Eye treatment may lift mood: PROSE lenses tested for depression relief

NCT ID NCT07195721

Recruiting now Symptom relief Sponsor: Boston Sight Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether PROSE treatment—a custom contact lens that soothes the eye surface—can also improve mental health in people with major depression. Researchers will track depression scores and eye symptoms in 200 adults over time. The goal is to see if treating severe dry eye can lift mood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PROSE treatment (a special contact lens that protects the eye surface)
What this could lead to: If it works, this could show that treating severe dry eye with PROSE lenses also eases depression symptoms.
What could go wrong: This is an early-stage trial with no control group, so results may not prove cause and effect. The effect on mood might be small or not last.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION - MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

BostonSight
RECRUITING

Needham, Massachusetts, 02494, United States

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Other studies related to the condition(s) this trial covers.