Can ketamine and talk therapy rewire the depressed brain?

NCT ID NCT07247006

Not yet recruiting Symptom relief Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether ketamine injections combined with psychotherapy can help people with treatment-resistant depression. Researchers will use brain scans to see if changes in brain activity link to improvements. About 25 adults will receive 1-2 doses of ketamine and several therapy sessions over two months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketamine hydrochloride injection
What this could lead to: If it works, this could point toward a faster-acting treatment for depression that doesn't respond to standard antidepressants.
What could go wrong: This is a small, early-phase study with only 25 people, so results may not apply widely. Ketamine can cause dissociative side effects, and the benefit may not last.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Depression Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PAIN TREATMENT RESISTANT DEPRESSION (TRD)

Contacts and locations

Locations

University of Rochester Medical Center

Rochester, New York, 14642, United States

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