University Of Rochester

This study is for people with advanced non-small cell lung cancer who are not well enough for standard strong chemotherapy. It tests a combination of one chemotherapy drug and an immunotherapy drug (pembrolizumab) to see if it is safe and helps shrink tumors. About 60 participant…

This study tests whether a preventive heart ablation procedure, done soon after implanting a defibrillator (ICD), can reduce dangerous heart rhythms in people with heart failure and weak heart muscle. About 62 high-risk adults will be randomly assigned to either receive the ablat…

This study tests a program called TEACH-ER that provides asthma education in the emergency room and virtual follow-up visits at home. Researchers will enroll 430 children aged 3-12 with asthma to see if this approach reduces the need for future ER visits or hospital stays. The pr…

This study tests whether destroying small areas of heart muscle that cause dangerous rhythms (ventricular tachycardia ablation) during LVAD implant surgery can reduce the number of these rhythms after surgery. About 100 adults with advanced heart failure who are getting an LVAD w…

This study compares a new type of heart pacing (His-bundle pacing) to standard pacing in 120 adults with heart failure and right bundle-branch block. The goal is to see if the new method better improves the heart's pumping ability over 6 months. Participants will receive one of t…

This phase III trial tests whether high-dose vitamin D can prevent bone loss in older men with prostate cancer who are receiving hormone therapy (ADT). The study will enroll 240 men aged 50 and older, giving them either high-dose vitamin D or a placebo for one year. Researchers w…

This study compares two common bone graft materials (freeze-dried bone allograft and collagen-enriched cow bone xenograft) used to preserve the jawbone after removing a front tooth. About 50 adults who need a tooth extraction and plan to get a dental implant will be randomly assi…

This phase 2 trial is testing whether a combination of two drugs, neratinib and capecitabine, can help people with HER2-negative breast cancer that has spread to the brain. The study enrolls 22 adults whose tumors show abnormal HER2 activity on a special test. Researchers will me…

This study tests whether adding a kidney nerve-zapping procedure (renal artery denervation) to the standard heart ablation procedure can better control persistent atrial fibrillation (AF). About 50 adults with persistent AF and controlled or no high blood pressure will be randoml…

This study is testing whether umbilical cord blood stem cells from unrelated donors can safely and effectively restore blood cell production in people with serious conditions like leukemia, immune deficiencies, and inherited blood disorders. The main goal is to see how quickly th…

This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol…

This study tests whether giving emergency department patients who are at high risk for lung cancer a direct referral to a screening program, plus text message reminders, increases the number who get screened. About 300 eligible adults will be randomly assigned to either basic inf…

This study tests whether offering a self-sampling kit for HPV in the emergency department can increase the number of people who get screened for cervical cancer. About 200 eligible individuals (ages 30-65 with a cervix) will be offered the kit while in the ED. The goal is to see …

This study tests whether a green dye called indocyanine green (ICG) can help surgeons find sentinel lymph nodes—the first nodes where cancer might spread—in children with solid tumors. Ten children under 18 will get the dye injected during surgery, and doctors will check if it li…

This study tests whether giving nurses and doctors special training and allowing nurses to give the HPV vaccine without a doctor's order can increase vaccination rates. About 16,000 teens aged 9-17 from 40 medical practices will take part. The goal is to prevent HPV-related cance…

This study tests whether a special iodine gel applied to teeth can prevent new cavities in children aged 2 to 6 who have severe early childhood cavities. After dental surgery, children will receive either the iodine gel plus fluoride varnish or a placebo plus fluoride varnish eve…

This study is testing whether a text messaging program can encourage people at high risk for lung cancer to get screened. Researchers will enroll 40 people aged 50-80 who smoke or quit recently and have not had their annual screening. Participants will receive texts and education…

This early-phase study is testing whether lisinopril, a widely used blood pressure drug, can prevent urinary side effects in men receiving radiation for prostate cancer. Thirty men with non-metastatic prostate cancer will take one of three daily doses (5, 10, or 20 mg) during the…

This study tests whether daridorexant, a sleep medication, can prevent delirium (sudden confusion) after heart surgery in adults aged 60 and older. Participants take the drug or a placebo for three nights after surgery and are monitored for delirium and sleep quality. The goal is…

This study looks at whether pumping fewer times a day (3-4 times) or following no extra pumping advice can help mothers with low milk supply produce more milk and breastfeed longer. Researchers will measure milk production and study the body's milk-making processes. The goal is t…

This study tests whether a walking program and cognitive rehabilitation exercises can improve memory and thinking in people aged 65 and older who have finished cancer treatment. Forty participants will be randomly assigned to one of four groups: exercise only, cognitive training …

This study tests a disposable silicone device that clips onto eyeglasses to trap moisture around the eyes. Thirty-five adults with mild to moderate dry eye will wear it for two hours. Researchers will measure tear film stability, tear volume, and symptom changes before and after …

This study tests whether a small electrical device (TENS) can reduce pain for women undergoing an in-office procedure for stress urinary incontinence. About 100 women will be randomly assigned to receive either real TENS or a placebo device during the procedure. The goal is to se…

This study is testing a culturally adapted online education program called Tele-Savvy for Latino caregivers of people with Alzheimer's or related dementias. The program includes weekly video group sessions and short instructional videos over seven weeks. Researchers want to see i…

This study tests whether a mobile app delivering cognitive behavioral therapy can help U.S. military veterans who have both insomnia and depression. 1,200 participants will receive either therapy for insomnia, depression, or both in sequence. The goal is to see which approach wor…

This study tests a program called Thrive that helps young adults (ages 18-25) with fetal alcohol spectrum disorders (FASD) set personal goals and build support networks. Participants are randomly assigned to start the program right away or after a delay, and then to work individu…

This pilot study tests a program called SONATA that helps older adults (65+) with advanced cancer strengthen their social connections. The program includes goal-setting, mapping out one's support network, and improving communication with loved ones. Researchers want to see if the…

This study tests whether getting daily texts or emails with healthy living tips can help people recover after being hospitalized for a pulmonary embolism (a blood clot in the lungs). One hundred adults will receive these tips for 8 weeks while also taking standard blood thinners.…

This study aims to find out which parts of behavioral therapy work best for children aged 8-17 with PTSD after a traumatic event. Researchers will compare different therapy components, like emotion regulation and exposure, to a placebo. 200 children and their caregivers will part…

This study tests whether a mobile app exercise program can improve physical function and reduce fatigue in older adults (age 60+) with myeloid neoplasms, a type of blood cancer. Participants will either use the app for guided walking and resistance exercises or receive standard e…

This pilot study is testing a combined program of mobile health exercise and cognitive rehabilitation for older cancer survivors (age 60+) who have concerns about memory or thinking after treatment. The program uses a smartphone app for exercise tracking and group workshops for b…

This study tests a 4-month coaching program called SONATA that helps older adults (age 60+) with advanced cancer build a support network of family and friends. The goal is to see if this social support makes it easier to stick with treatment and feel better. About 330 patients an…

This study tests whether the My Health Coach app can improve quality of life and daily functioning for adults with fetal alcohol spectrum disorders (FASD). Two hundred participants will be split into two groups: one gets the app right away, the other waits 12 weeks. Everyone comp…

This study tests a digital program called RITch®CBT that uses an avatar to guide men through cognitive behavioral therapy for addiction. The goal is to reduce cravings and substance use while also addressing relationship conflict. Forty men entering addiction treatment will use t…

This phase 3 trial tests whether a program called GEM-S (geriatric evaluation and management with survivorship health education) can improve physical function in older cancer survivors. About 668 participants who have completed chemotherapy for lymphoma or solid tumors will be ra…

This study tests whether reducing loneliness can help people with opioid use disorder. 300 adults who feel lonely and use opioids will receive 6 weekly sessions. Researchers will measure changes in loneliness and opioid use over time.

This pilot study tests whether taking a seaweed supplement called fucoidan for 8 to 16 weeks can reduce fatigue and inflammation in cancer survivors. Researchers will enroll 40 adults who have completed cancer treatment within the last 10 years and still feel tired. The main goal…

This study looks at whether daily text message reminders to do pelvic floor exercises can help men recover bladder control faster after prostate surgery. About 132 men who are planning to have prostate surgery will be split into two groups: one gets the text reminders, the other …

This study looks at whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study involves …

This study tests whether a home rehabilitation program using daily text or email messages with simple exercises can reduce the number of heartbeats needed during a 6-minute walk in people with pulmonary arterial hypertension (PAH). Researchers will enroll 55 adults with PAH and c…

This study tests whether a non-invasive electrical therapy, similar to acupuncture but without needles, can help relieve dry mouth in people who had radiation for head and neck cancer. Researchers will treat 75 participants twice a week for 12 weeks and measure changes in dry mou…

This study tests whether giving radiation to the chest early can prevent or delay symptoms like pain or trouble breathing in people with stage IV non-small cell lung cancer. About 48 participants will receive the radiation along with their usual cancer treatment. The goal is to s…

This study tests a program called the Total Health Action Plan (TAP) designed to help leaders in the Idaho Army National Guard better support soldiers' mental health and reduce suicide risk. About 450 soldiers and leaders will be randomly assigned to receive the enhanced program,…

This large study will follow 480 children with sickle cell disease to compare two treatment approaches: a stem cell transplant from a matched family donor versus standard disease-modifying therapies. The goal is to see which option leads to better quality of life and thinking ski…

This pilot study tests whether a personalized approach to heart imaging can safely reduce the number of echocardiograms women with early-stage breast cancer need during HER2-targeted therapy. The goal is to avoid unnecessary tests while still catching any heart side effects early…

This study aims to learn why myotonic dystrophy type 1 affects children differently than adults, and why symptoms vary even within the same family. Researchers will observe 100 children (ages 0-17) through video calls and simple at-home activities, and analyze their genes from a …

This study looks at 50 people with shortness of breath to see if a simple breathing test (oscillometry) can predict problems found during exercise testing. Participants will do both tests, and researchers will compare the results. The goal is to better understand what causes shor…

This study tests a special dye and camera to look at lymph vessels in the hands of people with rheumatoid arthritis. The dye is injected into the skin and glows under a near-infrared camera, allowing researchers to see how lymph fluid moves. The goal is to better understand how t…

This study explores how dopamine, a brain chemical linked to motivation, influences chronic pain. Ten adults with chronic pain will receive two dopamine-boosting drugs (methylphenidate and carbidopa-levodopa) or a placebo, then undergo brain scans to measure changes in key pain-r…

This observational study uses a noninvasive EEG test to measure how the brains of people with Rett syndrome respond to simple sounds. Researchers will also ask parents or caregivers about symptoms and daily functioning. The goal is to better understand brain activity patterns in …

This study follows 105 boys from birth to age 3 who have Duchenne muscular dystrophy (DMD), identified through newborn screening. Researchers will measure motor and cognitive skills over time to understand how the disease develops in early childhood. The goal is to gather informa…

This study tests two programs to help people aged 75 and older with advanced kidney disease decide on their treatment. One program provides standard information and support, while the other adds a video decision aid and coaching from a specialist. Researchers will compare which a…

This study looks at why breast cancer patients often have trouble with memory, focus, and thinking after chemotherapy. Researchers will compare 150 women with breast cancer to healthy women of the same age using cognitive tests, blood samples, and optional brain MRIs. The goal is…

This study aims to see if a quick bedside sensory test can predict which painkiller—pregabalin, duloxetine, or a placebo—works best for people with nerve pain in their feet. About 190 adults with diabetic, chemotherapy-related, or idiopathic nerve pain will try each treatment for…

This study looks at how body composition (like weight and fat distribution) relates to airway tone and reactivity. Researchers will use a device called an oscillometer to measure airway resistance in 100 people who are already scheduled for a methacholine challenge test. The goal…

This study tests a telehealth program that helps older adults (60+) with blood cancers like leukemia or MDS talk to their doctors about their care wishes. The program also helps them fill out advance directive forms. Researchers want to see if it improves communication and reduce…

This study tests a new approach called CHORDS, which uses short digital stories from past patients and simple values exercises to help people with myeloid cancers think through their decision about a stem cell transplant. About 120 patients will be randomly assigned to receive CH…

This study tests a special tool called UR-GOAL that helps older adults (age 60+) with newly diagnosed acute myeloid leukemia and their caregivers make informed treatment choices. About 1,020 participants will be randomly assigned to use the tool or receive standard information. T…

This study aims to understand why myotonic dystrophy type 1 affects people so differently. Researchers will remotely assess muscle strength, memory, and activity in 1,000 participants, and analyze their DNA from a blood sample. All activities are done from home using a mailed too…

This study tests a communication program called COACH-Cog for older adults with both dementia and cancer. It includes a training video for doctors and a coaching session for patients and their care partners. The goal is to see if this helps everyone work together better when maki…

This study tests whether PET scans and blood tests for tumor DNA can help doctors adjust chemotherapy for people with early-stage diffuse large B-cell lymphoma (DLBCL). About 40 participants will receive standard R-CHOP treatment, and their response will be monitored with imaging…

This study is testing whether wearable devices like smartwatches can accurately track movement problems in people with Huntington's disease. About 100 participants, including those with Huntington's and healthy volunteers, will wear sensors and complete surveys and interviews at …

This study in northern Uganda will track 1,100 people with meningitis symptoms and screen 10,000 HIV-positive patients for a fungal infection that can lead to meningitis. Researchers will use modern diagnostic tests to understand the causes and outcomes of the disease. The goal i…

This study measures how well people with and without vestibular (balance) disease can sense motion through vision and balance. Researchers hope to learn how aging and disease change motion perception. About 300 healthy adults and patients with balance disorders will participate i…

This study uses a virtual reality driving simulator to see how people with vision loss from a stroke steer a car. Researchers will compare driving accuracy between 40 participants with and without vision loss. The goal is to understand how the brain adapts to missing parts of the…

This study is observing 800 people with advanced lung, colorectal, or pancreatic cancer to understand why some lose weight and muscle (cachexia). Researchers hope to find distinct subtypes of cachexia, which could lead to better, more personalized treatments in the future. Partic…

This study looks at whether early telehealth visits can help people with aggressive brain tumors (high-grade glioma) discuss and document their end-of-life wishes soon after diagnosis. About 50 patients and their families will take part. The goal is to see if these visits are pra…

This study looks at how breast milk changes over time and throughout the day, and how these changes affect baby sleep and gut health. Researchers will compare 240 mothers who either breastfeed directly or pump milk. The goal is to help families make informed choices about feeding…

This study looks at how the brain changes after a stroke that causes vision loss. Researchers will use MRI scans to see which brain areas are damaged and how they respond to visual training. The goal is to better understand how the brain can adapt and restore some vision. About 1…

This study looks at how the brain processes visual information in people with schizophrenia, bipolar disorder, or schizoaffective disorder. Researchers will use a non-invasive EEG cap to measure brain waves while participants view simple visual patterns. The goal is to find early…

This study follows 52 teens (ages 12–17) getting braces to see if having a higher body weight leads to more gum inflammation, white spots on teeth, and higher levels of certain mouth bacteria. Researchers will compare overweight and normal-weight participants by checking saliva, …

This registry aims to connect people diagnosed with myotonic dystrophy (DM) or facioscapulohumeral muscular dystrophy (FSHD) with researchers. By joining, participants help scientists better understand these inherited muscle-weakening diseases and develop future treatments. The r…

This study aims to develop special lab tests that can find tiny numbers of cancer cells left behind after treatment for acute myeloid leukemia (AML) or high-grade myelodysplastic syndrome (MDS). Researchers will follow 400 patients over time to see if these tests can predict whic…

This study follows 500 children and adults with Batten disease to learn how the condition naturally changes over time. Researchers will measure movement, thinking, behavior, and daily function using a special rating scale. The goal is to better understand the disease and improve …