University Of Rochester

This study tests whether a combination of chemotherapy (FOLFOX) and a short course of radiation can eliminate advanced rectal cancer without needing surgery. 12 adults with locally advanced rectal cancer are being watched closely after treatment to see if the cancer fully respond…

This study tests a program called TEAM-UP for Teens that uses school-based telemedicine visits and video check-ins to help teenagers with hard-to-control asthma. The goal is to reduce asthma symptoms and emergency visits. About 333 teens aged 12-17 from low-income urban areas wil…

This study looks at whether high-dose vitamin D and a home exercise program (walking and strength training) can help prevent bone loss in women being treated for breast cancer. About 191 postmenopausal women with early-stage breast cancer will take either vitamin D or a placebo, …

This study compares two ways to repeat a heart ablation for people with persistent atrial fibrillation (AF) whose first ablation didn't work. The standard repeat method isolates the pulmonary veins; the experimental method also treats the left atrial posterior wall. Researchers w…

This study looks at how to best help primary care clinics adopt team-based home blood pressure monitoring. Over 5,700 patients and their care teams will use a program where patients send in their home readings and get support from doctors, nurses, and community resources. The goa…

This study tests whether adding a targeted drug called polatuzumab vedotin to a standard chemotherapy regimen (R-miniCHP) can help people aged 75 and older with a type of lymphoma called DLBCL. The goal is to see if the combination improves how long patients live without their ca…

This study tests whether using an implantable heart monitor (or a wearable patch) to detect atrial fibrillation early after catheter ablation can reduce the total time spent in AF. About 120 people with paroxysmal or persistent AF will be monitored for 15 months. The goal is to s…

This study aimed to see if giving less chemotherapy before surgery, followed by targeted therapy, could work well for women with early-stage HER2-positive breast cancer. It planned to enroll women with tumors at least 2 cm or lymph node involvement. However, the study was withdra…

This phase II trial is testing whether giving a chemotherapy combination called mFOLFOX6 before the usual chemoradiation and surgery can help prevent esophageal cancer from returning. The study involves 40 adults with locally advanced esophageal cancer that can be surgically remo…

This study adapts an existing HIV prevention program, Many Men Many Voices, into a version called LAFIYA for young sexual minority men living in slums in Ghana. The goal is to reduce stigma and increase the use of HIV self-testing kits. Researchers will test whether the program i…

This study tests a program called Wingman-Connect, designed to reduce suicide risk among U.S. Air Force personnel in training. Nearly 3,000 recruits will be randomly assigned to either the Wingman-Connect training or a standard control session. The program teaches skills like bui…

This study tests whether training school personnel in vaccine communication and providing promotional materials can increase flu vaccination rates among students. About 6,000 students from participating schools will be tracked. The goal is to see if these simple steps lead to mor…

This study looks at whether a training program called Wingman-Connect can reduce suicide attempts among junior Airmen. About 17,400 Airmen at 8 US Air Force bases will receive the training, which focuses on building strong relationships, finding purpose, seeking help, and managin…

This phase 2 trial tests whether a daily dose of EGCG, a compound found in green tea, can reduce frailty and inflammation in people aged 65 and older who have survived cancer. About 118 participants will take either EGCG or a placebo for 12 weeks. The study is currently suspended…

This study looks at whether a special follow-up program, including group sessions and phone calls, can help people after a suicidal crisis. About 100 adults who come to a crisis stabilization center will take part. The goal is to see if the program helps them feel less like a bur…

This study tests whether virtual yoga classes can help cancer survivors who have trouble sleeping. About 42 survivors will either take 8 virtual yoga sessions over 4 weeks or continue their usual care. Researchers will measure changes in insomnia and sleep quality to see if the o…

This study tests a phone-based sleep therapy for people who have insomnia and drink alcohol in ways that could harm their health. The therapy adapts standard insomnia treatment to also address alcohol-related thoughts and behaviors. Researchers will first refine the approach with…

This study looks at whether online community support and telemedicine can improve quality of life for people with Parkinson's disease, Lewy body dementia, and related conditions, as well as their caregivers. About 632 participants will receive palliative care training for their d…

This study planned to test a program called Lafiya (meaning 'Wellness') designed to reduce stigma and discrimination faced by young gay, bisexual, and other men who have sex with men living in Ghanaian slums. The goal was to see if the program could increase HIV testing, use of P…

This study is for heart failure patients who do not have a specific heart rhythm pattern called left bundle branch block (non-LBBB). These patients often get a device called CRT-D, which combines a pacemaker and a defibrillator, but not everyone responds well. Researchers will fo…

This study follows 298 older adults with HIV in Zambia to compare brain health between those who have had HIV for a long time (7+ years) and those with a shorter infection (1-2 years). Researchers will track memory, thinking, mental health, frailty, and nerve health over 6 years.…

This study follows 75 adults with benign or slow-growing brain tumors who are receiving partial brain radiation. Researchers will use memory tests and MRI scans before treatment and at 6 and 12 months after to see how radiation affects thinking and memory. The goal is to identify…

This study tests a special health program designed to improve the well-being of sign language interpreters. Researchers will compare the program to a general health program in 133 certified interpreters. The goal is to see if the tailored program leads to better mental and physic…

This study aimed to compare standard oxygen therapy with two different flow rates of high-flow nasal cannula in children aged 2-17 with moderate to severe asthma. The goal was to see if it was possible to enroll enough patients and measure breathing improvements. However, the stu…

This study tests whether a small device placed under the skin can detect hidden atrial fibrillation (an irregular heartbeat) in people with heart failure who are at high risk for stroke. About 477 participants either received the implant or standard care. The goal is to see if th…

This study tests whether trained peer coaches can help people with limited health literacy discuss heart disease prevention with their doctors. Researchers will enroll 60 patients at one clinic and analyze whether coaching leads to better conversations about treatment options. Th…

This study tests a new computer-based visual training task for people who have lost part of their vision due to a stroke. Participants watch moving patterns on a screen and learn to detect motion direction, with the goal of improving visual abilities. The study first checks if th…

This study looks at children having surgery to remove a common neck lump called a thyroglossal duct cyst. Some kids will have a small drain placed during surgery, and some will not. The goal is to see if using a drain reduces problems like infection, fluid buildup, or the need fo…

This study looks at whether offering cervical cancer screening in the emergency department helps more people get tested. About 200 women and transgender/non-binary individuals with a cervix, aged 25-65, will be offered a self-sampling kit or clinic referral. Researchers will call…

This study looks at how the brain's visual system changes in the year after a stroke that damages the vision center. Researchers will measure vision and brain structure over time, and give participants a home-based computer training program that asks them to detect moving dots. T…

This study aimed to test a focused radiation treatment (HDR brachytherapy) for men whose prostate cancer returned only in the prostate gland after earlier radiation therapy. It planned to enroll adults with biopsy-confirmed recurrence seen on a special PET scan. However, the stud…

This study looks at how the brain handles visual information by measuring eye movements in healthy adults. Researchers will show images on a screen and track participants' eye movements using a special camera. The goal is to better understand normal vision, not to treat any disea…

This study tracks 350 college athletes to see how repeated, non-concussive head impacts affect brain function. It also tests whether 2 weeks of daily aerobic exercise can help the brain recover faster compared to stretching. Researchers will use eye scans, blood tests, and brain …