University Of Rochester

This study tests whether giving radiation to the chest area can prevent or delay symptoms like pain or breathing trouble in people with Stage IV non-small cell lung cancer that has spread. About 48 participants will receive this preventive radiation along with their usual cancer …

This study compares two common bone graft materials (freeze-dried human bone and cow bone with collagen) used to preserve the jawbone after removing a front tooth. About 50 adults who need a tooth pulled and plan to get a dental implant will be randomly assigned to receive one of…

This study tests whether a preventive heart procedure (ablation) can reduce dangerous heart rhythms in people with heart failure who are getting an implantable defibrillator (ICD). About 62 high-risk participants will be randomly assigned to receive ablation within three months o…

This study tests whether destroying abnormal heart tissue (ablation) during LVAD surgery can reduce dangerous heart rhythms after the operation. About 100 adults with advanced heart failure who are getting an LVAD will be enrolled. The goal is to see if this extra procedure lower…

This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol. The goal is…

This study looks at how well umbilical cord blood stem cells from unrelated donors can restore blood cell counts in people with serious blood cancers, immune deficiencies, or genetic disorders. Researchers will track how often the transplant succeeds, how long it takes for blood …

This study tests whether adding a kidney nerve procedure (renal denervation) to the standard heart ablation can better control atrial fibrillation (AF) in people with controlled or no high blood pressure. About 50 adults with persistent AF will be randomly assigned to get either …

This study tests a combination of one chemotherapy drug and the immunotherapy pembrolizumab for people with advanced non-small cell lung cancer who have a lower performance status (ECOG PS 2), meaning they need to rest up to half the day. The goal is to see if this treatment is s…

This study explores whether offering a simple self-sampling test for HPV in the emergency department can help more people get screened for cervical cancer. About 200 eligible individuals (ages 30–65 with a cervix) will be invited to provide a self-sample during their ED visit. Th…

This study tests whether giving people a direct referral for lung cancer screening from the emergency room, plus text message reminders, helps more high-risk smokers get screened. About 300 people aged 50-80 who smoke or quit recently will be split into two groups: one gets basic…

This study tests a program called Dyadic Life Review (DLR) for people aged 65+ with advanced cancer and their caregivers. The program helps them talk about their lives together to improve emotional well-being and closeness. Researchers want to see if it's practical to run a large…

This study tests whether a home rehabilitation program can reduce the number of heartbeats needed during a 6-minute walk for people with pulmonary arterial hypertension (PAH). Researchers will enroll 55 adults with PAH to see if the program improves walking distance and quality o…

This study tests a digital therapy program called RITch®CBT that uses an avatar to guide men through cognitive behavioral therapy for addiction. The goal is to reduce cravings and substance use, and it can be done from home. The study involves 40 men with alcohol or stimulant use…

This study looks at whether two different healthy living programs, along with standard blood-thinning medication, can help people recover better after being hospitalized for a pulmonary embolism (a blood clot in the lungs). Researchers will measure heart effort during a 6-minute …

This study tests a program called SONATA that helps older adults (65+) with advanced cancer strengthen their social connections. Researchers want to see if this program is practical and can improve emotional, social, and overall well-being. 70 participants will be randomly assign…

This study tests a program called GEM-S, which combines a geriatric check-up with survivorship health education, to see if it helps older cancer survivors with daily activities, memory, and mental well-being. About 668 participants will be split into two groups: one gets GEM-S, t…

This study tests a new follow-up program for 100 adults who have had a suicidal crisis and are staying at a crisis stabilization center. The program includes group sessions and phone check-ins to help people feel less alone and more supported. The goal is to see if this approach …

This study tests whether a supplement made from seaweed, called fucoidan, can help reduce fatigue and inflammation in people who have finished cancer treatment. About 40 adult cancer survivors with ongoing fatigue will take the supplement for 8 weeks. The goal is to see if it's p…

This study aims to find the best way to treat insomnia and depression together using digital behavioral programs. Researchers will compare different treatment sequences to see which order works best. The study involves 1,500 U.S. military veterans who have both conditions. The go…

This study is testing a 4-month coaching program called SONATA for people aged 60 and older with advanced cancer. The program helps patients build a support network of family and friends to improve treatment adherence and quality of life. Up to 330 participants will receive 6 coa…

This early study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve eyesight in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study invo…

This early-phase study tests whether lisinopril, a blood pressure medicine, can reduce urinary side effects in men receiving radiation for prostate cancer. About 30 men will take lisinopril during and after treatment, and researchers will track their urinary symptoms and biomarke…

This study tests a remote education program called Tele-Savvy, designed specifically for Latino caregivers of people with Alzheimer's or related dementias. The program includes weekly group sessions and videos to help caregivers build skills and feel more confident. Researchers w…

This study looks at why people feel short of breath. Researchers will use a special breathing test called oscillometry to measure airway resistance and see if it relates to exercise test results. About 50 adults who are already scheduled for a cardiopulmonary exercise test will t…

This study looks at whether early telehealth visits can help patients with aggressive brain tumors (high-grade glioma) discuss and document their end-of-life wishes soon after diagnosis. About 50 patients and their families will take part. The goal is to see if these visits are p…

This study looks at whether combining PET scans with a blood test that measures tumor DNA can better track how well treatment is working in people with early-stage diffuse large B-cell lymphoma (DLBCL). About 40 adults with untreated limited-stage DLBCL will receive standard chem…

This study looks at how common meningitis is in northern Uganda, what causes it, and how to better diagnose and prevent it. Researchers will study 1,100 patients with meningitis symptoms and screen 10,000 HIV-positive people for a fungal infection that can lead to meningitis. The…

This study compares two programs to help people aged 75 and older with advanced kidney disease decide on their treatment. One program provides standard education, while the other offers personalized decision support. The goal is to see which approach helps patients feel more prep…

This study tests a special tool called UR-GOAL that helps older adults (age 60+) with newly diagnosed acute myeloid leukemia and their caregivers make treatment decisions. About 1,020 participants will be randomly assigned to use the tool or receive general health information. Th…

This study tests a communication program called COACH-Cog for older adults who have both Alzheimer's or related dementia and cancer. The goal is to help patients, their care partners, and doctors talk together more clearly about cancer treatment choices. About 300 people will tak…

This study aims to see if a quick, non-invasive sensory test can help predict which pain medication works best for people with nerve pain in their feet. About 190 adults with painful peripheral neuropathy will try three different treatments (pregabalin, duloxetine, and a placebo)…

This study looks at 800 people with advanced lung, pancreatic, or colorectal cancer to find different types of cancer-related weight and muscle loss (cachexia). Researchers will track symptoms, physical function, and blood markers over time. The goal is to identify distinct subty…

This study follows 105 boys with Duchenne muscular dystrophy (DMD) from birth to age 3 to understand how the disease affects early development. Researchers will measure motor and thinking skills using standard baby tests. The goal is to learn more about the earliest signs of DMD,…

This study follows 500 children and adults with Batten disease to learn how the condition changes over time. Researchers will measure movement, thinking, behavior, and daily function using special tests. The goal is to better understand the disease and improve tools for future cl…

This study tests whether watching digital stories from other patients helps people with myeloid cancers (like AML or MDS) make decisions about a stem cell transplant. About 120 adults will either watch these stories or receive usual care. The goal is to see if this approach is pr…

This study looks at whether a safe green dye, called ICG, can help surgeons see if cancer has spread to nearby lymph nodes in children with solid tumors. About 10 children under 18 who need lymph node surgery will get the dye injected during their operation. The goal is to see if…

This study aims to understand why some breast cancer patients experience memory and concentration problems after chemotherapy. Researchers will compare 150 women—those about to start chemo and healthy volunteers—using cognitive tests and blood samples over five months. An optiona…

This study aims to understand why myotonic dystrophy type 1 affects people so differently. Researchers will have 1,000 adults with DM1 do simple tests at home, like grip strength and memory games, and provide a blood sample for genetic analysis. The goal is to find better ways to…

This study looks at how breast milk changes over time and throughout the day, and how that affects baby sleep and gut health. Researchers will compare 240 mothers who either breastfeed directly or pump milk. The goal is to help families make informed choices about feeding their b…

This study tests a telehealth program to help older adults (60+) with blood cancers like leukemia talk with their doctors about their care wishes. It aims to reduce anxiety and improve completion of advance directives. About 207 patients and their caregivers will participate remo…