HIV study seeks clues to brain aging in Long-Term survivors

NCT ID NCT05678660

Ongoing Knowledge-focused Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 298 older adults with HIV in Zambia to compare brain health between those who have had HIV for a long time (7+ years) and those with a shorter infection (1-2 years). Researchers will track memory, thinking, mental health, frailty, and nerve health over 6 years. The goal is to understand if longer HIV infection leads to faster brain aging.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal how the length of HIV infection affects brain aging and frailty, pointing toward ways to support healthy aging in people with HIV.
What could go wrong: This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to all populations or regions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Frailty HIV infectious disease premature aging syndrome Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGING, PREMATURE

Contacts and locations

Locations

Chikankata Hospital

Mazabuka, Southern Province, Zambia
Chilenje Level 1 Hospital

Lusaka, Zambia
Monze Mission Hospital

Monze, Southern Province, Zambia

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