Brain zaps could predict who gets relief from stubborn depression

NCT ID NCT07207239

ENROLLING_BY_INVITATION Symptom relief Sponsor: Semmelweis University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a type of brain stimulation called theta-burst rTMS in 54 adults with depression that hasn't responded to other treatments. The goal is to see if it eases depression and thinking problems, and to use brain scans to predict who will benefit. Participants receive daily 9.5-minute sessions for four weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: repetitive transcranial magnetic stimulation (rTMS) using a theta-burst protocol
What this could lead to: If it works, this could offer a non-drug treatment option for people with depression that hasn't improved with standard therapies.
What could go wrong: This is a small, early-stage study with only 54 participants, so results may not apply to everyone. The treatment may not work for all, and side effects like headache or discomfort are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION - MAJOR DEPRESSIVE DISORDER TRANSCRANIAL MAGNETIC STIMULATION REPETITIVE

Contacts and locations

Locations

Department of Psychiatry and Psychotherapy

Budapest, Pest County, 1083, Hungary

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