TREATMENT RESISTANT DEPRESSION (TRD)
Clinical trials for TREATMENT RESISTANT DEPRESSION (TRD) explained in plain language.
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Ketamine and therapy: a new hope for stubborn depression?
Symptom relief Not yet recruitingThis study tests if ketamine, given alongside psychotherapy, can help people with depression that hasn't improved with other treatments. About 25 adults will receive 1-2 doses of ketamine and 3-4 therapy sessions. Researchers will use brain scans and surveys to see if the treatme…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE2 • Sponsor: University of Rochester • Aim: Symptom relief
Last updated May 15, 2026 11:56 UTC
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New brain zaps could lift depression when pills fail
Symptom relief Not yet recruitingThis study tests a quick, non-invasive brain stimulation technique called accelerated intermittent theta-burst stimulation (aiTBS) for people with depression that hasn't improved with at least two medications. About 247 adults aged 18-65 will be randomly assigned to receive eithe…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated May 15, 2026 11:53 UTC
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Precision brain zapping may ease tough depression
Symptom relief Not yet recruitingThis study tests a new method of brain stimulation for people with depression that hasn't improved with standard treatments. The approach uses brain surface mapping to target a specific area more precisely. About 60 adults will receive either standard or targeted stimulation to s…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE2 • Sponsor: Soterix Medical • Aim: Symptom relief
Last updated May 15, 2026 11:53 UTC
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Can a depression drug block the trip but keep the relief? new study investigates
Symptom relief Not yet recruitingThis study tests whether combining psilocybin (the active ingredient in magic mushrooms) with the antidepressant trazodone can reduce depression symptoms in people who haven't gotten better with other treatments. The key question is whether blocking the psychedelic 'trip' with tr…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE2 • Sponsor: Centre Hospitalier St Anne • Aim: Symptom relief
Last updated May 11, 2026 20:49 UTC
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Could a keto diet supercharge brain therapy for depression?
Symptom relief Not yet recruitingThis study tests whether adding a low-carb ketogenic diet to a personalized brain stimulation treatment (iTBS) can better reduce depression symptoms in adults with treatment-resistant depression. Sixty participants will follow either a ketogenic diet or a standard healthy diet fo…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: NA • Sponsor: Sunnybrook Health Sciences Centre • Aim: Symptom relief
Last updated May 11, 2026 20:48 UTC
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Brain wave test may predict Ketamine's power against depression
Knowledge-focused Not yet recruitingThis early-stage study aims to develop a brain wave (EEG) test that can measure how ketamine affects people with treatment-resistant depression. Researchers will give ketamine infusions to 20 participants and track changes in both their depression symptoms and brain signals. The …
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE1 • Sponsor: Soterix Medical • Aim: Knowledge-focused
Last updated May 17, 2026 03:08 UTC