New hope for seniors with stubborn depression?
NCT ID NCT07623135
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether lumateperone (Caplyta) can help older adults (60+) whose depression hasn't improved with other treatments. One hundred participants will take either the drug or a placebo alongside their current antidepressant for 10 weeks. Researchers will measure changes in depression scores to see if the drug works better than placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lumateperone (Caplyta)
What this could lead to
If it works, this could offer a new option to help older adults with hard-to-treat depression feel better.
What could go wrong
This is a Phase 3 trial, but it's still early and small (100 people). The drug may not work better than placebo, and side effects are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Arizona
Tucson, Arizona, 85713, United States
Contact
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
Contact