TREATMENT RESISTANT DEPRESSION (TRD)
Clinical trials for TREATMENT RESISTANT DEPRESSION (TRD) explained in plain language.
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Brain scans & ketamine: a new hope for stubborn depression?
Disease control Not yet recruitingThis study is testing whether a few doses of ketamine, given alongside guided therapy sessions, can help people with treatment-resistant depression. Researchers want to see if this combination changes brain activity in ways that reduce depression symptoms and improve emotional fl…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE2 • Sponsor: University of Rochester • Aim: Disease control
Last updated Apr 01, 2026 14:43 UTC
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Zapping the blues away: new brain stimulation trial offers hope for tough depression
Disease control Not yet recruitingThis study is testing two newer forms of magnetic brain stimulation to see if they can help people with depression that hasn't gotten better with standard medications or therapy. Researchers will compare a more precise, guided method against a standard method and a placebo treatm…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Brain zap & diet combo tested as new hope for tough depression
Disease control Not yet recruitingThis study aims to see if a low-carb ketogenic diet can make a type of non-invasive brain stimulation more effective for adults with depression that hasn't responded to standard medications. Participants will follow either the ketogenic diet or a standard healthy diet for several…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: NA • Sponsor: Sunnybrook Health Sciences Centre • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Magic mushroom drug tested to fight depression without the 'Trip'
Disease control Not yet recruitingThis study is testing a new approach for people with depression that hasn't improved with standard treatments. Researchers want to see if psilocybin, a compound from 'magic mushrooms,' can relieve depression even when its psychedelic effects are blocked by another drug called tra…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE2 • Sponsor: Centre Hospitalier St Anne • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Scientists test personalized brain mapping to boost depression treatment
Disease control Not yet recruitingThis study is testing whether a new, more precise method for targeting brain stimulation works better than the standard method for people with depression that hasn't improved with medication. Researchers will use MRI scans to create a personalized brain map for each participant t…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE2 • Sponsor: Soterix Medical • Aim: Disease control
Last updated Mar 16, 2026 15:26 UTC
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Scientists hunt for depression 'Fingerprint' in the brain
Knowledge-focused Not yet recruitingThis early-stage study aims to find a specific brain signal pattern (an EEG biomarker) that shows how ketamine affects people with treatment-resistant depression. Researchers will give small groups of 20 participants different doses of ketamine and measure changes in their depres…
Matched conditions: TREATMENT RESISTANT DEPRESSION (TRD)
Phase: PHASE1 • Sponsor: Soterix Medical • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:32 UTC