Sound waves to lift mood? new study tests ultrasound for depression

NCT ID NCT06902298

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new, non-invasive brain stimulation method using low-intensity ultrasound waves aimed at specific brain areas linked to depression. Researchers will personalize the treatment for each of the 30 participants based on their brain scans. The goal is to see if this approach can safely engage the target brain regions and improve mood in people with treatment-resistant depression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

low-intensity transcranial focused ultrasound

What this could lead to

If it works, this could point toward a new non-invasive treatment option for people with depression that hasn't responded to other therapies.

What could go wrong

This is an early-phase study with only 30 participants, so results may not apply to everyone. The treatment is still experimental, and its safety and effectiveness are not yet proven.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Utah

    RECRUITING

    Salt Lake City, Utah, 84108, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact