Could a Mother's diet during pregnancy prevent peanut and egg allergies in her baby?

NCT ID NCT06260956

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Recruiting now This study
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Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
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Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
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When the status isn't known

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First seen Jul 14, 2026 · Last updated Jul 21, 2026 · Updated 4 times

Summary

This study investigates whether a mother's consumption or avoidance of peanut and egg during pregnancy and breastfeeding influences her baby's risk of developing allergies to these foods. Pregnant women are assigned to either eat or avoid peanut and egg from 27 weeks of pregnancy through the first four months of breastfeeding. The main goal is to see if this dietary approach reduces the chance of the baby becoming sensitized to peanut or egg by four months of age.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
maternal consumption or avoidance of peanut and egg during pregnancy and breastfeeding
What this could lead to
If it works, this could point toward a simple dietary guideline for pregnant and breastfeeding mothers to help prevent peanut and egg allergies in their babies.
What could go wrong
This is an early-stage study with 500 participants, so results may not apply to all populations. It only measures sensitization at four months, not long-term allergy outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 day and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: • o Subject must be able to understand and provide informed consent. * Mothers will be English-speaking adults, 18 years or older. (Spanish speaking adults may be included after consent document is translated and Spanish speaking study representatives are available to conduct and answer questions during informed consent process and for study follow up.) * Maternal consent must be provided for infants. * Pregnant women from the time pregnancy is confirmed until 27 weeks of gestation. * Self-reported at time of enrollment: * no chronic inflammatory conditions that require long-term systemic immunosuppressive medications in first or second trimester * carrying a fetus with a first-degree relative (i.e., mother, father, full sibling) with any self-reported or physician-diagnosed allergic disease (asthma, allergic rhinitis, atopic dermatitis, or food allergy). * Intend to give their infant their own breast milk for more than 3 months. * Can confidently say they have eaten PN and egg and have tolerated consumption with no food allergy reactions. * Willing to be randomized to consumption or avoidance diet. * Uncomplicated pregnancy (no gestational diabetes, no preeclampsia, no hyperemesis gravidarum), self-reported at time of enrollment. Infants will be minimum age, 1 day (birth), through 365 days (12 months). Exclusion Criteria: * Inability or unwillingness of subject to give written informed consent or comply with study protocol. * Known history of renal/liver/cardiac insufficiency in the mother or infant. * Pregnant women with PN or egg allergy. * Pregnant women who refuse to eat PN (or peanut products) and/or eggs. * Physician diagnosed immunodeficiency in the mother or infant. * Current, diagnosed, mental illness or current, diagnosed, or self-reported, drug or alcohol abuse that, in the opinion of the investigator, would interfere with the subject's ability to comply with study requirements. * Past or current medical problems or findings from medical history that are not listed above, which, in the opinion of the investigator, may pose additional risks to the mother or infant from participation in the study, may interfere with the subject's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.

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Conditions

The condition(s) this trial relates to.

allergic disease Egg Hypersensitivity Nut and Peanut Hypersensitivity Peanut Hypersensitivity food allergy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • University of Rochester

    RECRUITING

    Rochester, New York, 14642, United States

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