TREATMENT-RESISTANT DEPRESSION (TRD)

This study tests whether adding a drug called NRX-101 (a mix of D-cycloserine and lurasidone) to transcranial magnetic stimulation (TMS) helps people with treatment-resistant depression more than TMS alone. About 400 adults who have not had TMS before will receive either the drug…

This study tests whether lumateperone (Caplyta) can help older adults (60+) whose depression hasn't improved with other treatments. One hundred participants will take either the drug or a placebo alongside their current antidepressant for 10 weeks. Researchers will measure change…

This study tests whether ketamine injections combined with psychotherapy can help people with treatment-resistant depression. Researchers will use brain scans to see if changes in brain activity link to improvements. About 25 adults will receive 1-2 doses of ketamine and several …

This study tests whether adding a ketogenic (low-carb) diet to a non-invasive brain stimulation treatment called iTBS helps people with treatment-resistant depression feel better. Sixty adults will follow either a keto diet or a standard healthy diet for three weeks, then receive…

This study tests two types of brain stimulation for people with depression that hasn't improved with medication. About 247 adults will receive either a precise, guided form of stimulation, a standard form, or a fake (sham) procedure. The goal is to see if these treatments can saf…

This study tests a new method of delivering repetitive transcranial magnetic stimulation (rTMS) for people with treatment-resistant depression. Instead of the standard approach, the new method uses brain surface mapping to target a specific area. The trial will compare the two me…

This phase 2 trial tests whether adding the antidepressant trazodone to psilocybin can reduce the intense psychedelic effects while keeping the mood-lifting benefits. 112 adults with treatment-resistant depression will receive either psilocybin alone, psilocybin plus a low or hig…

This study looks at how a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) affects symptoms and blood markers in people with treatment-resistant depression. Fifty patients will receive iTBS sessions over four weeks, while fifty healthy v…

This study aims to develop a brain wave (EEG) test that can measure how ketamine affects depression symptoms. Researchers will give ketamine infusions to 20 adults with treatment-resistant depression and track changes in their mood and brain signals. The goal is to find a reliabl…