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Brain stimulation plus exercise may lift depression and boost walking after stroke

NCT ID NCT07050355

Recruiting now Disease control Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This trial investigates whether combining repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise can treat depression and improve walking in people who have had a stroke. Participants will receive either real or sham rTMS along with exercise sessions over 12 weeks. The study aims to see if treating depression helps the brain recover better, leading to greater functional gains.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS) and aerobic exercise
What this could lead to
If successful, this combination could offer a new way to treat post-stroke depression while also helping people walk better.
What could go wrong
This is an early-phase trial with only 96 participants, so results may not apply to everyone. The treatments require multiple sessions and may not work for all individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder Motor Activity stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION - MAJOR DEPRESSIVE DISORDER STROKE WALKING IMPAIRMENT

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Duke University School of Medicine

    ACTIVE_NOT_RECRUITING

    Durham, North Carolina, 27710, United States

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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