TREATMENT-RESISTANT DEPRESSION (TRD)

This trial investigates whether vagus nerve stimulation (VNS) — a device implanted in the neck that sends electrical pulses to the brain — can help people with treatment-resistant depression. About 166 adults with depression that has not responded to standard treatments will rece…

This study tests a personalized approach to deep brain stimulation (DBS) for people with depression that hasn't improved with other treatments. Researchers use brain scans and recordings to find the best spot and settings for each person's implant. The goal is to see if this tail…

This study compares a personalized, step-by-step treatment algorithm to usual care for people with treatment-resistant depression. About 80 adults aged 18-65 who have not felt stable in the past year will participate. The goal is to see if the algorithm leads to greater symptom i…

This study tests an accelerated form of transcranial magnetic stimulation (TMS) for people with major depression that hasn't improved with medication. Over five days, 35 adults will receive multiple sessions of targeted brain stimulation. Researchers will track changes in depress…

This study at Massachusetts General Hospital tests whether adding coaching sessions to standard ketamine or esketamine treatment can help people with treatment-resistant depression. About 20 adults already on maintenance ketamine will receive 12 coaching sessions over 3 months. T…

This study tests a non-invasive light therapy called transcranial photobiomodulation (tPBM) on the forehead to help people with treatment-resistant depression. About 40 adults who still have moderate-to-severe depression despite taking antidepressants will receive tPBM at differe…

This study tests an experimental drug called ALTO-207 in adults whose depression has not improved with at least two prior treatments. About 178 participants will receive either the drug or a placebo for several weeks. The main goal is to see if ALTO-207 reduces depression symptom…

This study looks at whether adding special therapy sessions before and after esketamine (Spravato®) nasal spray can help people with depression that hasn't improved with other treatments. About 20 adults will be randomly assigned to get esketamine either with or without these the…

This study tests whether a safe, at-home brain stimulation device called tDCS can help people with depression that hasn't improved with standard treatments. Ten participants will use the device at home under remote supervision for two weeks. The goal is to see if the approach is …

This study tests whether giving transcranial magnetic stimulation (TMS) right before electroconvulsive therapy (ECT) can lower the amount of electricity needed for ECT and speed up its antidepressant effects. Fifty adults with major depression that hasn't responded to other treat…

This study tests if adding structured exercise to a brain stimulation treatment called iTBS can help people with depression that hasn't improved with medication. Twenty physically inactive adults with difficult-to-treat depression will either get iTBS alone or iTBS plus exercise.…

This study compares two accelerated forms of transcranial magnetic stimulation (TMS) for people with treatment-resistant depression. 60 participants will receive either intermittent or continuous theta burst stimulation over two weeks, with a 12-week follow-up. The goal is to see…

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray in real-world clinics. Researchers will track how well the drug works, who responds best, and how it affects daily life and thinking. The goal is to improve personalized ca…

This study tests how a single dose of intravenous ketamine changes brain chemicals like GABA and glutamate in people with treatment-resistant depression. Thirty adults will receive either ketamine or a placebo, and researchers will measure brain activity and depression symptoms. …