Can ketamine and talk therapy rewire the depressed brain?
NCT ID NCT07247006
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether ketamine injections combined with psychotherapy can help people with treatment-resistant depression. Researchers will use brain scans to see if changes in brain activity link to improvements. About 25 adults will receive 1-2 doses of ketamine and several therapy sessions over two months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine hydrochloride injection
What this could lead to
If it works, this could point toward a faster-acting treatment for depression that doesn't respond to standard antidepressants.
What could go wrong
This is a small, early-phase study with only 25 people, so results may not apply widely. Ketamine can cause dissociative side effects, and the benefit may not last.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Rochester Medical Center
Rochester, New York, 14642, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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