TREATMENT RESISTANT DEPRESSION (TRD)

This study is testing two faster versions of a non-invasive brain stimulation treatment for people whose depression hasn't improved with standard antidepressants. Researchers will compare two different stimulation patterns, both delivered in an intensive two-week schedule, to see…

This study is observing how esketamine nasal spray works for people with severe, treatment-resistant depression in real-world clinics. It aims to see who benefits most from the treatment and how it affects their daily life, work, and social functioning. Researchers will also look…

This study is testing if using a non-invasive magnetic brain stimulator (TMS) right before electroconvulsive therapy (ECT) can make the ECT treatment work with less electrical energy. Researchers want to see if this combination helps people with severe, hard-to-treat depression g…

This study is testing whether adding special therapy sessions before and after esketamine treatment helps people with severe depression that hasn't responded to other medications. Twenty adults will receive the FDA-approved nasal spray, with half also getting structured support s…

This small pilot study is testing whether adding a structured exercise program before and during a brain stimulation treatment makes it work better for people with difficult-to-treat depression. Researchers will compare the effects of exercise plus brain stimulation against brain…

This study is testing whether a type of gentle brain stimulation, called tDCS, can be safely done at home by people with depression that hasn't improved with standard treatments. Ten participants will self-administer the 20-minute stimulation sessions at home, five times a day fo…

This study aims to understand how a single dose of ketamine affects specific brain chemicals in people with depression that hasn't responded to other treatments. Researchers will use MRI brain scans and blood tests to measure changes in chemicals linked to mood, comparing them to…