Can talk therapy boost a depression nasal spray? new study aims to find out.

NCT ID NCT07369102

First seen Feb 01, 2026 · Last updated May 15, 2026 · Updated 14 times

Summary

This study tests whether adding therapy sessions before and after esketamine (Spravato®) nasal spray can improve mood and daily function in adults with treatment-resistant depression. About 20 people will be randomly assigned to receive esketamine with or without extra therapeutic support. The goal is to see if the therapy helps the medication work better and last longer.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for TREATMENT RESISTANT DEPRESSION (TRD) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Pravan Foundation

    RECRUITING

    San Juan, 00909, Puerto Rico

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Puerto Rico, Department of Psychiatry

    RECRUITING

    San Juan, 00936, Puerto Rico

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.