DEPRESSION - MAJOR DEPRESSIVE DISORDER
Clinical trials for DEPRESSION - MAJOR DEPRESSIVE DISORDER explained in plain language.
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Breathing workout may sharpen aging brains
Disease control Recruiting nowThis study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Participants must have at least one risk factor for dementia, such as high blood pressure or mild memory problems. Th…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Florida State University • Aim: Disease control
Last updated May 16, 2026 23:31 UTC
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New care model aims to untangle healthcare for older adults with depression
Disease control Recruiting nowThis study is testing a new coordinated care program called I-CONNECT for people aged 65 and older who have depression or bipolar disorder along with at least two other long-term health conditions like diabetes or high blood pressure. Researchers want to see if having a care coor…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: KU Leuven • Aim: Disease control
Last updated Apr 13, 2026 20:21 UTC
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AI therapist: a new hope for depression and anxiety?
Symptom relief Recruiting nowThis study tests whether an artificial intelligence (AI)-guided therapy program can help adults with mild depression or anxiety. Participants will either receive the AI-guided therapy or standard care over 10 weeks. The goal is to see if the AI approach reduces symptoms and impro…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Aleksandra Stojanovic • Aim: Symptom relief
Last updated May 16, 2026 23:34 UTC
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Short therapy for sleepless nights shows promise in new trial
Symptom relief Recruiting nowThis study tests a brief group therapy program (ACT-i) for adults with chronic insomnia who also have mild depression or anxiety. About 76 people will be randomly assigned to either the therapy or a control group. Researchers will check sleep quality, mood, and thinking before tr…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Babes-Bolyai University • Aim: Symptom relief
Last updated May 16, 2026 23:34 UTC
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New brain-zap therapy for teen depression tested in pilot trial
Symptom relief Recruiting nowThis study tests a non-invasive brain stimulation technique called rTMS, guided by MRI, to treat depression in 45 teenagers aged 12-18. Participants must have major depressive disorder and be on stable medication. The goal is to see if the treatment is safe, acceptable, and helps…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: First Affiliated Hospital of Chongqing Medical University • Aim: Symptom relief
Last updated May 16, 2026 23:34 UTC
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Can a step-by-step plan beat standard depression care?
Symptom relief Recruiting nowThis study looks at three ways to treat moderate depression in adults aged 18-65: usual care from a family doctor, therapy from a psychologist, or a structured step-by-step treatment plan from a doctor. The goal is to see which approach works best. About 171 people will take part…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Aalborg University Hospital • Aim: Symptom relief
Last updated May 16, 2026 23:33 UTC
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Virtual reality and a daily pill aim to sharpen aging minds
Symptom relief Recruiting nowThis study tests whether a three-week virtual reality brain-training program, combined with a daily supplement called sodium butyrate, can improve memory and thinking in 160 middle-aged and older adults who have had depression or bipolar disorder but are currently stable. Partici…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital • Aim: Symptom relief
Last updated May 16, 2026 23:32 UTC
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Phone prompts may lift mood by getting people moving
Symptom relief Recruiting nowThis study tests whether a 4-week digital program that sends activity prompts can increase physical activity and reduce depression, anxiety, and stress in adults with moderate symptoms. Fifty participants will be randomly assigned to receive the prompts or just have their symptom…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Auburn University • Aim: Symptom relief
Last updated May 16, 2026 23:32 UTC
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Brain zapping showdown: which depression treatment works better?
Symptom relief Recruiting nowThis study compares two types of brain stimulation for depression: right-sided 1-Hz rTMS and left-sided iTBS. Researchers want to see if the right-sided method works as well as the left-sided one. The trial will include 350 adults with unipolar or bipolar depression and measure s…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE4 • Sponsor: Region Örebro County • Aim: Symptom relief
Last updated May 16, 2026 23:32 UTC
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Poop pills for depression? new study tests gut bacteria fix
Symptom relief Recruiting nowThis study tests whether fecal microbiota transplantation (FMT) — transferring gut bacteria from a healthy donor — can help adults with major depression who don't get better quickly on standard antidepressants. About 214 participants will receive either FMT or a placebo, and rese…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Gang Wang • Aim: Symptom relief
Last updated May 16, 2026 23:17 UTC
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Can faster brain zaps beat daily therapy for late-life depression?
Symptom relief Recruiting nowThis study tests whether giving multiple brain stimulation sessions per day works better than one session per day for treating depression in people aged 60 and older. About 280 participants will receive active treatment, but some get the accelerated version and some get the stand…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Symptom relief
Last updated May 16, 2026 23:17 UTC
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AI chatbot aims to soothe anxiety and depression in cannabis users
Symptom relief Recruiting nowThis early-stage study is testing a generative AI chatbot called Therabot-CALM to see if it is acceptable and helpful for people who have cannabis use disorder along with anxiety or depression. Fifteen participants will use the app for four weeks and give feedback through intervi…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE1 • Sponsor: Trustees of Dartmouth College • Aim: Symptom relief
Last updated May 15, 2026 11:56 UTC
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Online CBT aims to ease depression and anxiety in cystic fibrosis community
Symptom relief Recruiting nowThis study tests whether an online group therapy program (cognitive behavioral therapy) can improve depression, anxiety, and other mental health symptoms in people with cystic fibrosis and their caregivers. About 52 participants will be randomly assigned to therapy or a control g…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Rakitzi, Stavroula • Aim: Symptom relief
Last updated May 15, 2026 11:56 UTC
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Can a Self-Guided online course ease depression and anxiety?
Symptom relief Recruiting nowThis study is testing whether a self-guided online course that teaches dialectical behavior therapy (DBT) skills is practical and helpful for adults with mild-to-moderate depression and anxiety. About 40 participants will take the 8-week course and complete surveys to measure how…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Windsor • Aim: Symptom relief
Last updated May 15, 2026 11:55 UTC
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Can talk therapy boost ketamine for dual diagnosis?
Symptom relief Recruiting nowThis study looks at whether adding a type of talk therapy called Acceptance and Commitment Therapy (ACT) to ketamine treatment is practical for people who have both alcohol use disorder and depression that hasn't improved with standard medications. The study will enroll 30 partic…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) • Aim: Symptom relief
Last updated May 15, 2026 11:54 UTC
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New pilot aims to ease PTSD and anxiety in ICU families
Symptom relief Recruiting nowThis study tests whether a telehealth-based mental health program can help family members of ICU survivors cope with anxiety, depression, and PTSD. About 150 family members will use an online platform and have check-ins. The goal is to see if this approach is practical and helpfu…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Medical University of South Carolina • Aim: Symptom relief
Last updated May 15, 2026 11:54 UTC
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Could a VR headset help seniors beat the blues?
Symptom relief Recruiting nowThis study explores whether using a virtual reality (VR) headset can make behavioral activation therapy more effective for older adults (65+) with major depression. Researchers will enroll 30 participants to see if VR-enhanced therapy is practical, well-liked, and helps reduce de…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Stanford University • Aim: Symptom relief
Last updated May 15, 2026 11:53 UTC
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New depression drug shows promise in Large-Scale trial
Symptom relief Recruiting nowThis study tests whether a new drug called CYB003 can safely reduce symptoms of major depression. About 330 adults with moderate to severe depression will receive either CYB003 or a placebo. The goal is to see if CYB003 improves mood and daily function better than a placebo.
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE3 • Sponsor: Cybin IRL Limited • Aim: Symptom relief
Last updated May 15, 2026 11:53 UTC
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AI therapy tailored to you: new study tackles depression with smart tech
Symptom relief Recruiting nowThis study is testing a new digital platform that uses artificial intelligence and smartphone data to personalize cognitive-behavioral therapy for people with major depression. Researchers aim to see if this approach can better track symptoms and improve treatment outcomes. The s…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: National Science and Technology Council, Taiwan • Aim: Symptom relief
Last updated May 14, 2026 12:04 UTC
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Magic mushroom therapy targets veteran depression after spinal injury
Symptom relief Recruiting nowThis study tests whether psilocybin, the active ingredient in magic mushrooms, is safe and can ease depression in veterans with spinal cord injury. Thirty participants will receive low, medium, or high doses and be monitored for side effects and mood changes over 13 months. The g…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE1, PHASE2 • Sponsor: James J. Peters Veterans Affairs Medical Center • Aim: Symptom relief
Last updated May 14, 2026 12:02 UTC
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New therapy targets depression rooted in childhood hardship
Symptom relief Recruiting nowThis study tests a new psychological therapy designed for adults with depression linked to difficult childhood experiences. The goal is to see if this therapy helps improve mood, emotional control, and distressing thoughts. Researchers will also take blood samples to study biolog…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: St. Joseph's Healthcare Hamilton • Aim: Symptom relief
Last updated May 13, 2026 16:02 UTC
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Can brain training get you back to work? new study targets depression and anxiety
Symptom relief Recruiting nowThis study looks at how memory, focus, and other thinking skills relate to work performance and sick leave in people with depression or anxiety. Researchers will give metacognitive therapy combined with work-focused support to 200 adults at risk of sick leave. The goal is to see …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Norwegian University of Science and Technology • Aim: Symptom relief
Last updated May 13, 2026 16:02 UTC
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Could a common ADHD drug also lift depression? new trial investigates
Symptom relief Recruiting nowThis study tests whether two different forms of dexamphetamine (a stimulant) can safely help adults who have both ADHD and moderate to severe depression. About 105 participants will receive either the drug or a placebo. The main goal is to check for side effects and see if the tr…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Prof. Dr. Frank Behrens • Aim: Symptom relief
Last updated May 13, 2026 16:00 UTC
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Can a phone app lift mood and cut cannabis use? new study seeks answers
Symptom relief Recruiting nowThis study tests a digital program called AMP-C for people who have both depression and cannabis use problems. About 80 adults will either use the AMP-C app or just track their symptoms. Researchers will check if the app improves mood, reduces cannabis use, and is easy to use.
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated May 13, 2026 15:59 UTC
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Can VR meditation lift depression when drugs fail?
Symptom relief Recruiting nowThis study tests whether adding virtual reality (VR) mindfulness sessions to standard treatment helps people with treatment-resistant depression feel better. Thirty adults will be randomly assigned to either VR mindfulness plus usual care or usual care alone for one month. Resear…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Hospital Universitari Vall d'Hebron Research Institute • Aim: Symptom relief
Last updated May 11, 2026 20:53 UTC
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New program aims to ease anxiety and depression after ICU stays
Symptom relief Recruiting nowThis study tests a mental health support program for 150 people who recently left the ICU. The program includes digital tools, coaching, and psychiatric help to reduce anxiety, depression, and PTSD symptoms. Participants are compared to those receiving usual care over six months.
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Medical University of South Carolina • Aim: Symptom relief
Last updated May 11, 2026 20:49 UTC
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Sweat away sadness: heated yoga and sauna tested as depression treatments
Symptom relief Recruiting nowThis study tests whether heated yoga, sauna sessions, or a mindfulness app can reduce symptoms of depression. Researchers will enroll 120 adults aged 18-65 with at least moderate depression. Participants will be assigned to one of the three approaches and monitored for changes in…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated May 11, 2026 20:49 UTC
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Instant help for waiting teens: online therapy cuts months-long queues
Symptom relief Recruiting nowThis study tests a free, online single-session therapy for teens aged 12-17 in Hong Kong who are waiting for in-person psychotherapy. The goal is to quickly reduce symptoms of anxiety and depression, and make teens feel more ready for future treatment. About 124 participants will…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: United Christian Hospital • Aim: Symptom relief
Last updated May 11, 2026 20:47 UTC
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Magic mushroom compound tested for mental health relief
Symptom relief Recruiting nowThis early-stage study at Yale tests whether a single 25mg dose of psilocybin is safe and tolerable for people whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug and be followed for up to 6 weeks, with optional l…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE1 • Sponsor: Yale University • Aim: Symptom relief
Last updated May 11, 2026 20:40 UTC
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Diet makeover for depression: college students test mediterranean diet and Time-Restricted eating
Symptom relief Recruiting nowThis study looks at whether changing eating habits can help college students with mild to moderate depression. About 30 students will either follow a Mediterranean diet or combine it with time-restricted eating (eating only during a 10-hour window). The goal is to see if these di…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of California, San Diego • Aim: Symptom relief
Last updated May 06, 2026 16:14 UTC
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Eye treatment may lift mood: 200-Patient trial launches
Symptom relief Recruiting nowThis study looks at whether PROSE treatment—a special lens that protects the eye's surface—can help improve mental health in people with depression. Researchers will track mood changes in 200 adults with eye surface disease. The goal is to see if treating eye discomfort can also …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Boston Sight • Aim: Symptom relief
Last updated May 05, 2026 11:55 UTC
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Blood tests could make antidepressants safer and more effective for teens
Symptom relief Recruiting nowThis study tests whether measuring drug levels in the blood can help doctors personalize antidepressant doses for people aged 12 and older with major depression. Participants will receive one of three common antidepressants (fluoxetine, sertraline, or escitalopram), and doses wil…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE4 • Sponsor: Poznan University of Medical Sciences • Aim: Symptom relief
Last updated May 05, 2026 11:52 UTC
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Can brain-training meditation lift depression?
Symptom relief Recruiting nowThis study tests a new approach that combines meditation with real-time brain feedback to help people with moderate depression. 27 adults will try the intervention to see if it reduces depression symptoms and improves mindfulness. No medications are used, and the goal is to ease …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of California, San Diego • Aim: Symptom relief
Last updated May 01, 2026 16:01 UTC
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Magic mushroom compound tested to restore joy in depressed patients
Symptom relief Recruiting nowThis early-stage study explores whether psilocybin, the active ingredient in magic mushrooms, can reduce anhedonia (loss of pleasure) in people with major depression. 85 participants, including healthy volunteers, will receive psilocybin in two sessions—one with a drug that block…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE1 • Sponsor: Medical University of Vienna • Aim: Symptom relief
Last updated May 01, 2026 16:00 UTC
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Sound waves aimed at the brain: a new hope for depression?
Knowledge-focused Recruiting nowThis study is testing a new, non-invasive way to stimulate the brain using focused ultrasound for people with depression. Researchers will use MRI scans to personalize the treatment for each of the 30 participants, aiming to see if it safely changes brain activity and improves mo…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE1, PHASE2 • Sponsor: Brian Mickey • Aim: Knowledge-focused
Last updated May 16, 2026 23:33 UTC
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Digital twins could revolutionize mental health care for diabetes patients
Knowledge-focused Recruiting nowThis study aims to identify subgroups of people with diabetes who share similar patterns in how their blood sugar and mental health are linked. By using smartphone surveys and continuous glucose monitors, researchers will collect detailed data from over 1,800 participants over tw…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Forschungsinstitut der Diabetes Akademie Mergentheim • Aim: Knowledge-focused
Last updated May 15, 2026 11:55 UTC
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Spinal zaps could unlock new depression treatments
Knowledge-focused Recruiting nowThis study explores whether mild electrical stimulation of the spine can change how the brain processes body signals, which may be disrupted in major depression. Researchers will test different stimulation levels in 67 adults with depression to see if it affects brain activity. T…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE1, PHASE2 • Sponsor: University of Cincinnati • Aim: Knowledge-focused
Last updated May 14, 2026 12:06 UTC
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Can your phone predict dementia? new study tracks stress and brain health in real time
Knowledge-focused Recruiting nowThis observational study in Seoul, Korea, looks at how everyday emotional stress impacts memory and thinking in adults aged 60 and older. Over 180 participants will use a smartphone app and a smartwatch to report their feelings and do quick brain games several times a day for two…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Korea University • Aim: Knowledge-focused
Last updated May 14, 2026 12:05 UTC
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Real-World study tracks Trazodone's effect on depression and memory in seniors
Knowledge-focused Recruiting nowThis study is watching how the drug trazodone works in everyday medical practice for people aged 55 and older who have both major depression and mild cognitive impairment (slight memory or thinking problems). Researchers will track changes in depression symptoms using a standard …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Aziende Chimiche Riunite Angelini Francesco S.p.A • Aim: Knowledge-focused
Last updated May 13, 2026 15:58 UTC
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Blood test could revolutionize mental health diagnosis
Knowledge-focused Recruiting nowThis study is testing a new blood test to see if it can help doctors tell the difference between depression and schizophrenia, and predict which treatments will work best. Researchers will collect blood samples and mental health surveys from 500 adults over three visits. The goal…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Fraser Health • Aim: Knowledge-focused
Last updated May 11, 2026 20:48 UTC
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Antidepressant's effect on anger in healthy youth under microscope
Knowledge-focused Recruiting nowThis study looks at how the antidepressant fluoxetine changes the way healthy young people (ages 18-24) process anger. Participants take either fluoxetine or a placebo daily for 7 days and complete tasks involving angry words, faces, and frustrating situations. Researchers measur…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Oxford • Aim: Knowledge-focused
Last updated May 08, 2026 12:03 UTC
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Brain mapping study aims to sharpen depression therapies
Knowledge-focused Recruiting nowThis study looks at how the brain works during tasks involving emotions, attention, and memory in both healthy volunteers and people with depression. Researchers use brain scans and gentle brain stimulation to measure activity. The goal is to gather information that could lead to…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Medical University of South Carolina • Aim: Knowledge-focused
Last updated May 07, 2026 18:41 UTC
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Scientists peer inside brains to unlock secrets of cognitive struggles
Knowledge-focused Recruiting nowThis study uses brain imaging (fMRI) to explore why people with schizophrenia or depression often have trouble with memory and managing emotions. Researchers will scan the brains of 90 adults while they perform tasks and at rest. The goal is to better understand the brain mechani…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: The Royal Ottawa Mental Health Centre • Aim: Knowledge-focused
Last updated May 04, 2026 16:23 UTC