a type of talk therapy called acceptance and commitment therapy (ACT) for people with mild dementia and their care partners. The goal is to see if it helps reduce depression, anxiety, and grief. About 100 pairs will take part, either in person or online.

This study tests whether a quick form of brain stimulation called SAINT can reduce symptoms of postpartum depression better than a fake treatment. It will include 192 women who are up to 12 months after giving birth and whose depression hasn't improved with standard care. The mai…

This study is testing whether cognitive behavioral therapy (CBT) can help children aged 4 to 17 who struggle with severe irritability, anxiety, or mood disorders. Researchers will track changes in irritability and overall functioning using clinician and parent reports. The goal i…

This study tests whether taking D-serine (an amino acid) before transcranial magnetic stimulation (TMS) can improve depression symptoms more than TMS alone. Sixty adults with major depressive disorder will receive either D-serine or a placebo before TMS sessions for six weeks. Th…

This study tests a 100% remote education program for adults with moderate depression who recently started antidepressants. The program aims to help them stick with their medication and improve their symptoms. Researchers will compare the program to usual care in 220 participants …

This study tests whether a mobile app delivering cognitive behavioral therapy can help U.S. military veterans who have both insomnia and depression. 1,200 participants will receive either therapy for insomnia, depression, or both in sequence. The goal is to see which approach wor…

This Phase 2 study tests whether LB-102 can reduce depressive symptoms in adults with bipolar I disorder who are currently in a major depressive episode. About 320 participants will receive either the drug or a placebo for 6 weeks. The main goal is to see if LB-102 improves depre…

This study tests a new type of talk therapy that is personalized for each person's emotional, relationship, and self-image struggles. It is for adults with depression that also involves personality problems or past trauma. 150 people in Chile's public health system will get eithe…

This study tests whether a culturally adapted version of Dialectical Behavior Therapy skills training (DBT-A-ST) helps teens aged 12-18 with emotional disorders like depression, anxiety, or ADHD. Participants are randomly assigned to either the DBT group or a standard support gro…

This study tests whether a low-dose melatonin pill (0.5 mg) combined with a behavioral sleep program can shift the body's internal clock earlier and improve mood in people with bipolar disorder who are night owls. Fifty participants will either get melatonin plus sleep therapy or…

This study looks at whether giving parents of children with chronic conditions a mental health questionnaire during clinic visits is practical and helpful. About 100 parents will fill out the survey and receive a list of support services. Researchers will follow up at 3 and 6 mon…

This study looks at people with depression that hasn't improved with other treatments. If they don't get better after four sessions of one type of ECT (right unilateral), they will either continue with that type or switch to another type (bitemporal). The goal is to see which app…

This study looks at whether the antidepressant vortioxetine can help people who suffer from both depression and migraine. Researchers will track 31 adults over 12 weeks to see if their mood and headache symptoms improve. The goal is to find a treatment that works for both conditi…

This study tests whether a higher dose of a gentle brain-zapping technique called tDCS can safely help people with major depression. About 20 adults will receive mild electrical pulses on their scalp over 5 days. Researchers will check for side effects and see if mood improves.

This study tests whether a mushroom supplement called Ganoderma lucidum spore powder can reduce depression in women who have had thyroid cancer surgery. Three hundred participants will take either the supplement or a placebo daily for three months. Researchers will measure change…

This phase 3 trial tests whether adding a low dose of ketamine to electroconvulsive therapy (ECT) can better relieve depression and reduce memory problems in people with treatment-resistant major depressive disorder. Thirty hospitalized adults will receive either ketamine or a pl…

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties, such as depression, anxiety, or PTSD, and assign them to practi…

This study tests a new medicated film placed inside the cheek (VLS-01) for people whose depression hasn't improved with at least two other treatments. About 142 adults aged 18-65 will receive either the film or a placebo to see if it safely eases depression symptoms. The goal is …

This study tests whether a virtual reality training program can help people with depression and low positive affect feel more joy and motivation. 80 adults will be randomly assigned to either a reward-focused VR training or a neutral memory VR training for 7 weeks. The goal is to…

This study is testing two types of talk therapy for major depression: supportive-expressive therapy and emotion-focused therapy. The goal is to see if people do better when the therapy matches their personal style—whether they tend to think deeply about their problems (insight) o…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least 6 months to live. Participants receive either two moderate-to-high doses (15mg then 25mg) or t…

This study tests whether an AI-guided cognitive behavioral therapy program can reduce symptoms of mild depression and anxiety in adults. Over 10 weeks, 120 participants will either receive AI-guided therapy through a digital platform or standard care. The goal is to see if AI can…

This study tests whether a daily probiotic supplement can help treat depression in people with Parkinson's disease. Sixty adults with mild to moderate Parkinson's and depression will take either the probiotic or a placebo for 12 weeks. Researchers will measure changes in mood and…

This study tests if Lemborexant, a sleep medication, can improve sleep in adults whose depression is already treated but who still have insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep with diaries and a wearable device. The…

This study tests a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve. Researchers want to see if it can improve attention and memory in 30 veterans with traumatic brain injury, depression, or PTSD. Participants will try both the real st…

This study is testing whether an online, self-guided dialectical behavior therapy (DBT) course is practical and helpful for adults with mild-to-moderate depression or anxiety. Up to 40 participants will take the 8-week course, which teaches skills like mindfulness and emotion reg…

This study compares two forms of ketamine for people with depression that hasn't improved with other treatments. One is given through an IV drip, the other as a nasal spray. Researchers want to see which works better, is more acceptable to patients, and has fewer side effects. Ab…

This study tests an online psychological program called MY-CHOICE for adults with ischemic heart disease who also have anxiety or depression. The program offers personalized online modules and therapist calls over 6-12 weeks. Researchers want to see if patients find it acceptable…

This pilot study tests whether a short, video-based sleep therapy can help prevent PTSD and depression in people who recently had a car accident. Twenty adults at high risk for PTSD will receive either the sleep therapy or a control session over three weeks. The goal is to see if…

This study compares a blended group therapy (online and in-person sessions) to standard in-person group therapy for adults with anxiety or depression. About 144 participants will receive 16 weeks of treatment. The goal is to see if the blended approach works as well and is accept…

This pilot study tests whether a home-use device that sends a mild electrical current to the brain (tDCS) can reduce depressive symptoms in people with borderline personality disorder (BPD). Sixty participants will receive either real or sham stimulation twice daily for one week.…

This study tests three versions of internet-delivered cognitive behaviour therapy (ICBT) for post-secondary students with depression or anxiety: a fast-track option, a 5-week course, and an 8-week course. About 200 students will choose their preferred option and receive optional …

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking skills. About 120 adults with moderate to severe depre…

This study tests a digital program called BSHAPE designed to help immigrant women who have experienced violence and suffer from PTSD or depression. The program includes education, skill-building, and mindfulness exercises. Researchers will compare it to a general wellness program…

This phase 3 trial tests whether adding roflumilast (a COPD drug) to the antidepressant fluoxetine helps people with major depression who haven't responded well to treatment. Sixty adults with moderate-to-severe depression will take either the combination or a placebo for 8 weeks…

This small pilot study tests whether a combination of buspirone (an anxiety medication) and melatonin (a sleep aid) can improve depression and thinking problems in people who have had a traumatic brain injury. Ten adults with mild or moderate TBI and depression will take the comb…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is practical, acce…

This study looks at whether a 16-week resistance exercise program can reduce symptoms of major depression in 200 adults. Participants will do either high or low dose strength training. Researchers will measure changes in mood, thinking, and blood flow in the brain to see if exerc…

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This study tests a new drug called mitizodone phosphate in 600 adults with major depression. The goal is to see if it reduces depression symptoms better than a placebo over 8 weeks. The trial has two phases: first to find the best dose, then to confirm how well it works and if it…

This pilot study will put a portable transcranial magnetic stimulation (TMS) device into a van and test it at three locations in South Carolina. Thirty adults with treatment-resistant depression will receive five days of TMS. Researchers will check if this mobile approach is feas…

This study tests a new treatment called Prism for people with major depression who have lost interest or pleasure in activities (anhedonia). Prism is a software device that uses neurofeedback to train the brain's reward system. About 170 participants will receive either real Pris…

This study tests a new, non-invasive brain stimulation method using low-intensity ultrasound waves aimed at specific brain areas linked to depression. Researchers will personalize the treatment for each of the 30 participants based on their brain scans. The goal is to see if this…

This study compares the safety and effectiveness of using a mild electrical brain stimulation device (tDCS) at home versus at a clinic for treating major depression. About 198 adults with moderate to severe depression will use the device daily for a few weeks. Researchers will me…

This Phase 2 trial tests whether DT-101 can reduce depression symptoms in adults with major depressive disorder. About 300 participants will receive either DT-101 or a placebo for 6 weeks, and researchers will track mood changes using standard depression scales. The study is curr…

This study tests a new approach for treating depression in people who have had a mild traumatic brain injury (concussion). Participants will receive a personalized cognitive training program combined with either real or sham brain stimulation over 4 weeks. The goal is to see if t…

This study is testing whether a lotion containing melatonin can improve sleep quality, mood, and anxiety in 60 young adults with mild sleep and mental health issues. Participants will wear a wrist monitor and heart rate strap, fill out surveys, and give saliva samples during two …

This study tests a smartphone app called Edra PRO that lets doctors check in on patients with moderate to severe depression remotely. About 594 adults will either use the app plus usual care or just usual care for 6 months. The goal is to see if the app helps reduce symptoms and …

This pilot study tests whether time-restricted eating (eating all food within a 10-hour window each day) is feasible and acceptable for people with bipolar disorder. 40 participants will either follow the eating schedule or receive nutritional counseling for 8 weeks. The goal is …

This study tests a smartphone app that prompts people with depression to reach out to friends or family for support at the right moments. Over 21 days, 120 adults awaiting therapy will be randomly assigned to different versions of the app or no app at all. The goal is to see if t…

This study aims to help families with food insecurity and mothers with depression by providing resources like food, rent help, and mental health support. Researchers will enroll 2,000 caregivers of young children in the hospital to see if these services improve mother-child bondi…

This study tests a non-invasive light therapy called transcranial photobiomodulation (tPBM) on the forehead to help people with treatment-resistant depression. About 40 adults who still have moderate-to-severe depression despite taking antidepressants will receive tPBM at differe…

This study tests whether a portable, home-use brain stimulation device (tDCS) can safely reduce depressive symptoms in people with bipolar disorder. 212 adults with bipolar depression will use either the active device or a sham (placebo) version at home for 10 weeks. The goal is …

This study tests an internet-based sleep course for adults who have trouble falling or staying asleep. The course teaches skills to improve sleep and reduce daytime distress. Researchers will check if the course is easy to use and helpful for people in Saskatchewan. About 56 adul…

This study tests whether taking high-dose vitamin B6 can reduce symptoms of anxiety and depression by changing brain activity. Researchers will measure brain waves with EEG and track mood changes in 44 adults who have mild to moderate symptoms. Participants will take either vitam…

This study is testing whether a daily practice of Tao Calligraphy meditation and drinking so-called 'energized water' can improve symptoms of unipolar depression in adults. Fifty participants will be split into two groups to compare the effects over 12 weeks. The goal is to see i…

This study is testing a virtual reality (VR) program called bWell to see if it is a practical and enjoyable way to help people with major depression who have trouble with thinking and memory. Forty adults aged 19-55 will either use the bWell cognitive training or experience VR sc…

This study tests two types of online cognitive behavioural therapy (CBT) for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of PTSD, anxiety, or depression. Participants can choose between a therapy focused on PTSD or one that cover…

This study looks at whether a gentle breathing exercise called Baduanjin can reduce symptoms of depression and anxiety. About 120 adults with mild to moderate symptoms will practice it regularly. Researchers will measure changes in mood and lung function to see if the exercises h…

This study tests whether estradiol patches can improve anhedonia (loss of pleasure) and psychosis symptoms that start during perimenopause. About 100 women aged 44-55 will receive either estradiol or a placebo patch for three weeks, plus a short course of progesterone. Researcher…

This study tests whether combining mindfulness meditation with real-time brain scan feedback can help teens with depression. Researchers will train 90 adolescents aged 13-18 to control brain circuits linked to rumination (repetitive negative thinking). The goal is to see if this …

This study tests whether inhaling lavender essential oil for four weeks can reduce anxiety, stress, and depression in women waiting for IVF treatment. 120 women will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no scent. Th…

This study tests whether a precise type of radiation, called stereotactic radiotherapy, can safely reduce symptoms in people with treatment-resistant depression. Nine adults aged 18 to 50 who have not improved after at least two antidepressant trials will receive the treatment. R…

This study tests whether tocilizumab, a drug that blocks inflammation, can help people with major depression who have lost interest or pleasure in things (anhedonia). About 20 adults with depression and signs of immune activation will receive the drug for 8 weeks, while 20 health…

This study tests whether low or moderate doses of LSD can reduce anxiety, pain, and depression in people with advanced or terminal illnesses. Sixty participants will receive either two moderate doses or two very low (placebo-like) doses of LSD in a double-blind setup. The goal is…

This study tests whether adding special content about loneliness to an internet-based cognitive behavioral therapy (ICBT) program helps people with depression and anxiety feel better. About 494 adults in Saskatchewan who report feeling lonely will take part. Some will get the sta…

This study tests a new, non-invasive brain stimulation technique called temporal interference stimulation (TIS) to see if it can reduce non-suicidal self-injury (like cutting) in adolescents with major depression. About 60 teens aged 12-22 will receive either real TIS or a sham t…

This study tests whether inhaling ketamine through a nebulizer can quickly reduce symptoms of moderate to severe depression in hospitalized adults. About 40 participants will receive either ketamine or a placebo (midazolam) and be monitored for changes in depression scores over 8…

This study tests whether adding sauna blanket sessions to an online insomnia therapy program helps people sleep better. Forty adults with insomnia will all receive digital cognitive behavioral therapy, and half will also use a sauna blanket for 15 minutes several times a week. Th…

This study tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue, anxiety, and depression in 100 adults with sarcoidosis. One group takes MBSR; the other joins a monthly virtual support group. Researchers will compare which approach …

This study tests whether a type of talk therapy called narrative therapy can reduce depression in people aged 60 and older. 110 participants with mild to moderate depression will be randomly assigned to either 8 weekly group therapy sessions or a waitlist. The therapy helps peopl…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests whether a natural hormone called pregnenolone can improve daily functioning in veterans with anxiety and depression. 84 veterans will take either pregnenolone or a placebo for 8 weeks. The goal is to see if it helps with mood, sleep, and pain, with minimal side e…

This study tests a 7-session therapeutic song-writing program for young people aged 13 to 24 with mild to moderate depression. Participants are randomly assigned to either the song-writing program or a waitlist group. The goal is to see if the program improves depressive symptoms…

This study tests a new digital therapy program designed to help people with anxiety or depression return to work. The program combines mental health support with practical work-focused strategies. Researchers will enroll 400 adults in Norway who are on sick leave and receiving me…

This study tests whether a 7-session playback theatre program can improve mental health in adolescents and young adults aged 13 to 24 with mild to moderate depression. Participants will attend weekly 90-minute sessions led by trained social workers and music therapists. The goal …

This study tests whether using a bright light device at home for 40 minutes each morning can help teens aged 13-17 with major depression. Participants are split into three groups: high-intensity light, medium-intensity light, or a dim red light placebo. The goal is to see if ligh…

This study tests whether a digital program on an iPad, combined with learning thinking strategies, can improve mood and mental skills in people who have had a stroke. The study will include 70 adults who had a first stroke at least 6 months ago and now have depression and trouble…

This study tests a new, single-session therapy called PATH-SS for people struggling with PTSD or depression after a sexual assault. Researchers want to see if this brief treatment reduces distress and is helpful to participants. The study involves 45 adults in Ohio who experience…

This study tests whether a proven sleep therapy (CBT-I) can improve how the brain regulates emotions, helping treat depression and anxiety. Researchers will use brain scans to see changes in emotion networks. 120 adults with insomnia and depression will participate. The goal is t…

This study tests whether a keto-like supplement, taken as a drink three times daily for 8 weeks, changes brain activity in people with moderate to severe depression. Researchers will use brain scans to compare the supplement to a placebo in 75 adults. The goal is to see if the su…

This large study tests a collaborative care model (COMPASS+) that adds a mental health care manager to regular obstetric care for pregnant and postpartum people. The care manager offers short-term therapy, tracks symptoms, and works with doctors and a psychiatrist to create perso…

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This study tests whether a 6-week music program—including drumming and rhythm exercises—can reduce stress, anxiety, depression, and chronic pain in adults living in rural residential care facilities. Sixty participants will attend weekly hour-long sessions and complete surveys be…

This study tests whether peer recovery specialists—people who have themselves recovered from mental health or substance use problems—can effectively deliver a therapy called behavioral activation to reduce depression and substance use. The trial will enroll 250 low-income adults …

This study tests an internet-delivered cognitive behaviour therapy (ICBT) course designed specifically for public safety personnel (like police, firefighters, paramedics) who experience anxiety, depression, or PTSD. The 164 participants will be randomly assigned to different ways…

This study aims to see if college students can effectively deliver cognitive-behavioral therapy (CBT) to high school students in rural Pennsylvania to reduce symptoms of depression, anxiety, and stress. About 40 teens aged 13-18 with mild to moderate symptoms will participate. Th…

This study compares a 3-session couples program (Brief Relationship Checkup) to standard individual care for 360 veterans and their partners who have relationship and mental health concerns. The goal is to see which approach better reduces suicide risk factors by improving relati…

This early-stage trial tests whether a single low-dose injection of ketamine is safe and practical for adults who come to the emergency department with severe suicidal thoughts. Researchers will monitor side effects and ask staff about their experience. If successful, it could of…

This study tests whether a sleep health program can help U.S. Marines sleep better and feel mentally healthier. About 860 Marines will be randomly assigned to one of five groups to receive different versions of the program. Researchers will use surveys and wearable sleep trackers…

This study tests a program called SUPERCEDE, which provides intensive case management to veterans who are at risk for suicide and receive care both from the VA and outside community providers. The goal is to improve care coordination, reduce suicidal thoughts, and improve daily f…

This early-stage trial tests BXCL501, a dissolving film placed under the tongue, to quickly reduce agitation in children and teens aged 10-17 with schizophrenia or bipolar disorder. About 140 participants will receive either the drug or a placebo. The study measures changes in ag…

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study tests whether adding a supportive text-messaging program (Text4Support) to repetitive transcranial magnetic stimulation (rTMS) improves depression symptoms more than rTMS alone. About 200 adults with treatment-resistant depression will be randomly assigned to one of tw…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests an 8-week group mindfulness program designed for African American adults who have both high blood pressure and depression. Researchers want to see if the program improves mood and blood pressure, and if it works well in a community setting. Participants will lear…

This study tests whether a single 25 mg dose of psilocybin can relieve major depression in 100 adults with cancer, compared to a very low 1 mg dose. Participants must be 20–80 years old, have had depression for at least a month after their cancer diagnosis, and stop other antidep…

This study tests whether a medication called dextromethorphan-bupropion (Auvelity) can change brain activity related to reward and motivation in adults with major depression. Thirty participants will take the pill daily for two weeks and undergo brain scans to see if the drug aff…

This study tests whether a type of talk therapy called Interpersonal Psychotherapy (IPT), delivered in groups by trained non-specialists, can reduce depressive symptoms in young adults aged 18-24 in Porto Alegre, Brazil. Half of the 50 participants will receive the 8-week group t…

This study tests whether sexual counseling during pregnancy can improve sexual function, marital adjustment, and emotional health. About 70 pregnant women will receive either counseling or standard care. Researchers will measure changes before delivery and three months after birt…

This study tests a program called BRIDGE for mothers with depression and their children aged 3-7 who have attention or behavior problems. The program aims to improve children's self-control and reduce problem behaviors by supporting mothers' mental health. About 60 families will …

This study uses PET scans to measure levels of COX-1 and COX-2, enzymes linked to inflammation, in the brains of people with major depressive disorder (MDD) during a depressive episode. Researchers will compare these levels between MDD participants and healthy volunteers. The goa…

This study investigates how depression and antidepressants influence the way older adults update their beliefs about future events. Researchers compare 31 patients aged 65+ with major depression who are switching antidepressants to 31 healthy volunteers of the same age. Participa…

This study aims to see if people with major depressive disorder have lower levels of an enzyme called PDE4B in their brains compared to healthy volunteers. Researchers will use PET and MRI scans along with an experimental radioactive tracer to measure this enzyme. The study invol…

This study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…

This study looks at whether parents of people with bipolar II disorder or major depressive disorder have certain personality traits (called Type D, which involves negative emotions and social inhibition) and lower life satisfaction. Researchers compare these parents to parents of…

This study looks at whether anxiety or depression makes asthma harder to control and aims to build a model that predicts when a serious asthma attack might happen. Researchers will follow 256 people with asthma for up to two years, tracking their symptoms, mental health, and lung…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This study aims to create a risk score that uses information from electronic medical records to predict the chance of developing dementia within 5, 9, or 13 years in older adults with depression. Researchers will analyze data from 44 participants aged 50 and older who have a depr…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better under…

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study examines whether a person's personality traits before they got sick are linked to the thinking and behavior problems seen in certain brain disorders. Researchers will ask caregivers about the patient's personality from the 10 years before the illness started. The goal …

This study gives 25 depressed individuals aged 15-25 a fake version of accelerated transcranial magnetic stimulation (no real brain stimulation). The goal is to see how their beliefs and expectations about treatment change over time and whether those expectations influence mood, …

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This NIH study aims to understand what causes depression in teenagers and how the brain changes with the condition. Researchers will compare depressed teens with healthy ones using interviews, computer tasks, and brain scans. Eligible participants may also receive free talk thera…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This early study is testing whether adding the drug memantine (used for Alzheimer's) to a standard antidepressant can improve how the brain processes memories in people with major depression. Thirty adults aged 18-50 will take an SSRI for 11 weeks, and for the last 6 weeks they w…

This early-stage study at Stanford tests whether giving magnetic brain stimulation during sleep is safe and practical for people with major depression. Fifteen adults who have not gotten better with at least one antidepressant will receive both real and fake stimulation in separa…

This study investigates why some adolescents act impulsively when experiencing negative emotions, a trait called negative urgency. Researchers will measure brain cell communication using transcranial magnetic stimulation and EEG in teens aged 13-21 with depression and suicidal th…

This study compares two sets of strategies to help HIV clinics in Cape Town, South Africa, treat depression and improve medication adherence. Ten clinics will be randomly assigned to receive either basic support or enhanced training and supervision. Researchers will track how man…

This study tests a new idea: that Borderline Personality Disorder (BPD) may be a form of addiction to close relationships, similar to substance use disorders. Researchers will give a special questionnaire to 194 people—those with BPD, those with bipolar disorder, and healthy volu…

This study tests whether spending more than 2 days in a kangaroo mother care (KMC) ward—where mothers hold their low birthweight babies skin-to-skin and get breastfeeding support—can lower the risk of postpartum depression. About 1,900 mothers and their preterm infants in Zambia …

This study looks at how tiny changes in your RNA (a molecule that reads your DNA) might help predict whether depression treatments will work. Researchers will follow 120 adults with unipolar or bipolar depression to see if these RNA changes match up with improvements in mood. The…

This observational study follows 74 pregnant individuals with severe mental illness to see how taking antipsychotics (versus other medications or no medication) affects psychiatric stability and infant development. Participants complete psychiatric interviews, donate blood, and h…

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This study looks at children and teens ages 7-17 who have severe mood problems like chronic anger, sadness, or irritability, along with extreme tantrums. Researchers will use interviews, tests, and brain imaging to understand what happens in the brain. Up to 2,350 participants wi…

This study looks at how mindfulness and fantasizing affect repetitive negative thinking in 100 adults whose depression is in remission. Participants will try both techniques and researchers will measure changes in thinking patterns, heart activity, and brain waves. The goal is to…

This study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…

This study looks at how loneliness impacts recovery from depression in 200 hospitalized patients. Researchers will track symptoms, social support, and collect blood, saliva, and stool samples at three points: start of treatment, discharge, and three months later. The goal is to u…

This study investigates how the gut and brain communicate in people with Irritable Bowel Syndrome (IBS) who also experience anxiety or depression. Researchers will compare 100 IBS patients with anxiety or depression to 100 healthy volunteers using brain scans, stool samples, and …

This research study examines how brain activity changes during emotional and thinking tasks in people with depression and healthy volunteers. Using brain scans (EEG, fMRI) and mild brain stimulation (TMS), researchers aim to understand the brain circuits involved in mood and suic…

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This study looks at how ketamine, a fast-acting antidepressant, affects the brain. Researchers want to understand if a specific brain receptor (AMPA) is key to its effects. Seventy adults with treatment-resistant depression will take part, receiving ketamine and a drug that block…

This study looks at whether a tool called the Decision Helper helps people with mental health conditions take a more active role in choosing their treatment. About 62 adults in Danish outpatient mental health clinics will have their consultations recorded and analyzed. The goal i…

This study tracks 217 people after their first psychotic episode to see if language patterns and blood markers can predict whether they will develop bipolar disorder or schizophrenia. Participants give a recorded interview and blood sample at the start, then are followed for two …

This early-stage study involves 18 healthy men to see how well the experimental drug MSP-2020 attaches to serotonin receptors in the brain. Researchers will also measure how much drug stays in the blood and check for side effects. The goal is to understand the drug's activity in …

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study aims to find out if a special algorithm can predict which antidepressant will work best for each person with major depression. Researchers will use brain scans, EEGs, and blood tests from 400 adults to see if they can match people to the right medication faster. The go…

This study looks at how depression and very early (preclinical) Alzheimer's disease affect driving habits in adults aged 65 and older who still drive regularly. Participants will have their driving tracked with a GPS device and undergo brain scans to measure Alzheimer-related pro…

This study aims to improve postpartum care for high-risk women in the Mississippi Delta, especially Black women. Researchers will test a community-based program that focuses on building trust, improving health literacy, and strengthening family support. The goal is to reduce seve…

This study tests whether a gentle brain stimulation technique called tDCS, done at home, can improve sleep quality in adults with moderate depression. Researchers will track sleep changes and see if better sleep leads to better mood. The study involves 35 participants and aims to…

This study aims to improve MRI imaging methods to better understand how mood and anxiety disorders affect the brain. Researchers will scan healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to refine these techniques …

This study tests a technique called real-time fMRI neurofeedback, where people with depression learn to control brain activity by watching a visual pattern change in real time during an MRI scan. Researchers want to see if this can help regulate brain networks linked to depressio…

This study tests a non-invasive brain stimulation technique called tDCS for depression. Researchers use MRI scans to see how the stimulation affects brain networks. 144 adults with depression will receive either real or sham tDCS while performing a memory task. The goal is to fin…

This study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…

This study is looking at how environmental factors in cities—like air pollution, noise, and lack of green space—affect people with depression, anxiety, or alcohol use disorder. Researchers will have 680 participants wear smartwatches to track heart rate, activity, and other body …

This study is testing a new way to help families decide if their children should be screened for early signs of mental health problems. The children are ages 7 to 21 and have a parent with bipolar disorder. The researchers are creating a video and FAQ to help parents understand t…

This study tests a program to help doctors in psychiatric clinics prescribe medications for alcohol use disorder to patients who also have serious mental illness. The program uses an external facilitator to work with clinic staff and overcome barriers to prescribing. The goal is …

This study looks at whether inflammation in the brain causes symptoms like loss of interest and slow movement in depressed people with HIV. Sixty participants will receive either the anti-inflammatory drug baricitinib or a placebo for 10 weeks. Researchers will use brain scans an…

This study tests whether a brief, self-guided computer program can alter how people with anxiety and intolerance of uncertainty make decisions when outcomes are unclear. Researchers will measure changes in brain activity and decision-making before and after the 30-minute session.…

This study looks at how a single dose of ketamine changes brain chemistry and decision-making in people with major depression. Researchers will measure brain glutamate levels and stress responses in 140 participants. The goal is to understand why ketamine helps some people with d…

This study looks at how cannabis ads that claim to help with anxiety or depression affect what people buy. About 2,000 light-to-moderate cannabis users with mild to severe anxiety or depression will shop in a realistic online store. Some see ads with mental health claims, others …

This study is collecting blood samples and questionnaires from 1,100 people with bipolar disorder or schizophrenia. Researchers are looking for links between genetics, inflammation, and a dormant virus called HERV-W. The goal is to find new biomarkers and pave the way for future …

This study checks how well a new version of a mental health interview (CIDI 5.0) can identify people who have had depression, anxiety, or PTSD at some point in their lives. Researchers in Hong Kong will interview 300 adults and compare the results with a detailed clinical assessm…

This study follows 252 people whose major depression is in remission to find early warning signs of relapse. Researchers will track symptoms, physical activity, sleep, thinking skills, and brain activity. The goal is to build a model that tells doctors who is likely to relapse an…

This study tests three types of non-invasive brain stimulation (intermittent, continuous, and sham) in 200 adults with major depression. Participants receive each type in separate sessions while undergoing MRI scans and mood assessments. The goal is to understand how different st…

This study looks at why people with depression sometimes get stuck in rigid thinking patterns. Researchers will use online tests to measure cognitive flexibility in 2,500 adults. The goal is to better understand how these thinking habits relate to depression symptoms, not to prov…

This study is a large survey of up to 20,000 adults with conditions like depression, anxiety, or borderline personality disorder. Researchers will ask about medical history and symptoms to see who might qualify for future industry-sponsored clinical trials. The goal is to make it…

This study tests a community-wide program in Harlem that trains health workers and coordinates services to help Black and Latino adults with depression or anxiety. About 700 participants from low-income housing or primary care clinics will be involved. The goal is to see if this …

This study looks at whether asking new mothers a few questions within 48 hours of an unplanned C-section can predict who will develop post-traumatic stress disorder (PTSD) related to childbirth. Researchers will follow 420 women for three months, comparing early screening scores …

This study looks at how stress and a sense of control affect brain activity in teenage girls with major depression. Researchers will use brain scans and smartphone surveys to understand these connections. The goal is to learn more about depression, not to test a new treatment. Ab…

This study tests an experimental drug to see if it can fix brain patterns linked to avoiding rewards in people with major depression or anxiety. About 112 unmedicated adults will have brain scans and do decision-making tasks. The goal is to understand how the drug works, not to c…

This study looks at how a natural brain chemical called allopregnanolone affects mood and thinking in women going through menopause. Researchers want to understand why some women feel depressed during this time. The study involves 80 healthy women aged 40 to 60 who have depressiv…

This study aims to understand how a specific type of brain stimulation, called continuous theta-burst stimulation (cTBS), affects brain activity in people with depression. Researchers will give participants a single dose of one of four FDA-approved drugs (or a placebo) that eithe…

This study looks at whether a child's genes can predict if they will have certain side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6 to 24 with depression, anxiety, or OCD. The goal is to find geneti…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these connections. The goal is to…

This study is for adults with depression who have recently attempted suicide. It tests a group program that teaches emotion regulation and values to improve daily functioning and prevent future suicide attempts. Researchers will also measure thinking skills, quality of life, and …

This observational study is testing whether a computer can predict when someone with bipolar disorder might relapse. Researchers will collect voice, text, eye movements, and brain signals from 200 patients and 200 healthy volunteers. The goal is to build a model that spots early …

This study at Yale University is testing whether blocking a specific brain receptor (AMPA) stops ketamine from reducing suicidal thoughts. Thirty adults with depression, bipolar disorder, or PTSD who have current suicidal thoughts will receive either perampanel (an AMPA blocker) …

This study will test if cameras, microphones, and wearable sensors can help doctors measure how severe a person's depression is. About 300 adults hospitalized for severe depression will be recorded during interviews and while wearing devices that track movement, heart rate, and b…

This study aims to create a more realistic brain-scan task that mimics social media interactions, like getting likes or comments. Researchers will scan the brains of 60 teens with depressive symptoms while they receive virtual peer feedback. The goal is to see how brain activity …

This study looks at how to measure cardiorespiratory fitness in people with severe mental illness, such as schizophrenia or bipolar disorder. Researchers will compare three different fitness tests in 50 patients and 25 healthy volunteers. The goal is to find a simple, accurate wa…

This study aims to identify different types of depression by tracking how people manage their emotions in daily life and how their nervous system responds. Researchers will test whether a simple biofeedback exercise done at home for 10 days can improve emotional regulation. The s…

This study explores whether mild electrical stimulation of the spine can change how the brain processes body signals, which may be disrupted in major depression. Researchers will test different stimulation levels in 67 adults with depression to see if it affects brain activity an…

This study is testing a mobile app called Wysa for Chronic Pain, designed to support people aged 45 and older who have chronic pain along with depression or anxiety. Researchers want to see if personalized in-app notifications can encourage people to use the app more often. Parti…

This study uses smartphone tracking and brain scans to see how your daily emotions, thoughts, and actions are linked. About 100 adults will answer quick surveys and share location data for four months. The goal is to better understand patterns in mood and thinking, not to test a …

This study looks at whether treating depression with a common antidepressant (escitalopram) can change brain and blood markers linked to Alzheimer's disease. Researchers will compare the drug to a placebo in 60 adults aged 60 and older who have major depression but no memory prob…

This study looks at how ketamine works in the brain to relieve depression. Researchers are giving people with hard-to-treat depression either a placebo or a drug called perampanel before a dose of ketamine. They will use brain scans to see if blocking certain brain receptors chan…

This study aims to find brain-based markers that can predict how individuals with major depression will respond to the antidepressant sertraline (Zoloft). Researchers will use fMRI and EEG brain scans to measure brain activity and connections before treatment. Fifty adults with c…

This study explores why ketamine, a fast-acting antidepressant, works better in people with a family history of alcohol use disorder. Researchers will give a single low-dose ketamine infusion to 60 adults with treatment-resistant depression while scanning their brains with powerf…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…

This study follows 415 people with difficult-to-treat depression for 5 years after they joined an earlier genetics study. Researchers will review medical records and registry data to see how patients' depression changes over time, including suicide attempts and treatment response…

This study records brain activity from epilepsy patients who already have electrodes implanted for seizure monitoring. While they perform thinking tasks like memory and attention games, researchers watch how different brain areas talk to each other. The goal is to better understa…

This study looks at whether adding patients' own goals and concerns to their mental health care plan can help them stay more engaged in treatment. About 2,400 adults with anxiety or depression who are already in collaborative care will use an enhanced questionnaire and dashboard.…

This study looks at how nitrous oxide (laughing gas) changes brain connections in people with hard-to-treat depression compared to healthy volunteers. About 50 participants will get either the gas or a placebo and have their brains scanned with MRI. The goal is to understand how …

This study looks at whether having your expectations for labor pain relief met or not affects your chance of developing postpartum depression. Researchers will follow 3640 women planning a vaginal delivery and compare depression rates six months after birth between those whose pa…

This Mayo Clinic study uses a safe, noninvasive light-based device called fNIRS to measure brain activity in 200 adults with major depression, bipolar disorder, or mild cognitive impairment. By comparing brain blood flow patterns across these groups, researchers hope to better un…

This study uses powerful 7T MRI scanners and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare brain chemistry and vision in 320 patients and healthy volunteers. The …

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study tests whether smartphone location data can give early warning of mood episodes (mania or depression) and drops in social activity for 200 veterans with bipolar disorder. Participants use an app that tracks their phone's GPS, and researchers will build computer algorith…

This observational study looks at how controlled sensory stimulation, such as music, changes brain activity in people with epilepsy and healthy volunteers. Researchers will measure brain networks and track anxiety and depression symptoms. The goal is to better understand brain fu…

This study aims to understand how ketamine produces rapid antidepressant effects by using a special brain scan (GluCEST) to measure changes in glutamate, a key brain chemical. Ten adults with treatment-resistant depression will receive a single ketamine infusion and undergo imagi…

This study looks at how the immune system and brain talk to each other in people with major depression. Researchers will give a harmless substance (LPS) to temporarily activate the immune system and then measure brain activity and mood changes. The goal is to understand the links…

This study looks at why people with mood disorders may be at risk for suicide. Researchers will collect blood, urine, and survey answers from 300 participants to find patterns and build a model that predicts suicide risk. The goal is to better understand the factors involved so d…

This study tests whether mild electrical stimulation of the vagus nerve (via the ear) can change how people learn from rewards and avoid threats. About 104 participants with high anxiety, high anhedonia, or both will play VR foraging tasks and brain-scan games. The goal is to und…

This study looks at how cannabis use changes brain function in teenagers who also have depression. About 280 teens will have brain scans (fMRI) and answer questionnaires at the start and again one year later, with a second year of follow-up. The goal is to understand the connecti…

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study uses brain scans (fMRI) to understand why people with bipolar disorder experience unstable moods compared to healthy individuals. Researchers will ask 72 participants to recall personal memories and practice boosting positive feelings while their brain activity is reco…

This study looks at how two types of energy—glucose and ketones—change brain activity and behavior in people with bipolar disorder. Participants will have MRI scans while playing money-winning games, before and after drinking either glucose or ketones. Researchers will compare re…

This study will collect data from 5,000 adults with depressed mood who are receiving esketamine, TMS, or SAINT therapy in routine care. Researchers will analyze this information to build models that could one day predict which treatment is most likely to help a given patient. The…

This online registry is studying the safety and effectiveness of the CEFALY device, a non-invasive nerve stimulator worn on the forehead, for treating migraines during and after pregnancy. Pregnant women aged 18-44 with migraines can join, regardless of whether they use the devic…

This study looks at medical records from over 150,000 people who received NeuroStar TMS (a non-invasive brain stimulation treatment) for depression, OCD, or anxiety. Researchers want to find out which patient traits and treatment settings lead to the best results. No new treatmen…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…