Can talk therapy make a depression nasal spray work better?

NCT ID NCT07369102

Recruiting now Symptom relief Sponsor: University of Puerto Rico Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding special therapy sessions before and after esketamine (Spravato®) nasal spray can help people with depression that hasn't improved with other treatments. About 20 adults will be randomly assigned to get esketamine either with or without these therapy sessions. The goal is to see if the extra support leads to longer-lasting mood improvements.

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Conditions

The condition(s) this trial relates to.

Depression Depressive Disorder, Treatment-Resistant dissociative disorder Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT-RESISTANT DEPRESSION (TRD)

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Pravan Foundation
RECRUITING

San Juan, 00909, Puerto Rico

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Puerto Rico, Department of Psychiatry
RECRUITING

San Juan, 00936, Puerto Rico

Contact Phone: •••-•••-•••• Email: •••••@•••••